PMC:7647877 / 20454-21516 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T287","span":{"begin":94,"end":108},"obj":"Body_part"},{"id":"T288","span":{"begin":109,"end":120},"obj":"Body_part"},{"id":"T289","span":{"begin":209,"end":223},"obj":"Body_part"},{"id":"T290","span":{"begin":267,"end":277},"obj":"Body_part"},{"id":"T291","span":{"begin":332,"end":339},"obj":"Body_part"},{"id":"T292","span":{"begin":451,"end":465},"obj":"Body_part"},{"id":"T293","span":{"begin":494,"end":499},"obj":"Body_part"},{"id":"T294","span":{"begin":774,"end":782},"obj":"Body_part"},{"id":"T295","span":{"begin":810,"end":818},"obj":"Body_part"},{"id":"T296","span":{"begin":938,"end":940},"obj":"Body_part"},{"id":"T297","span":{"begin":967,"end":976},"obj":"Body_part"},{"id":"T298","span":{"begin":989,"end":996},"obj":"Body_part"}],"attributes":[{"id":"A287","pred":"fma_id","subj":"T287","obj":"http://purl.org/sig/ont/fma/fma20110"},{"id":"A288","pred":"fma_id","subj":"T288","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A289","pred":"fma_id","subj":"T289","obj":"http://purl.org/sig/ont/fma/fma20110"},{"id":"A290","pred":"fma_id","subj":"T290","obj":"http://purl.org/sig/ont/fma/fma63880"},{"id":"A291","pred":"fma_id","subj":"T291","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A292","pred":"fma_id","subj":"T292","obj":"http://purl.org/sig/ont/fma/fma20110"},{"id":"A293","pred":"fma_id","subj":"T293","obj":"http://purl.org/sig/ont/fma/fma67498"},{"id":"A294","pred":"fma_id","subj":"T294","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A295","pred":"fma_id","subj":"T295","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A296","pred":"fma_id","subj":"T296","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A297","pred":"fma_id","subj":"T297","obj":"http://purl.org/sig/ont/fma/fma63880"},{"id":"A298","pred":"fma_id","subj":"T298","obj":"http://purl.org/sig/ont/fma/fma83365"}],"text":"As a result of the augmentation of the PBF in obesity, there is the proportional increment of adipose tissue macrophages. Consequently, the system undergoes to a massive pro-inflammatory response resulting by adipose tissue secretion of pro-inflammatory factors, the adipocytes stimulation of inflammation-inducing factors in other tissues and the reduction of anti-inflammatory and protective factors [42]. Understanding the relationship between the adipose tissue, classified as an endocrine organ, and its immune function, the development of new therapeutic and immunonutritional strategies for obesity in COVID-19, may have important implications especially because it may act as a reservoir for more severe viral spread, with increased shedding, immune activation, and cytokine amplification [43]. In the cytokine storm milieu in obesity and COVID-19, over 50 adipokines with diverse roles have been identified. Leptin, adiponectin, IL-6 and TNF-α mainly act in adipocyte metabolism, insulin sensitivity and metabolic disorders associated with obesity [44]."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T70","span":{"begin":94,"end":108},"obj":"Body_part"},{"id":"T71","span":{"begin":102,"end":108},"obj":"Body_part"},{"id":"T72","span":{"begin":209,"end":223},"obj":"Body_part"},{"id":"T73","span":{"begin":217,"end":223},"obj":"Body_part"},{"id":"T74","span":{"begin":451,"end":465},"obj":"Body_part"},{"id":"T75","span":{"begin":459,"end":465},"obj":"Body_part"},{"id":"T76","span":{"begin":494,"end":499},"obj":"Body_part"}],"attributes":[{"id":"A70","pred":"uberon_id","subj":"T70","obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"A71","pred":"uberon_id","subj":"T71","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A72","pred":"uberon_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"A73","pred":"uberon_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A74","pred":"uberon_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"A75","pred":"uberon_id","subj":"T75","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A76","pred":"uberon_id","subj":"T76","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"}],"text":"As a result of the augmentation of the PBF in obesity, there is the proportional increment of adipose tissue macrophages. Consequently, the system undergoes to a massive pro-inflammatory response resulting by adipose tissue secretion of pro-inflammatory factors, the adipocytes stimulation of inflammation-inducing factors in other tissues and the reduction of anti-inflammatory and protective factors [42]. Understanding the relationship between the adipose tissue, classified as an endocrine organ, and its immune function, the development of new therapeutic and immunonutritional strategies for obesity in COVID-19, may have important implications especially because it may act as a reservoir for more severe viral spread, with increased shedding, immune