PMC:7647877 / 31961-33934 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T362","span":{"begin":64,"end":86},"obj":"Body_part"},{"id":"T363","span":{"begin":103,"end":108},"obj":"Body_part"},{"id":"T364","span":{"begin":159,"end":169},"obj":"Body_part"},{"id":"T365","span":{"begin":348,"end":358},"obj":"Body_part"},{"id":"T366","span":{"begin":433,"end":438},"obj":"Body_part"},{"id":"T367","span":{"begin":465,"end":475},"obj":"Body_part"},{"id":"T368","span":{"begin":790,"end":795},"obj":"Body_part"},{"id":"T369","span":{"begin":887,"end":896},"obj":"Body_part"},{"id":"T370","span":{"begin":908,"end":910},"obj":"Body_part"},{"id":"T371","span":{"begin":917,"end":921},"obj":"Body_part"},{"id":"T372","span":{"begin":917,"end":919},"obj":"Body_part"},{"id":"T373","span":{"begin":1007,"end":1020},"obj":"Body_part"},{"id":"T374","span":{"begin":1219,"end":1227},"obj":"Body_part"},{"id":"T375","span":{"begin":1236,"end":1238},"obj":"Body_part"},{"id":"T376","span":{"begin":1860,"end":1865},"obj":"Body_part"}],"attributes":[{"id":"A362","pred":"fma_id","subj":"T362","obj":"http://purl.org/sig/ont/fma/fma71132"},{"id":"A363","pred":"fma_id","subj":"T363","obj":"http://purl.org/sig/ont/fma/fma67264"},{"id":"A364","pred":"fma_id","subj":"T364","obj":"http://purl.org/sig/ont/fma/fma82738"},{"id":"A365","pred":"fma_id","subj":"T365","obj":"http://purl.org/sig/ont/fma/fma82738"},{"id":"A366","pred":"fma_id","subj":"T366","obj":"http://purl.org/sig/ont/fma/fma67264"},{"id":"A367","pred":"fma_id","subj":"T367","obj":"http://purl.org/sig/ont/fma/fma63845"},{"id":"A368","pred":"fma_id","subj":"T368","obj":"http://purl.org/sig/ont/fma/fma68877"},{"id":"A369","pred":"fma_id","subj":"T369","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A370","pred":"fma_id","subj":"T370","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A371","pred":"fma_id","subj":"T371","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A372","pred":"fma_id","subj":"T372","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A373","pred":"fma_id","subj":"T373","obj":"http://purl.org/sig/ont/fma/fma9825"},{"id":"A374","pred":"fma_id","subj":"T374","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A375","pred":"fma_id","subj":"T375","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A376","pred":"fma_id","subj":"T376","obj":"http://purl.org/sig/ont/fma/fma67264"}],"text":"Oleoylethanolamide\nOleoylethanolamide (OEA), synthesized in the gastrointestinal tract, is a bioactive lipid mediator derived from the omega-9 monounsaturated fatty acid, oleic acid. Based on previous evidences, OEA showed anti-inflammatory activities, a role in modulation of immune response, anti-oxidant effects and stimulation of lipolysis and fatty acid oxidation [72].\nIn this context OEA is considered an endocannabinoid-like lipid, which interacts with the peroxisome proliferator-activated receptor-alpha (PPAR-α) and intervenes during the anti-inflammatory processes [73].\nScientific researchers recently showed that endocannabinoid system is involved in the management of infectious agents such as viruses, bacteria, and some protozoa, also reducing inflammation and pain in the lungs [74]. In view of the fact that SARS-CoV-2 infection leads to increase the pro-inflammatory cytokines, including IL-6 and IL-1β in COVID-19 patients via binding to the TLRs, an important components of the innate immune system, it is assumed that OEA inhibits this pathway through its anti-inflammatory properties [75]. OEA binds with high affinity to PPAR-α receptors and increases the expression level of anti-inflammatory cytokine such as IL-10, then initiates a cascade of events, which can attenuate the inflammatory responses [73]. Furthermore, OEA attenuates the inflammatory responses modulating the expression of TLR-4, and interfering with the ERK1/2/AP-1/STAT3 signaling cascade [73]. OEA may modulate cross-talk between PPAR-α and TLRs and regulates the inflammatory responses with beneficial synergistic effect against SARS-CoV-2. Nowadays, discovering therapeutic options from currently available agents appears to be essential for the treatment and prophylaxis of this pandemic, especially in obese patients with comorbidities [76] and this bioactive lipid mediator can be considered as a novel potential pharmacological alternative for the management of COVID-19."