PMC:7665480 / 18936-19721 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7665480","sourcedb":"PMC","sourceid":"7665480","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7665480","text":"Only 2 of our 5 hospitalized patients were treated with ritonavir/lopinavir therapy. At the beginning of the Northern Italy pandemic, the Italian government agency for the regulation of drugs developed several protocols for off-label usage of antiretrovirals [26]. These 2 patients had fulfilled inclusion criteria for enrolment in one of the first randomized clinical trials for these drugs against COVID-19. With increasing evidence of both the absence of clinical benefit from ritonavir/lopinavir in the more seriously ill patients and the risk of toxicity associated with the combined administration of hydroxychloroquine and azithromycin, their usage in the general COVID-19 population has been limited. As a result, we have abandoned their use in our heart transplant population.","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"414","span":{"begin":29,"end":37},"obj":"Species"},{"id":"415","span":{"begin":273,"end":281},"obj":"Species"},{"id":"416","span":{"begin":526,"end":534},"obj":"Species"},{"id":"417","span":{"begin":56,"end":65},"obj":"Chemical"},{"id":"418","span":{"begin":66,"end":75},"obj":"Chemical"},{"id":"419","span":{"begin":480,"end":489},"obj":"Chemical"},{"id":"420","span":{"begin":490,"end":499},"obj":"Chemical"},{"id":"421","span":{"begin":607,"end":625},"obj":"Chemical"},{"id":"422","span":{"begin":630,"end":642},"obj":"Chemical"},{"id":"423","span":{"begin":400,"end":408},"obj":"Disease"},{"id":"424","span":{"begin":551,"end":559},"obj":"Disease"},{"id":"425","span":{"begin":671,"end":679},"obj":"Disease"}],"attributes":[{"id":"A414","pred":"tao:has_database_id","subj":"414","obj":"Tax:9606"},{"id":"A415","pred":"tao:has_database_id","subj":"415","obj":"Tax:9606"},{"id":"A416","pred":"tao:has_database_id","subj":"416","obj":"Tax:9606"},{"id":"A417","pred":"tao:has_database_id","subj":"417","obj":"MESH:D019438"},{"id":"A418","pred":"tao:has_database_id","subj":"418","obj":"MESH:D061466"},{"id":"A419","pred":"tao:has_database_id","subj":"419","obj":"MESH:D019438"},{"id":"A420","pred":"tao:has_database_id","subj":"420","obj":"MESH:D061466"},{"id":"A421","pred":"tao:has_database_id","subj":"421","obj":"MESH:D006886"},{"id":"A422","pred":"tao:has_database_id","subj":"422","obj":"MESH:D017963"},{"id":"A423","pred":"tao:has_database_id","subj":"423","obj":"MESH:C000657245"},{"id":"A424","pred":"tao:has_database_id","subj":"424","obj":"MESH:D064420"},{"id":"A425","pred":"tao:has_database_id","subj":"425","obj":"MESH:C000657245"},{"subj":"414","pred":"source","obj":"LitCovid-PubTator"},{"subj":"415","pred":"source","obj":"LitCovid-PubTator"},{"subj":"416","pred":"source","obj":"LitCovid-PubTator"},{"subj":"417","pred":"source","obj":"LitCovid-PubTator"},{"subj":"418","pred":"source","obj":"LitCovid-PubTator"},{"subj":"419","pred":"source","obj":"LitCovid-PubTator"},{"subj":"420","pred":"source","obj":"LitCovid-PubTator"},{"subj":"421","pred":"source","obj":"LitCovid-PubTator"},{"subj":"422","pred":"source","obj":"LitCovid-PubTator"},{"subj":"423","pred":"source","obj":"LitCovid-PubTator"},{"subj":"424","pred":"source","obj":"LitCovid-PubTator"},{"subj":"425","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T208","span":{"begin":0,"end":84},"obj":"Sentence"},{"id":"T209","span":{"begin":85,"end":264},"obj":"Sentence"},{"id":"T210","span":{"begin":265,"end":409},"obj":"Sentence"},{"id":"T211","span":{"begin":410,"end":708},"obj":"Sentence"},{"id":"T212","span":{"begin":709,"end":785},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T208","pred":"source","obj":"LitCovid-sentences"},{"subj":"T209","pred":"source","obj":"LitCovid-sentences"},{"subj":"T210","pred":"source","obj":"LitCovid-sentences"},{"subj":"T211","pred":"source","obj":"LitCovid-sentences"},{"subj":"T212","pred":"source","obj":"LitCovid-sentences"}]},{"project":"testtesttest","denotations":[{"id":"T117","span":{"begin":224,"end":227},"obj":"Body_part"},{"id":"T118","span":{"begin":757,"end":762},"obj":"Body_part"}],"attributes":[{"id":"A117","pred":"uberon_id","subj":"T117","obj":"http://purl.obolibrary.org/obo/UBERON_0034754"},{"id":"A118","pred":"uberon_id","subj":"T118","obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"id":"A119","pred":"uberon_id","subj":"T118","obj":"http://purl.obolibrary.org/obo/UBERON_0007100"},{"id":"A120","pred":"uberon_id","subj":"T118","obj":"http://purl.obolibrary.org/obo/UBERON_0015228"},{"id":"A121","pred":"uberon_id","subj":"T118","obj":"http://purl.obolibrary.org/obo/UBERON_0015230"},{"subj":"T117","pred":"source","obj":"testtesttest"},{"subj":"T118","pred":"source","obj":"testtesttest"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#93a5ec","default":true},{"id":"LitCovid-sentences","color":"#bfec93"},{"id":"testtesttest","color":"#ec93d9"}]}]}}