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LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T134 345-364 Phenotype denotes autoimmune diseases http://purl.obolibrary.org/obo/HP_0002960
T135 374-394 Phenotype denotes rheumatoid arthritis http://purl.obolibrary.org/obo/HP_0001370
T136 396-424 Phenotype denotes systemic lupus erythematosus http://purl.obolibrary.org/obo/HP_0002725
T137 2578-2587 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T138 5994-6000 Phenotype denotes nausea http://purl.obolibrary.org/obo/HP_0002018
T139 6002-6010 Phenotype denotes pruritus http://purl.obolibrary.org/obo/HP_0000989
T140 6012-6020 Phenotype denotes headache http://purl.obolibrary.org/obo/HP_0002315
T141 6022-6034 Phenotype denotes hypoglycemia http://purl.obolibrary.org/obo/HP_0001943
T142 6080-6096 Phenotype denotes hypersensitivity http://purl.obolibrary.org/obo/HP_0041092
T143 6149-6160 Phenotype denotes retinopathy http://purl.obolibrary.org/obo/HP_0000488
T144 6171-6179 Phenotype denotes myopathy http://purl.obolibrary.org/obo/HP_0003198
T145 6181-6191 Phenotype denotes neuropathy http://purl.obolibrary.org/obo/HP_0009830
T146 6193-6219 Phenotype denotes restrictive cardiomyopathy http://purl.obolibrary.org/obo/HP_0001723
T147 6351-6362 Phenotype denotes arrhythmias http://purl.obolibrary.org/obo/HP_0011675
T148 6678-6686 Phenotype denotes vomiting http://purl.obolibrary.org/obo/HP_0002013
T149 6688-6702 Phenotype denotes abdominal pain http://purl.obolibrary.org/obo/HP_0002027
T150 6704-6710 Phenotype denotes nausea http://purl.obolibrary.org/obo/HP_0002018
T151 6712-6720 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T152 6735-6740 Phenotype denotes cough http://purl.obolibrary.org/obo/HP_0012735
T153 6746-6765 Phenotype denotes shortness of breath http://purl.obolibrary.org/obo/HP_0002098
T154 7225-7234 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T155 7593-7613 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T156 8557-8589 Phenotype denotes increased creatine phosphokinase http://purl.obolibrary.org/obo/HP_0003236

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T486 0-34 Sentence denotes Chloroquine and Hydroxychloroquine
T487 35-188 Sentence denotes Chloroquine and hydroxychloroquine have been used worldwide for more than 70 years, and they are part of the WHO model list of essential medicines (346).
T488 189-527 Sentence denotes They were synthesized specifically for the treatment and chemoprevention of malaria, but their immunomodulatory activity led these drugs to be used against autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, and other inflammatory rheumatic diseases; they also show broad-spectrum antiviral effects (347–349).
T489 528-714 Sentence denotes Regarding the chemical structure, hydroxychloroquine differs from chloroquine in the presence of a hydroxyl group at the end of the side chain: the N-ethyl substituent is β-hydroxylated.
T490 715-970 Sentence denotes Both drugs have similar pharmacokinetics, with rapid gastrointestinal absorption and renal elimination, but different clinical indications and toxic doses, in which hydroxychloroquine is less toxic and more clinically used in the malaria model (348, 350).
T491 971-1099 Sentence denotes The action mechanism of these drugs has direct molecular effects on lysosomal activity, autophagy, and signaling pathways (347).
T492 1100-1298 Sentence denotes As antivirals, chloroquine is known to block SARS-CoV-1-infection by increasing endosomal pH required for virus entry, as well as interfering with the glycosylation of cellular receptors (351, 352).
T493 1299-1595 Sentence denotes The possible mechanism against SARS-CoV-2 is the inhibition of virus entry by altering the glycosylation of ACE2, reducing the binding efficiency between ACE2 in host cells and the S protein on the surface of the SARS-CoV-2, thus preventing the virus from binding to target cells (348, 351, 353).
T494 1596-1725 Sentence denotes In addition to a potent antiviral inhibition, the immunomodulatory activity of these drugs is well established in the literature.