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T96","span":{"begin":1007,"end":1020},"obj":"Body_part"}],"attributes":[{"id":"A96","pred":"uberon_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/UBERON_0002405"}],"text":"Oleoylethanolamide\nOleoylethanolamide (OEA), synthesized in the gastrointestinal tract, is a bioactive lipid mediator derived from the omega-9 monounsaturated fatty acid, oleic acid. Based on previous evidences, OEA showed anti-inflammatory activities, a role in modulation of immune response, anti-oxidant effects and stimulation of lipolysis and fatty acid oxidation [72].\nIn this context OEA is considered an endocannabinoid-like lipid, which interacts with the peroxisome proliferator-activated receptor-alpha (PPAR-α) and intervenes during the anti-inflammatory processes [73].\nScientific researchers recently showed that endocannabinoid system is involved in the management of infectious agents such as viruses, bacteria, and some protozoa, also reducing inflammation and pain in the lungs [74]. In view of the fact that SARS-CoV-2 infection leads to increase the pro-inflammatory cytokines, including IL-6 and IL-1β in COVID-19 patients via binding to the TLRs, an important components of the innate immune system, it is assumed that OEA inhibits this pathway through its anti-inflammatory properties [75]. OEA binds with high affinity to PPAR-α receptors and increases the expression level of anti-inflammatory cytokine such as IL-10, then initiates a cascade of events, which can attenuate the inflammatory responses [73]. Furthermore, OEA attenuates the inflammatory responses modulating the expression of TLR-4, and interfering with the ERK1/2/AP-1/STAT3 signaling cascade [73]. OEA may modulate cross-talk between PPAR-α and TLRs and regulates the inflammatory responses with beneficial synergistic effect against SARS-CoV-2. Nowadays, discovering therapeutic options from currently available agents appears to be essential for the treatment and prophylaxis of this pandemic, especially in obese patients with comorbidities [76] and this bioactive lipid mediator can be considered as a novel potential pharmacological alternative for the management of COVID-19."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T194","span":{"begin":683,"end":693},"obj":"Disease"},{"id":"T195","span":{"begin":761,"end":773},"obj":"Disease"},{"id":"T196","span":{"begin":827,"end":835},"obj":"Disease"},{"id":"T197","span":{"begin":838,"end":847},"obj":"Disease"},{"id":"T198","span":{"begin":926,"end":934},"obj":"Disease"},{"id":"T199","span":{"begin":1626,"end":1634},"obj":"Disease"},{"id":"T200","span":{"begin":1964,"end":1972},"obj":"Disease"}],"attributes":[{"id":"A194","pred":"mondo_id","subj":"T194","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A195","pred":"mondo_id","subj":"T195","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A196","pred":"mondo_id","subj":"T196","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A197","pred":"mondo_id","subj":"T197","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A198","pred":"mondo_id","subj":"T198","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A199","pred":"mondo_id","subj":"T199","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A200","pred":"mondo_id","subj":"T200","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Oleoylethanolamide\nOleoylethanolamide (OEA), synthesized in the gastrointestinal tract, is a bioactive lipid mediator derived from the omega-9 monounsaturated fatty acid, oleic acid. Based on previous evidences, OEA showed anti-inflammatory activities, a role in modulation of immune response, anti-oxidant effects and stimulation of lipolysis and fatty acid oxidation [72].\nIn this context OEA is considered an endocannabinoid-like lipid, which interacts with the peroxisome proliferator-activated receptor-alpha (PPAR-α) and intervenes during the anti-inflammatory processes [73].