PMC:7647877 / 41690-42478 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T459","span":{"begin":53,"end":61},"obj":"Body_part"},{"id":"T460","span":{"begin":236,"end":245},"obj":"Body_part"},{"id":"T461","span":{"begin":296,"end":305},"obj":"Body_part"},{"id":"T462","span":{"begin":309,"end":320},"obj":"Body_part"},{"id":"T463","span":{"begin":363,"end":371},"obj":"Body_part"},{"id":"T464","span":{"begin":433,"end":443},"obj":"Body_part"},{"id":"T465","span":{"begin":506,"end":516},"obj":"Body_part"},{"id":"T466","span":{"begin":562,"end":567},"obj":"Body_part"},{"id":"T467","span":{"begin":619,"end":633},"obj":"Body_part"},{"id":"T468","span":{"begin":634,"end":641},"obj":"Body_part"},{"id":"T469","span":{"begin":643,"end":653},"obj":"Body_part"},{"id":"T470","span":{"begin":678,"end":687},"obj":"Body_part"}],"attributes":[{"id":"A459","pred":"fma_id","subj":"T459","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A460","pred":"fma_id","subj":"T460","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A461","pred":"fma_id","subj":"T461","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A462","pred":"fma_id","subj":"T462","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A463","pred":"fma_id","subj":"T463","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A464","pred":"fma_id","subj":"T464","obj":"http://purl.org/sig/ont/fma/fma7199"},{"id":"A465","pred":"fma_id","subj":"T465","obj":"http://purl.org/sig/ont/fma/fma7199"},{"id":"A466","pred":"fma_id","subj":"T466","obj":"http://purl.org/sig/ont/fma/fma68877"},{"id":"A467","pred":"fma_id","subj":"T467","obj":"http://purl.org/sig/ont/fma/fma67397"},{"id":"A468","pred":"fma_id","subj":"T468","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A469","pred":"fma_id","subj":"T469","obj":"http://purl.org/sig/ont/fma/fma61792"},{"id":"A470","pred":"fma_id","subj":"T470","obj":"http://purl.org/sig/ont/fma/fma7199"}],"text":"Calcitriol regulates the expression of antimicrobial proteins (cathelicidin and defensin), which directly kill pathogens, especially bacteria [99]. It inhibits the production of IFN-γ [71] and reduces the expression of pro-inflammatory cytokines by increasing the expression of anti-inflammatory cytokines by macrophages [105]. Calcitriol modulates antimicrobial proteins (cathelicidin and β-defensin), responsible for modifying the intestinal microbiota, favoring a healthy composition and supporting the intestinal barrier [80, 106]. It also helps protect the lungs against infection, increases the expression of the tight junction protein, E-cadherin and connexion 43 in the intestine, maintains renal-epithelial barrier function and improves corneal epithelial barrier function [104]."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T113","span":{"begin":678,"end":687},"obj":"Body_part"}],"attributes":[{"id":"A113","pred":"uberon_id","subj":"T113","obj":"http://purl.obolibrary.org/obo/UBERON_0000160"}],"text":"Calcitriol regulates the expression of antimicrobial proteins (cathelicidin and defensin), which directly kill pathogens, especially bacteria [99]. It inhibits the production of IFN-γ [71] and reduces the expression of pro-inflammatory cytokines by increasing the expression of anti-inflammatory cytokines by macrophages [105]. Calcitriol modulates antimicrobial proteins (cathelicidin and β-defensin), responsible for modifying the intestinal microbiota, favoring a healthy composition and supporting the intestinal barrier [80, 106]. It also helps protect the lungs against infection, increases the expression of the tight junction protein, E-cadherin and connexion 43 in the intestine, maintains renal-epithelial barrier function and improves corneal epithelial barrier function [104]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T227","span":{"begin":576,"end":585},"obj":"Disease"}],"attributes":[{"id":"A227","pred":"mondo_id","subj":"T227","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"Calcitriol regulates the expression of antimicrobial