PMC:7647877 / 18757-19651 JSONTXT

Annnotations TAB JSON ListView MergeView

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7647877","sourcedb":"PMC","sourceid":"7647877","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7647877","text":"Adiposopathy, also known as “sick fat”, is at the basis of obesity condition. It is defined as pathological dysfunction of both anatomical and functional within adipose tissue. It is promoted by an excess of caloric energy intake and a sedentary lifestyle in genetically and environmentally susceptible individuals. This latter may cause or worsen metabolic disease in adverse endocrine and immune response. Modifiable lifestyle choices play a role in fat function and dysfunction, but the strong genetic component has a real chance on predisposition to dysfunctional fat [38]. The disruption of adipose tissue processes, as occurs in adipocyte hypertrophy and visceral fat accumulation, results in the production of pro-inflammatory components (like the plethora of cytokines) and adipocyte factors dysregulation, which may be both genesis and/or main contributors to metabolic disorders [39].","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T268","span":{"begin":161,"end":175},"obj":"Body_part"},{"id":"T269","span":{"begin":596,"end":610},"obj":"Body_part"},{"id":"T270","span":{"begin":635,"end":644},"obj":"Body_part"},{"id":"T271","span":{"begin":767,"end":776},"obj":"Body_part"},{"id":"T272","span":{"begin":782,"end":791},"obj":"Body_part"}],"attributes":[{"id":"A268","pred":"fma_id","subj":"T268","obj":"http://purl.org/sig/ont/fma/fma20110"},{"id":"A269","pred":"fma_id","subj":"T269","obj":"http://purl.org/sig/ont/fma/fma20110"},{"id":"A270","pred":"fma_id","subj":"T270","obj":"http://purl.org/sig/ont/fma/fma63880"},{"id":"A271","pred":"fma_id","subj":"T271","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A272","pred":"fma_id","subj":"T272","obj":"http://purl.org/sig/ont/fma/fma63880"},{"subj":"T268","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T269","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T270","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T271","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T272","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T55","span":{"begin":161,"end":175},"obj":"Body_part"},{"id":"T56","span":{"begin":169,"end":175},"obj":"Body_part"},{"id":"T57","span":{"begin":596,"end":610},"obj":"Body_part"},{"id":"T58","span":{"begin":604,"end":610},"obj":"Body_part"},{"id":"T59","span":{"begin":661,"end":673},"obj":"Body_part"}],"attributes":[{"id":"A55","pred":"uberon_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"A56","pred":"uberon_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A57","pred":"uberon_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"A58","pred":"uberon_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A59","pred":"uberon_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/UBERON_0035818"},{"subj":"T55","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T56","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T57","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T58","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T59","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T119","span":{"begin":59,"end":66},"obj":"Disease"},{"id":"T120","span":{"begin":348,"end":365},"obj":"Disease"},{"id":"T121","span":{"begin":869,"end":888},"obj":"Disease"}],"attributes":[{"id":"A119","pred":"mondo_id","subj":"T119","obj":"http://purl.obolibrary.org/obo/MONDO_0011122"},{"id":"A120","pred":"mondo_id","subj":"T120","obj":"http://purl.obolibrary.org/obo/MONDO_0005066"},{"id":"A121","pred":"mondo_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/MONDO_0005066"},{"subj":"T119","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T120","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T121","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T276","span":{"begin":34,"end":37},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T277","span":{"begin":161,"end":175},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T278","span":{"begin":234,"end":235},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T279","span":{"begin":442,"end":443},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T280","span":{"begin":452,"end":455},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T281","span":{"begin":515,"end":518},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T282","span":{"begin":519,"end":520},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T283","span":{"begin":568,"end":571},