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PMC:7696151 / 8596-9883 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
227 258-261 Gene denotes CD4 Gene:920
228 305-308 Gene denotes CD4 Gene:920
229 562-565 Gene denotes CD4 Gene:920
230 845-865 Gene denotes Toll-like receptor 4 Gene:7099
231 867-872 Gene denotes TLR-4 Gene:7099
232 1133-1138 Gene denotes gp120 Gene:3700
233 1207-1212 Gene denotes gp120 Gene:3700
234 99-104 Species denotes HIV-1 Tax:11676
235 109-114 Species denotes HIV-2 Tax:11709
236 152-157 Species denotes HIV-1 Tax:11676
237 340-345 Species denotes human Tax:9606
238 0-3 Species denotes HIV Tax:12721
239 236-239 Species denotes HIV Tax:12721
240 1043-1046 Species denotes HIV Tax:12721
241 740-759 Chemical denotes lipopolysaccharides MESH:D008070
242 968-971 Chemical denotes HCQ MESH:D006886
243 187-201 Disease denotes HIV infections MESH:D015658
244 507-520 Disease denotes HIV infection MESH:D015658
245 935-948 Disease denotes HIV infection MESH:D015658

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T74 0-115 Sentence denotes HIV is part of the genus Lentivirus, of the Retroviridae family, and it is divided into two lines: HIV-1 and HIV-2.
T75 116-215 Sentence denotes The most virulent and infectious is HIV-1, since it causes most of the HIV infections in the world.
T76 216-355 Sentence denotes The target cells of HIV are those rich in CD4 receptors, such as some lymphocytes called CD4+, which play a crucial role in human immunity.
T77 356-486 Sentence denotes Indeed, these lymphocytes activate different immune system cells depending on the type of unwanted host they come in contact with.
T78 487-598 Sentence denotes It seems that acute HIV infection is highly linked to a rapid depletion of CD4+ T cells in gut lymphoid tissue.
T79 599-771 Sentence denotes This event is related to an alteration of the intestinal mucosa integrity, resulting in bloodstream translocation of microbial products like lipopolysaccharides (LPS) [42].
T80 772-949 Sentence denotes It has been hypothesized that LPS, through the binding and activation of Toll-like receptor 4 (TLR-4), is responsible for the immune system activation observed in HIV infection.
T81 950-1164 Sentence denotes Although the real HCQ mechanism of action has not been well assessed, it seems that the anti-HIV effects are highly linked to the post-translational modification of glycoprotein 120 (gp120) in monocyte and T cells.
T82 1165-1287 Sentence denotes Consequently, there was a modification of gp120 immunogenic properties and a reduction of new virions infectivity [15,16].