PMC:7647877 / 31961-33934
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T362 | 64-86 | Body_part | denotes | gastrointestinal tract | http://purl.org/sig/ont/fma/fma71132 |
| T363 | 103-108 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
| T364 | 159-169 | Body_part | denotes | fatty acid | http://purl.org/sig/ont/fma/fma82738 |
| T365 | 348-358 | Body_part | denotes | fatty acid | http://purl.org/sig/ont/fma/fma82738 |
| T366 | 433-438 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
| T367 | 465-475 | Body_part | denotes | peroxisome | http://purl.org/sig/ont/fma/fma63845 |
| T368 | 790-795 | Body_part | denotes | lungs | http://purl.org/sig/ont/fma/fma68877 |
| T369 | 887-896 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T370 | 908-910 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T371 | 917-921 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T372 | 917-919 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T373 | 1007-1020 | Body_part | denotes | immune system | http://purl.org/sig/ont/fma/fma9825 |
| T374 | 1219-1227 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T375 | 1236-1238 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T376 | 1860-1865 | Body_part | denotes | lipid | http://purl.org/sig/ont/fma/fma67264 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T96 | 1007-1020 | Body_part | denotes | immune system | http://purl.obolibrary.org/obo/UBERON_0002405 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T194 | 683-693 | Disease | denotes | infectious | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T195 | 761-773 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T196 | 827-835 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T197 | 838-847 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T198 | 926-934 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T199 | 1626-1634 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T200 | 1964-1972 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T395 | 64-86 | http://purl.obolibrary.org/obo/UBERON_0005409 | denotes | gastrointestinal tract |
| T396 | 91-92 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T397 | 241-251 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activities |
| T398 | 253-254 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T399 | 489-498 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
| T400 | 709-716 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T401 | 718-726 | http://purl.obolibrary.org/obo/NCBITaxon_2 | denotes | bacteria |
| T402 | 790-795 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lungs |
| T403 | 1007-1020 | http://purl.obolibrary.org/obo/UBERON_0002405 | denotes | immune system |
| T404 | 1258-1259 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T405 | 1455-1457 | http://purl.obolibrary.org/obo/CLO_0001547 | denotes | AP |
| T406 | 1466-1475 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T407 | 1896-1897 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T299 | 39-42 | Chemical | denotes | OEA | http://purl.obolibrary.org/obo/CHEBI_71466 |
| T300 | 103-108 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T301 | 143-169 | Chemical | denotes | monounsaturated fatty acid | http://purl.obolibrary.org/obo/CHEBI_25413 |
| T302 | 159-169 | Chemical | denotes | fatty acid | http://purl.obolibrary.org/obo/CHEBI_35366 |
| T303 | 165-169 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T304 | 171-181 | Chemical | denotes | oleic acid | http://purl.obolibrary.org/obo/CHEBI_16196 |
| T305 | 177-181 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T306 | 212-215 | Chemical | denotes | OEA | http://purl.obolibrary.org/obo/CHEBI_71466 |
| T307 | 299-306 | Chemical | denotes | oxidant | http://purl.obolibrary.org/obo/CHEBI_63248 |
| T308 | 348-358 | Chemical | denotes | fatty acid | http://purl.obolibrary.org/obo/CHEBI_35366 |
| T309 | 354-358 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T310 | 391-394 | Chemical | denotes | OEA | http://purl.obolibrary.org/obo/CHEBI_71466 |
| T311 | 412-427 | Chemical | denotes | endocannabinoid | http://purl.obolibrary.org/obo/CHEBI_67197 |
| T312 | 433-438 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
| T313 | 508-513 | Chemical | denotes | alpha | http://purl.obolibrary.org/obo/CHEBI_30216 |
| T314 | 627-642 | Chemical | denotes | endocannabinoid | http://purl.obolibrary.org/obo/CHEBI_67197 |
| T315 | 908-910 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T317 | 917-919 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T319 | 1041-1044 | Chemical | denotes | OEA | http://purl.obolibrary.org/obo/CHEBI_71466 |
| T320 | 1114-1117 | Chemical | denotes | OEA | http://purl.obolibrary.org/obo/CHEBI_71466 |
| T321 | 1236-1238 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T323 | 1345-1348 | Chemical | denotes | OEA | http://purl.obolibrary.org/obo/CHEBI_71466 |
| T324 | 1455-1457 | Chemical | denotes | AP | http://purl.obolibrary.org/obo/CHEBI_28971|http://purl.obolibrary.org/obo/CHEBI_73393|http://purl.obolibrary.org/obo/CHEBI_81686 |
| T327 | 1490-1493 | Chemical | denotes | OEA | http://purl.obolibrary.org/obo/CHEBI_71466 |
| T328 | 1860-1865 | Chemical | denotes | lipid | http://purl.obolibrary.org/obo/CHEBI_18059 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T71 | 778-782 | Phenotype | denotes | pain | http://purl.obolibrary.org/obo/HP_0012531 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T144 | 277-292 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
