PMC:7647877 / 20454-21516
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T287 | 94-108 | Body_part | denotes | adipose tissue | http://purl.org/sig/ont/fma/fma20110 |
| T288 | 109-120 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
| T289 | 209-223 | Body_part | denotes | adipose tissue | http://purl.org/sig/ont/fma/fma20110 |
| T290 | 267-277 | Body_part | denotes | adipocytes | http://purl.org/sig/ont/fma/fma63880 |
| T291 | 332-339 | Body_part | denotes | tissues | http://purl.org/sig/ont/fma/fma9637 |
| T292 | 451-465 | Body_part | denotes | adipose tissue | http://purl.org/sig/ont/fma/fma20110 |
| T293 | 494-499 | Body_part | denotes | organ | http://purl.org/sig/ont/fma/fma67498 |
| T294 | 774-782 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T295 | 810-818 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T296 | 938-940 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T297 | 967-976 | Body_part | denotes | adipocyte | http://purl.org/sig/ont/fma/fma63880 |
| T298 | 989-996 | Body_part | denotes | insulin | http://purl.org/sig/ont/fma/fma83365 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T70 | 94-108 | Body_part | denotes | adipose tissue | http://purl.obolibrary.org/obo/UBERON_0001013 |
| T71 | 102-108 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T72 | 209-223 | Body_part | denotes | adipose tissue | http://purl.obolibrary.org/obo/UBERON_0001013 |
| T73 | 217-223 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T74 | 451-465 | Body_part | denotes | adipose tissue | http://purl.obolibrary.org/obo/UBERON_0001013 |
| T75 | 459-465 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T76 | 494-499 | Body_part | denotes | organ | http://purl.obolibrary.org/obo/UBERON_0000062 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T125 | 46-53 | Disease | denotes | obesity | http://purl.obolibrary.org/obo/MONDO_0011122 |
| T126 | 293-305 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T127 | 598-605 | Disease | denotes | obesity | http://purl.obolibrary.org/obo/MONDO_0011122 |
| T128 | 609-617 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T129 | 835-842 | Disease | denotes | obesity | http://purl.obolibrary.org/obo/MONDO_0011122 |
| T130 | 847-855 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T131 | 1013-1032 | Disease | denotes | metabolic disorders | http://purl.obolibrary.org/obo/MONDO_0005066 |
| T132 | 1049-1056 | Disease | denotes | obesity | http://purl.obolibrary.org/obo/MONDO_0011122 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T304 | 3-4 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T305 | 94-108 | http://purl.obolibrary.org/obo/UBERON_0001013 | denotes | adipose tissue |
| T306 | 160-161 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T307 | 209-223 | http://purl.obolibrary.org/obo/UBERON_0001013 | denotes | adipose tissue |
| T308 | 267-277 | http://purl.obolibrary.org/obo/CL_0000136 | denotes | adipocytes |
| T309 | 451-465 | http://purl.obolibrary.org/obo/UBERON_0001013 | denotes | adipose tissue |
| T310 | 494-499 | http://purl.obolibrary.org/obo/UBERON_0003103 | denotes | organ |
| T311 | 684-685 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T312 | 758-768 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T313 | 967-976 | http://purl.obolibrary.org/obo/CL_0000136 | denotes | adipocyte |
| T314 | 989-996 | http://purl.obolibrary.org/obo/PR_000009054 | denotes | insulin |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T198 | 484-493 | Chemical | denotes | endocrine | http://purl.obolibrary.org/obo/CHEBI_24621 |
| T199 | 917-923 | Chemical | denotes | Leptin | http://purl.obolibrary.org/obo/CHEBI_81571 |
| T200 | 938-940 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T202 | 989-996 | Chemical | denotes | insulin | http://purl.obolibrary.org/obo/CHEBI_145810 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T43 | 46-53 | Phenotype | denotes | obesity | http://purl.obolibrary.org/obo/HP_0001513 |
| T44 | 598-605 | Phenotype | denotes | obesity | http://purl.obolibrary.org/obo/HP_0001513 |
| T45 | 810-824 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
| T46 | 835-842 | Phenotype | denotes | obesity | http://purl.obolibrary.org/obo/HP_0001513 |
| T47 | 1049-1056 | Phenotype | denotes | obesity | http://purl.obolibrary.org/obo/HP_0001513 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T102 | 174-195 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory response |
| T103 | 217-233 | http://purl.obolibrary.org/obo/GO_0032941 | denotes | tissue secretion |
| T104 | 224-233 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
| T105 | 293-305 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T106 | 977-987 | http://purl.obolibrary.org/obo/GO_0008152 | denotes | metabolism |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T126 | 0-121 | Sentence | denotes | As a result of the augmentation of the PBF in obesity, there is the proportional increment of adipose tissue macrophages. |
| T127 | 122-407 | Sentence | denotes | Consequently, the system undergoes to a massive pro-inflammatory response resulting by adipose tissue secretion of pro-inflammatory factors, the adipocytes stimulation of inflammation-inducing factors in other tissues and the reduction of anti-inflammatory and protective factors [42]. |
| T128 | 408-802 | Sentence | denotes | Understanding the relationship between the adipose tissue, classified as an endocrine organ, and its immune function, the development of new therapeutic and immunonutritional strategies for obesity in COVID-19, may have important implications especially because it may act as a reservoir for more severe viral spread, with increased shedding, immune activation, and cytokine amplification [43]. |
| T129 | 803-916 | Sentence | denotes | In the cytokine storm milieu in obesity and COVID-19, over 50 adipokines with diverse roles have been identified. |
| T130 | 917-1062 | Sentence | denotes | Leptin, adiponectin, IL-6 and TNF-α mainly act in adipocyte metabolism, insulin sensitivity and metabolic disorders associated with obesity [44]. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 599 | 917-923 | Gene | denotes | Leptin | Gene:3952 |
| 600 | 925-936 | Gene | denotes | adiponectin | Gene:9370 |
| 601 | 938-942 | Gene | denotes | IL-6 | Gene:3569 |
| 602 | 947-952 | Gene | denotes | TNF-α | Gene:7124 |
| 603 | 989-996 | Gene | denotes | insulin | Gene:3630 |
| 604 | 46-53 | Disease | denotes | obesity | MESH:D009765 |
| 605 | 293-305 | Disease | denotes | inflammation | MESH:D007249 |
| 606 | 598-605 | Disease | denotes | obesity | MESH:D009765 |
| 607 | 609-617 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 608 | 835-842 | Disease | denotes | obesity | MESH:D009765 |
| 609 | 847-855 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 610 | 1013-1032 | Disease | denotes | metabolic disorders | MESH:D008659 |
| 611 | 1049-1056 | Disease | denotes | obesity | MESH:D009765 |