\nScientific researchers recently showed that endocannabinoid system is involved in the management of infectious agents such as viruses, bacteria, and some protozoa, also reducing inflammation and pain in the lungs [74]. In view of the fact that SARS-CoV-2 infection leads to increase the pro-inflammatory cytokines, including IL-6 and IL-1β in COVID-19 patients via binding to the TLRs, an important components of the innate immune system, it is assumed that OEA inhibits this pathway through its anti-inflammatory properties [75]. OEA binds with high affinity to PPAR-α receptors and increases the expression level of anti-inflammatory cytokine such as IL-10, then initiates a cascade of events, which can attenuate the inflammatory responses [73]. Furthermore, OEA attenuates the inflammatory responses modulating the expression of TLR-4, and interfering with the ERK1/2/AP-1/STAT3 signaling cascade [73]. OEA may modulate cross-talk between PPAR-α and TLRs and regulates the inflammatory responses with beneficial synergistic effect against SARS-CoV-2. Nowadays, discovering therapeutic options from currently available agents appears to be essential for the treatment and prophylaxis of this pandemic, especially in obese patients with comorbidities [76] and this bioactive lipid mediator can be considered as a novel potential pharmacological alternative for the management of COVID-19."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T395","span":{"begin":64,"end":86},"obj":"http://purl.obolibrary.org/obo/UBERON_0005409"},{"id":"T396","span":{"begin":91,"end":92},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T397","span":{"begin":241,"end":251},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T398","span":{"begin":253,"end":254},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T399","span":{"begin":489,"end":498},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T400","span":{"begin":709,"end":716},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T401","span":{"begin":718,"end":726},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_2"},{"id":"T402","span":{"begin":790,"end":795},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T403","span":{"begin":1007,"end":1020},"obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"T404","span":{"begin":1258,"end":1259},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T405","span":{"begin":1455,"end":1457},"obj":"http://purl.obolibrary.org/obo/CLO_0001547"},{"id":"T406","span":{"begin":1466,"end":1475},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T407","span":{"begin":1896,"end":1897},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Oleoylethanolamide\nOleoylethanolamide (OEA), synthesized in the gastrointestinal tract, is a bioactive lipid mediator derived from the omega-9 monounsaturated fatty acid, oleic acid. Based on previous evidences, OEA showed anti-inflammatory activities, a role in modulation of immune response, anti-oxidant effects and stimulation of lipolysis and fatty acid oxidation [72].\nIn this context OEA is considered an endocannabinoid-like lipid, which interacts with the peroxisome proliferator-activated receptor-alpha (PPAR-α) and intervenes during the anti-inflammatory processes [73].\nScientific researchers recently showed that endocannabinoid system is involved in the management of infectious agents such as viruses, bacteria, and some protozoa, also reducing inflammation and pain in the lungs [74]. In view of the fact that SARS-CoV-2 infection leads to increase the pro-inflammatory cytokines, including IL-6 and IL-1β in COVID-19 patients via binding to the TLRs, an important components of the innate immune system, it is assumed that OEA inhibits this pathway through its anti-inflammatory properties [75]. OEA binds with high affinity to PPAR-α receptors and increases the expression level of anti-inflammatory cytokine such as IL-10, then initiates a cascade of events, which can attenuate the inflammatory responses [73]. Furthermore, OEA attenuates the inflammatory responses modulating the expression of TLR-4, and interfering with the ERK1/2/AP-1/STAT3 signaling cascade [73]. OEA may modulate cross-talk between PPAR-α and TLRs and regulates the inflammatory responses with beneficial synergistic effect against SARS-CoV-2. Nowadays, discovering therapeutic options from currently available agents appears to be essential for the treatment and prophylaxis of this pandemic, especially in obese patients with comorbidities [76] and this bioactive lipid mediator can be considered as a novel potential pharmacological alternative for the management of COVID-19."