Thus, we hypothesize that the lack of mDC generation and consequent inability of the infected individual to produce IL-12 may be among the main factors of innate immunity-related pathogenesis of COVID-19. As further discussed, the increase in naïve T cells, reduced cell functionality of CD4+, CD8+, and natural killers (NK), and delay in the appearance of humoral response found in these patients indicates a failure in the generation and function of mDC. Therefore, it is urgent to carry out studies aimed at analyzing the effect of SARS-CoV-2 on dendritic cells.