PMC:7647877 / 18757-19651 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T268","span":{"begin":161,"end":175},"obj":"Body_part"},{"id":"T269","span":{"begin":596,"end":610},"obj":"Body_part"},{"id":"T270","span":{"begin":635,"end":644},"obj":"Body_part"},{"id":"T271","span":{"begin":767,"end":776},"obj":"Body_part"},{"id":"T272","span":{"begin":782,"end":791},"obj":"Body_part"}],"attributes":[{"id":"A268","pred":"fma_id","subj":"T268","obj":"http://purl.org/sig/ont/fma/fma20110"},{"id":"A269","pred":"fma_id","subj":"T269","obj":"http://purl.org/sig/ont/fma/fma20110"},{"id":"A270","pred":"fma_id","subj":"T270","obj":"http://purl.org/sig/ont/fma/fma63880"},{"id":"A271","pred":"fma_id","subj":"T271","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A272","pred":"fma_id","subj":"T272","obj":"http://purl.org/sig/ont/fma/fma63880"}],"text":"Adiposopathy, also known as “sick fat”, is at the basis of obesity condition. It is defined as pathological dysfunction of both anatomical and functional within adipose tissue. It is promoted by an excess of caloric energy intake and a sedentary lifestyle in genetically and environmentally susceptible individuals. This latter may cause or worsen metabolic disease in adverse endocrine and immune response. Modifiable lifestyle choices play a role in fat function and dysfunction, but the strong genetic component has a real chance on predisposition to dysfunctional fat [38]. The disruption of adipose tissue processes, as occurs in adipocyte hypertrophy and visceral fat accumulation, results in the production of pro-inflammatory components (like the plethora of cytokines) and adipocyte factors dysregulation, which may be both genesis and/or main contributors to metabolic disorders [39]."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T55","span":{"begin":161,"end":175},"obj":"Body_part"},{"id":"T56","span":{"begin":169,"end":175},"obj":"Body_part"},{"id":"T57","span":{"begin":596,"end":610},"obj":"Body_part"},{"id":"T58","span":{"begin":604,"end":610},"obj":"Body_part"},{"id":"T59","span":{"begin":661,"end":673},"obj":"Body_part"}],"attributes":[{"id":"A55","pred":"uberon_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"A56","pred":"uberon_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A57","pred":"uberon_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"A58","pred":"uberon_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A59","pred":"uberon_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/UBERON_0035818"}],"text":"Adiposopathy, also known as “sick fat”, is at the basis of obesity condition. It is defined as pathological dysfunction of both anatomical and functional within adipose tissue. It is promoted by an excess of caloric energy intake and a sedentary lifestyle in genetically and environmentally susceptible individuals. This latter may cause or worsen metabolic disease in adverse endocrine and immune response. Modifiable lifestyle choices play a role in fat function and dysfunction, but the strong genetic component has a real chance on predisposition to dysfunctional fat [38]. The disruption of adipose tissue processes, as occurs in adipocyte hypertrophy and visceral fat accumulation, results in the production of pro-inflammatory components (like the plethora of cytokines) and adipocyte factors dysregulation, which may be both genesis and/or main contributors to metabolic disorders [39]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T119","span":{"begin":59,"end":66},"obj":"Disease"},{"id":"T120","span":{"begin":348,"end":365},"obj":"Disease"},{"id":"T121","span":{"begin":869,"end":888},"obj":"Disease"}],"attributes":[{"id":"A119","pred":"mondo_id","subj":"T119","obj":"http://purl.obolibrary.org/obo/MONDO_0011122"},{"id":"A120","pred":"mondo_id","subj":"T120","obj":"http://purl.obolibrary.org/obo/MONDO_0005066"},{"id":"A121","pred":"mondo_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/MONDO_0005066"}],"text":"Adiposopathy, also known as “sick fat”, is at the basis of obesity condition. It is defined as pathological dysfunction of both anatomical and functional within adipose tissue. It is promoted by an excess of caloric energy intake and a sedentary lifestyle in genetically and environmentally susceptible individuals. This latter may cause or worsen metabolic disease in adverse endocrine and immune response. Modifiable lifestyle choices play a role in fat function and dysfunction, but the strong genetic component has a real chance on predisposition to dysfunctional fat [38]. The disruption of adipose