activation, and cytokine amplification [43]. In the cytokine storm milieu in obesity and COVID-19, over 50 adipokines with diverse roles have been identified. Leptin, adiponectin, IL-6 and TNF-α mainly act in adipocyte metabolism, insulin sensitivity and metabolic disorders associated with obesity [44]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T125","span":{"begin":46,"end":53},"obj":"Disease"},{"id":"T126","span":{"begin":293,"end":305},"obj":"Disease"},{"id":"T127","span":{"begin":598,"end":605},"obj":"Disease"},{"id":"T128","span":{"begin":609,"end":617},"obj":"Disease"},{"id":"T129","span":{"begin":835,"end":842},"obj":"Disease"},{"id":"T130","span":{"begin":847,"end":855},"obj":"Disease"},{"id":"T131","span":{"begin":1013,"end":1032},"obj":"Disease"},{"id":"T132","span":{"begin":1049,"end":1056},"obj":"Disease"}],"attributes":[{"id":"A125","pred":"mondo_id","subj":"T125","obj":"http://purl.obolibrary.org/obo/MONDO_0011122"},{"id":"A126","pred":"mondo_id","subj":"T126","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A127","pred":"mondo_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/MONDO_0011122"},{"id":"A128","pred":"mondo_id","subj":"T128","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A129","pred":"mondo_id","subj":"T129","obj":"http://purl.obolibrary.org/obo/MONDO_0011122"},{"id":"A130","pred":"mondo_id","subj":"T130","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A131","pred":"mondo_id","subj":"T131","obj":"http://purl.obolibrary.org/obo/MONDO_0005066"},{"id":"A132","pred":"mondo_id","subj":"T132","obj":"http://purl.obolibrary.org/obo/MONDO_0011122"}],"text":"As a result of the augmentation of the PBF in obesity, there is the proportional increment of adipose tissue macrophages. Consequently, the system undergoes to a massive pro-inflammatory response resulting by adipose tissue secretion of pro-inflammatory factors, the adipocytes stimulation of inflammation-inducing factors in other tissues and the reduction of anti-inflammatory and protective factors [42]. Understanding the relationship between the adipose tissue, classified as an endocrine organ, and its immune function, the development of new therapeutic and immunonutritional strategies for obesity in COVID-19, may have important implications especially because it may act as a reservoir for more severe viral spread, with increased shedding, immune activation, and cytokine amplification [43]. In the cytokine storm milieu in obesity and COVID-19, over 50 adipokines with diverse roles have been identified. Leptin, adiponectin, IL-6 and TNF-α mainly act in adipocyte metabolism, insulin sensitivity and metabolic disorders associated with obesity [44]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T304","span":{"begin":3,"end":4},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T305","span":{"begin":94,"end":108},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T306","span":{"begin":160,"end":161},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T307","span":{"begin":209,"end":223},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T308","span":{"begin":267,"end":277},"obj":"http://purl.obolibrary.org/obo/CL_0000136"},{"id":"T309","span":{"begin":451,"end":465},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T310","span":{"begin":494,"end":499},"obj":"http://purl.obolibrary.org/obo/UBERON_0003103"},{"id":"T311","span":{"begin":684,"end":685},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T312","span":{"begin":758,"end":768},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T313","span":{"begin":967,"end":976},"obj":"http://purl.obolibrary.org/obo/CL_0000136"},{"id":"T314","span":{"begin":989,"end":996},"obj":"http://purl.obolibrary.org/obo/PR_000009054"}],"text":"As a result of the augmentation of the PBF in obesity, there is the proportional increment of adipose tissue macrophages. Consequently, the system undergoes to a massive pro-inflammatory response resulting by adipose tissue secretion of pro-inflammatory factors, the adipocytes stimulation of inflammation-inducing factors in other tissues and the reduction of anti-inflammatory and protective factors [42]. Understanding the relationship between the adipose tissue, classified as an endocrine organ, and its immune function, the development of new therapeutic and immunonutritional strategies for obesity in COVID-19, may have important implications especially because it may act as a reservoir for more severe viral spread, with increased shedding, immune activation, and cytokine amplification [43]. In the cytokine storm milieu in obesity and COVID-19, over 50 adipokines with diverse roles have been identified. Leptin, adiponectin, IL-6 and TNF-α mainly act in adipocyte metabolism, insulin sensitivity and metabolic disorders associated with obesity [44]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T198","span":{"begin":484,"end":493},"obj":"Chemical"},{"id":"T199","span":{"begin":917,"end":923},"obj":"Chemical"},{"id":"T200","span":{"begin":938,"end":940},"obj":"Chemical"},{"id":"T202","span":{"begin":989,"end":996},"obj":"Chemical"}],"attributes":[{"id":"A198","pred":"chebi_id","subj":"T198","obj":"http://purl.obolibrary.org/obo/CHEBI_24621"},{"id":"A199","pred":"chebi_id","subj":"T199","obj":"http://purl.obolibrary.org/obo/CHEBI_81571"},{"id":"A200","pred":"chebi_id","subj":"T200","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A201","pred":"chebi_id","subj":"T200","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A202","pred":"chebi_id","subj":"T202","obj":"http://purl.obolibrary.org/obo/CHEBI_145810"}],"text":"As a result of the augmentation of the PBF in obesity, there is the proportional increment of adipose tissue macrophages. Consequently, the system undergoes to a massive pro-inflammatory response resulting by adipose tissue secretion of pro-inflammatory factors, the adipocytes stimulation of inflammation-inducing factors in other tissues and the reduction of anti-inflammatory and protective factors [42]. Understanding the relationship between the adipose tissue, classified as an endocrine organ, and its immune function, the development of new therapeutic and immunonutritional strategies for obesity in COVID-19, may have important implications especially because it may act as a reservoir for more severe viral spread, with increased shedding, immune activation, and cytokine amplification [43]. In the cytokine storm milieu in obesity and COVID-19, over 50 adipokines with diverse roles have been identified. Leptin, adiponectin, IL-6 and TNF-α mainly act in adipocyte metabolism, insulin sensitivity and metabolic disorders associated with obesity [44]."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T43","span":{"begin":46,"end":53},"obj":"Phenotype"},{"id":"T44","span":{"begin":598,"end":605},"obj":"Phenotype"},{"id":"T45","span":{"begin":810,"end":824},"obj":"Phenotype"},{"id":"T46","span":{"begin":835,"end":842},"obj":"Phenotype"},{"id":"T47","span":{"begin":1049,"end":1056},"obj":"Phenotype"}],"attributes":[{"id":"A43","pred":"hp_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/HP_0001513"},{"id":"A44","pred":"hp_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/HP_0001513"},{"id":"A45","pred":"hp_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/HP_0033041"},{"id":"A46","pred":"hp_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/HP_0001513"},{"id":"A47","pred":"hp_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/HP_0001513"}],"text":"As a result of the augmentation of the PBF in obesity, there is the proportional increment of adipose tissue macrophages. Consequently, the system undergoes to a massive pro-inflammatory response resulting by adipose tissue secretion of pro-inflammatory factors, the adipocytes stimulation of inflammation-inducing factors in other tissues and the reduction of anti-inflammatory and protective factors [42]. Understanding the relationship between the adipose tissue, classified as an endocrine organ, and its immune function, the development of new therapeutic and immunonutritional strategies for obesity in COVID-19, may have important implications especially because it may act as a reservoir for more severe viral spread, with increased shedding, immune activation, and cytokine amplification [43]. In the cytokine storm milieu in obesity and COVID-19, over 50 adipokines with diverse roles have been identified. Leptin, adiponectin, IL-6 and TNF-α mainly act in adipocyte metabolism, insulin sensitivity and metabolic disorders associated with obesity [44]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T102","span":{"begin":174,"end":195},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T103","span":{"begin":217,"end":233},"obj":"http://purl.obolibrary.org/obo/GO_0032941"},{"id":"T104","span":{"begin":224,"end":233},"obj":"http://purl.obolibrary.org/obo/GO_0046903"},{"id":"T105","span":{"begin":293,"end":305},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T106","span":{"begin":977,"end":987},"obj":"http://purl.obolibrary.org/obo/GO_0008152"}],"text":"As a result of the augmentation of the PBF in obesity, there is the proportional increment of adipose tissue macrophages. Consequently, the system undergoes to a massive pro-inflammatory response resulting by adipose tissue secretion of pro-inflammatory factors, the adipocytes stimulation of inflammation-inducing factors in other tissues and the reduction of anti-inflammatory and protective factors [42]. Understanding the relationship between the adipose tissue, classified as an endocrine organ, and its immune function, the development of new therapeutic and immunonutritional strategies for obesity