T495 1726-2180 Sentence denotes Proposed effects of chloroquine on the immune system include increasing the export of soluble antigens into the cytosol of dendritic cells, the blocking of TLR7 and TLR9 signaling, thus reconstructing CD8+ cytotoxic viral response, and inhibiting and/or reducing the production of inflammatory cytokines like IL-1, IL-6, TNF, and IFN-α (347, 354–359), which has an important role in the immunopathogenesis of COVID-19, as previously reported in item 4.1.
T496 2181-2336 Sentence denotes In vitro studies on SARS-CoV-2 have demonstrated the low-dose action of these drugs, having found the lowest half-maximal effective concentrations (EC50s).
T497 2337-2443 Sentence denotes In addition, their association with azithromycin significantly inhibited viral replication (326, 360–362).
T498 2444-2696 Sentence denotes In humans, a study by Gao, Tian, and Yang (363) showed that patients treated with chloroquine phosphate had inhibited exacerbation of pneumonia, improving lung imaging findings, promoting a virus-negative conversion, and shortening the COVID-19 course.
T499 2697-2939 Sentence denotes The association of hydroxychloroquine with other drugs is also suggested, with emphasis on studies using azithromycin, a broad-spectrum macrolide antibiotic primarily used to treat respiratory, enteric, and genitourinary bacterial infections.
T500 2940-3089 Sentence denotes Despite not yet being approved for antiviral therapy, it has been studied in vitro and in clinical trials for activity against several viruses (364).
T501 3090-3254 Sentence denotes Gautret et al. (365) demonstrated the effectiveness of the hydroxychloroquine-azithromycin combination in a non-randomized clinical trial with 36 COVID-19 patients.
T502 3255-3414 Sentence denotes A 57.1% rate of cure was attributed to the patients treated with hydroxychloroquine, however, when combined with azithromycin, 100% of the patients were cured.
T503 3415-3573 Sentence denotes The authors suggested a synergistic effect of the drug combination since both were reported to have antiviral and immunomodulatory activity in the literature.
T504 3574-3828 Sentence denotes Gautret et al. (366) conducted another analysis to provide evidence of a beneficial effect of co-administration of hydroxychloroquine with azithromycin in a non-comparative and uncontrolled observational study with 80 mildly infected SARS-CoV-2 patients.
T505 3829-4048 Sentence denotes The hydroxychloroquine/azithromycin treatment showed that 81.3% of the patients had a favorable result with a rapid decrease in nasopharyngeal viral load at day 8 (93%), reducing the mean length of stay in the hospital.
T506 4049-4152 Sentence denotes Arshad et al. (367) performed a multicenter observational study, which included 2541 COVID-19 patients.
T507 4153-4348 Sentence denotes Patients were separated into four groups: untreated (n = 409), treated with hydroxychloroquine (n = 1202), the association of hydroxychloroquine and azithromycin, and azithromycin only (n = 147).
T508 4349-4568 Sentence denotes The authors suggested that the treatment with hydroxychloroquine alone and in combination with azithromycin was associated with a reduction in the hazard ratio for death when compared with receipt of neither medication.
T509 4569-4774 Sentence denotes However, a lot of controversy has been raised about these data, and many important limitations of this study were considered by several authors (368–373), threatening the validity of the reported findings.
T510 4775-5066 Sentence denotes Among these, there is the potential for immortal time bias and selection bias, the administration of corticosteroids in most patients treated with hydroxychloroquine than in other groups, and a disproportionately high share of patients with cardiovascular comorbidity in the untreated group.
T511 5067-5255 Sentence denotes Seeking to analyze the efficacy of early treatment using hydroxychloroquine and azithromycin, Million et al. (374) carried out a retrospective study with 1061 SARS-CoV-2 infected patients.
T512 5256-5418 Sentence denotes In the study, 91.7% of the patients reached good clinical results and virological cure within 10 days, while 4.3% had a poor outcome associated with advanced age.
T513 5419-5524 Sentence denotes However, it is worth mentioning that the study did not include a control group to establish a comparison.
T514 5525-5767 Sentence denotes To assess the use of hydroxychloroquine as a prophylactic measure, Boulware et al. (375) performed a randomized, double-blind trial in adults who had been exposed to individuals diagnosed with COVID-19, either in the home or work environment.
T515 5768-5863 Sentence denotes The authors found that postexposure prophylaxis did not prevent the development of the disease.
T516 5864-6107 Sentence denotes An important question that may be considered about chloroquine and its derivate is the numerous adverse effects reported, such as nausea, pruritus, headache, hypoglycemia, neuropsychiatric effects, and idiosyncratic hypersensitivity reactions.
