PMC:7647877 / 23290-23840 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T311","span":{"begin":19,"end":27},"obj":"Body_part"},{"id":"T312","span":{"begin":75,"end":86},"obj":"Body_part"},{"id":"T313","span":{"begin":98,"end":103},"obj":"Body_part"},{"id":"T314","span":{"begin":194,"end":198},"obj":"Body_part"},{"id":"T315","span":{"begin":199,"end":215},"obj":"Body_part"},{"id":"T316","span":{"begin":210,"end":215},"obj":"Body_part"},{"id":"T317","span":{"begin":270,"end":272},"obj":"Body_part"},{"id":"T318","span":{"begin":290,"end":295},"obj":"Body_part"},{"id":"T319","span":{"begin":336,"end":341},"obj":"Body_part"},{"id":"T320","span":{"begin":362,"end":366},"obj":"Body_part"},{"id":"T321","span":{"begin":422,"end":424},"obj":"Body_part"},{"id":"T322","span":{"begin":474,"end":483},"obj":"Body_part"}],"attributes":[{"id":"A311","pred":"fma_id","subj":"T311","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A312","pred":"fma_id","subj":"T312","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A313","pred":"fma_id","subj":"T313","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A314","pred":"fma_id","subj":"T314","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A315","pred":"fma_id","subj":"T315","obj":"http://purl.org/sig/ont/fma/fma66768"},{"id":"A316","pred":"fma_id","subj":"T316","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A317","pred":"fma_id","subj":"T317","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A318","pred":"fma_id","subj":"T318","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A319","pred":"fma_id","subj":"T319","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A320","pred":"fma_id","subj":"T320","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A321","pred":"fma_id","subj":"T321","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A322","pred":"fma_id","subj":"T322","obj":"http://purl.org/sig/ont/fma/fma84050"}],"text":"TNF-α is a pyrogen cytokine released in the acute phase of inflammation by macrophages and immune cells. It is well known that during influenzae and viral infections, the expression of TNF-α in lung epithelial cells is higher. In patients with COVID-19 and obesity, the IL-6 and TNF-α high serum levels are negatively associated with T-cells. On the contrary, T cell levels are restored by reducing concentrations of both IL-6 and TNF-α. These findings suggested that these cytokines could represent important targets of anti-COVID-19 therapies [48]."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T80","span":{"begin":194,"end":198},"obj":"Body_part"},{"id":"T81","span":{"begin":290,"end":295},"obj":"Body_part"}],"attributes":[{"id":"A80","pred":"uberon_id","subj":"T80","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A81","pred":"uberon_id","subj":"T81","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"}],"text":"TNF-α is a pyrogen cytokine released in the acute phase of inflammation by macrophages and immune cells. It is well known that during influenzae and viral infections, the expression of TNF-α in lung epithelial cells is higher. In patients with COVID-19 and obesity, the IL-6 and TNF-α high serum levels are negatively associated with T-cells. On the contrary, T cell levels are restored by reducing concentrations of both IL-6 and TNF-α. These findings suggested that these cytokines could represent important targets of anti-COVID-19 therapies [48]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T144","span":{"begin":59,"end":71},"obj":"Disease"},{"id":"T145","span":{"begin":134,"end":144},"obj":"Disease"},{"id":"T146","span":{"begin":149,"end":165},"obj":"Disease"},{"id":"T147","span":{"begin":244,"end":252},"obj":"Disease"},{"id":"T148","span":{"begin":257,"end":264},"obj":"Disease"},{"id":"T149","span":{"begin":526,"end":534},"obj":"Disease"}],"attributes":[{"id":"A144","pred":"mondo_id","subj":"T144","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A145","pred":"mondo_id","subj":"T145","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A146","pred":"mondo_id","subj":"T146","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A147","pred":"mondo_id","subj":"T147","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A148","pred":"mondo_id","subj":"T148","obj":"http://purl.obolibrary.org/obo/MONDO_0011122"},{"id":"A149","pred":"mondo_id","subj":"T149","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"TNF-α is a pyrogen cytokine released in the acute phase of inflammation by macrophages and immune cells. It is well known that during influenzae and viral infections, the expression of TNF-α in lung epithelial cells is higher. In patients with COVID-19 and obesity, the IL-6 and TNF-α high serum levels are negatively associated with T-cells. On the contrary, T cell levels are restored by reducing concentrations of both IL-6 and TNF-α. These findings suggested that these cytokines could represent important targets of anti-COVID-19 therapies [48]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T329","span":{"begin":9,"end":10},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T330","span":{"begin":98,"end":103},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T331","span":{"begin":194,"end":215},"obj":"http://purl.obolibrary.org/obo/CL_0000082"},{"id":"T332","span":{"begin":334,"end":341},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T333","span":{"begin":360,"end":366},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T334","span":{"begin":546,"end":548},"obj":"http://purl.obolibrary.org/obo/CLO_0001382"}],"text":"TNF-α is a pyrogen cytokine released in the acute phase of inflammation by macrophages and immune cells. It is well known that during influenzae and viral infections, the expression of TNF-α in lung epithelial cells is higher. In patients with COVID-19 and obesity, the IL-6 and TNF-α high serum levels are negatively associated with T-cells. On the contrary, T cell levels are restored by reducing concentrations of both IL-6 and