PMC:7652766 / 99378-109033 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7652766","sourcedb":"PMC","sourceid":"7652766","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7652766","text":"Chloroquine and Hydroxychloroquine\nChloroquine and hydroxychloroquine have been used worldwide for more than 70 years, and they are part of the WHO model list of essential medicines (346). They were synthesized specifically for the treatment and chemoprevention of malaria, but their immunomodulatory activity led these drugs to be used against autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and other inflammatory rheumatic diseases; they also show broad-spectrum antiviral effects (347–349).\nRegarding the chemical structure, hydroxychloroquine differs from chloroquine in the presence of a hydroxyl group at the end of the side chain: the N-ethyl substituent is β-hydroxylated. Both drugs have similar pharmacokinetics, with rapid gastrointestinal absorption and renal elimination, but different clinical indications and toxic doses, in which hydroxychloroquine is less toxic and more clinically used in the malaria model (348, 350).\nThe action mechanism of these drugs has direct molecular effects on lysosomal activity, autophagy, and signaling pathways (347). As antivirals, chloroquine is known to block SARS-CoV-1-infection by increasing endosomal pH required for virus entry, as well as interfering with the glycosylation of cellular receptors (351, 352). The possible mechanism against SARS-CoV-2 is the inhibition of virus entry by altering the glycosylation of ACE2, reducing the binding efficiency between ACE2 in host cells and the S protein on the surface of the SARS-CoV-2, thus preventing the virus from binding to target cells (348, 351, 353). In addition to a potent antiviral inhibition, the immunomodulatory activity of these drugs is well established in the literature. Proposed effects of chloroquine on the immune system include increasing the export of soluble antigens into the cytosol of dendritic cells, the blocking of TLR7 and TLR9 signaling, thus reconstructing CD8+ cytotoxic viral response, and inhibiting and/or reducing the production of inflammatory cytokines like IL-1, IL-6, TNF, and IFN-α (347, 354–359), which has an important role in the immunopathogenesis of COVID-19, as previously reported in item 4.1.\nIn vitro studies on SARS-CoV-2 have demonstrated the low-dose action of these drugs, having found the lowest half-maximal effective concentrations (EC50s). In addition, their association with azithromycin significantly inhibited viral replication (326, 360–362). In humans, a study by Gao, Tian, and Yang (363) showed that patients treated with chloroquine phosphate had inhibited exacerbation of pneumonia, improving lung imaging findings, promoting a virus-negative conversion, and shortening the COVID-19 course.\nThe association of hydroxychloroquine with other drugs is also suggested, with emphasis on studies using azithromycin, a broad-spectrum macrolide antibiotic primarily used to treat respiratory, enteric, and genitourinary bacterial infections. Despite not yet being approved for antiviral therapy, it has been studied in vitro and in clinical trials for activity against several viruses (364).\nGautret et al. (365) demonstrated the effectiveness of the hydroxychloroquine-azithromycin combination in a non-randomized clinical trial with 36 COVID-19 patients. A 57.1% rate of cure was attributed to the patients treated with hydroxychloroquine, however, when combined with azithromycin, 100% of the patients were cured. The authors suggested a synergistic effect of the drug combination since both were reported to have antiviral and immunomodulatory activity in the literature.\nGautret et al. (366) conducted another analysis to provide evidence of a beneficial effect of co-administration of hydroxychloroquine with azithromycin in a non-comparative and uncontrolled observational study with 80 mildly infected SARS-CoV-2 patients. The hydroxychloroquine/azithromycin treatment showed that 81.3% of the patients had a favorable result with a rapid decrease in nasopharyngeal viral load at day 8 (93%), reducing the mean length of stay in the hospital.\nArshad et al. (367) performed a multicenter observational study, which included 2541 COVID-19 patients. Patients were separated into four groups: untreated (n = 409), treated with hydroxychloroquine (n = 1202), the association of hydroxychloroquine and azithromycin, and azithromycin only (n = 147). The authors suggested that the treatment with hydroxychloroquine alone and in combination with azithromycin was associated with a reduction in the hazard ratio for death when compared with receipt of neither medication.