T517 6108-6272 Sentence denotes In long-term treatments, effects such as retinopathy, vacuolar myopathy, neuropathy, restrictive cardiomyopathy, and cardiac conduction disorders are also reported.
T518 6273-6416 Sentence denotes Furthermore, its concomitant use with azithromycin may predispose patients to arrhythmias (213), which represents a major negative implication.
T519 6417-6562 Sentence denotes Huang et al. (376) conducted a randomized clinical trial with 22 patients in China to compare the effects of chloroquine and lopinavir/ritonavir.
T520 6563-6766 Sentence denotes Even though chloroquine led to some clinical improvement, half of the patients experienced adverse effects such as vomiting, abdominal pain, nausea, diarrhea, skin rashes, cough, and shortness of breath.
T521 6767-7106 Sentence denotes Satlin et al. (377), Magagnoli et al. (378), Rosenberg et al. (379), and Ip et al. (380) reported that treatment with hydroxychloroquine, azithromycin, or both were not associated with a survival benefit among patients and there were no significant differences in mortality for patients receiving hydroxychloroquine during hospitalization.
T522 7107-7319 Sentence denotes Similarly, Mahévas et al. (381) analyzed the efficacy of hydroxychloroquine in patients hospitalized with coronavirus pneumonia who needed oxygen but not intensive care, through a comparative observational study.
T523 7320-7387 Sentence denotes 181 patients were analyzed, 84 of whom received hydroxychloroquine.
T524 7388-7658 Sentence denotes Data showed there was no effect on reducing admissions to intensive care or deaths on day 21 after hospital admission and the hydroxychloroquine treatment did not have any effect on survival without acute respiratory distress syndrome on day 21 after hospital admission.
T525 7659-7875 Sentence denotes Tang et al. (382) carried out a multicenter, open, randomized, and controlled clinical trial evaluating 150 patients admitted with confirmed mild to severe COVID-19; of these, 75 were treated with hydroxychloroquine.
T526 7876-7968 Sentence denotes The authors demonstrated that treatment does not contribute to the elimination of the virus.
T527 7969-8241 Sentence denotes Borba et al. (383) conducted a phase IIb, double-blind, randomized clinical trial comparing the effects of high doses (600 mg/twice daily for 10 days) and low doses (450 mg twice daily at day 1 and once daily for 4 days) of chloroquine in 81 and 40 patients, respectively.
T528 8242-8357 Sentence denotes The results did not evidence lower viral load in respiratory secretions, not even in combination with azithromycin.
T529 8358-8464 Sentence denotes The mortality rate for the high-dose group was over twice as high as the low-dose group (39.0% vs. 16.0%).
T530 8465-8690 Sentence denotes Additionally, some patients, mainly in the high-dose group, showed adverse effects, such as increased creatine phosphokinase (CK) and CK-MB, while the high-dosage group exhibited more corrected QT (QTc) interval prolongation.
T531 8691-8746 Sentence denotes Neither of the dosages was able to influence lethality.
T532 8747-8843 Sentence denotes The authors concluded that critically ill patients should not receive chloroquine at high doses.
T533 8844-9082 Sentence denotes In the meantime, a cohort study with 201 patients showed that the use of chloroquine or hydroxychloroquine combined with azithromycin generated a higher increase in QT prolongation than chloroquine or hydroxychloroquine monotherapy (384).
T534 9083-9280 Sentence denotes More recently, another large observational study involving 1376 cases of COVID-19 from New York found no significant association between the use of hydroxychloroquine and intubation or death (385).
T535 9281-9454 Sentence denotes Currently, chloroquine and hydroxychloroquine are the most largely studied compounds in the context of COVID-19 treatment, encompassing at least 320 ongoing clinical trials.
T536 9455-9655 Sentence denotes However, considering that more recent studies failed to prove any favorable effect of their use in COVID-19 patients, the WHO discontinued the study of hydroxychloroquine in the Solidarity Trial (13).

