PMC:7696151 / 7129-7784 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"178","span":{"begin":0,"end":3},"obj":"Chemical"},{"id":"179","span":{"begin":109,"end":112},"obj":"Chemical"},{"id":"180","span":{"begin":313,"end":316},"obj":"Chemical"},{"id":"181","span":{"begin":91,"end":107},"obj":"Disease"},{"id":"182","span":{"begin":253,"end":262},"obj":"Disease"},{"id":"183","span":{"begin":645,"end":654},"obj":"Disease"}],"attributes":[{"id":"A178","pred":"tao:has_database_id","subj":"178","obj":"MESH:D006886"},{"id":"A179","pred":"tao:has_database_id","subj":"179","obj":"MESH:D006886"},{"id":"A180","pred":"tao:has_database_id","subj":"180","obj":"MESH:D006886"},{"id":"A181","pred":"tao:has_database_id","subj":"181","obj":"MESH:D001102"},{"id":"A182","pred":"tao:has_database_id","subj":"182","obj":"MESH:D007239"},{"id":"A183","pred":"tao:has_database_id","subj":"183","obj":"MESH:D007239"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"HCQ has been used mainly as an antimalarial drug, but it has also proven effective against viral infections. HCQ demonstrated its antiviral efficacy in inhibiting the endosomal-lysosomal acidification, which is essential for the entry, replication, and infection process of different viruses [12]. In particular, HCQ-induced alkalinization processes cause the expansion and vacuolization of lysosomes, inhibiting their functions. This activity can reduce post-transcriptional protein modification, enzyme release, receptor recycling, activation of cell signaling pathways, and cell membranes repair. As a result, there is the prevention of cell infection."}

{"project":"LitCovid-sentences","denotations":[{"id":"T63","span":{"begin":0,"end":108},"obj":"Sentence"},{"id":"T64","span":{"begin":109,"end":297},"obj":"Sentence"},{"id":"T65","span":{"begin":298,"end":429},"obj":"Sentence"},{"id":"T66","span":{"begin":430,"end":599},"obj":"Sentence"},{"id":"T67","span":{"begin":600,"end":655},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"HCQ has been used mainly as an antimalarial drug, but it has also proven effective against viral infections. HCQ demonstrated its antiviral efficacy in inhibiting the endosomal-lysosomal acidification, which is essential for the entry, replication, and infection process of different viruses [12]. In particular, HCQ-induced alkalinization processes cause the expansion and vacuolization of lysosomes, inhibiting their functions. This activity can reduce post-transcriptional protein modification, enzyme release, receptor recycling, activation of cell signaling pathways, and cell membranes repair. As a result, there is the prevention of cell infection."}