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PMC:7647877 / 54653-56197 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T577 201-210 Body_part denotes glutamine http://purl.org/sig/ont/fma/fma82752
T578 240-250 Body_part denotes lymphocyte http://purl.org/sig/ont/fma/fma62863
T579 269-277 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T580 290-300 Body_part denotes macrophage http://purl.org/sig/ont/fma/fma63261
T581 363-374 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T582 386-391 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T583 393-400 Body_part denotes glucose http://purl.org/sig/ont/fma/fma82743
T584 454-463 Body_part denotes glutamine http://purl.org/sig/ont/fma/fma82752
T585 507-514 Body_part denotes alanine http://purl.org/sig/ont/fma/fma82749
T586 689-698 Body_part denotes Glutamine http://purl.org/sig/ont/fma/fma82752
T587 747-760 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T588 814-822 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T589 1008-1012 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T590 1059-1068 Body_part denotes glutamine http://purl.org/sig/ont/fma/fma82752
T591 1116-1128 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T592 1116-1120 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T593 1136-1147 Body_part denotes lymphocytes http://purl.org/sig/ont/fma/fma62863
T594 1165-1174 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T595 1189-1191 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578
T596 1260-1269 Body_part denotes glutamine http://purl.org/sig/ont/fma/fma82752
T597 1448-1457 Body_part denotes glutamine http://purl.org/sig/ont/fma/fma82752
T598 1493-1503 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T128 747-760 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T670 15-25 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T671 301-311 http://purl.obolibrary.org/obo/CL_0000234 denotes phagocytes
T672 327-337 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T673 386-391 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T674 526-527 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T675 568-569 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T676 632-633 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T677 734-735 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T678 747-760 http://purl.obolibrary.org/obo/UBERON_0002405 denotes immune system
T679 761-766 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T680 800-810 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T681 882-892 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T682 937-939 http://purl.obolibrary.org/obo/CLO_0001547 denotes AP
T683 982-987 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T684 1008-1012 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T685 1037-1038 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T686 1116-1120 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T687 1243-1244 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T688 1442-1443 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T62592 34-42 Chemical denotes nutrient http://purl.obolibrary.org/obo/CHEBI_33284
T67 102-108 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T43333 169-180 Chemical denotes glutathione http://purl.obolibrary.org/obo/CHEBI_16856|http://purl.obolibrary.org/obo/CHEBI_57925
T77116 201-210 Chemical denotes glutamine http://purl.obolibrary.org/obo/CHEBI_28300
T71 227-235 Chemical denotes nutrient http://purl.obolibrary.org/obo/CHEBI_33284
T66188 393-400 Chemical denotes glucose http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167
T32762 426-433 Chemical denotes lactate http://purl.obolibrary.org/obo/CHEBI_24996
T75 454-463 Chemical denotes glutamine http://purl.obolibrary.org/obo/CHEBI_28300
T27899 482-491 Chemical denotes glutamate http://purl.obolibrary.org/obo/CHEBI_14321|http://purl.obolibrary.org/obo/CHEBI_29987
T37658 493-502 Chemical denotes aspartate http://purl.obolibrary.org/obo/CHEBI_132943|http://purl.obolibrary.org/obo/CHEBI_29995|http://purl.obolibrary.org/obo/CHEBI_72314
T89190 507-514 Chemical denotes alanine http://purl.obolibrary.org/obo/CHEBI_16449
T71685 549-563 Chemical denotes carbon dioxide http://purl.obolibrary.org/obo/CHEBI_16526
T74041 549-555 Chemical denotes carbon http://purl.obolibrary.org/obo/CHEBI_27594|http://purl.obolibrary.org/obo/CHEBI_33415