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3644 0-11 Chemical denotes Chloroquine MESH:D002738
3645 16-34 Chemical denotes Hydroxychloroquine MESH:D006886
3654 326-328 Gene denotes to Gene:6999
3655 35-46 Chemical denotes Chloroquine MESH:D002738
3656 51-69 Chemical denotes hydroxychloroquine MESH:D006886
3657 265-272 Disease denotes malaria MESH:D008288
3658 345-364 Disease denotes autoimmune diseases MESH:D001327
3659 374-394 Disease denotes rheumatoid arthritis MESH:D001172
3660 396-424 Disease denotes systemic lupus erythematosus MESH:D008180
3661 449-467 Disease denotes rheumatic diseases MESH:D012216
3667 625-626 Gene denotes a Gene:351
3668 562-580 Chemical denotes hydroxychloroquine MESH:D006886
3669 594-605 Chemical denotes chloroquine MESH:D002738
3670 880-898 Chemical denotes hydroxychloroquine MESH:D006886
3671 945-952 Disease denotes malaria MESH:D008288
3692 1407-1411 Gene denotes ACE2 Gene:59272
3693 1453-1457 Gene denotes ACE2 Gene:59272
3694 1882-1886 Gene denotes TLR7 Gene:51284
3695 1891-1895 Gene denotes TLR9 Gene:54106
3696 1927-1930 Gene denotes CD8 Gene:925
3697 2035-2039 Gene denotes IL-1 Gene:3552
3698 2041-2045 Gene denotes IL-6 Gene:3569
3699 2047-2050 Gene denotes TNF Gene:7124
3700 2056-2061 Gene denotes IFN-α Gene:3439
3701 1480-1481 Gene denotes S Gene:43740568
3702 1608-1610 Gene denotes to Gene:6999
3703 1563-1565 Gene denotes to Gene:6999
3704 1136-1138 Gene denotes to Gene:6999
3705 1330-1340 Species denotes SARS-CoV-2 Tax:2697049
3706 1512-1522 Species denotes SARS-CoV-2 Tax:2697049
3707 1611-1612 Gene denotes a Gene:351
3708 1115-1126 Chemical denotes chloroquine MESH:D002738
3709 1746-1757 Chemical denotes chloroquine MESH:D002738
3710 1145-1165 Disease denotes SARS-CoV-1-infection MESH:C000657245
3711 2135-2143 Disease denotes COVID-19 MESH:C000657245
3721 2201-2211 Species denotes SARS-CoV-2 Tax:2697049
3722 2447-2453 Species denotes humans Tax:9606
3723 2504-2512 Species denotes patients Tax:9606
3724 2632-2633 Gene denotes a Gene:351
3725 2455-2456 Gene denotes a Gene:351
3726 2373-2385 Chemical denotes azithromycin MESH:D017963
3727 2526-2547 Chemical denotes chloroquine phosphate MESH:C023676
3728 2578-2587 Disease denotes pneumonia MESH:D011014
3729 2680-2688 Disease denotes COVID-19 MESH:C000657245
3737 2869-2871 Gene denotes to Gene:6999
3738 2878-2889 Species denotes respiratory Tax:12814
3739 2816-2817 Gene denotes a Gene:351
3740 2716-2734 Chemical denotes hydroxychloroquine MESH:D006886
3741 2802-2814 Chemical denotes azithromycin MESH:D017963
3742 2833-2842 Chemical denotes macrolide MESH:D018942
3743 2918-2938 Disease denotes bacterial infections MESH:D001424
3757 3507-3509 Gene denotes to Gene:6999
3758 3291-3293 Gene denotes to Gene:6999
3759 3245-3253 Species denotes patients Tax:9606
3760 3298-3306 Species denotes patients Tax:9606
3761 3394-3402 Species denotes patients Tax:9606
3762 3437-3438 Gene denotes a Gene:351
3763 3255-3256 Gene denotes A Gene:351
3764 3196-3197 Gene denotes a Gene:351
3765 3149-3167 Chemical denotes hydroxychloroquine MESH:D006886
3766 3168-3180 Chemical denotes azithromycin MESH:D017963
3767 3320-3338 Chemical denotes hydroxychloroquine MESH:D006886
3768 3368-3380 Chemical denotes azithromycin MESH:D017963
3769 3236-3244 Disease denotes COVID-19 MESH:C000657245
3783 3622-3624 Gene denotes to Gene:6999
3784 3808-3818 Species denotes SARS-CoV-2 Tax:2697049