| T145 | 334-343 | http://purl.obolibrary.org/obo/GO_0016042 | denotes | lipolysis |
| T146 | 348-368 | http://purl.obolibrary.org/obo/GO_0019395 | denotes | fatty acid oxidation |
| T147 | 465-488 | http://purl.obolibrary.org/obo/GO_0016559 | denotes | peroxisome proliferator |
| T148 | 761-773 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T149 | 1000-1013 | http://purl.obolibrary.org/obo/GO_0045087 | denotes | innate immune |
| T150 | 1303-1325 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory responses |
| T151 | 1364-1386 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory responses |
| T152 | 1448-1452 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | ERK1 |
| T153 | 1466-1483 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signaling cascade |
| T154 | 1466-1475 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T155 | 1546-1582 | http://purl.obolibrary.org/obo/GO_0050727 | denotes | regulates the inflammatory responses |
| T156 | 1560-1582 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory responses |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T200 | 0-18 | Sentence | denotes | Oleoylethanolamide |
| T201 | 19-182 | Sentence | denotes | Oleoylethanolamide (OEA), synthesized in the gastrointestinal tract, is a bioactive lipid mediator derived from the omega-9 monounsaturated fatty acid, oleic acid. |
| T202 | 183-374 | Sentence | denotes | Based on previous evidences, OEA showed anti-inflammatory activities, a role in modulation of immune response, anti-oxidant effects and stimulation of lipolysis and fatty acid oxidation [72]. |
| T203 | 375-582 | Sentence | denotes | In this context OEA is considered an endocannabinoid-like lipid, which interacts with the peroxisome proliferator-activated receptor-alpha (PPAR-α) and intervenes during the anti-inflammatory processes [73]. |
| T204 | 583-801 | Sentence | denotes | Scientific researchers recently showed that endocannabinoid system is involved in the management of infectious agents such as viruses, bacteria, and some protozoa, also reducing inflammation and pain in the lungs [74]. |
| T205 | 802-1113 | Sentence | denotes | In view of the fact that SARS-CoV-2 infection leads to increase the pro-inflammatory cytokines, including IL-6 and IL-1β in COVID-19 patients via binding to the TLRs, an important components of the innate immune system, it is assumed that OEA inhibits this pathway through its anti-inflammatory properties [75]. |
| T206 | 1114-1331 | Sentence | denotes | OEA binds with high affinity to PPAR-α receptors and increases the expression level of anti-inflammatory cytokine such as IL-10, then initiates a cascade of events, which can attenuate the inflammatory responses [73]. |
| T207 | 1332-1489 | Sentence | denotes | Furthermore, OEA attenuates the inflammatory responses modulating the expression of TLR-4, and interfering with the ERK1/2/AP-1/STAT3 signaling cascade [73]. |
| T208 | 1490-1637 | Sentence | denotes | OEA may modulate cross-talk between PPAR-α and TLRs and regulates the inflammatory responses with beneficial synergistic effect against SARS-CoV-2. |
| T209 | 1638-1973 | Sentence | denotes | Nowadays, discovering therapeutic options from currently available agents appears to be essential for the treatment and prophylaxis of this pandemic, especially in obese patients with comorbidities [76] and this bioactive lipid mediator can be considered as a novel potential pharmacological alternative for the management of COVID-19. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 841 | 0-18 | Chemical | denotes | Oleoylethanolamide | MESH:C488250 |
| 848 | 19-37 | Chemical | denotes | Oleoylethanolamide | MESH:C488250 |
| 849 | 39-42 | Chemical | denotes | OEA | MESH:C488250 |
| 850 | 103-108 | Chemical | denotes | lipid | MESH:D008055 |
| 851 | 135-169 | Chemical | denotes | omega-9 monounsaturated fatty acid | |
| 852 | 171-181 | Chemical | denotes | oleic acid | MESH:D019301 |
| 853 | 348-358 | Chemical | denotes | fatty acid | MESH:D005227 |
| 857 | 465-513 | Gene | denotes | peroxisome proliferator-activated receptor-alpha | Gene:5465 |
| 858 | 515-521 | Gene | denotes | PPAR-α | Gene:5465 |
| 859 | 433-438 | Chemical | denotes | lipid | MESH:D008055 |
| 881 | 908-912 | Gene | denotes | IL-6 | Gene:3569 |
| 882 | 917-922 | Gene | denotes | IL-1β | Gene:3552 |
| 883 | 1236-1241 | Gene | denotes | IL-10 | Gene:3586 |
| 884 | 1416-1421 | Gene | denotes | TLR-4 | Gene:7099 |
| 885 | 1448-1454 | Gene | denotes | ERK1/2 | Gene:5595 |
| 886 | 1455-1459 | Gene | denotes | AP-1 | Gene:3726 |
| 887 | 1460-1465 | Gene | denotes | STAT3 | Gene:6774 |
| 888 | 1526-1532 | Gene | denotes | PPAR-α | Gene:5465 |
| 889 | 935-943 | Species | denotes | patients | Tax:9606 |
| 890 | 1626-1636 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 891 | 1808-1816 | Species | denotes | patients | Tax:9606 |
| 892 | 1146-1152 | Gene | denotes | PPAR-α | Gene:5465 |
| 893 | 627-642 | Chemical | denotes | endocannabinoid | MESH:D063388 |
| 894 | 1345-1348 | Chemical | denotes | OEA | MESH:C488250 |
| 895 | 1860-1865 | Chemical | denotes | lipid | MESH:D008055 |
| 896 | 761-773 | Disease | denotes | inflammation | MESH:D007249 |
| 897 | 778-782 | Disease | denotes | pain | MESH:D010146 |
| 898 | 827-847 | Disease | denotes | SARS-CoV-2 infection | MESH:C000657245 |
| 899 | 926-934 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 900 | 1802-1807 | Disease | denotes | obese | MESH:D009765 |
| 901 | 1964-1972 | Disease | denotes | COVID-19 | MESH:C000657245 |