PMC:7650537 / 9623-12674 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7650537","sourcedb":"PMC","sourceid":"7650537","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7650537","text":"2.2. Investigated SARS-CoV-2 Antibody Tests\nSeven SARS-CoV-2 IgG assays (Abbott SARS-CoV-2 IgG, Wiesbaden, Germany; DiaSorin Liaison® SARS-CoV-2 S1/2 IgG, DiaSorin, Dietzenbach, Germany; Epitope EDI™ Novel Coronavirus COVID-19 IgG ELISA Kit, Epitope Diagnostics, San Diego, CA, USA; Euroimmun Anti-SARS-CoV-2 ELISA (IgG), EUROIMMUN AG, Lübeck, Germany; Mikrogen recomWell SARS-CoV-2 IgG, Mikrogen GmbH, Neuried, Germany; SARS-CoV-2 ViraChip® IgG Test, Viramed Biotech AG, Planegg, Germany; and SERION ELISA agile SARS-COV-2 IgG, Institute Virion-Serion GmbH, Würzburg, Germany), as well as one total SARS-CoV-2 antibody test (Roche Elecsys Anti-SARS-CoV-2, Roche Diagnostics, Mannheim, Germany), were included in this study. The recombinant antigens of these tests cover the N protein (Abbott, Epitope, Mikrogen, Roche) and the entire S protein (Virion-Serion), as well as its S1 domain alone (Euroimmun) or together with the S2 domain (DiaSorin). The SARS-CoV-2 ViraChip® IgG test kit uses the purified viral surface antigens S1 and S2 and the N antigen, which are all presented separately at a defined position on a nitrocellulose film (Table S1).\nAll tests were conducted strictly following the recommendations of the manufacturers on an Architect or Alinity machine (Abbott), a Liaison XL (DiaSorin), or a Cobas e 411 (Roche) or, for the assays of Epitope, Euroimmun, Mikrogen Viramed, and Virion-Serion, on the BEP 2000 system (Siemens Healthcare GmbH, Erlangen, Germany), respectively. The ViraChip® test was then evaluated automatically by help of a ViraChip® reader and the ViraChip® Software.\nAll borderline/gray zone results were counted as positive. Furthermore, raw data from seven assays were converted into relative indices according to the decision limits set by the manufacturer. Thereby, a signal (S)/cut-off (CO) value of \u003c1 was valued as negative and ≥1 as positive, which corresponds to a previous study [22]. Results of the SARS-CoV-2 ViraChip® IgG could not be converted into relative indices and were only given qualitatively as negative or positive. The proportion of correctly identified samples per test relative to the chosen reference method was calculated and given as assay accuracy.\nThe convalescent sera were also tested with and without avidity reagent (contains urea in denaturating concentrations) in two versions of an IgG line assay (blot v1: Mikrogen recomLine Coronavirus IgG (Avidität), prototype and blot v2: Mikrogen recomLine SARS-CoV-2 IgG (Avidität)/RUO). The first version is based on the N protein of the human coronaviruses (HCoVs) 229E, HKU1, NL63, and OC43, which are used separately as antigens, and on the N protein of the “classic” SARS-CoV from 2002/2003 and SARS-CoV-2. The second improved version still uses the N proteins of the aforementioned HCoVs and of SARS-CoV-2 but has been expanded to include the S1 antigen and its RBD. A Dynablot Plus system was used to process all samples. Blots were then evaluated automatically with a BLOTrix reader and the recomScan software (all from Mikrogen).","divisions":[{"label":"title","span":{"begin":0,"end":43}},{"label":"p","span":{"begin":44,"end":1149}},{"label":"p","span":{"begin":1150,"end":1601}},{"label":"p","span":{"begin":1602,"end":2213}}],"tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T66","span":{"begin":29,"end":37},"obj":"Body_part"},{"id":"T67","span":{"begin":61,"end":64},"obj":"Body_part"},{"id":"T68","span":{"begin":91,"end":94},"obj":"Body_part"},{"id":"T69","span":{"begin":150,"end":153},"obj":"Body_part"},{"id":"T70","span":{"begin":227,"end":230},"obj":"Body_part"},{"id":"T71","span":{"begin":316,"end":319},"obj":"Body_part"},{"id":"T72","span":{"begin":332,"end":334},"obj":"Body_part"},{"id":"T73","span":{"begin":383,"end":386},"obj":"Body_part"},{"id":"T74","span":{"begin":442,"end":445},"obj":"Body_part"},{"id":"T75","span":{"begin":468,"end":470},"obj":"Body_part"},{"id":"T76","span":{"begin":524,"end":527},"obj":"Body_part"},{"id":"T77","span":{"begin":611,"end":619},"obj":"Body_part"},{"id":"T78","span":{"begin":777,"end":784},"obj":"Body_part"},{"id":"T79","span":{"begin":837,"end":844},"obj":"Body_part"},{"id":"T80","span":{"begin":973,"end":976},"obj":"Body_part"},{"id":"T81","span":{"begin":1966,"end":1969},"obj":"Body_part"},{"id":"T82","span":{"begin":2355,"end":2358},"obj":"Body_part"},{"id":"T83","span":{"begin":2376,"end":2378},"obj":"Body_part"},{"id":"T85","span":{"begin":2411,"end":2414},"obj":"Body_part"},{"id":"T86","span":{"begin":2446,"end":2448},"obj":"Body_part"},{"id":"T88","span":{