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T299","span":{"begin":39,"end":42},"obj":"Chemical"},{"id":"T300","span":{"begin":103,"end":108},"obj":"Chemical"},{"id":"T301","span":{"begin":143,"end":169},"obj":"Chemical"},{"id":"T302","span":{"begin":159,"end":169},"obj":"Chemical"},{"id":"T303","span":{"begin":165,"end":169},"obj":"Chemical"},{"id":"T304","span":{"begin":171,"end":181},"obj":"Chemical"},{"id":"T305","span":{"begin":177,"end":181},"obj":"Chemical"},{"id":"T306","span":{"begin":212,"end":215},"obj":"Chemical"},{"id":"T307","span":{"begin":299,"end":306},"obj":"Chemical"},{"id":"T308","span":{"begin":348,"end":358},"obj":"Chemical"},{"id":"T309","span":{"begin":354,"end":358},"obj":"Chemical"},{"id":"T310","span":{"begin":391,"end":394},"obj":"Chemical"},{"id":"T311","span":{"begin":412,"end":427},"obj":"Chemical"},{"id":"T312","span":{"begin":433,"end":438},"obj":"Chemical"},{"id":"T313","span":{"begin":508,"end":513},"obj":"Chemical"},{"id":"T314","span":{"begin":627,"end":642},"obj":"Chemical"},{"id":"T315","span":{"begin":908,"end":910},"obj":"Chemical"},{"id":"T317","span":{"begin":917,"end":919},"obj":"Chemical"},{"id":"T319","span":{"begin":1041,"end":1044},"obj":"Chemical"},{"id":"T320","span":{"begin":1114,"end":1117},"obj":"Chemical"},{"id":"T321","span":{"begin":1236,"end":1238},"obj":"Chemical"},{"id":"T323","span":{"begin":1345,"end":1348},"obj":"Chemical"},{"id":"T324","span":{"begin":1455,"end":1457},"obj":"Chemical"},{"id":"T327","span":{"begin":1490,"end":1493},"obj":"Chemical"},{"id":"T328","span":{"begin":1860,"end":1865},"obj":"Chemical"}],"attributes":[{"id":"A299","pred":"chebi_id","subj":"T299","obj":"http://purl.obolibrary.org/obo/CHEBI_71466"},{"id":"A300","pred":"chebi_id","subj":"T300","obj":"http://purl.obolibrary.org/obo/CHEBI_18059"},{"id":"A301","pred":"chebi_id","subj":"T301","obj":"http://purl.obolibrary.org/obo/CHEBI_25413"},{"id":"A302","pred":"chebi_id","subj":"T302","obj":"http://purl.obolibrary.org/obo/CHEBI_35366"},{"id":"A303","pred":"chebi_id","subj":"T303","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A304","pred":"chebi_id","subj":"T304","obj":"http://purl.obolibrary.org/obo/CHEBI_16196"},{"id":"A305","pred":"chebi_id","subj":"T305","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A306","pred":"chebi_id","subj":"T306","obj":"http://purl.obolibrary.org/obo/CHEBI_71466"},{"id":"A307","pred":"chebi_id","subj":"T307","obj":"http://purl.obolibrary.org/obo/CHEBI_63248"},{"id":"A308","pred":"chebi_id","subj":"T308","obj":"http://purl.obolibrary.org/obo/CHEBI_35366"},{"id":"A309","pred":"chebi_id","subj":"T309","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A310","pred":"chebi_id","subj":"T310","obj":"http://purl.obolibrary.org/obo/CHEBI_71466"},{"id":"A311","pred":"chebi_id","subj":"T311","obj":"http://purl.obolibrary.org/obo/CHEBI_67197"},{"id":"A312","pred":"chebi_id","subj":"T312","obj":"http://purl.obolibrary.org/obo/CHEBI_18059"},{"id":"A313","pred":"chebi_id","subj":"T313","obj":"http://purl.obolibrary.org/obo/CHEBI_30216"},{"id":"A314","pred":"chebi_id","subj":"T314","obj":"http://purl.obolibrary.org/obo/CHEBI_67197"},{"id":"A315","pred":"chebi_id","subj":"T315","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A316","pred":"chebi_id","subj":"T315","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A317","pred":"chebi_id","subj":"T317","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A318","pred":"chebi_id","subj":"T317","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A319","pred":"chebi_id","subj":"T319","obj":"http://purl.obolibrary.org/obo/CHEBI_71466"},{"id":"A320","pred":"chebi_id","subj":"T320","obj":"http://purl.obolibrary.org/obo/CHEBI_71466"},{"id":"A321","pred":"chebi_id","subj":"T321","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A322","pred":"chebi_id","subj":"T321","