PMC:7647877 / 46742-47880 JSON TXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-FMA-UBERON

LitCovid-PD-UBERON

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T122","span":{"begin":76,"end":80},"obj":"Body_part"}],"attributes":[{"id":"A122","pred":"uberon_id","subj":"T122","obj":"http://purl.obolibrary.org/obo/UBERON_0000014"}],"text":"Among the main activities of zinc in immune function there are: maintaining skin and mucosal integrity (e.g., cofactor for metalloenzymes required for cell membrane repair) [118]; improving the cytotoxic activity of NK cells [79, 82] and the phagocytic capacity of monocytes [64]. It is involved in the complement activity and in the production of IFN-γ [92, 95]; it is an important anti-inflammatory agent [119] and helps modulate the release of cytokines [95] by attenuating the development of pro-inflammatory Th17 and Th9 cells [64]. Furthermore, by influencing the generation of cytokines such as IL-2, IL-6 and TNF, it has antioxidant effects that protect against ROS and reactive nitrogen species [120]. Zinc also induces the proliferation of cytotoxic T cells [62] and is involved in the production of Th1 cytokines and thus supports the Th1 response [95]. It is essential for the intracellular binding of tyrosine kinase to T cell receptors, which is required for T cell development, differentiation and activation [118] and induces the development of Treg cells and is therefore important for maintaining immune tolerance [120]."}

LitCovid-PD-CLO

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T591","span":{"begin":15,"end":25},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T592","span":{"begin":76,"end":80},"obj":"http://purl.obolibrary.org/obo/UBERON_0000014"},{"id":"T593","span":{"begin":76,"end":80},"obj":"http://purl.obolibrary.org/obo/UBERON_0001003"},{"id":"T594","span":{"begin":76,"end":80},"obj":"http://purl.obolibrary.org/obo/UBERON_0002097"},{"id":"T595","span":{"begin":76,"end":80},"obj":"http://purl.obolibrary.org/obo/UBERON_0002199"},{"id":"T596","span":{"begin":76,"end":80},"obj":"http://www.ebi.ac.uk/efo/EFO_0000962"},{"id":"T597","span":{"begin":151,"end":155},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T598","span":{"begin":156,"end":164},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T599","span":{"begin":204,"end":212},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T600","span":{"begin":216,"end":224},"obj":"http://purl.obolibrary.org/obo/CL_0000623"},{"id":"T601","span":{"begin":242,"end":252},"obj":"http://purl.obolibrary.org/obo/CL_0000234"},{"id":"T602","span":{"begin":265,"end":274},"obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"T603","span":{"begin":314,"end":322},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T604","span":{"begin":526,"end":531},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T605","span":{"begin":602,"end":606},"obj":"http://purl.obolibrary.org/obo/PR_000001379"},{"id":"T606","span":{"begin":625,"end":628},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T607","span":{"begin":760,"end":767},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T608","span":{"begin":933,"end":939},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T609","span":{"begin":973,"end":979},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T610","span":{"begin":1013,"end":1023},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T611","span":{"begin":1061,"end":1065},"obj":"http://purl.obolibrary.org/obo/CL_0000792"},{"id":"T612","span":{"begin":1066,"end":1071},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Among the main activities of zinc in immune function there are: maintaining skin and mucosal integrity (e.g., cofactor for metalloenzymes required for cell membrane repair) [118]; improving the cytotoxic activity of NK cells [79, 82] and the phagocytic capacity of monocytes [64]. It is involved in the complement activity and in the production of IFN-γ [92, 95]; it is an important anti-inflammatory agent [119] and helps modulate the release of cytokines [95] by attenuating the development of pro-inflammatory Th17 and Th9 cells [64]. Furthermore, by influencing the generation of cytokines such as IL-2, IL-6 and TNF, it has antioxidant effects that protect against ROS and reactive nitrogen species [120]. Zinc also induces the proliferation of cytotoxic T cells [62] and is involved in the production of Th1 cytokines and thus supports the Th1 response [95]. It is essential for the intracellular binding of tyrosine kinase to T cell receptors, which is required for T cell development, differentiation and activation [118] and induces the development of Treg cells and is therefore important for maintaining immune tolerance [120]."}

