PMC:7640975 / 745-2099 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T11","span":{"begin":234,"end":241},"obj":"Body_part"},{"id":"T12","span":{"begin":614,"end":627},"obj":"Body_part"},{"id":"T13","span":{"begin":629,"end":645},"obj":"Body_part"},{"id":"T14","span":{"begin":720,"end":724},"obj":"Body_part"},{"id":"T15","span":{"begin":823,"end":828},"obj":"Body_part"},{"id":"T16","span":{"begin":1019,"end":1022},"obj":"Body_part"},{"id":"T17","span":{"begin":1023,"end":1029},"obj":"Body_part"}],"attributes":[{"id":"A11","pred":"fma_id","subj":"T11","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A12","pred":"fma_id","subj":"T12","obj":"http://purl.org/sig/ont/fma/fma9825"},{"id":"A13","pred":"fma_id","subj":"T13","obj":"http://purl.org/sig/ont/fma/fma7152"},{"id":"A14","pred":"fma_id","subj":"T14","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A15","pred":"fma_id","subj":"T15","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A16","pred":"fma_id","subj":"T16","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A17","pred":"fma_id","subj":"T17","obj":"http://purl.org/sig/ont/fma/fma84116"}],"text":"are available via ProteomeXchange with identifier PXD019975. To ensure reliability of the proteomics data, two randomly selected DEPs, the downregulated anaphase-promoting complex subunit 7 (ANAPC7) and upregulated interferon-induced protein with tetratricopeptide repeats 1 (IFIT1), were verified by real-time PCR and Western blot, and the results of which indicate that the proteomics data were reliable and valid. Bioinformatics analyses, including GO, COG, KEGG, and STRING, further demonstrated that a majority of the DEPs are involved in numerous crucial biological processes and signaling pathways, such as immune system, digestive system, signal transduction, RIG-I-like receptor, mTOR, PI3K-AKT, autophagy, and cell cycle signaling pathways. Altogether, this is the first study on proteomes of PDCoV-infected host cells, which shall provide valuable clues for further investigation of PDCoV pathogenesis.\n\n1 Introduction\nPorcine deltacoronavirus (PDCoV) is enveloped and has a single-stranded, positive-sense RNA genome, which is classified in the genus Deltacoronavirus within the Coronaviridae family.1 Although PDCoV was initially identified in rectal swabs of pigs during a molecular epidemiological investigation conducted in Hong Kong, China in 2012,2 diarrheal diseases in pigs associated with PDCoV infection were first recorded in the "}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T2","span":{"begin":614,"end":627},"obj":"Body_part"},{"id":"T3","span":{"begin":629,"end":645},"obj":"Body_part"}],"attributes":[{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0001007"}],"text":"are available via ProteomeXchange with identifier PXD019975. To ensure reliability of the proteomics data, two randomly selected DEPs, the downregulated anaphase-promoting complex subunit 7 (ANAPC7) and upregulated interferon-induced protein with tetratricopeptide repeats 1 (IFIT1), were verified by real-time PCR and Western blot, and the results of which indicate that the proteomics data were reliable and valid. Bioinformatics analyses, including GO, COG, KEGG, and STRING, further demonstrated that a majority of the DEPs are involved in numerous crucial biological processes and signaling pathways, such as immune system, digestive system, signal transduction, RIG-I-like receptor, mTOR, PI3K-AKT, autophagy, and cell cycle signaling pathways. Altogether, this is the first study on proteomes of PDCoV-infected host cells, which shall provide valuable clues for further investigation of PDCoV pathogenesis.\n\n1 Introduction\nPorcine deltacoronavirus (PDCoV) is enveloped and has a single-stranded, positive-sense RNA genome, which is classified in the genus Deltacoronavirus within the Coronaviridae family.1 Although PDCoV was initially identified in rectal swabs of pigs during a molecular epidemiological investigation conducted in Hong Kong, China in 2012,2 diarrheal diseases in pigs associated with PDCoV infection were first recorded in the "}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T3","span":{"begin":1268,"end":1286},"obj":"Disease"},{"id":"T4","span":{"begin":1317,"end":1326},"obj":"Disease"}],"attributes":[{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0001673"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"are