"begin":2480,"end":2483},"obj":"Body_part"},{"id":"T89","span":{"begin":2537,"end":2544},"obj":"Body_part"},{"id":"T90","span":{"begin":2660,"end":2667},"obj":"Body_part"},{"id":"T91","span":{"begin":2770,"end":2778},"obj":"Body_part"}],"attributes":[{"id":"A66","pred":"fma_id","subj":"T66","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A67","pred":"fma_id","subj":"T67","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A68","pred":"fma_id","subj":"T68","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A69","pred":"fma_id","subj":"T69","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A70","pred":"fma_id","subj":"T70","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A71","pred":"fma_id","subj":"T71","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A72","pred":"fma_id","subj":"T72","obj":"http://purl.org/sig/ont/fma/fma61898"},{"id":"A73","pred":"fma_id","subj":"T73","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A74","pred":"fma_id","subj":"T74","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A75","pred":"fma_id","subj":"T75","obj":"http://purl.org/sig/ont/fma/fma61898"},{"id":"A76","pred":"fma_id","subj":"T76","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A77","pred":"fma_id","subj":"T77","obj":"http://purl.org/sig/ont/fma/fma62871"},{"id":"A78","pred":"fma_id","subj":"T78","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A79","pred":"fma_id","subj":"T79","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A80","pred":"fma_id","subj":"T80","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A81","pred":"fma_id","subj":"T81","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A82","pred":"fma_id","subj":"T82","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A83","pred":"fma_id","subj":"T83","obj":"http://purl.org/sig/ont/fma/fma13444"},{"id":"A84","pred":"fma_id","subj":"T83","obj":"http://purl.org/sig/ont/fma/fma68614"},{"id":"A85","pred":"fma_id","subj":"T85","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A86","pred":"fma_id","subj":"T86","obj":"http://purl.org/sig/ont/fma/fma13443"},{"id":"A87","pred":"fma_id","subj":"T86","obj":"http://purl.org/sig/ont/fma/fma68615"},{"id":"A88","pred":"fma_id","subj":"T88","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A89","pred":"fma_id","subj":"T89","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A90","pred":"fma_id","subj":"T90","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A91","pred":"fma_id","subj":"T91","obj":"http://purl.org/sig/ont/fma/fma67257"},{"subj":"T66","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T67","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T68","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T69","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T70","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T71","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T72","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T73","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T74","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T75","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T76","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T77","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T78","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T79","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T80","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T81","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T82","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T83","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T85","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T86","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T88","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T89","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T90","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T91","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T44","span":{"begin":18,"end":26},"obj":"Disease"},{"id":"T45","span":{"begin":50,"end":58},"obj":"Disease"},{"id":"T46","span":{"begin":80,"end":88},"obj":"Disease"},{"id":"T47","span":{"begin":134,"end":142},"obj":"Disease"},{"id":"T48","span":{"begin":218,"end":226},"obj":"Disease"},{"id":"T49","span":{"begin":298,"end":306},"obj":"Disease"},{"id":"T50","span":{"begin":372,"end":380},"obj":"Disease"},{"id":"T51","span":{"begin":421,"end":429},"obj":"Disease"},{"id":"T52","span":{"begin":513,"end":517},"obj":"Disease"},{"id":"T53","span":{"begin":600,"end":608},"obj":"Disease"},{"id":"T54","span":{"begin":645,"end":653},"obj":"Disease"},{"id":"T55","span":{"begin":952,"end":960},"obj":"Disease"},{"id":"T56","span":{"begin":1945,"end":1953},"obj":"Disease"},{"id":"T57","span":{"begin":2469,"end":2477},