PMC:7640975 / 62551-63431 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T509","span":{"begin":71,"end":78},"obj":"Body_part"},{"id":"T510","span":{"begin":114,"end":119},"obj":"Body_part"},{"id":"T511","span":{"begin":246,"end":254},"obj":"Body_part"},{"id":"T512","span":{"begin":276,"end":284},"obj":"Body_part"},{"id":"T513","span":{"begin":328,"end":333},"obj":"Body_part"},{"id":"T514","span":{"begin":500,"end":516},"obj":"Body_part"},{"id":"T515","span":{"begin":518,"end":531},"obj":"Body_part"},{"id":"T516","span":{"begin":610,"end":614},"obj":"Body_part"},{"id":"T517","span":{"begin":874,"end":879},"obj":"Body_part"}],"attributes":[{"id":"A509","pred":"fma_id","subj":"T509","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A510","pred":"fma_id","subj":"T510","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A511","pred":"fma_id","subj":"T511","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A512","pred":"fma_id","subj":"T512","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A513","pred":"fma_id","subj":"T513","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A514","pred":"fma_id","subj":"T514","obj":"http://purl.org/sig/ont/fma/fma7152"},{"id":"A515","pred":"fma_id","subj":"T515","obj":"http://purl.org/sig/ont/fma/fma9825"},{"id":"A516","pred":"fma_id","subj":"T516","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A517","pred":"fma_id","subj":"T517","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"The present study provides the first systematic analysis of the global protein profiles of PDCoV-infected IPEC-J2 cells using a quantitative proteomics approach in which iTRAQ was coupled to LC-MS/MS. A total of 78 DEPs, including 23 upregulated proteins and 55 downregulated proteins, were identified in PDCoV-infected IPEC-J2 cells at 24 hpi. Bioinformatics analyses further revealed that a majority of the DEPs were involved in various crucial biological processes and signaling pathways, such as digestive system, immune system, signal transduction, and RIG-I-like receptor, mTOR, PI3K-AKT, autophagy, and cell cycle signaling pathways. Although further investigations are required to elucidate the functions of the DEPs of interest, our current data provide valuable clues for the in-depth investigation of pathogenic mechanisms of PDCoV and defense mechanisms of host cells."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T42","span":{"begin":500,"end":516},"obj":"Body_part"},{"id":"T43","span":{"begin":518,"end":531},"obj":"Body_part"}],"attributes":[{"id":"A42","pred":"uberon_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/UBERON_0001007"},{"id":"A43","pred":"uberon_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/UBERON_0002405"}],"text":"The present study provides the first systematic analysis of the global protein profiles of PDCoV-infected IPEC-J2 cells using a quantitative proteomics approach in which iTRAQ was coupled to LC-MS/MS. A total of 78 DEPs, including 23 upregulated proteins and 55 downregulated proteins, were identified in PDCoV-infected IPEC-J2 cells at 24 hpi. Bioinformatics analyses further revealed that a majority of the DEPs were involved in various crucial biological processes and signaling pathways, such as digestive system, immune system, signal transduction, and RIG-I-like receptor, mTOR, PI3K-AKT, autophagy, and cell cycle signaling pathways. Although further investigations are required to elucidate the functions of the DEPs of interest, our current data provide valuable clues for the in-depth investigation of pathogenic mechanisms of PDCoV and defense mechanisms of host cells."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T696","span":{"begin":114,"end":119},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T697","span":{"begin":126,"end":127},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T698","span":{"begin":191,"end":193},"obj":"http://purl.obolibrary.org/obo/CL_0000453"},{"id":"T699","span":{"begin":194,"end":196},"obj":"http://purl.obolibrary.org/obo/CLO_0007874"},{"id":"T700","span":{"begin":197,"end":199},"obj":"http://purl.obolibrary.org/obo/CLO_0007874"},{"id":"T701","span":{"begin":201,"end":202},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T702","span":{"begin":328,"end":333},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T703","span":{"begin":391,"end":392},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T704","span":{"begin":472,"end":481},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T705","span":{"begin":500,"end":516},"obj":"http://purl.obolibrary.org/obo/UBERON_0001007"},{"id":"T706","span":{"begin":500,"end":516},"obj":"http://www.ebi.ac.uk/efo/EFO_0000793"},{"id":"T707","span":{"begin":518,"end":531},"obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"T708","span":{"begin":533,"end":539},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T709","span":{"begin":610,"end":614},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T710","span":{"begin":621,"end":630},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T711","span":{"begin":874,"end":879},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"The present study provides the first systematic analysis of the global protein profiles of PDCoV-infected IPEC-J2 cells using a quantitative proteomics approach in which iTRAQ was coupled to LC-MS/MS. A total of 78 DEPs, including 23 upregulated proteins and 55 downregulated proteins, were identified in PDCoV-infected IPEC-J2 cells at 24 hpi. Bioinformatics analyses further revealed that a majority of the DEPs were involved in various crucial biological processes and signaling pathways, such as digestive system, immune system, signal transduction, and RIG-I-like receptor, mTOR, PI3K-AKT, autophagy, and cell cycle signaling pathways. Although further investigations are required to elucidate the functions of the DEPs of interest, our current data provide valuable clues for the in-depth investigation of pathogenic mechanisms of PDCoV and defense mechanisms of host cells."