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A323","pred":"chebi_id","subj":"T323","obj":"http://purl.obolibrary.org/obo/CHEBI_71466"},{"id":"A324","pred":"chebi_id","subj":"T324","obj":"http://purl.obolibrary.org/obo/CHEBI_28971"},{"id":"A325","pred":"chebi_id","subj":"T324","obj":"http://purl.obolibrary.org/obo/CHEBI_73393"},{"id":"A326","pred":"chebi_id","subj":"T324","obj":"http://purl.obolibrary.org/obo/CHEBI_81686"},{"id":"A327","pred":"chebi_id","subj":"T327","obj":"http://purl.obolibrary.org/obo/CHEBI_71466"},{"id":"A328","pred":"chebi_id","subj":"T328","obj":"http://purl.obolibrary.org/obo/CHEBI_18059"}],"text":"Oleoylethanolamide\nOleoylethanolamide (OEA), synthesized in the gastrointestinal tract, is a bioactive lipid mediator derived from the omega-9 monounsaturated fatty acid, oleic acid. Based on previous evidences, OEA showed anti-inflammatory activities, a role in modulation of immune response, anti-oxidant effects and stimulation of lipolysis and fatty acid oxidation [72].\nIn this context OEA is considered an endocannabinoid-like lipid, which interacts with the peroxisome proliferator-activated receptor-alpha (PPAR-α) and intervenes during the anti-inflammatory processes [73].\nScientific researchers recently showed that endocannabinoid system is involved in the management of infectious agents such as viruses, bacteria, and some protozoa, also reducing inflammation and pain in the lungs [74]. In view of the fact that SARS-CoV-2 infection leads to increase the pro-inflammatory cytokines, including IL-6 and IL-1β in COVID-19 patients via binding to the TLRs, an important components of the innate immune system, it is assumed that OEA inhibits this pathway through its anti-inflammatory properties [75]. OEA binds with high affinity to PPAR-α receptors and increases the expression level of anti-inflammatory cytokine such as IL-10, then initiates a cascade of events, which can attenuate the inflammatory responses [73]. Furthermore, OEA attenuates the inflammatory responses modulating the expression of TLR-4, and interfering with the ERK1/2/AP-1/STAT3 signaling cascade [73]. OEA may modulate cross-talk between PPAR-α and TLRs and regulates the inflammatory responses with beneficial synergistic effect against SARS-CoV-2. Nowadays, discovering therapeutic options from currently available agents appears to be essential for the treatment and prophylaxis of this pandemic, especially in obese patients with comorbidities [76] and this bioactive lipid mediator can be considered as a novel potential pharmacological alternative for the management of COVID-19."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T71","span":{"begin":778,"end":782},"obj":"Phenotype"}],"attributes":[{"id":"A71","pred":"hp_id","subj":"T71","obj":"http://purl.obolibrary.org/obo/HP_0012531"}],"text":"Oleoylethanolamide\nOleoylethanolamide (OEA), synthesized in the gastrointestinal tract, is a bioactive lipid mediator derived from the omega-9 monounsaturated fatty acid, oleic acid. Based on previous evidences, OEA showed anti-inflammatory activities, a role in modulation of immune response, anti-oxidant effects and stimulation of lipolysis and fatty acid oxidation [72].\nIn this context OEA is considered an endocannabinoid-like lipid, which interacts with the peroxisome proliferator-activated receptor-alpha (PPAR-α) and intervenes during the anti-inflammatory processes [73].\nScientific researchers recently showed that endocannabinoid system is involved in the management of infectious agents such as viruses, bacteria, and some protozoa, also reducing inflammation and pain in the lungs [74]. In view of the fact that SARS-CoV-2 infection leads to increase the pro-inflammatory cytokines, including IL-6 and IL-1β in COVID-19 patients via binding to the TLRs, an important components of the innate immune system, it is assumed that OEA inhibits this pathway through its anti-inflammatory properties [75]. OEA binds with high affinity to PPAR-α receptors and increases the expression level of anti-inflammatory cytokine such as IL-10, then initiates a cascade of events, which can attenuate the inflammatory responses [73]. Furthermore, OEA attenuates the inflammatory responses modulating the expression of TLR-4, and interfering with the ERK1/2/AP-1/STAT3 signaling cascade [73]. OEA may modulate cross-talk between PPAR-α and TLRs and regulates the inflammatory responses with beneficial synergistic effect against SARS-CoV-2. Nowadays, discovering therapeutic options from currently available agents appears to be essential for the treatment and prophylaxis of this pandemic, especially in obese patients with comorbidities [76] and this bioactive lipid mediator can be considered as a novel potential pharmacological alternative for the management of COVID-19."