PMC:7647877 / 43770-45723
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T475 | 313-319 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
| T476 | 334-338 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T477 | 414-420 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
| T478 | 514-528 | Body_part | denotes | cell membranes | http://purl.org/sig/ont/fma/fma63841 |
| T479 | 514-518 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T480 | 695-710 | Body_part | denotes | dendritic cells | http://purl.org/sig/ont/fma/fma273565 |
| T481 | 705-710 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T482 | 760-774 | Body_part | denotes | immune systems | http://purl.org/sig/ont/fma/fma9825 |
| T483 | 912-920 | Body_part | denotes | NK cells | http://purl.org/sig/ont/fma/fma63147 |
| T484 | 915-920 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T485 | 1131-1138 | Body_part | denotes | synapse | http://purl.org/sig/ont/fma/fma67408 |
| T486 | 1160-1165 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T487 | 1299-1309 | Body_part | denotes | lymphocyte | http://purl.org/sig/ont/fma/fma62863 |
| T488 | 1330-1334 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T489 | 1932-1937 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T118 | 760-774 | Body_part | denotes | immune systems | http://purl.obolibrary.org/obo/UBERON_0002405 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T239 | 248-257 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T240 | 447-460 | Disease | denotes | infections in | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T241 | 1473-1483 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T242 | 1492-1501 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T548 | 265-266 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T549 | 313-319 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T550 | 334-338 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T551 | 372-373 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T552 | 414-420 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T553 | 514-518 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T554 | 519-528 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membranes |
| T555 | 595-605 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
| T556 | 631-634 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T557 | 695-710 | http://purl.obolibrary.org/obo/CL_0000451 | denotes | dendritic cells |
| T558 | 760-774 | http://purl.obolibrary.org/obo/UBERON_0002405 | denotes | immune systems |
| T559 | 900-908 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T560 | 912-920 | http://purl.obolibrary.org/obo/CL_0000623 | denotes | NK cells |
| T561 | 952-954 | http://purl.obolibrary.org/obo/CLO_0002860 | denotes | E2 |
| T562 | 1019-1027 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T563 | 1152-1165 | http://purl.obolibrary.org/obo/CL_0000898 | denotes | naive T cells |
| T564 | 1328-1334 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cell |
| T565 | 1502-1505 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T566 | 1553-1559 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | humans |
| T567 | 1572-1575 | http://purl.obolibrary.org/obo/CLO_0053001 | denotes | 114 |
| T568 | 1814-1817 | http://purl.obolibrary.org/obo/UBERON_0001013 | denotes | fat |
| T569 | 1932-1937 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T470 | 0-9 | Chemical | denotes | Vitamin E | http://purl.obolibrary.org/obo/CHEBI_18145 |
| T471 | 0-7 | Chemical | denotes | Vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T472 | 10-19 | Chemical | denotes | Vitamin E | http://purl.obolibrary.org/obo/CHEBI_18145 |
| T473 | 10-17 | Chemical | denotes | Vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T474 | 49-60 | Chemical | denotes | tocopherols | http://purl.obolibrary.org/obo/CHEBI_27013 |
| T475 | 121-133 | Chemical | denotes | tocotrienols | http://purl.obolibrary.org/obo/CHEBI_33235 |
| T476 | 189-196 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T477 | 320-329 | Chemical | denotes | vitamin E | http://purl.obolibrary.org/obo/CHEBI_33234 |
| T478 | 320-327 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T479 | 421-430 | Chemical | denotes | vitamin E | http://purl.obolibrary.org/obo/CHEBI_33234 |
| T480 | 421-428 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T481 | 556-564 | Chemical | denotes | radicals | http://purl.obolibrary.org/obo/CHEBI_26519 |
| T482 | 621-630 | Chemical | denotes | Vitamin E | http://purl.obolibrary.org/obo/CHEBI_18145 |
| T483 | 621-628 | Chemical | denotes | Vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T484 | 822-831 | Chemical | denotes | vitamin E | http://purl.obolibrary.org/obo/CHEBI_33234 |
| T485 | 822-829 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T486 | 938-954 | Chemical | denotes | prostaglandin E2 | http://purl.obolibrary.org/obo/CHEBI_15551|http://purl.obolibrary.org/obo/CHEBI_606564 |
| T488 | 938-951 | Chemical | denotes | prostaglandin | http://purl.obolibrary.org/obo/CHEBI_26333 |
| T489 | 956-960 | Chemical | denotes | PGE2 | http://purl.obolibrary.org/obo/CHEBI_15551 |
| T490 | 1060-1072 | Chemical | denotes | nitric oxide | http://purl.obolibrary.org/obo/CHEBI_16480 |
