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PMC:7712180 / 99502-101407 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
4391 367-376 Gene denotes Neu5,9Ac2
4392 531-543 Gene denotes α2,3 to α2,6 Gene:170589
4393 994-998 Gene denotes α2,3 Gene:28923
4394 1004-1015 Gene denotes α2,6 [148]. Gene:28906
4395 1557-1561 Gene denotes ACE2 Gene:59272
4396 169-173 Species denotes CoVs Tax:11118
4397 265-274 Species denotes HCoV-OC43 Tax:31631
4398 577-582 Species denotes human Tax:9606
4399 680-689 Species denotes HCoV-OC43 Tax:31631
4400 908-916 Species denotes MERS-CoV Tax:1335626
4401 920-924 Species denotes CoVs Tax:11118
4402 953-961 Species denotes MERS-CoV Tax:1335626
4403 1041-1045 Species denotes CoVs Tax:11118
4404 1242-1262 Species denotes Hipposideros armiger Tax:186990
4405 1281-1292 Species denotes dromedaries Tax:9838
4406 1301-1321 Species denotes Hipposideros armiger Tax:186990
4407 1355-1374 Species denotes Rhinolophus sinicus Tax:89399
4408 1404-1429 Species denotes Rhinolophus ferrumequinum Tax:59479
4409 1463-1477 Species denotes Paguma larvata Tax:9675
4410 1510-1524 Species denotes Manis javanica Tax:9974
4411 1551-1556 Species denotes human Tax:9606
4412 1596-1604 Species denotes SARS-CoV Tax:694009
4413 1610-1620 Species denotes SARS-CoV-2 Tax:2697049
4414 1629-1650 Species denotes Tylonycteris pachypus Tax:258959
4415 1661-1679 Species denotes Camelus bactrianus Tax:9837
4416 1273-1280 Species denotes Camelus Tax:9837
4417 280-284 Species denotes HKU1 Tax:290028
4418 695-699 Species denotes HKU1 Tax:290028
4419 1586-1590 Species denotes NL63 Tax:277944
4420 105-108 Species denotes IAV Tax:11320
4421 188-191 Species denotes IAV Tax:11320
4422 944-947 Species denotes IAV Tax:11320
4423 1190-1193 Gene denotes CTD Gene:1283
4424 965-968 Gene denotes NTD Gene:80199
4425 224-230 Chemical denotes Neu5Ac
4426 303-309 Chemical denotes Neu5Ac
4427 878-884 Chemical denotes Neu5Ac
4428 1695-1701 Chemical denotes glycan MESH:D011134
4429 113-127 Disease denotes CoV infections MESH:D018352

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T525 0-174 Sentence denotes Figure 4 Sialyl glycans and proteins on the epithelial cell surface that are important determinants for IAV and CoV infections. (a) Sialyl glycan receptors of IAVs and CoVs.
T526 175-386 Sentence denotes Whereas most IAV HAs prefer the most common Sia, Neu5Ac, over Neu5Gc as a receptor [192], HCoV-OC43 and -HKU1 S1-NTDs recognize Neu5Ac modified with an O-acetyl group at the C9-position (R1), Neu5,9Ac2 [92,193].
T527 387-600 Sentence denotes It is well known that sialyl linkage at the C2-position (R2) is a key host determinant of IAVs and that change of their binding preference from α2,3 to α2,6 is a critical factor of avian-to-human host switch [10].
T528 601-802 Sentence denotes In contrast, there has not been sufficient study on the linkage specificity of HCoV-OC43 and -HKU1 binding, although it is known that HCoV-43 can bind to Neu5,9Ac2α2,6Galβ1,4GlcNAc (9-O-Ac-6SLN) [193].
T529 803-932 Sentence denotes Distinct from β1CoVs, additional O-acetylation at the C7 or C9-position to Neu5Ac impedes the binding of MERS-CoV (β3CoVs) [112].
T530 933-1046 Sentence denotes Like avian IAV HAs, MERS-CoV S1-NTD prefers Neu5Ac linked to α2,3 over α2,6 [148]. (b) Protein receptors of CoVs.
T531 1047-1207 Sentence denotes Only virus binding site (VBS), receptor amino acids covering the area of the interface between the protein receptor and the indicated viral S1-CTD, are colored.
T532 1208-1211 Sentence denotes Ac.
T533 1212-1680 Sentence denotes No., accession number; BatHa, Hipposideros armiger; camelCd, Camelus dromedaries, batHa, Hipposideros armiger (Ac.No., XP_019522954.1); batRs, Rhinolophus sinicus (Ac.No., AGZ48803.1); batRf, Rhinolophus ferrumequinum (Ac.No., XP_032963186.1); civet, Paguma larvata (Ac.No., AAX63775.1); pangolin, Manis javanica (Ac.No., XP_017505752.1); human ACE2 (Ac.No., ACT66268); NL, NL63; S1, SARS-CoV; S2, SARS-CoV-2; batTp, Tylonycteris pachypus; camelCb, Camelus bactrianus.
T534 1681-1687 Sentence denotes Right:
T535 1688-1780 Sentence denotes Sialyl glycan structure and top view and side view of surface diagrams of protein receptors.
T536 1781-1850 Sentence denotes VBSs are colored according to the aa sequences on the left-hand side.
T537 1851-1905 Sentence denotes 6u7e, 6m17, 1pfq are from [194,195,196], respectively.