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T144","span":{"begin":277,"end":292},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T145","span":{"begin":334,"end":343},"obj":"http://purl.obolibrary.org/obo/GO_0016042"},{"id":"T146","span":{"begin":348,"end":368},"obj":"http://purl.obolibrary.org/obo/GO_0019395"},{"id":"T147","span":{"begin":465,"end":488},"obj":"http://purl.obolibrary.org/obo/GO_0016559"},{"id":"T148","span":{"begin":761,"end":773},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T149","span":{"begin":1000,"end":1013},"obj":"http://purl.obolibrary.org/obo/GO_0045087"},{"id":"T150","span":{"begin":1303,"end":1325},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T151","span":{"begin":1364,"end":1386},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T152","span":{"begin":1448,"end":1452},"obj":"http://purl.obolibrary.org/obo/GO_0004707"},{"id":"T153","span":{"begin":1466,"end":1483},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T154","span":{"begin":1466,"end":1475},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T155","span":{"begin":1546,"end":1582},"obj":"http://purl.obolibrary.org/obo/GO_0050727"},{"id":"T156","span":{"begin":1560,"end":1582},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"Oleoylethanolamide\nOleoylethanolamide (OEA), synthesized in the gastrointestinal tract, is a bioactive lipid mediator derived from the omega-9 monounsaturated fatty acid, oleic acid. Based on previous evidences, OEA showed anti-inflammatory activities, a role in modulation of immune response, anti-oxidant effects and stimulation of lipolysis and fatty acid oxidation [72].\nIn this context OEA is considered an endocannabinoid-like lipid, which interacts with the peroxisome proliferator-activated receptor-alpha (PPAR-α) and intervenes during the anti-inflammatory processes [73].\nScientific researchers recently showed that endocannabinoid system is involved in the management of infectious agents such as viruses, bacteria, and some protozoa, also reducing inflammation and pain in the lungs [74]. In view of the fact that SARS-CoV-2 infection leads to increase the pro-inflammatory cytokines, including IL-6 and IL-1β in COVID-19 patients via binding to the TLRs, an important components of the innate immune system, it is assumed that OEA inhibits this pathway through its anti-inflammatory properties [75]. OEA binds with high affinity to PPAR-α receptors and increases the expression level of anti-inflammatory cytokine such as IL-10, then initiates a cascade of events, which can attenuate the inflammatory responses [73]. Furthermore, OEA attenuates the inflammatory responses modulating the expression of TLR-4, and interfering with the ERK1/2/AP-1/STAT3 signaling cascade [73]. OEA may modulate cross-talk between PPAR-α and TLRs and regulates the inflammatory responses with beneficial synergistic effect against SARS-CoV-2. Nowadays, discovering therapeutic options from currently available agents appears to be essential for the treatment and prophylaxis of this pandemic, especially in obese patients with comorbidities [76] and this bioactive lipid mediator can be considered as a novel potential pharmacological alternative for the management of COVID-19."}

