PMC:7652766 / 117928-119920 JSONTXT

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LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T169 708-727 Phenotype denotes respiratory failure http://purl.obolibrary.org/obo/HP_0002878

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T582 0-10 Sentence denotes Conclusion
T583 11-192 Sentence denotes In conclusion, this collection of works suggests that the genomic changes of SARS-CoV-2 are responsible for its higher transmissibility rate and severity in relation to other hCoVs.
T584 193-334 Sentence denotes Furthermore, the process of tropism and invasion of the virus is favored by its capacity of high-affinity bonding to the human ACE2 receptor.
T585 335-477 Sentence denotes Cytokines have a direct role in the immunopathogenesis of COVID-19 by inducing the hyper inflammation and lung injury peculiar to the disease.
T586 478-655 Sentence denotes Benefits of IFN-mediated response seem to occur only during early infection, and the failed control of its production over time might be related to the worsening of the disease.
T587 656-894 Sentence denotes Monocytes and macrophages have an important role in respiratory failure during COVID-19; several studies have reported that these cells migrate to the lungs, producing pro-inflammatory cytokines, like IL-6, and inducing epithelial damage.
T588 895-1111 Sentence denotes Controversially, at later stages, COVID-19 patients present an impaired immune response due to exhausted phenotype and lower effector T cells, CD8+ T lymphocytes, and NK cells, culminating in antiviral immunity loss.
T589 1112-1378 Sentence denotes Theoretically, the production of specific antibodies against SARS-CoV-2 by the immune system should be able to combat the virus and reduce viral load, but in critically ill patients, it does not seem to occur effectively, contributing to the severity of the disease.
T590 1379-1678 Sentence denotes Unfortunately, no effective vaccines or therapeutic antiviral agents have been approved for the treatment of COVID-19 so far, but immunotherapy and some repositioned drugs originally used to treat inflammatory and coagulation disorders and viral and parasitic infections are ongoing clinical trials.
T591 1679-1881 Sentence denotes This is a unique moment in science and humanity, with some mismatched information, as well as novel, important discoveries being made every day, therefore, all information must be interpreted carefully.
T592 1882-1992 Sentence denotes Our review encompassed the most relevant articles in the area seeking to disseminate good-quality information.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
4385 320-324 Gene denotes ACE2 Gene:59272
4386 857-861 Gene denotes IL-6 Gene:3569
4387 1038-1041 Gene denotes CD8 Gene:925
4388 1952-1954 Gene denotes to Gene:6999
4389 1567-1569 Gene denotes to Gene:6999
4390 1347-1349 Gene denotes to Gene:6999
4391 1312-1314 Gene denotes to Gene:6999
4392 1220-1222 Gene denotes to Gene:6999
4393 987-989 Gene denotes to Gene:6999
4394 800-802 Gene denotes to Gene:6999
4395 623-625 Gene denotes to Gene:6999
4396 517-519 Gene denotes to Gene:6999
4397 307-309 Gene denotes to Gene:6999
4398 177-179 Gene denotes to Gene:6999
4399 88-98 Species denotes SARS-CoV-2 Tax:2697049
4400 314-319 Species denotes human Tax:9606
4401 938-946 Species denotes patients Tax:9606
4402 1173-1183 Species denotes SARS-CoV-2 Tax:2697049
4403 1285-1293 Species denotes patients Tax:9606
4404 1687-1688 Gene denotes a Gene:351
4405 350-351 Gene denotes a Gene:351
4406 490-493 Gene denotes IFN Gene:3439
4407 393-401 Disease denotes COVID-19 MESH:C000657245
4408 418-436 Disease denotes hyper inflammation MESH:D007249
4409 441-476 Disease denotes lung injury peculiar to the disease MESH:D008171
4410 544-553 Disease denotes infection MESH:D007239
4411 708-727 Disease denotes respiratory failure MESH:D012131
4412 735-743 Disease denotes COVID-19 MESH:C000657245
4413 929-937 Disease denotes COVID-19 MESH:C000657245
4414 1270-1284 Disease denotes critically ill MESH:D016638
4415 1488-1496 Disease denotes COVID-19 MESH:C000657245
4416 1593-1614 Disease denotes coagulation disorders MESH:D001778
4417 1619-1649 Disease denotes viral and parasitic infections MESH:D001102