TNF-α. These findings suggested that these cytokines could represent important targets of anti-COVID-19 therapies [48]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T213","span":{"begin":270,"end":272},"obj":"Chemical"},{"id":"T215","span":{"begin":422,"end":424},"obj":"Chemical"}],"attributes":[{"id":"A213","pred":"chebi_id","subj":"T213","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A214","pred":"chebi_id","subj":"T213","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A215","pred":"chebi_id","subj":"T215","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A216","pred":"chebi_id","subj":"T215","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"}],"text":"TNF-α is a pyrogen cytokine released in the acute phase of inflammation by macrophages and immune cells. It is well known that during influenzae and viral infections, the expression of TNF-α in lung epithelial cells is higher. In patients with COVID-19 and obesity, the IL-6 and TNF-α high serum levels are negatively associated with T-cells. On the contrary, T cell levels are restored by reducing concentrations of both IL-6 and TNF-α. These findings suggested that these cytokines could represent important targets of anti-COVID-19 therapies [48]."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T52","span":{"begin":257,"end":264},"obj":"Phenotype"}],"attributes":[{"id":"A52","pred":"hp_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/HP_0001513"}],"text":"TNF-α is a pyrogen cytokine released in the acute phase of inflammation by macrophages and immune cells. It is well known that during influenzae and viral infections, the expression of TNF-α in lung epithelial cells is higher. In patients with COVID-19 and obesity, the IL-6 and TNF-α high serum levels are negatively associated with T-cells. On the contrary, T cell levels are restored by reducing concentrations of both IL-6 and TNF-α. These findings suggested that these cytokines could represent important targets of anti-COVID-19 therapies [48]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T116","span":{"begin":59,"end":71},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T117","span":{"begin":149,"end":165},"obj":"http://purl.obolibrary.org/obo/GO_0016032"}],"text":"TNF-α is a pyrogen cytokine released in the acute phase of inflammation by macrophages and immune cells. It is well known that during influenzae and viral infections, the expression of TNF-α in lung epithelial cells is higher. In patients with COVID-19 and obesity, the IL-6 and TNF-α high serum levels are negatively associated with T-cells. On the contrary, T cell levels are restored by reducing concentrations of both IL-6 and TNF-α. These findings suggested that these cytokines could represent important targets of anti-COVID-19 therapies [48]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T143","span":{"begin":0,"end":104},"obj":"Sentence"},{"id":"T144","span":{"begin":105,"end":226},"obj":"Sentence"},{"id":"T145","span":{"begin":227,"end":342},"obj":"Sentence"},{"id":"T146","span":{"begin":343,"end":437},"obj":"Sentence"},{"id":"T147","span":{"begin":438,"end":550},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"TNF-α is a pyrogen cytokine released in the acute phase of inflammation by macrophages and immune cells. It is well known that during influenzae and viral infections, the expression of TNF-α in lung epithelial cells is higher. In patients with COVID-19 and obesity, the IL-6 and TNF-α high serum levels are negatively associated with T-cells. On the contrary, T cell levels are restored by reducing concentrations of both IL-6 and TNF-α. These findings suggested that these cytokines could represent important targets of anti-COVID-19 therapies [48]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"672","span":{"begin":0,"end":5},"obj":"Gene"},{"id":"673","span":{"begin":185,"end":190},"obj":"Gene"},{"id":"674","span":{"begin":270,"end":274},"obj":"Gene"},{"id":"675","span":{"begin":279,"end":284},"obj":"Gene"},{"id":"676","span":{"begin":422,"end":426},"obj":"Gene"},{"id":"677","span":{"begin":431,"end":436},"obj":"Gene"},{"id":"678","span":{"begin":230,"end":238},"obj":"Species"},{"id":"679","span":{"begin":59,"end":71},"obj":"Disease"},{"id":"680","span":{"begin":149,"end":165},"obj":"Disease"},{"id":"681","span":{"begin":244,"end":252},"obj":"Disease"},{"id":"682","span":{"begin":257,"end":264},"obj":"Disease"},{"id":"683","span":{"begin":526,"end":534},"obj":"Disease"}],"attributes":[{"id":"A672","pred":"tao:has_database_id","subj":"672","obj":"Gene:7124"},{"id":"A673","pred":"tao:has_database_id","subj":"673","obj":"Gene:7124"},{"id":"A674","pred":"tao:has_database_id","subj":"674","obj":"Gene:3569"},{"id":"A675","pred":"tao:has_database_id","subj":"675","obj":"Gene:7124"},{"id":"A676","pred":"tao:has_database_id","subj":"676","obj":"Gene:3569"},{"id":"A677","pred":"tao:has_database_id","subj":"677","obj":"Gene:7124"},{"id":"A678","pred":"tao:has_database_id","subj":"678","obj":"Tax:9606"},{"id":"A679","pred":"tao:has_database_id","subj":"679","obj":"MESH:D007249"},{"id":"A680","pred":"tao:has_database_id","subj":"680","obj":"MESH:D001102"},{"id":"A681","pred":"tao:has_database_id","subj":"681","obj":"MESH:C000657245"},{"id":"A682","pred":"tao:has_database_id","subj":"682","obj":"MESH:D009765"},{"id":"A683","pred":"tao:has_database_id","subj":"683","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"TNF-α is a pyrogen cytokine released in the acute phase of inflammation by macrophages and immune cells. It is well known that during influenzae and viral infections, the expression of TNF-α in lung epithelial cells is higher. In patients with COVID-19 and obesity, the IL-6 and TNF-α high serum levels are negatively associated with T-cells. On the contrary, T cell levels are restored by reducing concentrations of both IL-6 and TNF-α. These findings suggested that these cytokines could represent important targets of anti-COVID-19 therapies [48]."}