available via ProteomeXchange with identifier PXD019975. To ensure reliability of the proteomics data, two randomly selected DEPs, the downregulated anaphase-promoting complex subunit 7 (ANAPC7) and upregulated interferon-induced protein with tetratricopeptide repeats 1 (IFIT1), were verified by real-time PCR and Western blot, and the results of which indicate that the proteomics data were reliable and valid. Bioinformatics analyses, including GO, COG, KEGG, and STRING, further demonstrated that a majority of the DEPs are involved in numerous crucial biological processes and signaling pathways, such as immune system, digestive system, signal transduction, RIG-I-like receptor, mTOR, PI3K-AKT, autophagy, and cell cycle signaling pathways. Altogether, this is the first study on proteomes of PDCoV-infected host cells, which shall provide valuable clues for further investigation of PDCoV pathogenesis.\n\n1 Introduction\nPorcine deltacoronavirus (PDCoV) is enveloped and has a single-stranded, positive-sense RNA genome, which is classified in the genus Deltacoronavirus within the Coronaviridae family.1 Although PDCoV was initially identified in rectal swabs of pigs during a molecular epidemiological investigation conducted in Hong Kong, China in 2012,2 diarrheal diseases in pigs associated with PDCoV infection were first recorded in the "}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T18","span":{"begin":505,"end":506},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T19","span":{"begin":586,"end":595},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T20","span":{"begin":614,"end":627},"obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"T21","span":{"begin":629,"end":645},"obj":"http://purl.obolibrary.org/obo/UBERON_0001007"},{"id":"T22","span":{"begin":629,"end":645},"obj":"http://www.ebi.ac.uk/efo/EFO_0000793"},{"id":"T23","span":{"begin":647,"end":653},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T24","span":{"begin":720,"end":724},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T25","span":{"begin":731,"end":740},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T26","span":{"begin":823,"end":828},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T27","span":{"begin":981,"end":984},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T28","span":{"begin":985,"end":986},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T29","span":{"begin":1186,"end":1187},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"are available via ProteomeXchange with identifier PXD019975. To ensure reliability of the proteomics data, two randomly selected DEPs, the downregulated anaphase-promoting complex subunit 7 (ANAPC7) and upregulated interferon-induced protein with tetratricopeptide repeats 1 (IFIT1), were verified by real-time PCR and Western blot, and the results of which indicate that the proteomics data were reliable and valid. Bioinformatics analyses, including GO, COG, KEGG, and STRING, further demonstrated that a majority of the DEPs are involved in numerous crucial biological processes and signaling pathways, such as immune system, digestive system, signal transduction, RIG-I-like receptor, mTOR, PI3K-AKT, autophagy, and cell cycle signaling pathways. Altogether, this is the first study on proteomes of PDCoV-infected host cells, which shall provide valuable clues for further investigation of PDCoV pathogenesis.\n\n1 Introduction\nPorcine deltacoronavirus (PDCoV) is enveloped and has a single-stranded, positive-sense RNA genome, which is classified in the genus Deltacoronavirus within the Coronaviridae family.1 Although PDCoV was initially identified in rectal swabs of pigs during a molecular epidemiological investigation conducted in Hong Kong, China in 2012,2 diarrheal diseases in pigs associated with PDCoV infection were first recorded in the "}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T9","span":{"begin":215,"end":225},"obj":"Chemical"},{"id":"T10","span":{"begin":234,"end":241},"obj":"Chemical"}],"attributes":[{"id":"A9","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_52999"},{"id":"A10","pred":"chebi_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"are available via ProteomeXchange with identifier PXD019975. To