"obj":"Disease"},{"id":"T58","span":{"begin":2685,"end":2693},"obj":"Disease"},{"id":"T59","span":{"begin":2713,"end":2721},"obj":"Disease"},{"id":"T60","span":{"begin":2814,"end":2822},"obj":"Disease"}],"attributes":[{"id":"A44","pred":"mondo_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A45","pred":"mondo_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A46","pred":"mondo_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A47","pred":"mondo_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A48","pred":"mondo_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A49","pred":"mondo_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A50","pred":"mondo_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A51","pred":"mondo_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A52","pred":"mondo_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A53","pred":"mondo_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A54","pred":"mondo_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A55","pred":"mondo_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A56","pred":"mondo_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A57","pred":"mondo_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A58","pred":"mondo_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A59","pred":"mondo_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A60","pred":"mondo_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T44","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T45","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T46","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T47","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T48","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T49","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T50","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T51","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T52","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T53","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T54","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T55","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T56","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T57","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T58","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T59","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T60","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T87","span":{"begin":38,"end":43},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T88","span":{"begin":145,"end":147},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T89","span":{"begin":446,"end":450},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T90","span":{"begin":620,"end":624},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T91","span":{"begin":759,"end":764},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T92","span":{"begin":877,"end":879},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T93","span":{"begin":926,"end":928},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T94","span":{"begin":926,"end":928},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"},{"id":"T95","span":{"begin":977,"end":981},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T96","span":{"begin":1027,"end":1029},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T97","span":{"begin":1034,"end":1036},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T98","span":{"begin":1034,"end":1036},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"},{"id":"T99","span":{"begin":1094,"end":1095},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T100","span":{"begin":1116,"end":1117},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T101","span":{"begin":1145,"end":1147},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T102","span":{"begin":1154,"end":1159},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T103","span":{"begin":1280,"end":1281},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T104","span":{"begin":1308,"end":1309},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T105","span":{"begin":1506,"end":1514},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T106","span":{"begin":1555,"end":1556},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T107","span":{"begin":1805,"end":1806},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T108","span":{"begin":1807,"end":1813},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T109","span":{"begin":1907,"end":1908},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T110","span":{"begin":1925,"end":1927},"obj":"http://purl.obolibrary.org/obo/CLO_0050507"},{"id":"T111","span":{"begin":2125,"end":2129},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T112","span":{"begin":