PMC:7696151 / 3520-4065 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"106","span":{"begin":10,"end":15},"obj":"Chemical"},{"id":"107","span":{"begin":146,"end":149},"obj":"Chemical"},{"id":"108","span":{"begin":225,"end":227},"obj":"Chemical"},{"id":"109","span":{"begin":232,"end":235},"obj":"Chemical"},{"id":"110","span":{"begin":386,"end":391},"obj":"Chemical"},{"id":"111","span":{"begin":446,"end":451},"obj":"Chemical"}],"attributes":[{"id":"A106","pred":"tao:has_database_id","subj":"106","obj":"MESH:D014867"},{"id":"A107","pred":"tao:has_database_id","subj":"107","obj":"MESH:D006886"},{"id":"A108","pred":"tao:has_database_id","subj":"108","obj":"MESH:D002738"},{"id":"A109","pred":"tao:has_database_id","subj":"109","obj":"MESH:D006886"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"These are water-soluble molecules and, for their chemical nature, can pass the cell membranes; however, the presence of the hydroxyl group in the HCQ makes it more polar and less lipophilic [8]. Moreover, the accumulation of CQ and HCQ in intracellular compartments is due principally to the side chain and both have enantiomers (R and S isomers). Researches also demonstrated that the R-HCQ is present in the blood at higher concentrations than S-HCQ. These results suggested the stereoselective processes in the metabolism of the molecule [9]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T29","span":{"begin":0,"end":194},"obj":"Sentence"},{"id":"T30","span":{"begin":195,"end":347},"obj":"Sentence"},{"id":"T31","span":{"begin":348,"end":452},"obj":"Sentence"},{"id":"T32","span":{"begin":453,"end":545},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"These are water-soluble molecules and, for their chemical nature, can pass the cell membranes; however, the presence of the hydroxyl group in the HCQ makes it more polar and less lipophilic [8]. Moreover, the accumulation of CQ and HCQ in intracellular compartments is due principally to the side chain and both have enantiomers (R and S isomers). Researches also demonstrated that the R-HCQ is present in the blood at higher concentrations than S-HCQ. These results suggested the stereoselective processes in the metabolism of the molecule [9]."}