| T491 | 1067-1072 | Chemical | denotes | oxide | http://purl.obolibrary.org/obo/CHEBI_25741|http://purl.obolibrary.org/obo/CHEBI_29356 |
| T493 | 1224-1231 | Chemical | denotes | antigen | http://purl.obolibrary.org/obo/CHEBI_59132 |
| T494 | 1444-1451 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T495 | 1607-1616 | Chemical | denotes | vitamin E | http://purl.obolibrary.org/obo/CHEBI_33234 |
| T496 | 1607-1614 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T497 | 1670-1676 | Chemical | denotes | oxygen | http://purl.obolibrary.org/obo/CHEBI_25805 |
| T498 | 1826-1837 | Chemical | denotes | antioxidant | http://purl.obolibrary.org/obo/CHEBI_22586 |
| T499 | 1886-1894 | Chemical | denotes | radicals | http://purl.obolibrary.org/obo/CHEBI_26519 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T95 | 230-257 | Phenotype | denotes | susceptibility to infection | http://purl.obolibrary.org/obo/HP_0002719 |
| T96 | 1695-1711 | Phenotype | denotes | oxidative stress | http://purl.obolibrary.org/obo/HP_0025464 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T183 | 334-364 | http://purl.obolibrary.org/obo/GO_0002443 | denotes | cell-mediated immune responses |
| T184 | 786-801 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
| T185 | 1139-1148 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
| T186 | 1196-1202 | http://purl.obolibrary.org/obo/GO_0007613 | denotes | memory |
| T187 | 1299-1323 | http://purl.obolibrary.org/obo/GO_0046651 | denotes | lymphocyte proliferation |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T268 | 0-9 | Sentence | denotes | Vitamin E |
| T269 | 10-183 | Sentence | denotes | Vitamin E exists mainly in the form of tocopherols present in high amounts in nuts and vegetable oils, whereas tocotrienols are found predominantly in some seeds and grains. |
| T270 | 184-264 | Sentence | denotes | This vitamin is involved in immunity and host susceptibility to infection [112]. |
| T271 | 265-501 | Sentence | denotes | A positive association was demonstrated between plasma vitamin E and cell-mediated immune responses, while a negative association was observed among plasma vitamin E and the risk of infections in healthy adults over 60 years of age [8]. |
| T272 | 502-620 | Sentence | denotes | It protects cell membranes from damage caused by free radicals and supports the integrity of epithelial barriers [79]. |
| T273 | 621-781 | Sentence | denotes | Vitamin E has also been shown to regulate the maturation and functions of dendritic cells, which are important for the innate and adaptive immune systems [112]. |
| T274 | 782-1279 | Sentence | denotes | The immune response mechanisms in which vitamin E is involved are as follows: (i) maintains or improves the cytotoxic activity of NK cells [82] and reduces prostaglandin E2 (PGE2) production by the inhibition of cyclooxygenase-2 (COX-2) activity, mediated through decreasing of nitric oxide production [64, 112, 113]; (ii) the improvement of immune synapse formation in naive T cells, increasing the percentage of memory experienced with the antigen [112]; (iii) the modulation of Th1/Th2 balance. |
| T275 | 1280-1426 | Sentence | denotes | Indeed it improves lymphocyte proliferation and T cell mediated functions, optimizes and improves the Th1 response and suppress Th2 response [95]. |
| T276 | 1427-1577 | Sentence | denotes | The role of this vitamin in the prevention of infections such as influenza has been discussed, but more controlled studies in humans are needed [114]. |
| T277 | 1578-1768 | Sentence | denotes | Notably, it is accepted that vitamin E may exert its immune-enhancing effects by scavenging oxygen species to reduce oxidative stress [112] and it may induce anti-inflammatory effects [113]. |
| T278 | 1769-1953 | Sentence | denotes | In particular, it appears to be an important fat-soluble antioxidant that hinders the chain reaction induced by free radicals (chain breaking effect) and protects cells from them [95]. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1129 | 0-9 | Chemical | denotes | Vitamin E | |
| 1134 | 10-19 | Chemical | denotes | Vitamin E | |
| 1135 | 49-60 | Chemical | denotes | tocopherols | MESH:D024505 |
| 1136 | 121-133 | Chemical | denotes | tocotrienols | MESH:D024508 |
| 1137 | 248-257 | Disease | denotes | infection | MESH:D007239 |
| 1141 | 320-329 | Chemical | denotes | vitamin E | |
| 1142 | 421-430 | Chemical | denotes | vitamin E | |
| 1143 | 447-457 | Disease | denotes | infections | MESH:D007239 |
| 1154 | 994-1010 | Gene | denotes | cyclooxygenase-2 | Gene:5743 |
| 1155 | 1012-1017 | Gene | denotes | COX-2 | Gene:5743 |
| 1156 | 1553-1559 | Species | denotes | humans | Tax:9606 |
| 1157 | 1492-1501 | Species | denotes | influenza | Tax:11320 |
| 1158 | 621-630 | Chemical | denotes | Vitamin E | |
| 1159 | 822-831 | Chemical | denotes | vitamin E | |
| 1160 | 938-954 | Chemical | denotes | prostaglandin E2 | MESH:D015232 |
| 1161 | 956-960 | Chemical | denotes | PGE2 | MESH:D015232 |
| 1162 | 1060-1072 | Chemical | denotes | nitric oxide | MESH:D009569 |
| 1163 | 1473-1483 | Disease | denotes | infections | MESH:D007239 |
| 1166 | 1607-1616 | Chemical | denotes | vitamin E | |
| 1167 | 1670-1676 | Chemical | denotes | oxygen | MESH:D010100 |