tissue processes, as occurs in adipocyte hypertrophy and visceral fat accumulation, results in the production of pro-inflammatory components (like the plethora of cytokines) and adipocyte factors dysregulation, which may be both genesis and/or main contributors to metabolic disorders [39]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T276","span":{"begin":34,"end":37},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T277","span":{"begin":161,"end":175},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T278","span":{"begin":234,"end":235},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T279","span":{"begin":442,"end":443},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T280","span":{"begin":452,"end":455},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T281","span":{"begin":515,"end":518},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T282","span":{"begin":519,"end":520},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T283","span":{"begin":568,"end":571},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T284","span":{"begin":596,"end":610},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T285","span":{"begin":635,"end":644},"obj":"http://purl.obolibrary.org/obo/CL_0000136"},{"id":"T286","span":{"begin":670,"end":673},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T287","span":{"begin":782,"end":791},"obj":"http://purl.obolibrary.org/obo/CL_0000136"}],"text":"Adiposopathy, also known as “sick fat”, is at the basis of obesity condition. It is defined as pathological dysfunction of both anatomical and functional within adipose tissue. It is promoted by an excess of caloric energy intake and a sedentary lifestyle in genetically and environmentally susceptible individuals. This latter may cause or worsen metabolic disease in adverse endocrine and immune response. Modifiable lifestyle choices play a role in fat function and dysfunction, but the strong genetic component has a real chance on predisposition to dysfunctional fat [38]. The disruption of adipose tissue processes, as occurs in adipocyte hypertrophy and visceral fat accumulation, results in the production of pro-inflammatory components (like the plethora of cytokines) and adipocyte factors dysregulation, which may be both genesis and/or main contributors to metabolic disorders [39]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T195","span":{"begin":377,"end":386},"obj":"Chemical"}],"attributes":[{"id":"A195","pred":"chebi_id","subj":"T195","obj":"http://purl.obolibrary.org/obo/CHEBI_24621"}],"text":"Adiposopathy, also known as “sick fat”, is at the basis of obesity condition. It is defined as pathological dysfunction of both anatomical and functional within adipose tissue. It is promoted by an excess of caloric energy intake and a sedentary lifestyle in genetically and environmentally susceptible individuals. This latter may cause or worsen metabolic disease in adverse endocrine and immune response. Modifiable lifestyle choices play a role in fat function and dysfunction, but the strong genetic component has a real chance on predisposition to dysfunctional fat [38]. The disruption of adipose tissue processes, as occurs in adipocyte hypertrophy and visceral fat accumulation, results in the production of pro-inflammatory components (like the plethora of cytokines) and adipocyte factors dysregulation, which may be both genesis and/or main contributors to metabolic disorders [39]."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T37","span":{"begin":59,"end":66},"obj":"Phenotype"},{"id":"T38","span":{"begin":635,"end":656},"obj":"Phenotype"},{"id":"T39","span":{"begin":755,"end":763},"obj":"Phenotype"}],"attributes":[{"id":"A37","pred":"hp_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/HP_0001513"},{"id":"A38","pred":"hp_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/HP_0030759"},{"id":"A39","pred":"hp_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/HP_0001050"}],"text":"Adiposopathy, also known as “sick fat”, is at the basis of obesity condition. It is defined as pathological dysfunction of both anatomical and functional within adipose tissue. It is promoted by an excess of caloric energy intake and a sedentary lifestyle in genetically and environmentally susceptible individuals. This latter may cause or worsen metabolic disease in adverse endocrine and immune response. Modifiable lifestyle choices play a role in fat function and dysfunction, but the strong genetic component has a real chance on predisposition to dysfunctional fat [38]. The disruption of