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PMC:7696151 / 20678-22332 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
612 153-161 Species denotes patients Tax:9606
613 410-418 Species denotes patients Tax:9606
614 583-591 Species denotes patients Tax:9606
615 907-915 Species denotes patients Tax:9606
616 1132-1140 Species denotes patients Tax:9606
617 1597-1605 Species denotes patients Tax:9606
618 940-951 Species denotes chikungunya Tax:37124
619 52-57 Species denotes CHIKV Tax:37124
620 202-207 Species denotes CHIKV Tax:37124
621 13-16 Chemical denotes HCQ MESH:D006886
622 129-132 Chemical denotes HCQ MESH:D006886
623 662-665 Chemical denotes HCQ MESH:D006886
624 686-689 Chemical denotes MXT MESH:D008727
625 694-707 Chemical denotes sulfasalazine MESH:D012460
626 827-830 Chemical denotes HCQ MESH:D006886
627 866-869 Chemical denotes MTX MESH:D008727
628 874-887 Chemical denotes sulfasalazine MESH:D012460
629 989-992 Chemical denotes HCQ MESH:D006886
630 1061-1064 Chemical denotes MTX MESH:D008727
631 1074-1087 Chemical denotes sulfasalazine MESH:D012460
632 1104-1107 Chemical denotes HCQ MESH:D006886
633 1244-1254 Chemical denotes prednisone MESH:D011241
634 1521-1524 Chemical denotes MTX MESH:D008727
635 1547-1550 Chemical denotes HCQ MESH:D006886
636 312-318 Disease denotes nausea MESH:D009325
637 320-330 Disease denotes stomatitis MESH:D013280
638 332-336 Disease denotes rash MESH:D005076
639 338-346 Disease denotes headache MESH:D006261
640 371-384 Disease denotes CHIKV disease MESH:D003141
641 465-474 Disease denotes synovitis MESH:D013585
642 952-961 Disease denotes arthritis MESH:D001168
643 1381-1385 Disease denotes pain MESH:D010146
644 1582-1596 Disease denotes CHIKV infected MESH:D007239
645 1635-1648 Disease denotes polyarthritis MESH:D001168

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T16 312-318 Phenotype denotes nausea http://purl.obolibrary.org/obo/HP_0002018
T17 320-330 Phenotype denotes stomatitis http://purl.obolibrary.org/obo/HP_0010280
T18 332-336 Phenotype denotes rash http://purl.obolibrary.org/obo/HP_0000988
T19 338-346 Phenotype denotes headache http://purl.obolibrary.org/obo/HP_0002315
T20 465-474 Phenotype denotes synovitis http://purl.obolibrary.org/obo/HP_0100769
T21 952-961 Phenotype denotes arthritis http://purl.obolibrary.org/obo/HP_0001369
T22 1381-1385 Phenotype denotes pain http://purl.obolibrary.org/obo/HP_0012531

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T147 0-81 Sentence denotes In contrast, HCQ seems to affect the improvement of CHIKV chronic phase diseases.
T148 82-222 Sentence denotes In a recent multicenter study, the efficacy of HCQ was evaluated in 39 patients with rheumatic manifestation related to CHIKV chronic phase.
T149 223-419 Sentence denotes In four subjects, the treatment was interrupted due to the onset of side effects such as nausea, stomatitis, rash, headache, while the evolution of CHIKV disease was evaluated in only 22 patients.
T150 420-605 Sentence denotes After three months of treatment, evidence of synovitis was disappeared in 10 of 20 subjects (50%) with swollen joins while complete remission was verified in five patients (19.2%) [27].
T151 606-752 Sentence denotes However, another study demonstrated that the effects of HCQ in combination with MXT and sulfasalazine were superior to those shown in monotherapy.
T152 753-962 Sentence denotes In particular, in a randomized controlled open-label study, the impact of HCQ in monotherapy or association with MTX and sulfasalazine was assessed in 72 patients with chronic persistent chikungunya arthritis.
T153 963-1141 Sentence denotes In this trial, 400 mg/day HCQ were administrated to 35 subjects, while a combination of 15 mg/day MTX, 1 g/day sulfasalazine, and 400 mg/day HCQ was administrated to 37 patients.
T154 1142-1268 Sentence denotes Either treatment lasted 24 weeks and for the first 6 weeks, both groups received an escalated dose of prednisone (7.5 mg/day).
T155 1269-1391 Sentence denotes At the end of the 24th week, only the combination of drugs improved disease activity and reduced disability and pain [28].
T156 1392-1654 Sentence denotes These results, following those obtained in a previous uncontrolled 16-week study, since a reduction in ACR score was shown after MTX (15–20 mg/weekly) and HCQ (400 mg/day) administration to CHIKV infected patients with persistent inflammatory polyarthritis [29].