PMC:7652766 / 9852-10584 JSONTXT

{"project":"LitCovid-sentences","denotations":[{"id":"T53","span":{"begin":0,"end":202},"obj":"Sentence"},{"id":"T54","span":{"begin":203,"end":732},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The genomic changes of SARS-CoV-2 appear in both non-structural and structural proteins – notably in proteins S, M, and N – affecting viral multiplication, encapsulation, tropism, and transmission (39). Two important characteristics were described in the genome of SARS-CoV-2 that lead to alterations in the S protein: (i) receptor-binding domain (RBD), which is the most variable part of the viral genome, appears to be optimized for binding to the human ACE2 receptor, and (ii) presence of a polybasic (furin) cleavage site at the S1 and S2 boundary, via the insertion of twelve nucleotides, which allows effective cleavage by furin and other proteases and has a role in determining viral tropism, infectivity, and host range (4)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"437","span":{"begin":456,"end":460},"obj":"Gene"},{"id":"438","span":{"begin":629,"end":634},"obj":"Gene"},{"id":"439","span":{"begin":505,"end":510},"obj":"Gene"},{"id":"440","span":{"begin":120,"end":121},"obj":"Gene"},{"id":"441","span":{"begin":110,"end":111},"obj":"Gene"},{"id":"442","span":{"begin":443,"end":445},"obj":"Gene"},{"id":"443","span":{"begin":415,"end":417},"obj":"Gene"},{"id":"444","span":{"begin":286,"end":288},"obj":"Gene"},{"id":"445","span":{"begin":23,"end":33},"obj":"Species"},{"id":"446","span":{"begin":265,"end":275},"obj":"Species"},{"id":"447","span":{"begin":450,"end":455},"obj":"Species"},{"id":"448","span":{"begin":663,"end":664},"obj":"Gene"},{"id":"449","span":{"begin":492,"end":493},"obj":"Gene"}],"attributes":[{"id":"A437","pred":"tao:has_database_id","subj":"437","obj":"Gene:59272"},{"id":"A438","pred":"tao:has_database_id","subj":"438","obj":"Gene:5045"},{"id":"A439","pred":"tao:has_database_id","subj":"439","obj":"Gene:5045"},{"id":"A440","pred":"tao:has_database_id","subj":"440","obj":"Gene:43740575"},{"id":"A441","pred":"tao:has_database_id","subj":"441","obj":"Gene:43740568"},{"id":"A442","pred":"tao:has_database_id","subj":"442","obj":"Gene:6999"},{"id":"A443","pred":"tao:has_database_id","subj":"443","obj":"Gene:6999"},{"id":"A444","pred":"tao:has_database_id","subj":"444","obj":"Gene:6999"},{"id":"A445","pred":"tao:has_database_id","subj":"445","obj":"Tax:2697049"},{"id":"A446","pred":"tao:has_database_id","subj":"446","obj":"Tax:2697049"},{"id":"A447","pred":"tao:has_database_id","subj":"447","obj":"Tax:9606"},{"id":"A448","pred":"tao:has_database_id","subj":"448","obj":"Gene:351"},{"id":"A449","pred":"tao:has_database_id","subj":"449","obj":"Gene:351"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The genomic changes of SARS-CoV-2 appear in both non-structural and structural proteins – notably in proteins S, M, and N – affecting viral multiplication, encapsulation, tropism, and transmission (39). Two important characteristics were described in the genome of SARS-CoV-2 that lead to alterations in the S protein: (i) receptor-binding domain (RBD), which is the most variable part of the viral genome, appears to be optimized for binding to the human ACE2 receptor, and (ii) presence of a polybasic (furin) cleavage site at the S1 and S2 boundary, via the insertion of twelve nucleotides, which allows effective cleavage by furin and other proteases and has a role in determining viral tropism, infectivity, and host range (4)."}