PMC:7652766 / 63789-64983 JSONTXT

{"project":"LitCovid-sentences","denotations":[{"id":"T308","span":{"begin":0,"end":198},"obj":"Sentence"},{"id":"T309","span":{"begin":199,"end":343},"obj":"Sentence"},{"id":"T310","span":{"begin":344,"end":543},"obj":"Sentence"},{"id":"T311","span":{"begin":544,"end":678},"obj":"Sentence"},{"id":"T312","span":{"begin":679,"end":921},"obj":"Sentence"},{"id":"T313","span":{"begin":922,"end":1194},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The appearance of IgG near the third stage of the disease may be related to the clinical evolution of patients and those who fail to establish an efficient immune response might be at risk of death. Interestingly, Guo et al. (197) found that approximately 22% of COVID-19 patients confirmed by RTq-PCR did not present detectable levels of IgM. Most of these individuals were tested in the first seven days after the onset of symptoms, therefore the lack of IgM can be justified by the delay in generating a humoral response against SARS-CoV-2. However, some critically ill patients followed for a longer period remained negative for IgM even 22 days after the onset of symptoms. As for IgG levels, some patients took 30 to 40 days after the appearance of symptoms to show some detectable level of IgG, suggesting a possible failure in the production of antibodies that may have contributed to the severity of the disease. It is possible that the generation of antibodies in more advanced stages of COVID-19 does not benefit the recovery process since most pathological mechanisms at this stage might be more related to the excess of inflammatory mediators than the presence of the virus itself."}

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