PMC:7652766 / 51534-52099 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7652766","sourcedb":"PMC","sourceid":"7652766","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7652766","text":"Thus, we hypothesize that the lack of mDC generation and consequent inability of the infected individual to produce IL-12 may be among the main factors of innate immunity-related pathogenesis of COVID-19. As further discussed, the increase in naïve T cells, reduced cell functionality of CD4+, CD8+, and natural killers (NK), and delay in the appearance of humoral response found in these patients indicates a failure in the generation and function of mDC. Therefore, it is urgent to carry out studies aimed at analyzing the effect of SARS-CoV-2 on dendritic cells.","tracks":[{"project":"LitCovid-sentences","denotations":[{"id":"T251","span":{"begin":0,"end":204},"obj":"Sentence"},{"id":"T252","span":{"begin":205,"end":456},"obj":"Sentence"},{"id":"T253","span":{"begin":457,"end":565},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T251","pred":"source","obj":"LitCovid-sentences"},{"subj":"T252","pred":"source","obj":"LitCovid-sentences"},{"subj":"T253","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1996","span":{"begin":38,"end":41},"obj":"Gene"},{"id":"1997","span":{"begin":288,"end":291},"obj":"Gene"},{"id":"1998","span":{"begin":294,"end":297},"obj":"Gene"},{"id":"1999","span":{"begin":452,"end":455},"obj":"Gene"},{"id":"2000","span":{"begin":481,"end":483},"obj":"Gene"},{"id":"2001","span":{"begin":105,"end":107},"obj":"Gene"},{"id":"2002","span":{"begin":389,"end":397},"obj":"Species"},{"id":"2003","span":{"begin":535,"end":545},"obj":"Species"},{"id":"2004","span":{"begin":408,"end":409},"obj":"Gene"},{"id":"2005","span":{"begin":68,"end":93},"obj":"Disease"},{"id":"2006","span":{"begin":195,"end":203},"obj":"Disease"},{"id":"2007","span":{"begin":410,"end":417},"obj":"Disease"}],"attributes":[{"id":"A1996","pred":"tao:has_database_id","subj":"1996","obj":"Gene:13179"},{"id":"A1997","pred":"tao:has_database_id","subj":"1997","obj":"Gene:920"},{"id":"A1998","pred":"tao:has_database_id","subj":"1998","obj":"Gene:925"},{"id":"A1999","pred":"tao:has_database_id","subj":"1999","obj":"Gene:13179"},{"id":"A2000","pred":"tao:has_database_id","subj":"2000","obj":"Gene:6999"},{"id":"A2001","pred":"tao:has_database_id","subj":"2001","obj":"Gene:6999"},{"id":"A2002","pred":"tao:has_database_id","subj":"2002","obj":"Tax:9606"},{"id":"A2003","pred":"tao:has_database_id","subj":"2003","obj":"Tax:2697049"},{"id":"A2004","pred":"tao:has_database_id","subj":"2004","obj":"Gene:351"},{"id":"A2005","pred":"tao:has_database_id","subj":"2005","obj":"MESH:D007319"},{"id":"A2006","pred":"tao:has_database_id","subj":"2006","obj":"MESH:C000657245"},{"id":"A2007","pred":"tao:has_database_id","subj":"2007","obj":"MESH:D006333"},{"subj":"1996","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1997","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1998","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1999","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2000","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2001","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2002","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2003","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2004","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2005","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2006","pred":"source","obj":"LitCovid-PubTator"},{"subj":"2007","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-sentences","color":"#de93ec","default":true},{"id":"LitCovid-PubTator","color":"#93ecc4"}]}]}}