LitCovid-PD-CHEBI

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T508","span":{"begin":29,"end":33},"obj":"Chemical"},{"id":"T510","span":{"begin":110,"end":118},"obj":"Chemical"},{"id":"T511","span":{"begin":383,"end":406},"obj":"Chemical"},{"id":"T512","span":{"begin":602,"end":604},"obj":"Chemical"},{"id":"T514","span":{"begin":608,"end":610},"obj":"Chemical"},{"id":"T516","span":{"begin":629,"end":640},"obj":"Chemical"},{"id":"T517","span":{"begin":670,"end":673},"obj":"Chemical"},{"id":"T518","span":{"begin":678,"end":703},"obj":"Chemical"},{"id":"T519","span":{"begin":687,"end":695},"obj":"Chemical"},{"id":"T520","span":{"begin":914,"end":922},"obj":"Chemical"}],"attributes":[{"id":"A508","pred":"chebi_id","subj":"T508","obj":"http://purl.obolibrary.org/obo/CHEBI_27363"},{"id":"A509","pred":"chebi_id","subj":"T508","obj":"http://purl.obolibrary.org/obo/CHEBI_30185"},{"id":"A510","pred":"chebi_id","subj":"T510","obj":"http://purl.obolibrary.org/obo/CHEBI_23357"},{"id":"A511","pred":"chebi_id","subj":"T511","obj":"http://purl.obolibrary.org/obo/CHEBI_67079"},{"id":"A512","pred":"chebi_id","subj":"T512","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A513","pred":"chebi_id","subj":"T512","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A514","pred":"chebi_id","subj":"T514","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A515","pred":"chebi_id","subj":"T514","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A516","pred":"chebi_id","subj":"T516","obj":"http://purl.obolibrary.org/obo/CHEBI_22586"},{"id":"A517","pred":"chebi_id","subj":"T517","obj":"http://purl.obolibrary.org/obo/CHEBI_26523"},{"id":"A518","pred":"chebi_id","subj":"T518","obj":"http://purl.obolibrary.org/obo/CHEBI_62764"},{"id":"A519","pred":"chebi_id","subj":"T519","obj":"http://purl.obolibrary.org/obo/CHEBI_25555"},{"id":"A520","pred":"chebi_id","subj":"T520","obj":"http://purl.obolibrary.org/obo/CHEBI_18186"}],"text":"Among the main activities of zinc in immune function there are: maintaining skin and mucosal integrity (e.g., cofactor for metalloenzymes required for cell membrane repair) [118]; improving the cytotoxic activity of NK cells [79, 82] and the phagocytic capacity of monocytes [64]. It is involved in the complement activity and in the production of IFN-γ [92, 95]; it is an important anti-inflammatory agent [119] and helps modulate the release of cytokines [95] by attenuating the development of pro-inflammatory Th17 and Th9 cells [64]. Furthermore, by influencing the generation of cytokines such as IL-2, IL-6 and TNF, it has antioxidant effects that protect against ROS and reactive nitrogen species [120]. Zinc also induces the proliferation of cytotoxic T cells [62] and is involved in the production of Th1 cytokines and thus supports the Th1 response [95]. It is essential for the intracellular binding of tyrosine kinase to T cell receptors, which is required for T cell development, differentiation and activation [118] and induces the development of Treg cells and is therefore important for maintaining immune tolerance [120]."}

LitCovid-PD-GO-BP

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T194","span":{"begin":303,"end":322},"obj":"http://purl.obolibrary.org/obo/GO_0006956"},{"id":"T195","span":{"begin":973,"end":991},"obj":"http://purl.obolibrary.org/obo/GO_0030217"},{"id":"T196","span":{"begin":975,"end":991},"obj":"http://purl.obolibrary.org/obo/GO_0048468"}],"text":"Among the main activities of zinc in immune function there are: maintaining skin and mucosal integrity (e.g., cofactor for metalloenzymes required for cell membrane repair) [118]; improving the cytotoxic activity of NK cells [79, 82] and the phagocytic capacity of monocytes [64]. It is involved in the complement activity and in the production of IFN-γ [92, 95]; it is an important anti-inflammatory agent [119] and helps modulate the release of cytokines [95] by attenuating the development of pro-inflammatory Th17 and Th9 cells [64]. Furthermore, by influencing the generation of cytokines such as IL-2, IL-6 and TNF, it has antioxidant effects that protect against ROS and reactive nitrogen species [120]. Zinc also induces the proliferation of cytotoxic T cells [62] and is involved in the production of Th1 cytokines and thus supports the Th1 response [95]. It is essential for the intracellular binding of tyrosine kinase to T cell receptors, which is required for T cell development, differentiation and activation [118] and induces the development of Treg cells and is therefore important for maintaining immune tolerance [120]."}