2246,"end":2252},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T113","span":{"begin":2552,"end":2557},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T114","span":{"begin":2829,"end":2832},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T115","span":{"begin":2862,"end":2864},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T116","span":{"begin":2886,"end":2887},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T117","span":{"begin":2987,"end":2988},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T87","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T88","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T89","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T90","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T91","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T92","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T93","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T94","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T95","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T96","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T97","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T98","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T99","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T100","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T101","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T102","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T103","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T104","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T105","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T106","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T107","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T108","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T109","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T110","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T111","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T112","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T113","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T114","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T115","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T116","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T117","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T44","span":{"begin":195,"end":198},"obj":"Chemical"},{"id":"T45","span":{"begin":332,"end":334},"obj":"Chemical"},{"id":"T48","span":{"begin":468,"end":470},"obj":"Chemical"},{"id":"T51","span":{"begin":741,"end":749},"obj":"Chemical"},{"id":"T52","span":{"begin":777,"end":784},"obj":"Chemical"},{"id":"T53","span":{"begin":837,"end":844},"obj":"Chemical"},{"id":"T54","span":{"begin":926,"end":928},"obj":"Chemical"},{"id":"T55","span":{"begin":1018,"end":1026},"obj":"Chemical"},{"id":"T56","span":{"begin":1034,"end":1036},"obj":"Chemical"},{"id":"T57","span":{"begin":1047,"end":1054},"obj":"Chemical"},{"id":"T58","span":{"begin":1118,"end":1132},"obj":"Chemical"},{"id":"T59","span":{"begin":1827,"end":1829},"obj":"Chemical"},{"id":"T60","span":{"begin":2278,"end":2285},"obj":"Chemical"},{"id":"T61","span":{"begin":2296,"end":2300},"obj":"Chemical"},{"id":"T62","span":{"begin":2537,"end":2544},"obj":"Chemical"},{"id":"T63","span":{"begin":2637,"end":2645},"obj":"Chemical"},{"id":"T64","span":{"begin":2660,"end":2667},"obj":"Chemical"},{"id":"T65","span":{"begin":2770,"end":2778},"obj":"Chemical"},{"id":"T66","span":{"begin":2865,"end":2872},"obj":"Chemical"}],"attributes":[{"id":"A44","pred":"chebi_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/CHEBI_73491"},{"id":"A45","pred":"chebi_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/CHEBI_27569"},{"id":"A46","pred":"chebi_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/CHEBI_40618"},{"id":"A47","pred":"chebi_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/CHEBI_73757"},{"id":"A48","pred":"chebi_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/CHEBI_27569"},{"id":"A49","pred":"chebi_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/CHEBI_40618"},{"id":"A50","pred":"chebi_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/CHEBI_73757"},{"id":"A51","pred":"chebi_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A52","pred":"chebi_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A53","pred":"chebi_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A54","pred":"chebi_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"},{"id":"A55","pred":"chebi_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A56","pred":"chebi_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/CHEBI_29387"},{"id":"A57","pred":"chebi_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