adipose tissue processes, as occurs in adipocyte hypertrophy and visceral fat accumulation, results in the production of pro-inflammatory components (like the plethora of cytokines) and adipocyte factors dysregulation, which may be both genesis and/or main contributors to metabolic disorders [39]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T92","span":{"begin":391,"end":406},"obj":"http://purl.obolibrary.org/obo/GO_0006955"}],"text":"Adiposopathy, also known as “sick fat”, is at the basis of obesity condition. It is defined as pathological dysfunction of both anatomical and functional within adipose tissue. It is promoted by an excess of caloric energy intake and a sedentary lifestyle in genetically and environmentally susceptible individuals. This latter may cause or worsen metabolic disease in adverse endocrine and immune response. Modifiable lifestyle choices play a role in fat function and dysfunction, but the strong genetic component has a real chance on predisposition to dysfunctional fat [38]. The disruption of adipose tissue processes, as occurs in adipocyte hypertrophy and visceral fat accumulation, results in the production of pro-inflammatory components (like the plethora of cytokines) and adipocyte factors dysregulation, which may be both genesis and/or main contributors to metabolic disorders [39]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T115","span":{"begin":0,"end":77},"obj":"Sentence"},{"id":"T116","span":{"begin":78,"end":176},"obj":"Sentence"},{"id":"T117","span":{"begin":177,"end":315},"obj":"Sentence"},{"id":"T118","span":{"begin":316,"end":407},"obj":"Sentence"},{"id":"T119","span":{"begin":408,"end":577},"obj":"Sentence"},{"id":"T120","span":{"begin":578,"end":894},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Adiposopathy, also known as “sick fat”, is at the basis of obesity condition. It is defined as pathological dysfunction of both anatomical and functional within adipose tissue. It is promoted by an excess of caloric energy intake and a sedentary lifestyle in genetically and environmentally susceptible individuals. This latter may cause or worsen metabolic disease in adverse endocrine and immune response. Modifiable lifestyle choices play a role in fat function and dysfunction, but the strong genetic component has a real chance on predisposition to dysfunctional fat [38]. The disruption of adipose tissue processes, as occurs in adipocyte hypertrophy and visceral fat accumulation, results in the production of pro-inflammatory components (like the plethora of cytokines) and adipocyte factors dysregulation, which may be both genesis and/or main contributors to metabolic disorders [39]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"563","span":{"begin":0,"end":12},"obj":"Disease"},{"id":"564","span":{"begin":59,"end":66},"obj":"Disease"},{"id":"565","span":{"begin":348,"end":365},"obj":"Disease"},{"id":"566","span":{"begin":369,"end":386},"obj":"Disease"},{"id":"567","span":{"begin":554,"end":571},"obj":"Disease"},{"id":"568","span":{"begin":645,"end":656},"obj":"Disease"},{"id":"569","span":{"begin":869,"end":888},"obj":"Disease"}],"attributes":[{"id":"A564","pred":"tao:has_database_id","subj":"564","obj":"MESH:D009765"},{"id":"A565","pred":"tao:has_database_id","subj":"565","obj":"MESH:D008659"},{"id":"A566","pred":"tao:has_database_id","subj":"566","obj":"MESH:D004700"},{"id":"A567","pred":"tao:has_database_id","subj":"567","obj":"MESH:D005218"},{"id":"A568","pred":"tao:has_database_id","subj":"568","obj":"MESH:D006984"},{"id":"A569","pred":"tao:has_database_id","subj":"569","obj":"MESH:D008659"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Adiposopathy, also known as “sick fat”, is at the basis of obesity condition. It is defined as pathological dysfunction of both anatomical and functional within adipose tissue. It is promoted by an excess of caloric energy intake and a sedentary lifestyle in genetically and environmentally susceptible individuals. This latter may cause or worsen metabolic disease in adverse endocrine and immune response. Modifiable lifestyle choices play a role in fat function and dysfunction, but the strong genetic component has a real chance on predisposition to dysfunctional fat [38]. The disruption of adipose tissue processes, as occurs in adipocyte hypertrophy and visceral fat accumulation, results in the production of pro-inflammatory components (like the plethora of cytokines) and adipocyte factors dysregulation, which may be both genesis and/or main contributors to metabolic disorders [39]."}