\nHowever, a lot of controversy has been raised about these data, and many important limitations of this study were considered by several authors (368–373), threatening the validity of the reported findings. Among these, there is the potential for immortal time bias and selection bias, the administration of corticosteroids in most patients treated with hydroxychloroquine than in other groups, and a disproportionately high share of patients with cardiovascular comorbidity in the untreated group.\nSeeking to analyze the efficacy of early treatment using hydroxychloroquine and azithromycin, Million et al. (374) carried out a retrospective study with 1061 SARS-CoV-2 infected patients. In the study, 91.7% of the patients reached good clinical results and virological cure within 10 days, while 4.3% had a poor outcome associated with advanced age. However, it is worth mentioning that the study did not include a control group to establish a comparison.\nTo assess the use of hydroxychloroquine as a prophylactic measure, Boulware et al. (375) performed a randomized, double-blind trial in adults who had been exposed to individuals diagnosed with COVID-19, either in the home or work environment. The authors found that postexposure prophylaxis did not prevent the development of the disease.\nAn important question that may be considered about chloroquine and its derivate is the numerous adverse effects reported, such as nausea, pruritus, headache, hypoglycemia, neuropsychiatric effects, and idiosyncratic hypersensitivity reactions. In long-term treatments, effects such as retinopathy, vacuolar myopathy, neuropathy, restrictive cardiomyopathy, and cardiac conduction disorders are also reported. Furthermore, its concomitant use with azithromycin may predispose patients to arrhythmias (213), which represents a major negative implication.\nHuang et al. (376) conducted a randomized clinical trial with 22 patients in China to compare the effects of chloroquine and lopinavir/ritonavir. Even though chloroquine led to some clinical improvement, half of the patients experienced adverse effects such as vomiting, abdominal pain, nausea, diarrhea, skin rashes, cough, and shortness of breath.\nSatlin et al. (377), Magagnoli et al. (378), Rosenberg et al. (379), and Ip et al. (380) reported that treatment with hydroxychloroquine, azithromycin, or both were not associated with a survival benefit among patients and there were no significant differences in mortality for patients receiving hydroxychloroquine during hospitalization. Similarly, Mahévas et al. (381) analyzed the efficacy of hydroxychloroquine in patients hospitalized with coronavirus pneumonia who needed oxygen but not intensive care, through a comparative observational study. 181 patients were analyzed, 84 of whom received hydroxychloroquine. Data showed there was no effect on reducing admissions to intensive care or deaths on day 21 after hospital admission and the hydroxychloroquine treatment did not have any effect on survival without acute respiratory distress syndrome on day 21 after hospital admission.\nTang et al. (382) carried out a multicenter, open, randomized, and controlled clinical trial evaluating 150 patients admitted with confirmed mild to severe COVID-19; of these, 75 were treated with hydroxychloroquine. The authors demonstrated that treatment does not contribute to the elimination of the virus.\nBorba et al. (383) conducted a phase IIb, double-blind, randomized clinical trial comparing the effects of high doses (600 mg/twice daily for 10 days) and low doses (450 mg twice daily at day 1 and once daily for 4 days) of chloroquine in 81 and 40 patients, respectively. The results did not evidence lower viral load in respiratory secretions, not even in combination with azithromycin. The mortality rate for the high-dose group was over twice as high as the low-dose group (39.0% vs. 16.0%). Additionally, some patients, mainly in the high-dose group, showed adverse effects, such as increased creatine phosphokinase (CK) and CK-MB, while the high-dosage group exhibited more corrected QT (QTc) interval prolongation. Neither of the dosages was able to influence lethality. The authors concluded that critically ill patients should not receive chloroquine at high doses.\nIn the meantime, a cohort study with 201 patients showed that the use of chloroquine or hydroxychloroquine combined with azithromycin generated a higher increase in QT prolongation than chloroquine or hydroxychloroquine monotherapy (384). More recently, another large observational study involving 1376 cases of COVID-19 from New York found no significant association between the use of hydroxychloroquine and intubation or death (385).\nCurrently, chloroquine and hydroxychloroquine are the most largely studied compounds in the context of COVID-19 treatment, encompassing at least 320 ongoing clinical trials. However, considering that more recent studies failed to prove any favorable effect of their use in COVID-19 patients, the WHO discontinued the study of hydroxychloroquine in the Solidarity Trial 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