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T284","span":{"begin":596,"end":610},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T285","span":{"begin":635,"end":644},"obj":"http://purl.obolibrary.org/obo/CL_0000136"},{"id":"T286","span":{"begin":670,"end":673},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T287","span":{"begin":782,"end":791},"obj":"http://purl.obolibrary.org/obo/CL_0000136"}],"attributes":[{"subj":"T276","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T277","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T278","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T279","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T280","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T281","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T282","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T283","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T284","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T285","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T286","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T287","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T195","span":{"begin":377,"end":386},"obj":"Chemical"}],"attributes":[{"id":"A195","pred":"chebi_id","subj":"T195","obj":"http://purl.obolibrary.org/obo/CHEBI_24621"},{"subj":"T195","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T37","span":{"begin":59,"end":66},"obj":"Phenotype"},{"id":"T38","span":{"begin":635,"end":656},"obj":"Phenotype"},{"id":"T39","span":{"begin":755,"end":763},"obj":"Phenotype"}],"attributes":[{"id":"A37","pred":"hp_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/HP_0001513"},{"id":"A38","pred":"hp_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/HP_0030759"},{"id":"A39","pred":"hp_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/HP_0001050"},{"subj":"T37","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T38","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T39","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T92","span":{"begin":391,"end":406},"obj":"http://purl.obolibrary.org/obo/GO_0006955"}],"attributes":[{"subj":"T92","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T115","span":{"begin":0,"end":77},"obj":"Sentence"},{"id":"T116","span":{"begin":78,"end":176},"obj":"Sentence"},{"id":"T117","span":{"begin":177,"end":315},"obj":"Sentence"},{"id":"T118","span":{"begin":316,"end":407},"obj":"Sentence"},{"id":"T119","span":{"begin":408,"end":577},"obj":"Sentence"},{"id":"T120","span":{"begin":578,"end":894},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T115","pred":"source","obj":"LitCovid-sentences"},{"subj":"T116","pred":"source","obj":"LitCovid-sentences"},{"subj":"T117","pred":"source","obj":"LitCovid-sentences"},{"subj":"T118","pred":"source","obj":"LitCovid-sentences"},{"subj":"T119","pred":"source","obj":"LitCovid-sentences"},{"subj":"T120","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"563","span":{"begin":0,"end":12},"obj":"Disease"},{"id":"564","span":{"begin":59,"end":66},"obj":"Disease"},{"id":"565","span":{"begin":348,"end":365},"obj":"Disease"},{"id":"566","span":{"begin":369,"end":386},"obj":"Disease"},{"id":"567","span":{"begin":554,"end":571},"obj":"Disease"},{"id":"568","span":{"begin":645,"end":656},"obj":"Disease"},{"id":"569","span":{"begin":869,"end":888},"obj":"Disease"}],"attributes":[{"id":"A564","pred":"tao:has_database_id","subj":"564","obj":"MESH:D009765"},{"id":"A565","pred":"tao:has_database_id","subj":"565","obj":"MESH:D008659"},{"id":"A566","pred":"tao:has_database_id","subj":"566","obj":"MESH:D004700"},{"id":"A567","pred":"tao:has_database_id","subj":"567","obj":"MESH:D005218"},{"id":"A568","pred":"tao:has_database_id","subj":"568","obj":"MESH:D006984"},{"id":"A569","pred":"tao:has_database_id","subj":"569","obj":"MESH:D008659"},{"subj":"563","pred":"source","obj":"LitCovid-PubTator"},{"subj":"564","pred":"source","obj":"LitCovid-PubTator"},{"subj":"565","pred":"source","obj":"LitCovid-PubTator"},{"subj":"566","pred":"source","obj":"LitCovid-PubTator"},{"subj":"567","pred":"source","obj":"LitCovid-PubTator"},{"subj":"568","pred":"source","obj":"LitCovid-PubTator"},{"subj":"569","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#ecaa93","default":true},{"id":"LitCovid-PD-UBERON","color":"#9395ec"},{"id":"LitCovid-PD-MONDO","color":"#afec93"},{"id":"LitCovid-PD-CLO","color":"#ec93c9"},{"id":"LitCovid-PD-CHEBI","color":"#93e4ec"},{"id":"LitCovid-PD-HP","color":"#ecda93"},{"id":"LitCovid-PD-GO-BP","color":"#c093ec"},{"id":"LitCovid-sentences","color":"#93eca6"},{"id":"LitCovid-PubTator","color":"#ec9399"}]}]}}