PMC:7652766 / 44624-45158 JSONTXT

{"project":"LitCovid-sentences","denotations":[{"id":"T218","span":{"begin":0,"end":181},"obj":"Sentence"},{"id":"T219","span":{"begin":182,"end":402},"obj":"Sentence"},{"id":"T220","span":{"begin":403,"end":534},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The innate immune system is the first line of defense against pathogens through the activation of PRR in macrophages, neutrophils, and dendritic cells by the interaction with PAMPs. An effective innate immune response against viruses like SARS-CoV-2 is essential not only to initiate the response but also to structure the basis for the production of a robust and more specific adaptive response (162). Changes in this process, commonly observed in viral infections, can cause an immune imbalance and susceptibility of the host (163)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1740","span":{"begin":98,"end":101},"obj":"Gene"},{"id":"1741","span":{"begin":306,"end":308},"obj":"Gene"},{"id":"1742","span":{"begin":272,"end":274},"obj":"Gene"},{"id":"1743","span":{"begin":239,"end":249},"obj":"Species"},{"id":"1744","span":{"begin":351,"end":352},"obj":"Gene"},{"id":"1745","span":{"begin":449,"end":465},"obj":"Disease"}],"attributes":[{"id":"A1740","pred":"tao:has_database_id","subj":"1740","obj":"Gene:10159"},{"id":"A1741","pred":"tao:has_database_id","subj":"1741","obj":"Gene:6999"},{"id":"A1742","pred":"tao:has_database_id","subj":"1742","obj":"Gene:6999"},{"id":"A1743","pred":"tao:has_database_id","subj":"1743","obj":"Tax:2697049"},{"id":"A1744","pred":"tao:has_database_id","subj":"1744","obj":"Gene:351"},{"id":"A1745","pred":"tao:has_database_id","subj":"1745","obj":"MESH:D001102"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The innate immune system is the first line of defense against pathogens through the activation of PRR in macrophages, neutrophils, and dendritic cells by the interaction with PAMPs. An effective innate immune response against viruses like SARS-CoV-2 is essential not only to initiate the response but also to structure the basis for the production of a robust and more specific adaptive response (162). Changes in this process, commonly observed in viral infections, can cause an immune imbalance and susceptibility of the host (163)."}