PMC:7712180 / 99502-101407
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
4391 | 367-376 | Gene | denotes | Neu5,9Ac2 | |
4392 | 531-543 | Gene | denotes | α2,3 to α2,6 | Gene:170589 |
4393 | 994-998 | Gene | denotes | α2,3 | Gene:28923 |
4394 | 1004-1015 | Gene | denotes | α2,6 [148]. | Gene:28906 |
4395 | 1557-1561 | Gene | denotes | ACE2 | Gene:59272 |
4396 | 169-173 | Species | denotes | CoVs | Tax:11118 |
4397 | 265-274 | Species | denotes | HCoV-OC43 | Tax:31631 |
4398 | 577-582 | Species | denotes | human | Tax:9606 |
4399 | 680-689 | Species | denotes | HCoV-OC43 | Tax:31631 |
4400 | 908-916 | Species | denotes | MERS-CoV | Tax:1335626 |
4401 | 920-924 | Species | denotes | CoVs | Tax:11118 |
4402 | 953-961 | Species | denotes | MERS-CoV | Tax:1335626 |
4403 | 1041-1045 | Species | denotes | CoVs | Tax:11118 |
4404 | 1242-1262 | Species | denotes | Hipposideros armiger | Tax:186990 |
4405 | 1281-1292 | Species | denotes | dromedaries | Tax:9838 |
4406 | 1301-1321 | Species | denotes | Hipposideros armiger | Tax:186990 |
4407 | 1355-1374 | Species | denotes | Rhinolophus sinicus | Tax:89399 |
4408 | 1404-1429 | Species | denotes | Rhinolophus ferrumequinum | Tax:59479 |
4409 | 1463-1477 | Species | denotes | Paguma larvata | Tax:9675 |
4410 | 1510-1524 | Species | denotes | Manis javanica | Tax:9974 |
4411 | 1551-1556 | Species | denotes | human | Tax:9606 |
4412 | 1596-1604 | Species | denotes | SARS-CoV | Tax:694009 |
4413 | 1610-1620 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
4414 | 1629-1650 | Species | denotes | Tylonycteris pachypus | Tax:258959 |
4415 | 1661-1679 | Species | denotes | Camelus bactrianus | Tax:9837 |
4416 | 1273-1280 | Species | denotes | Camelus | Tax:9837 |
4417 | 280-284 | Species | denotes | HKU1 | Tax:290028 |
4418 | 695-699 | Species | denotes | HKU1 | Tax:290028 |
4419 | 1586-1590 | Species | denotes | NL63 | Tax:277944 |
4420 | 105-108 | Species | denotes | IAV | Tax:11320 |
4421 | 188-191 | Species | denotes | IAV | Tax:11320 |
4422 | 944-947 | Species | denotes | IAV | Tax:11320 |
4423 | 1190-1193 | Gene | denotes | CTD | Gene:1283 |
4424 | 965-968 | Gene | denotes | NTD | Gene:80199 |
4425 | 224-230 | Chemical | denotes | Neu5Ac | |
4426 | 303-309 | Chemical | denotes | Neu5Ac | |
4427 | 878-884 | Chemical | denotes | Neu5Ac | |
4428 | 1695-1701 | Chemical | denotes | glycan | MESH:D011134 |
4429 | 113-127 | Disease | denotes | CoV infections | MESH:D018352 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T525 | 0-174 | Sentence | denotes | Figure 4 Sialyl glycans and proteins on the epithelial cell surface that are important determinants for IAV and CoV infections. (a) Sialyl glycan receptors of IAVs and CoVs. |
T526 | 175-386 | Sentence | denotes | Whereas most IAV HAs prefer the most common Sia, Neu5Ac, over Neu5Gc as a receptor [192], HCoV-OC43 and -HKU1 S1-NTDs recognize Neu5Ac modified with an O-acetyl group at the C9-position (R1), Neu5,9Ac2 [92,193]. |
T527 | 387-600 | Sentence | denotes | It is well known that sialyl linkage at the C2-position (R2) is a key host determinant of IAVs and that change of their binding preference from α2,3 to α2,6 is a critical factor of avian-to-human host switch [10]. |
T528 | 601-802 | Sentence | denotes | In contrast, there has not been sufficient study on the linkage specificity of HCoV-OC43 and -HKU1 binding, although it is known that HCoV-43 can bind to Neu5,9Ac2α2,6Galβ1,4GlcNAc (9-O-Ac-6SLN) [193]. |
T529 | 803-932 | Sentence | denotes | Distinct from β1CoVs, additional O-acetylation at the C7 or C9-position to Neu5Ac impedes the binding of MERS-CoV (β3CoVs) [112]. |
T530 | 933-1046 | Sentence | denotes | Like avian IAV HAs, MERS-CoV S1-NTD prefers Neu5Ac linked to α2,3 over α2,6 [148]. (b) Protein receptors of CoVs. |
T531 | 1047-1207 | Sentence | denotes | Only virus binding site (VBS), receptor amino acids covering the area of the interface between the protein receptor and the indicated viral S1-CTD, are colored. |
T532 | 1208-1211 | Sentence | denotes | Ac. |
T533 | 1212-1680 | Sentence | denotes | No., accession number; BatHa, Hipposideros armiger; camelCd, Camelus dromedaries, batHa, Hipposideros armiger (Ac.No., XP_019522954.1); batRs, Rhinolophus sinicus (Ac.No., AGZ48803.1); batRf, Rhinolophus ferrumequinum (Ac.No., XP_032963186.1); civet, Paguma larvata (Ac.No., AAX63775.1); pangolin, Manis javanica (Ac.No., XP_017505752.1); human ACE2 (Ac.No., ACT66268); NL, NL63; S1, SARS-CoV; S2, SARS-CoV-2; batTp, Tylonycteris pachypus; camelCb, Camelus bactrianus. |
T534 | 1681-1687 | Sentence | denotes | Right: |
T535 | 1688-1780 | Sentence | denotes | Sialyl glycan structure and top view and side view of surface diagrams of protein receptors. |
T536 | 1781-1850 | Sentence | denotes | VBSs are colored according to the aa sequences on the left-hand side. |
T537 | 1851-1905 | Sentence | denotes | 6u7e, 6m17, 1pfq are from [194,195,196], respectively. |