ensure reliability of the proteomics data, two randomly selected DEPs, the downregulated anaphase-promoting complex subunit 7 (ANAPC7) and upregulated interferon-induced protein with tetratricopeptide repeats 1 (IFIT1), were verified by real-time PCR and Western blot, and the results of which indicate that the proteomics data were reliable and valid. Bioinformatics analyses, including GO, COG, KEGG, and STRING, further demonstrated that a majority of the DEPs are involved in numerous crucial biological processes and signaling pathways, such as immune system, digestive system, signal transduction, RIG-I-like receptor, mTOR, PI3K-AKT, autophagy, and cell cycle signaling pathways. Altogether, this is the first study on proteomes of PDCoV-infected host cells, which shall provide valuable clues for further investigation of PDCoV pathogenesis.\n\n1 Introduction\nPorcine deltacoronavirus (PDCoV) is enveloped and has a single-stranded, positive-sense RNA genome, which is classified in the genus Deltacoronavirus within the Coronaviridae family.1 Although PDCoV was initially identified in rectal swabs of pigs during a molecular epidemiological investigation conducted in Hong Kong, China in 2012,2 diarrheal diseases in pigs associated with PDCoV infection were first recorded in the "}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T1","span":{"begin":153,"end":161},"obj":"http://purl.obolibrary.org/obo/GO_0051322"},{"id":"T2","span":{"begin":586,"end":604},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T3","span":{"begin":586,"end":595},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T4","span":{"begin":647,"end":666},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T5","span":{"begin":654,"end":666},"obj":"http://purl.obolibrary.org/obo/GO_0009293"},{"id":"T6","span":{"begin":695,"end":699},"obj":"http://purl.obolibrary.org/obo/GO_0016303"},{"id":"T7","span":{"begin":705,"end":714},"obj":"http://purl.obolibrary.org/obo/GO_0016236"},{"id":"T8","span":{"begin":705,"end":714},"obj":"http://purl.obolibrary.org/obo/GO_0006914"},{"id":"T9","span":{"begin":720,"end":730},"obj":"http://purl.obolibrary.org/obo/GO_0007049"},{"id":"T10","span":{"begin":731,"end":749},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T11","span":{"begin":731,"end":740},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T12","span":{"begin":900,"end":912},"obj":"http://purl.obolibrary.org/obo/GO_0009405"}],"text":"are available via ProteomeXchange with identifier PXD019975. To ensure reliability of the proteomics data, two randomly selected DEPs, the downregulated anaphase-promoting complex subunit 7 (ANAPC7) and upregulated interferon-induced protein with tetratricopeptide repeats 1 (IFIT1), were verified by real-time PCR and Western blot, and the results of which indicate that the proteomics data were reliable and valid. Bioinformatics analyses, including GO, COG, KEGG, and STRING, further demonstrated that a majority of the DEPs are involved in numerous crucial biological processes and signaling pathways, such as immune system, digestive system, signal transduction, RIG-I-like receptor, mTOR, PI3K-AKT, autophagy, and cell cycle signaling pathways. Altogether, this is the first study on proteomes of PDCoV-infected host cells, which shall provide valuable clues for further investigation of PDCoV pathogenesis.\n\n1 Introduction\nPorcine deltacoronavirus (PDCoV) is enveloped and has a single-stranded, positive-sense RNA genome, which is classified in the genus Deltacoronavirus within the Coronaviridae family.1 Although PDCoV was initially identified in rectal swabs of pigs during a molecular epidemiological investigation conducted in Hong Kong, China in 2012,2 diarrheal diseases in pigs associated with PDCoV infection were first recorded in the "}