3785 3819-3827 Species denotes patients Tax:9606
3786 3900-3908 Species denotes patients Tax:9606
3787 3937-3938 Gene denotes a Gene:351
3788 3913-3914 Gene denotes a Gene:351
3789 3729-3730 Gene denotes a Gene:351
3790 3645-3646 Gene denotes a Gene:351
3791 3689-3707 Chemical denotes hydroxychloroquine MESH:D006886
3792 3713-3725 Chemical denotes azithromycin MESH:D017963
3793 3833-3851 Chemical denotes hydroxychloroquine MESH:D006886
3794 3852-3864 Chemical denotes azithromycin MESH:D017963
3795 3799-3807 Disease denotes infected MESH:D007239
3808 4143-4151 Species denotes patients Tax:9606
3809 4153-4161 Species denotes Patients Tax:9606
3810 4477-4478 Gene denotes a Gene:351
3811 4079-4080 Gene denotes a Gene:351
3812 4229-4247 Chemical denotes hydroxychloroquine MESH:D006886
3813 4279-4297 Chemical denotes hydroxychloroquine MESH:D006886
3814 4302-4314 Chemical denotes azithromycin MESH:D017963
3815 4320-4332 Chemical denotes azithromycin MESH:D017963
3816 4395-4413 Chemical denotes hydroxychloroquine MESH:D006886
3817 4444-4456 Chemical denotes azithromycin MESH:D017963
3818 4134-4142 Disease denotes COVID-19 MESH:C000657245
3819 4513-4518 Disease denotes death MESH:D003643
3825 4900-4908 Species denotes patients Tax:9606
3826 5002-5010 Species denotes patients Tax:9606
3827 4967-4968 Gene denotes a Gene:351
3828 4578-4579 Gene denotes a Gene:351
3829 4922-4940 Chemical denotes hydroxychloroquine MESH:D006886
3841 5498-5500 Gene denotes to Gene:6999
3842 5075-5077 Gene denotes to Gene:6999
3843 5246-5254 Species denotes patients Tax:9606
3844 5283-5291 Species denotes patients Tax:9606
3845 5511-5512 Gene denotes a Gene:351
3846 5482-5483 Gene denotes a Gene:351
3847 5374-5375 Gene denotes a Gene:351
3848 5194-5195 Gene denotes a Gene:351
3849 5124-5142 Chemical denotes hydroxychloroquine MESH:D006886
3850 5147-5159 Chemical denotes azithromycin MESH:D017963
3851 5231-5245 Disease denotes CoV-2 infected MESH:C000657245
3858 5688-5690 Gene denotes to Gene:6999
3859 5525-5527 Gene denotes To Gene:6999
3860 5624-5625 Gene denotes a Gene:351
3861 5568-5569 Gene denotes a Gene:351
3862 5546-5564 Chemical denotes hydroxychloroquine MESH:D006886
3863 5718-5726 Disease denotes COVID-19 MESH:C000657245
3880 6348-6350 Gene denotes to Gene:6999
3881 6339-6347 Species denotes patients Tax:9606
3882 6387-6388 Gene denotes a Gene:351
3883 5915-5926 Chemical denotes chloroquine MESH:D002738
3884 6311-6323 Chemical denotes azithromycin MESH:D017963
3885 5994-6000 Disease denotes nausea MESH:D009325
3886 6002-6010 Disease denotes pruritus MESH:D011537
3887 6012-6020 Disease denotes headache MESH:D006261
3888 6022-6034 Disease denotes hypoglycemia MESH:D007003
3889 6066-6106 Disease denotes idiosyncratic hypersensitivity reactions MESH:D004342
3890 6149-6160 Disease denotes retinopathy MESH:D012164
3891 6162-6179 Disease denotes vacuolar myopathy MESH:C536522
3892 6181-6191 Disease denotes neuropathy MESH:D009422
3893 6205-6219 Disease denotes cardiomyopathy MESH:D009202
3894 6225-6253 Disease denotes cardiac conduction disorders MESH:D001145
3895 6351-6362 Disease denotes arrhythmias MESH:D001145
3911 6591-6593 Gene denotes to Gene:6999
3912 6500-6502 Gene denotes to Gene:6999
3913 6482-6490 Species denotes patients Tax:9606
3914 6633-6641 Species denotes patients Tax:9606
3915 6446-6447 Gene denotes a Gene:351
3916 6526-6537 Chemical denotes chloroquine MESH:D002738