T43905 689-698 Chemical denotes Glutamine http://purl.obolibrary.org/obo/CHEBI_28300
T86 814-822 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T63511 937-939 Chemical denotes AP http://purl.obolibrary.org/obo/CHEBI_28971|http://purl.obolibrary.org/obo/CHEBI_73393|http://purl.obolibrary.org/obo/CHEBI_81686
T90 1059-1068 Chemical denotes glutamine http://purl.obolibrary.org/obo/CHEBI_28300
T33400 1189-1191 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T93 1260-1269 Chemical denotes glutamine http://purl.obolibrary.org/obo/CHEBI_28300
T83525 1448-1457 Chemical denotes glutamine http://purl.obolibrary.org/obo/CHEBI_28300
T64768 1493-1503 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T63899 1493-1498 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T97 1499-1503 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T239 240-264 http://purl.obolibrary.org/obo/GO_0046651 denotes lymphocyte proliferation
T240 269-288 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine production
T241 435-445 http://purl.obolibrary.org/obo/GO_0006096 denotes glycolysis
T242 896-917 http://purl.obolibrary.org/obo/GO_0000981 denotes transcription factors
T243 896-909 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T244 965-978 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T245 1008-1026 http://purl.obolibrary.org/obo/GO_0008283 denotes cell proliferation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T338 0-187 Sentence denotes The biological activities of this nutrient are also associated with the reduced cellular potential of oxygen, which mainly depends on the ratio between reduced/oxidized glutathione [143].
T339 188-375 Sentence denotes In addition, glutamine is an essential nutrient for lymphocyte proliferation and cytokine production, macrophage phagocytes plus secretory activities and bacterial killing of neutrophils.
T340 376-602 Sentence denotes In immune cells, glucose is mainly converted into lactate (glycolysis), while glutamine is converted into glutamate, aspartate and alanine undergoing a partial oxidation in carbon dioxide, in a process of glutaminolysis [142].
T341 603-688 Sentence denotes This unique conversion plays a crucial role in the effective functioning of immunity.
T342 689-1027 Sentence denotes Glutamine is necessary for the expression of a variety of immune system genes [144], in particular through the activation of proteins, such as the ERK and JNK kinases which are involved in the activation of transcription factors, including JNK and AP-1, finally promoting the transcription of genes that participate in cell proliferation.
T343 1028-1217 Sentence denotes Besides, a sufficient level of glutamine is important to express the key markers of the cell surface of the lymphocytes and also various cytokines, for example, IL-6, IFN and TNF [143–145].
T344 1218-1544 Sentence denotes In healthy subjects with a balanced diet, glutamine supplementation does not increase the effectiveness of immune surveillance or prevent disease episodes, as reported by some reviews, but in some catabolic situations or in a low glutamine intake obtained from the diet, the amino acid supplementation could be required [142].

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1345 836-839 Gene denotes ERK Gene:5594
1346 929-932 Gene denotes JNK Gene:5599
1347 937-941 Gene denotes AP-1 Gene:3726
1348 1189-1193 Gene denotes IL-6 Gene:3569
1349 1195-1198 Gene denotes IFN Gene:3439
1350 1203-1206 Gene denotes TNF Gene:7124
1351 844-847 Gene denotes JNK Gene:5599
1352 102-108 Chemical denotes oxygen MESH:D010100
1353 169-180 Chemical denotes glutathione MESH:D005978
1354 201-210 Chemical denotes glutamine MESH:D005973
1355 393-400 Chemical denotes glucose MESH:D005947
1356 426-433 Chemical denotes lactate MESH:D019344
1357 454-463 Chemical denotes glutamine MESH:D005973
1358 482-491 Chemical denotes glutamate MESH:D018698
1359 493-502 Chemical denotes aspartate MESH:D001224
1360 507-514 Chemical denotes alanine MESH:D000409
1361 549-563 Chemical denotes carbon dioxide MESH:D002245
1362 689-698 Chemical denotes Glutamine MESH:D005973
1363 1059-1068 Chemical denotes glutamine MESH:D005973
1364 1260-1269 Chemical denotes glutamine MESH:D005973
1365 1448-1457 Chemical denotes glutamine MESH:D005973