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T285","span":{"begin":0,"end":280},"obj":"Sentence"},{"id":"T286","span":{"begin":281,"end":537},"obj":"Sentence"},{"id":"T287","span":{"begin":538,"end":710},"obj":"Sentence"},{"id":"T288","span":{"begin":711,"end":864},"obj":"Sentence"},{"id":"T289","span":{"begin":865,"end":1138},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Among the main activities of zinc in immune function there are: maintaining skin and mucosal integrity (e.g., cofactor for metalloenzymes required for cell membrane repair) [118]; improving the cytotoxic activity of NK cells [79, 82] and the phagocytic capacity of monocytes [64]. It is involved in the complement activity and in the production of IFN-γ [92, 95]; it is an important anti-inflammatory agent [119] and helps modulate the release of cytokines [95] by attenuating the development of pro-inflammatory Th17 and Th9 cells [64]. Furthermore, by influencing the generation of cytokines such as IL-2, IL-6 and TNF, it has antioxidant effects that protect against ROS and reactive nitrogen species [120]. Zinc also induces the proliferation of cytotoxic T cells [62] and is involved in the production of Th1 cytokines and thus supports the Th1 response [95]. It is essential for the intracellular binding of tyrosine kinase to T cell receptors, which is required for T cell development, differentiation and activation [118] and induces the development of Treg cells and is therefore important for maintaining immune tolerance [120]."}

LitCovid-PubTator

{"project":"LitCovid-PubTator","denotations":[{"id":"1181","span":{"begin":348,"end":353},"obj":"Gene"},{"id":"1182","span":{"begin":602,"end":606},"obj":"Gene"},{"id":"1183","span":{"begin":608,"end":612},"obj":"Gene"},{"id":"1184","span":{"begin":617,"end":620},"obj":"Gene"},{"id":"1185","span":{"begin":156,"end":164},"obj":"Gene"},{"id":"1186","span":{"begin":670,"end":673},"obj":"Chemical"},{"id":"1187","span":{"begin":687,"end":695},"obj":"Chemical"}],"attributes":[{"id":"A1181","pred":"tao:has_database_id","subj":"1181","obj":"Gene:3458"},{"id":"A1182","pred":"tao:has_database_id","subj":"1182","obj":"Gene:3558"},{"id":"A1183","pred":"tao:has_database_id","subj":"1183","obj":"Gene:3569"},{"id":"A1184","pred":"tao:has_database_id","subj":"1184","obj":"Gene:7124"},{"id":"A1185","pred":"tao:has_database_id","subj":"1185","obj":"Gene:43740571"},{"id":"A1186","pred":"tao:has_database_id","subj":"1186","obj":"MESH:D017382"},{"id":"A1187","pred":"tao:has_database_id","subj":"1187","obj":"MESH:D009584"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Among the main activities of zinc in immune function there are: maintaining skin and mucosal integrity (e.g., cofactor for metalloenzymes required for cell membrane repair) [118]; improving the cytotoxic activity of NK cells [79, 82] and the phagocytic capacity of monocytes [64]. It is involved in the complement activity and in the production of IFN-γ [92, 95]; it is an important anti-inflammatory agent [119] and helps modulate the release of cytokines [95] by attenuating the development of pro-inflammatory Th17 and Th9 cells [64]. Furthermore, by influencing the generation of cytokines such as IL-2, IL-6 and TNF, it has antioxidant effects that protect against ROS and reactive nitrogen species [120]. Zinc also induces the proliferation of cytotoxic T cells [62] and is involved in the production of Th1 cytokines and thus supports the Th1 response [95]. It is essential for the intracellular binding of tyrosine kinase to T cell receptors, which is required for T cell development, differentiation and activation [118] and induces the development of Treg cells and is therefore important for maintaining immune tolerance [120]."}