{"project":"LitCovid-sentences","denotations":[{"id":"T200","span":{"begin":0,"end":18},"obj":"Sentence"},{"id":"T201","span":{"begin":19,"end":182},"obj":"Sentence"},{"id":"T202","span":{"begin":183,"end":374},"obj":"Sentence"},{"id":"T203","span":{"begin":375,"end":582},"obj":"Sentence"},{"id":"T204","span":{"begin":583,"end":801},"obj":"Sentence"},{"id":"T205","span":{"begin":802,"end":1113},"obj":"Sentence"},{"id":"T206","span":{"begin":1114,"end":1331},"obj":"Sentence"},{"id":"T207","span":{"begin":1332,"end":1489},"obj":"Sentence"},{"id":"T208","span":{"begin":1490,"end":1637},"obj":"Sentence"},{"id":"T209","span":{"begin":1638,"end":1973},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Oleoylethanolamide\nOleoylethanolamide (OEA), synthesized in the gastrointestinal tract, is a bioactive lipid mediator derived from the omega-9 monounsaturated fatty acid, oleic acid. Based on previous evidences, OEA showed anti-inflammatory activities, a role in modulation of immune response, anti-oxidant effects and stimulation of lipolysis and fatty acid oxidation [72].\nIn this context OEA is considered an endocannabinoid-like lipid, which interacts with the peroxisome proliferator-activated receptor-alpha (PPAR-α) and intervenes during the anti-inflammatory processes [73].\nScientific researchers recently showed that endocannabinoid system is involved in the management of infectious agents such as viruses, bacteria, and some protozoa, also reducing inflammation and pain in the lungs [74]. In view of the fact that SARS-CoV-2 infection leads to increase the pro-inflammatory cytokines, including IL-6 and IL-1β in COVID-19 patients via binding to the TLRs, an important components of the innate immune system, it is assumed that OEA inhibits this pathway through its anti-inflammatory properties [75]. OEA binds with high affinity to PPAR-α receptors and increases the expression level of anti-inflammatory cytokine such as IL-10, then initiates a cascade of events, which can attenuate the inflammatory responses [73]. Furthermore, OEA attenuates the inflammatory responses modulating the expression of TLR-4, and interfering with the ERK1/2/AP-1/STAT3 signaling cascade [73]. OEA may modulate cross-talk between PPAR-α and TLRs and regulates the inflammatory responses with beneficial synergistic effect against SARS-CoV-2. Nowadays, discovering therapeutic options from currently available agents appears to be essential for the treatment and prophylaxis of this pandemic, especially in obese patients with comorbidities [76] and this bioactive lipid mediator can be considered as a novel potential pharmacological alternative for the management of COVID-19."}

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Based on previous evidences, OEA showed anti-inflammatory activities, a role in modulation of immune response, anti-oxidant effects and stimulation of lipolysis and fatty acid oxidation [72].\nIn this context OEA is considered an endocannabinoid-like lipid, which interacts with the peroxisome proliferator-activated receptor-alpha (PPAR-α) and intervenes during the anti-inflammatory processes [73].\nScientific researchers recently showed that endocannabinoid system is involved in the management of infectious agents such as viruses, bacteria, and some protozoa, also reducing inflammation and pain in the lungs [74]. In view of the fact that SARS-CoV-2 infection leads to increase the pro-inflammatory cytokines, including IL-6 and IL-1β in COVID-19 patients via binding to the TLRs, an important components of the innate immune system, it is assumed that OEA inhibits this pathway through its anti-inflammatory properties [75]. OEA binds with high affinity to PPAR-α receptors and increases the expression level of anti-inflammatory cytokine such as IL-10, then initiates a cascade of events, which can attenuate the inflammatory responses [73]. Furthermore, OEA attenuates the inflammatory responses modulating the expression of TLR-4, and interfering with the ERK1/2/AP-1/STAT3 signaling cascade [73]. OEA may modulate cross-talk between PPAR-α and TLRs and regulates the inflammatory responses with beneficial synergistic effect against SARS-CoV-2. Nowadays, discovering therapeutic options from currently available agents appears to be essential for the treatment and prophylaxis of this pandemic, especially in obese patients with comorbidities [76] and this bioactive lipid mediator can be considered as a novel potential pharmacological alternative for the management of COVID-19."}