A58","pred":"chebi_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/CHEBI_53325"},{"id":"A59","pred":"chebi_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/CHEBI_17245"},{"id":"A60","pred":"chebi_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/CHEBI_33893"},{"id":"A61","pred":"chebi_id","subj":"T61","obj":"http://purl.obolibrary.org/obo/CHEBI_16199"},{"id":"A62","pred":"chebi_id","subj":"T62","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A63","pred":"chebi_id","subj":"T63","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"id":"A64","pred":"chebi_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A65","pred":"chebi_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A66","pred":"chebi_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/CHEBI_59132"},{"subj":"T44","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T45","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T48","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T51","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T52","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T53","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T54","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T55","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T56","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T57","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T58","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T59","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T60","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T61","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T62","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T63","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T64","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T65","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T66","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T74","span":{"begin":0,"end":4},"obj":"Sentence"},{"id":"T75","span":{"begin":5,"end":43},"obj":"Sentence"},{"id":"T76","span":{"begin":44,"end":724},"obj":"Sentence"},{"id":"T77","span":{"begin":725,"end":947},"obj":"Sentence"},{"id":"T78","span":{"begin":948,"end":1149},"obj":"Sentence"},{"id":"T79","span":{"begin":1150,"end":1491},"obj":"Sentence"},{"id":"T80","span":{"begin":1492,"end":1601},"obj":"Sentence"},{"id":"T81","span":{"begin":1602,"end":1660},"obj":"Sentence"},{"id":"T82","span":{"begin":1661,"end":1795},"obj":"Sentence"},{"id":"T83","span":{"begin":1796,"end":1929},"obj":"Sentence"},{"id":"T84","span":{"begin":1930,"end":2073},"obj":"Sentence"},{"id":"T85","span":{"begin":2074,"end":2213},"obj":"Sentence"},{"id":"T86","span":{"begin":2214,"end":2379},"obj":"Sentence"},{"id":"T87","span":{"begin":2380,"end":2449},"obj":"Sentence"},{"id":"T88","span":{"begin":2450,"end":2500},"obj":"Sentence"},{"id":"T89","span":{"begin":2501,"end":2724},"obj":"Sentence"},{"id":"T90","span":{"begin":2725,"end":2885},"obj":"Sentence"},{"id":"T91","span":{"begin":2886,"end":2941},"obj":"Sentence"},{"id":"T92","span":{"begin":2942,"end":3051},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T74","pred":"source","obj":"LitCovid-sentences"},{"subj":"T75","pred":"source","obj":"LitCovid-sentences"},{"subj":"T76","pred":"source","obj":"LitCovid-sentences"},{"subj":"T77","pred":"source","obj":"LitCovid-sentences"},{"subj":"T78","pred":"source","obj":"LitCovid-sentences"},{"subj":"T79","pred":"source","obj":"LitCovid-sentences"},{"subj":"T80","pred":"source","obj":"LitCovid-sentences"},{"subj":"T81","pred":"source","obj":"LitCovid-sentences"},{"subj":"T82","pred":"source","obj":"LitCovid-sentences"},{"subj":"T83","pred":"source","obj":"LitCovid-sentences"},{"subj":"T84","pred":"source","obj":"LitCovid-sentences"},{"subj":"T85","pred":"source","obj":"LitCovid-sentences"},{"subj":"T86","pred":"source","obj":"LitCovid-sentences"},{"subj":"T87","pred":"source","obj":"LitCovid-sentences"},{"subj":"T88","pred":"source","obj":"LitCovid-sentences"},{"subj":"T89","pred":"source","obj":"LitCovid-sentences"},{"subj":"T90","pred":"source","obj":"LitCovid-sentences"},{"subj":"T91","pred":"source","obj":"LitCovid-sentences"},{"subj":"T92","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"175","span":{"begin":18,"end":28},"obj":"Species"},{"id":"190","span":{"begin":1045,"end":1046},"obj":"Gene"},{"id":"191","span":{"begin":775,"end":776},"obj":"Gene"},{"id":"192","span":{"begin":134,"end":144},"obj":"Species"},{"id":"193","span":{"begin":200,"end":217},"obj":"Species"},{"id":"194","span":{"begin":50,"end":60},"obj":"Species"},{"id":"195","span":{"begin":80,"end":90},"obj":"Species"},{"id":"196","span":{"begin":298,"end":308},"obj":"Species"},{"id":"197","span":{"begin":372,"end":382},"obj":"Species"},{"id":"198