{"project":"LitCovid-sentences","denotations":[{"id":"T8","span":{"begin":61,"end":416},"obj":"Sentence"},{"id":"T9","span":{"begin":417,"end":750},"obj":"Sentence"},{"id":"T10","span":{"begin":751,"end":913},"obj":"Sentence"},{"id":"T11","span":{"begin":915,"end":930},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"are available via ProteomeXchange with identifier PXD019975. To ensure reliability of the proteomics data, two randomly selected DEPs, the downregulated anaphase-promoting complex subunit 7 (ANAPC7) and upregulated interferon-induced protein with tetratricopeptide repeats 1 (IFIT1), were verified by real-time PCR and Western blot, and the results of which indicate that the proteomics data were reliable and valid. Bioinformatics analyses, including GO, COG, KEGG, and STRING, further demonstrated that a majority of the DEPs are involved in numerous crucial biological processes and signaling pathways, such as immune system, digestive system, signal transduction, RIG-I-like receptor, mTOR, PI3K-AKT, autophagy, and cell cycle signaling pathways. Altogether, this is the first study on proteomes of PDCoV-infected host cells, which shall provide valuable clues for further investigation of PDCoV pathogenesis.\n\n1 Introduction\nPorcine deltacoronavirus (PDCoV) is enveloped and has a single-stranded, positive-sense RNA genome, which is classified in the genus Deltacoronavirus within the Coronaviridae family.1 Although PDCoV was initially identified in rectal swabs of pigs during a molecular epidemiological investigation conducted in Hong Kong, China in 2012,2 diarrheal diseases in pigs associated with PDCoV infection were first recorded in the "}

{"project":"LitCovid-PubTator","denotations":[{"id":"21","span":{"begin":153,"end":189},"obj":"Gene"},{"id":"22","span":{"begin":191,"end":197},"obj":"Gene"},{"id":"23","span":{"begin":215,"end":274},"obj":"Gene"},{"id":"24","span":{"begin":276,"end":281},"obj":"Gene"},{"id":"25","span":{"begin":689,"end":693},"obj":"Gene"},{"id":"26","span":{"begin":700,"end":703},"obj":"Gene"},{"id":"34","span":{"begin":803,"end":817},"obj":"Disease"},{"id":"50","span":{"begin":931,"end":955},"obj":"Species"},{"id":"51","span":{"begin":1092,"end":1105},"obj":"Species"},{"id":"52","span":{"begin":1174,"end":1178},"obj":"Species"},{"id":"53","span":{"begin":1290,"end":1294},"obj":"Species"},{"id":"56","span":{"begin":1268,"end":1286},"obj":"Disease"},{"id":"57","span":{"begin":1311,"end":1326},"obj":"Disease"}],"attributes":[{"id":"A21","pred":"tao:has_database_id","subj":"21","obj":"Gene:51434"},{"id":"A22","pred":"tao:has_database_id","subj":"22","obj":"Gene:51434"},{"id":"A23","pred":"tao:has_database_id","subj":"23","obj":"Gene:3434"},{"id":"A24","pred":"tao:has_database_id","subj":"24","obj":"Gene:3434"},{"id":"A25","pred":"tao:has_database_id","subj":"25","obj":"Gene:2475"},{"id":"A26","pred":"tao:has_database_id","subj":"26","obj":"Gene:207"},{"id":"A34","pred":"tao:has_database_id","subj":"34","obj":"MESH:D007239"},{"id":"A50","pred":"tao:has_database_id","subj":"50","obj":"Tax:1586324"},{"id":"A51","pred":"tao:has_database_id","subj":"51","obj":"Tax:11118"},{"id":"A52","pred":"tao:has_database_id","subj":"52","obj":"Tax:9823"},{"id":"A53","pred":"tao:has_database_id","subj":"53","obj":"Tax:9823"},{"id":"A56","pred":"tao:has_database_id","subj":"56","obj":"MESH:D004403"},{"id":"A57","pred":"tao:has_database_id","subj":"57","obj":"MESH:D007239"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"are available via ProteomeXchange with identifier PXD019975. To ensure reliability of the proteomics data, two randomly selected DEPs, the downregulated anaphase-promoting complex subunit 7 (ANAPC7) and upregulated interferon-induced protein with tetratricopeptide repeats 1 (IFIT1), were verified by real-time PCR and Western blot, and the results of which indicate that the proteomics data were reliable and valid. Bioinformatics analyses, including GO, COG, KEGG, and STRING, further demonstrated that a majority of the DEPs are involved in numerous crucial biological processes and signaling pathways, such as immune system, digestive system, signal transduction, RIG-I-like receptor, mTOR, PI3K-AKT, autophagy, and cell cycle signaling pathways. Altogether, this is the first study on proteomes of PDCoV-infected host cells, which shall provide valuable clues for further investigation of PDCoV pathogenesis.\n\n1 Introduction\nPorcine deltacoronavirus (PDCoV) is enveloped and has a single-stranded, positive-sense RNA genome, which is classified in the genus Deltacoronavirus within the Coronaviridae family.1 Although PDCoV was initially identified in rectal swabs of pigs during a molecular epidemiological investigation conducted in Hong Kong, China in 2012,2 diarrheal diseases in pigs associated with PDCoV infection were first recorded in the "}