in COVID-19, may have important implications especially because it may act as a reservoir for more severe viral spread, with increased shedding, immune activation, and cytokine amplification [43]. In the cytokine storm milieu in obesity and COVID-19, over 50 adipokines with diverse roles have been identified. Leptin, adiponectin, IL-6 and TNF-α mainly act in adipocyte metabolism, insulin sensitivity and metabolic disorders associated with obesity [44]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T126","span":{"begin":0,"end":121},"obj":"Sentence"},{"id":"T127","span":{"begin":122,"end":407},"obj":"Sentence"},{"id":"T128","span":{"begin":408,"end":802},"obj":"Sentence"},{"id":"T129","span":{"begin":803,"end":916},"obj":"Sentence"},{"id":"T130","span":{"begin":917,"end":1062},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"As a result of the augmentation of the PBF in obesity, there is the proportional increment of adipose tissue macrophages. Consequently, the system undergoes to a massive pro-inflammatory response resulting by adipose tissue secretion of pro-inflammatory factors, the adipocytes stimulation of inflammation-inducing factors in other tissues and the reduction of anti-inflammatory and protective factors [42]. Understanding the relationship between the adipose tissue, classified as an endocrine organ, and its immune function, the development of new therapeutic and immunonutritional strategies for obesity in COVID-19, may have important implications especially because it may act as a reservoir for more severe viral spread, with increased shedding, immune activation, and cytokine amplification [43]. In the cytokine storm milieu in obesity and COVID-19, over 50 adipokines with diverse roles have been identified. Leptin, adiponectin, IL-6 and TNF-α mainly act in adipocyte metabolism, insulin sensitivity and metabolic disorders associated with obesity [44]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"599","span":{"begin":917,"end":923},"obj":"Gene"},{"id":"600","span":{"begin":925,"end":936},"obj":"Gene"},{"id":"601","span":{"begin":938,"end":942},"obj":"Gene"},{"id":"602","span":{"begin":947,"end":952},"obj":"Gene"},{"id":"603","span":{"begin":989,"end":996},"obj":"Gene"},{"id":"604","span":{"begin":46,"end":53},"obj":"Disease"},{"id":"605","span":{"begin":293,"end":305},"obj":"Disease"},{"id":"606","span":{"begin":598,"end":605},"obj":"Disease"},{"id":"607","span":{"begin":609,"end":617},"obj":"Disease"},{"id":"608","span":{"begin":835,"end":842},"obj":"Disease"},{"id":"609","span":{"begin":847,"end":855},"obj":"Disease"},{"id":"610","span":{"begin":1013,"end":1032},"obj":"Disease"},{"id":"611","span":{"begin":1049,"end":1056},"obj":"Disease"}],"attributes":[{"id":"A599","pred":"tao:has_database_id","subj":"599","obj":"Gene:3952"},{"id":"A600","pred":"tao:has_database_id","subj":"600","obj":"Gene:9370"},{"id":"A601","pred":"tao:has_database_id","subj":"601","obj":"Gene:3569"},{"id":"A602","pred":"tao:has_database_id","subj":"602","obj":"Gene:7124"},{"id":"A603","pred":"tao:has_database_id","subj":"603","obj":"Gene:3630"},{"id":"A604","pred":"tao:has_database_id","subj":"604","obj":"MESH:D009765"},{"id":"A605","pred":"tao:has_database_id","subj":"605","obj":"MESH:D007249"},{"id":"A606","pred":"tao:has_database_id","subj":"606","obj":"MESH:D009765"},{"id":"A607","pred":"tao:has_database_id","subj":"607","obj":"MESH:C000657245"},{"id":"A608","pred":"tao:has_database_id","subj":"608","obj":"MESH:D009765"},{"id":"A609","pred":"tao:has_database_id","subj":"609","obj":"MESH:C000657245"},{"id":"A610","pred":"tao:has_database_id","subj":"610","obj":"MESH:D008659"},{"id":"A611","pred":"tao:has_database_id","subj":"611","obj":"MESH:D009765"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"As a result of the augmentation of the PBF in obesity, there is the proportional increment of adipose tissue macrophages. Consequently, the system undergoes to a massive pro-inflammatory response resulting by adipose tissue secretion of pro-inflammatory factors, the adipocytes stimulation of inflammation-inducing factors in other tissues and the reduction of anti-inflammatory and protective factors [42]. Understanding the relationship between the adipose tissue, classified as an endocrine organ, and its immune function, the development of new therapeutic and immunonutritional strategies for obesity in COVID-19, may have important implications especially because it may act as a reservoir for more severe viral spread, with increased shedding, immune activation, and cytokine amplification [43]. In the cytokine storm milieu in obesity and COVID-19, over 50 adipokines with diverse roles have been identified. Leptin, adiponectin, IL-6 and TNF-α mainly act in adipocyte metabolism, insulin sensitivity and metabolic disorders associated with obesity [44]."}