","span":{"begin":421,"end":431},"obj":"Species"},{"id":"199","span":{"begin":513,"end":523},"obj":"Species"},{"id":"200","span":{"begin":600,"end":610},"obj":"Species"},{"id":"201","span":{"begin":645,"end":655},"obj":"Species"},{"id":"202","span":{"begin":952,"end":962},"obj":"Species"},{"id":"203","span":{"begin":218,"end":226},"obj":"Disease"},{"id":"206","span":{"begin":1815,"end":1816},"obj":"Gene"},{"id":"207","span":{"begin":1945,"end":1955},"obj":"Species"},{"id":"217","span":{"begin":2768,"end":2769},"obj":"Gene"},{"id":"218","span":{"begin":2552,"end":2557},"obj":"Species"},{"id":"219","span":{"begin":2558,"end":2571},"obj":"Species"},{"id":"220","span":{"begin":2685,"end":2693},"obj":"Species"},{"id":"221","span":{"begin":2713,"end":2723},"obj":"Species"},{"id":"222","span":{"begin":2814,"end":2824},"obj":"Species"},{"id":"223","span":{"begin":2399,"end":2410},"obj":"Species"},{"id":"224","span":{"begin":2469,"end":2479},"obj":"Species"},{"id":"225","span":{"begin":2296,"end":2300},"obj":"Chemical"}],"attributes":[{"id":"A175","pred":"tao:has_database_id","subj":"175","obj":"Tax:2697049"},{"id":"A190","pred":"tao:has_database_id","subj":"190","obj":"Gene:43740575"},{"id":"A191","pred":"tao:has_database_id","subj":"191","obj":"Gene:43740575"},{"id":"A192","pred":"tao:has_database_id","subj":"192","obj":"Tax:2697049"},{"id":"A193","pred":"tao:has_database_id","subj":"193","obj":"Tax:2697049"},{"id":"A194","pred":"tao:has_database_id","subj":"194","obj":"Tax:2697049"},{"id":"A195","pred":"tao:has_database_id","subj":"195","obj":"Tax:2697049"},{"id":"A196","pred":"tao:has_database_id","subj":"196","obj":"Tax:2697049"},{"id":"A197","pred":"tao:has_database_id","subj":"197","obj":"Tax:2697049"},{"id":"A198","pred":"tao:has_database_id","subj":"198","obj":"Tax:2697049"},{"id":"A199","pred":"tao:has_database_id","subj":"199","obj":"Tax:2697049"},{"id":"A200","pred":"tao:has_database_id","subj":"200","obj":"Tax:2697049"},{"id":"A201","pred":"tao:has_database_id","subj":"201","obj":"Tax:2697049"},{"id":"A202","pred":"tao:has_database_id","subj":"202","obj":"Tax:2697049"},{"id":"A203","pred":"tao:has_database_id","subj":"203","obj":"MESH:C000657245"},{"id":"A206","pred":"tao:has_database_id","subj":"206","obj":"Gene:43740568"},{"id":"A207","pred":"tao:has_database_id","subj":"207","obj":"Tax:2697049"},{"id":"A217","pred":"tao:has_database_id","subj":"217","obj":"Gene:43740575"},{"id":"A218","pred":"tao:has_database_id","subj":"218","obj":"Tax:9606"},{"id":"A219","pred":"tao:has_database_id","subj":"219","obj":"Tax:11118"},{"id":"A220","pred":"tao:has_database_id","subj":"220","obj":"Tax:694009"},{"id":"A221","pred":"tao:has_database_id","subj":"221","obj":"Tax:2697049"},{"id":"A222","pred":"tao:has_database_id","subj":"222","obj":"Tax:2697049"},{"id":"A223","pred":"tao:has_database_id","subj":"223","obj":"Tax:11118"},{"id":"A224","pred":"tao:has_database_id","subj":"224","obj":"Tax:2697049"},{"id":"A225","pred":"tao:has_database_id","subj":"225","obj":"MESH:D014508"},{"subj":"175","pred":"source","obj":"LitCovid-PubTator"},{"subj":"190","pred":"source","obj":"LitCovid-PubTator"},{"subj":"191","pred":"source","obj":"LitCovid-PubTator"},{"subj":"192","pred":"source","obj":"LitCovid-PubTator"},{"subj":"193","pred":"source","obj":"LitCovid-PubTator"},{"subj":"194","pred":"source","obj":"LitCovid-PubTator"},{"subj":"195","pred":"source","obj":"LitCovid-PubTator"},{"subj":"196","pred":"source","obj":"LitCovid-PubTator"},{"subj":"197","pred":"source","obj":"LitCovid-PubTator"},{"subj":"198","pred":"source","obj":"LitCovid-PubTator"},{"subj":"199","pred":"source","obj":"LitCovid-PubTator"},{"subj":"200","pred":"source","obj":"LitCovid-PubTator"},{"subj":"201","pred":"source","obj":"LitCovid-PubTator"},{"subj":"202","pred":"source","obj":"LitCovid-PubTator"},{"subj":"203","pred":"source","obj":"LitCovid-PubTator"},{"subj":"206","pred":"source","obj":"LitCovid-PubTator"},{"subj":"207","pred":"source","obj":"LitCovid-PubTator"},{"subj":"217","pred":"source","obj":"LitCovid-PubTator"},{"subj":"218","pred":"source","obj":"LitCovid-PubTator"},{"subj":"219","pred":"source","obj":"LitCovid-PubTator"},{"subj":"220","pred":"source","obj":"LitCovid-PubTator"},{"subj":"221","pred":"source","obj":"LitCovid-PubTator"},{"subj":"222","pred":"source","obj":"LitCovid-PubTator"},{"subj":"223","pred":"source","obj":"LitCovid-PubTator"},{"subj":"224","pred":"source","obj":"LitCovid-PubTator"},{"subj":"225","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#ec93e2","default":true},{"id":"LitCovid-PD-MONDO","color":"#93ecdc"},{"id":"LitCovid-PD-CLO","color":"#ecc293"},{"id":"LitCovid-PD-CHEBI","color":"#a893ec"},{"id":"LitCovid-sentences","color":"#97ec93"},{"id":"LitCovid-PubTator","color":"#ec93b2"}]}]}}