PMC:7650537 / 3801-5459
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7650537","sourcedb":"PMC","sourceid":"7650537","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7650537","text":"It is believed that the majority of antibodies are raised against the abundant N protein, while antibodies directed against the S protein are considered more specific and correlate with the neutralizing capacity [7,8]. Earlier works on the antibody response in SARS (2002/2003) patients showed a significantly higher sensitivity of tests based on the N protein as the antigen [10,11]. The diagnostic value of SARS-CoV-2 antibody tests, however, may be limited due to their potential cross-reactivity with other human coronaviruses. So far, the duration of the acquired immunity after a SARS-CoV-2 infection is unclear. However, based on experience with reinfections from other human coronaviruses, it remains yet open if the immunity is long-lasting [12]. Several studies reported a rapid decay of SARS-CoV-2 immunoglobulin G (IgG) in asymptomatic individuals [13] and mild COVID-19 cases [14] but, more surprisingly, also in hospitalized patients presenting with the full clinical spectrum of COVID-19 [5,15]. Very recently, differences in the kinetics of N- or S-specific IgG came into the focus of research [16]. While a decline in the IgG directed against the N protein was evident, the response to the S protein or its RBD was found to be more stable [16,17] and was associated with the presence of virus-neutralizing antibodies [17]. To the best of our knowledge, clinically validated assays for the specific detection of IgG directed against the SARS-CoV-2 surface proteins E and M are not yet available. However, it would make sense to investigate such antibody responses as well, since they can also correlate with virus-neutralizing capacities 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