3917 6542-6561 Chemical denotes lopinavir/ritonavir MESH:C558899
3918 6575-6586 Chemical denotes chloroquine MESH:D002738
3919 6678-6686 Disease denotes vomiting MESH:D014839
3920 6688-6702 Disease denotes abdominal pain MESH:D015746
3921 6704-6710 Disease denotes nausea MESH:D009325
3922 6712-6720 Disease denotes diarrhea MESH:D003967
3923 6722-6733 Disease denotes skin rashes MESH:D005076
3924 6735-6740 Disease denotes cough MESH:D003371
3925 6746-6765 Disease denotes shortness of breath MESH:D004417
3944 7443-7445 Gene denotes to Gene:6999
3945 6977-6985 Species denotes patients Tax:9606
3946 7045-7053 Species denotes patients Tax:9606
3947 7186-7194 Species denotes patients Tax:9606
3948 7324-7332 Species denotes patients Tax:9606
3949 7285-7286 Gene denotes a Gene:351
3950 6952-6953 Gene denotes a Gene:351
3951 6885-6903 Chemical denotes hydroxychloroquine MESH:D006886
3952 6905-6917 Chemical denotes azithromycin MESH:D017963
3953 7064-7082 Chemical denotes hydroxychloroquine MESH:D006886
3954 7164-7182 Chemical denotes hydroxychloroquine MESH:D006886
3955 7246-7252 Chemical denotes oxygen MESH:D010100
3956 7368-7386 Chemical denotes hydroxychloroquine MESH:D006886
3957 7514-7532 Chemical denotes hydroxychloroquine MESH:D006886
3958 7031-7040 Disease denotes mortality MESH:D003643
3959 7213-7234 Disease denotes coronavirus pneumonia MESH:D018352
3960 7464-7470 Disease denotes deaths MESH:D003643
3961 7587-7622 Disease denotes acute respiratory distress syndrome MESH:D012128
3968 7936-7938 Gene denotes to Gene:6999
3969 7805-7807 Gene denotes to Gene:6999
3970 7767-7775 Species denotes patients Tax:9606
3971 7689-7690 Gene denotes a Gene:351
3972 7856-7874 Chemical denotes hydroxychloroquine MESH:D006886
3973 7815-7823 Disease denotes COVID-19 MESH:C000657245
3986 8723-8725 Gene denotes to Gene:6999
3987 8218-8226 Species denotes patients Tax:9606
3988 8484-8492 Species denotes patients Tax:9606
3989 8789-8797 Species denotes patients Tax:9606
3990 8291-8302 Species denotes respiratory Tax:12814
3991 7998-7999 Gene denotes a Gene:351
3992 8193-8204 Chemical denotes chloroquine MESH:D002738
3993 8344-8356 Chemical denotes azithromycin MESH:D017963
3994 8567-8575 Chemical denotes creatine MESH:D003401
3995 8817-8828 Chemical denotes chloroquine MESH:D002738
3996 8362-8371 Disease denotes mortality MESH:D003643
3997 8774-8788 Disease denotes critically ill MESH:D016638
4010 8885-8893 Species denotes patients Tax:9606
4011 8988-8989 Gene denotes a Gene:351
4012 8861-8862 Gene denotes a Gene:351
4013 8917-8928 Chemical denotes chloroquine MESH:D002738
4014 8932-8950 Chemical denotes hydroxychloroquine MESH:D006886
4015 8965-8977 Chemical denotes azithromycin MESH:D017963
4016 9030-9041 Chemical denotes chloroquine MESH:D002738
4017 9045-9063 Chemical denotes hydroxychloroquine MESH:D006886
4018 9231-9249 Chemical denotes hydroxychloroquine MESH:D006886
4019 9009-9024 Disease denotes QT prolongation MESH:D008133
4020 9156-9164 Disease denotes COVID-19 MESH:C000657245
4021 9268-9273 Disease denotes death MESH:D003643
4029 9508-9510 Gene denotes to Gene:6999
4030 9563-9571 Species denotes patients Tax:9606
4031 9292-9303 Chemical denotes chloroquine MESH:D002738
4032 9308-9326 Chemical denotes hydroxychloroquine MESH:D006886
4033 9607-9625 Chemical denotes hydroxychloroquine MESH:D006886
4034 9384-9392 Disease denotes COVID-19 MESH:C000657245
4035 9554-9562 Disease denotes COVID-19 MESH:C000657245