proteins (cathelicidin and defensin), which directly kill pathogens, especially bacteria [99]. It inhibits the production of IFN-γ [71] and reduces the expression of pro-inflammatory cytokines by increasing the expression of anti-inflammatory cytokines by macrophages [105]. Calcitriol modulates antimicrobial proteins (cathelicidin and β-defensin), responsible for modifying the intestinal microbiota, favoring a healthy composition and supporting the intestinal barrier [80, 106]. It also helps protect the lungs against infection, increases the expression of the tight junction protein, E-cadherin and connexion 43 in the intestine, maintains renal-epithelial barrier function and improves corneal epithelial barrier function [104]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T524","span":{"begin":133,"end":141},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_2"},{"id":"T525","span":{"begin":185,"end":187},"obj":"http://purl.obolibrary.org/obo/CLO_0054055"},{"id":"T526","span":{"begin":433,"end":443},"obj":"http://purl.obolibrary.org/obo/UBERON_0000160"},{"id":"T527","span":{"begin":433,"end":443},"obj":"http://www.ebi.ac.uk/efo/EFO_0000834"},{"id":"T528","span":{"begin":465,"end":466},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T529","span":{"begin":506,"end":516},"obj":"http://purl.obolibrary.org/obo/UBERON_0000160"},{"id":"T530","span":{"begin":506,"end":516},"obj":"http://www.ebi.ac.uk/efo/EFO_0000834"},{"id":"T531","span":{"begin":562,"end":567},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T532","span":{"begin":625,"end":633},"obj":"http://purl.obolibrary.org/obo/UBERON_0007651"},{"id":"T533","span":{"begin":645,"end":653},"obj":"http://purl.obolibrary.org/obo/PR_000001327"},{"id":"T534","span":{"begin":678,"end":687},"obj":"http://purl.obolibrary.org/obo/UBERON_0000160"},{"id":"T535","span":{"begin":678,"end":687},"obj":"http://www.ebi.ac.uk/efo/EFO_0000834"},{"id":"T536","span":{"begin":705,"end":715},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T537","span":{"begin":754,"end":764},"obj":"http://purl.obolibrary.org/obo/CL_0000066"}],"text":"Calcitriol regulates the expression of antimicrobial proteins (cathelicidin and defensin), which directly kill pathogens, especially bacteria [99]. It inhibits the production of IFN-γ [71] and reduces the expression of pro-inflammatory cytokines by increasing the expression of anti-inflammatory cytokines by macrophages [105]. Calcitriol modulates antimicrobial proteins (cathelicidin and β-defensin), responsible for modifying the intestinal microbiota, favoring a healthy composition and supporting the intestinal barrier [80, 106]. It also helps protect the lungs against infection, increases the expression of the tight junction protein, E-cadherin and connexion 43 in the intestine, maintains renal-epithelial barrier function and improves corneal epithelial barrier function [104]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T448","span":{"begin":0,"end":10},"obj":"Chemical"},{"id":"T449","span":{"begin":39,"end":52},"obj":"Chemical"},{"id":"T450","span":{"begin":53,"end":61},"obj":"Chemical"},{"id":"T451","span":{"begin":80,"end":88},"obj":"Chemical"},{"id":"T452","span":{"begin":328,"end":338},"obj":"Chemical"},{"id":"T453","span":{"begin":349,"end":362},"obj":"Chemical"},{"id":"T454","span":{"begin":363,"end":371},"obj":"Chemical"},{"id":"T455","span":{"begin":392,"end":400},"obj":"Chemical"},{"id":"T456","span":{"begin":634,"end":641},"obj":"Chemical"}],"attributes":[{"id":"A448","pred":"chebi_id","subj":"T448","obj":"http://purl.obolibrary.org/obo/CHEBI_17823"},{"id":"A449","pred":"chebi_id","subj":"T449","obj":"http://purl.obolibrary.org/obo/CHEBI_33281"},{"id":"A450","pred":"chebi_id","subj":"T450","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A451","pred":"chebi_id","subj":"T451","obj":"http://purl.obolibrary.org/obo/CHEBI_82761"},{"id":"A452","pred":"chebi_id","subj":"T452","obj":"http://purl.obolibrary.org/obo/CHEBI_17823"},{"id":"A453","pred":"chebi_id","subj":"T453","obj":"http://purl.obolibrary.org/obo/CHEBI_33281"},{"id":"A454","pred":"chebi_id","subj":"T454","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A455","pred":"chebi_id","subj":"T455","obj":"http://purl.obolibrary.org/obo/CHEBI_82761"},{"id":"A456","pred":"chebi_id","subj":"T456","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"Calcitriol