PMC:7652766 / 54701-55138 JSONTXT

{"project":"LitCovid-sentences","denotations":[{"id":"T267","span":{"begin":0,"end":234},"obj":"Sentence"},{"id":"T268","span":{"begin":235,"end":437},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Similarly, Chen et al. (154) demonstrated that CD4+ T lymphocytes from COVID-19 patients showed increased expressions of T cell immunoglobulin-3 (Tim-3), a type I transmembrane protein that acts as a negative regulator of Th1 pattern. CD4+ cells showed low expression of this marker at the early phase of infection, having progressively increased over time, indicating that the exhaustion of these cells occurs as the disease progresses."}

{"project":"LitCovid-PubTator","denotations":[{"id":"2109","span":{"begin":47,"end":50},"obj":"Gene"},{"id":"2110","span":{"begin":121,"end":144},"obj":"Gene"},{"id":"2111","span":{"begin":146,"end":151},"obj":"Gene"},{"id":"2112","span":{"begin":235,"end":238},"obj":"Gene"},{"id":"2113","span":{"begin":80,"end":88},"obj":"Species"},{"id":"2114","span":{"begin":198,"end":199},"obj":"Gene"},{"id":"2115","span":{"begin":154,"end":155},"obj":"Gene"},{"id":"2116","span":{"begin":71,"end":79},"obj":"Disease"},{"id":"2117","span":{"begin":305,"end":314},"obj":"Disease"}],"attributes":[{"id":"A2109","pred":"tao:has_database_id","subj":"2109","obj":"Gene:920"},{"id":"A2110","pred":"tao:has_database_id","subj":"2110","obj":"Gene:84868"},{"id":"A2111","pred":"tao:has_database_id","subj":"2111","obj":"Gene:84868"},{"id":"A2112","pred":"tao:has_database_id","subj":"2112","obj":"Gene:920"},{"id":"A2113","pred":"tao:has_database_id","subj":"2113","obj":"Tax:9606"},{"id":"A2114","pred":"tao:has_database_id","subj":"2114","obj":"Gene:351"},{"id":"A2115","pred":"tao:has_database_id","subj":"2115","obj":"Gene:351"},{"id":"A2116","pred":"tao:has_database_id","subj":"2116","obj":"MESH:C000657245"},{"id":"A2117","pred":"tao:has_database_id","subj":"2117","obj":"MESH:D007239"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Similarly, Chen et al. (154) demonstrated that CD4+ T lymphocytes from COVID-19 patients showed increased expressions of T cell immunoglobulin-3 (Tim-3), a type I transmembrane protein that acts as a negative regulator of Th1 pattern. CD4+ cells showed low expression of this marker at the early phase of infection, having progressively increased over time, indicating that the exhaustion of these cells occurs as the disease progresses."}