PMC:7652766 / 9852-10584 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T53	0-202	Sentence	denotes	The genomic changes of SARS-CoV-2 appear in both non-structural and structural proteins – notably in proteins S, M, and N – affecting viral multiplication, encapsulation, tropism, and transmission (39).
T54	203-732	Sentence	denotes	Two important characteristics were described in the genome of SARS-CoV-2 that lead to alterations in the S protein: (i) receptor-binding domain (RBD), which is the most variable part of the viral genome, appears to be optimized for binding to the human ACE2 receptor, and (ii) presence of a polybasic (furin) cleavage site at the S1 and S2 boundary, via the insertion of twelve nucleotides, which allows effective cleavage by furin and other proteases and has a role in determining viral tropism, infectivity, and host range (4).

Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
437	456-460	Gene	denotes	ACE2	Gene:59272
438	629-634	Gene	denotes	furin	Gene:5045
439	505-510	Gene	denotes	furin	Gene:5045
440	120-121	Gene	denotes	N	Gene:43740575
441	110-111	Gene	denotes	S	Gene:43740568
442	443-445	Gene	denotes	to	Gene:6999
443	415-417	Gene	denotes	to	Gene:6999
444	286-288	Gene	denotes	to	Gene:6999
445	23-33	Species	denotes	SARS-CoV-2	Tax:2697049
446	265-275	Species	denotes	SARS-CoV-2	Tax:2697049
447	450-455	Species	denotes	human	Tax:9606
448	663-664	Gene	denotes	a	Gene:351
449	492-493	Gene	denotes	a	Gene:351