regulates the expression of antimicrobial proteins (cathelicidin and defensin), which directly kill pathogens, especially bacteria [99]. It inhibits the production of IFN-γ [71] and reduces the expression of pro-inflammatory cytokines by increasing the expression of anti-inflammatory cytokines by macrophages [105]. Calcitriol modulates antimicrobial proteins (cathelicidin and β-defensin), responsible for modifying the intestinal microbiota, favoring a healthy composition and supporting the intestinal barrier [80, 106]. It also helps protect the lungs against infection, increases the expression of the tight junction protein, E-cadherin and connexion 43 in the intestine, maintains renal-epithelial barrier function and improves corneal epithelial barrier function [104]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T257","span":{"begin":0,"end":147},"obj":"Sentence"},{"id":"T258","span":{"begin":148,"end":327},"obj":"Sentence"},{"id":"T259","span":{"begin":328,"end":535},"obj":"Sentence"},{"id":"T260","span":{"begin":536,"end":788},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Calcitriol regulates the expression of antimicrobial proteins (cathelicidin and defensin), which directly kill pathogens, especially bacteria [99]. It inhibits the production of IFN-γ [71] and reduces the expression of pro-inflammatory cytokines by increasing the expression of anti-inflammatory cytokines by macrophages [105]. Calcitriol modulates antimicrobial proteins (cathelicidin and β-defensin), responsible for modifying the intestinal microbiota, favoring a healthy composition and supporting the intestinal barrier [80, 106]. It also helps protect the lungs against infection, increases the expression of the tight junction protein, E-cadherin and connexion 43 in the intestine, maintains renal-epithelial barrier function and improves corneal epithelial barrier function [104]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1084","span":{"begin":178,"end":183},"obj":"Gene"},{"id":"1085","span":{"begin":643,"end":653},"obj":"Gene"},{"id":"1086","span":{"begin":0,"end":10},"obj":"Chemical"},{"id":"1087","span":{"begin":328,"end":338},"obj":"Chemical"},{"id":"1088","span":{"begin":576,"end":585},"obj":"Disease"},{"id":"1089","span":{"begin":746,"end":753},"obj":"Disease"}],"attributes":[{"id":"A1084","pred":"tao:has_database_id","subj":"1084","obj":"Gene:3458"},{"id":"A1085","pred":"tao:has_database_id","subj":"1085","obj":"Gene:999"},{"id":"A1086","pred":"tao:has_database_id","subj":"1086","obj":"MESH:D002117"},{"id":"A1087","pred":"tao:has_database_id","subj":"1087","obj":"MESH:D002117"},{"id":"A1088","pred":"tao:has_database_id","subj":"1088","obj":"MESH:D007239"},{"id":"A1089","pred":"tao:has_database_id","subj":"1089","obj":"MESH:D003316"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Calcitriol regulates the expression of antimicrobial proteins (cathelicidin and defensin), which directly kill pathogens, especially bacteria [99]. It inhibits the production of IFN-γ [71] and reduces the expression of pro-inflammatory cytokines by increasing the expression of anti-inflammatory cytokines by macrophages [105]. Calcitriol modulates antimicrobial proteins (cathelicidin and β-defensin), responsible for modifying the intestinal microbiota, favoring a healthy composition and supporting the intestinal barrier [80, 106]. It also helps protect the lungs against infection, increases the expression of the tight junction protein, E-cadherin and connexion 43 in the intestine, maintains renal-epithelial barrier function and improves corneal epithelial barrier function [104]."}