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T18811","span":{"begin":71,"end":78},"obj":"Chemical"},{"id":"T55089","span":{"begin":191,"end":193},"obj":"Chemical"},{"id":"T81472","span":{"begin":194,"end":196},"obj":"Chemical"},{"id":"T38162","span":{"begin":197,"end":199},"obj":"Chemical"},{"id":"T21097","span":{"begin":246,"end":254},"obj":"Chemical"},{"id":"T1741","span":{"begin":276,"end":284},"obj":"Chemical"}],"attributes":[{"id":"A67072","pred":"chebi_id","subj":"T18811","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A61337","pred":"chebi_id","subj":"T55089","obj":"http://purl.obolibrary.org/obo/CHEBI_73582"},{"id":"A88837","pred":"chebi_id","subj":"T81472","obj":"http://purl.obolibrary.org/obo/CHEBI_73613"},{"id":"A18791","pred":"chebi_id","subj":"T38162","obj":"http://purl.obolibrary.org/obo/CHEBI_73613"},{"id":"A17309","pred":"chebi_id","subj":"T21097","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A22367","pred":"chebi_id","subj":"T1741","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"The present study provides the first systematic analysis of the global protein profiles of PDCoV-infected IPEC-J2 cells using a quantitative proteomics approach in which iTRAQ was coupled to LC-MS/MS. A total of 78 DEPs, including 23 upregulated proteins and 55 downregulated proteins, were identified in PDCoV-infected IPEC-J2 cells at 24 hpi. Bioinformatics analyses further revealed that a majority of the DEPs were involved in various crucial biological processes and signaling pathways, such as digestive system, immune system, signal transduction, and RIG-I-like receptor, mTOR, PI3K-AKT, autophagy, and cell cycle signaling pathways. Although further investigations are required to elucidate the functions of the DEPs of interest, our current data provide valuable clues for the in-depth investigation of pathogenic mechanisms of PDCoV and defense mechanisms of host cells."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T397","span":{"begin":472,"end":490},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T398","span":{"begin":472,"end":481},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T399","span":{"begin":533,"end":552},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T400","span":{"begin":540,"end":552},"obj":"http://purl.obolibrary.org/obo/GO_0009293"},{"id":"T401","span":{"begin":585,"end":589},"obj":"http://purl.obolibrary.org/obo/GO_0016303"},{"id":"T402","span":{"begin":595,"end":604},"obj":"http://purl.obolibrary.org/obo/GO_0016236"},{"id":"T403","span":{"begin":595,"end":604},"obj":"http://purl.obolibrary.org/obo/GO_0006914"},{"id":"T404","span":{"begin":610,"end":620},"obj":"http://purl.obolibrary.org/obo/GO_0007049"},{"id":"T405","span":{"begin":621,"end":639},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T406","span":{"begin":621,"end":630},"obj":"http://purl.obolibrary.org/obo/GO_0023052"}],"text":"The present study provides the first systematic analysis of the global protein profiles of PDCoV-infected IPEC-J2 cells using a quantitative proteomics approach in which iTRAQ was coupled to LC-MS/MS. A total of 78 DEPs, including 23 upregulated proteins and 55 downregulated proteins, were identified in PDCoV-infected IPEC-J2 cells at 24 hpi. Bioinformatics analyses further revealed that a majority of the DEPs were involved in various crucial biological processes and signaling pathways, such as digestive system, immune system, signal transduction, and RIG-I-like receptor, mTOR, PI3K-AKT, autophagy, and cell cycle signaling pathways. Although further investigations are required to elucidate the functions of the DEPs of interest, our current data provide valuable clues for the in-depth investigation of pathogenic mechanisms of PDCoV and defense mechanisms of host cells."}

{"project":"LitCovid-sentences","denotations":[{"id":"T351","span":{"begin":0,"end":200},"obj":"Sentence"},{"id":"T352","span":{"begin":201,"end":344},"obj":"Sentence"},{"id":"T353","span":{"begin":345,"end":640},"obj":"Sentence"},{"id":"T354","span":{"begin":641,"end":880},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The present study provides the first systematic analysis of the global protein profiles of PDCoV-infected IPEC-J2 cells using a quantitative proteomics approach in which iTRAQ was coupled to LC-MS/MS. A total of 78 DEPs, including 23 upregulated proteins and 55 downregulated proteins, were identified in PDCoV-infected IPEC-J2 cells at 24 hpi. Bioinformatics analyses further revealed that a majority of the DEPs were involved in various crucial biological processes and signaling pathways, such as digestive system, immune system, signal transduction, and RIG-I-like receptor, mTOR, PI3K-AKT, autophagy, and cell cycle signaling pathways. Although further investigations are required to elucidate the functions of the DEPs of interest, our current data provide valuable clues for the in-depth investigation of pathogenic mechanisms of PDCoV and defense mechanisms of host cells."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1250","span":{"begin":579,"end":583},"obj":"Gene"},{"id":"1251","span":{"begin":590,"end":593},"obj":"Gene"},{"id":"1252","span":{"begin":91,"end":105},"obj":"Disease"},{"id":"1253","span":{"begin":305,"end":319},"obj":"Disease"},{"id":"1254","span":{"begin":106,"end":113},"obj":"CellLine"},{"id":"1255","span":{"begin":320,"end":327},"obj":"CellLine"}],"attributes":[{"id":"A1250","pred":"tao:has_database_id","subj":"1250","obj":"Gene:2475"},{"id":"A1251","pred":"tao:has_database_id","subj":"1251","obj":"Gene:207"},{"id":"A1252","pred":"tao:has_database_id","subj":"1252","obj":"MESH:D007239"},{"id":"A1253","pred":"tao:has_database_id","subj":"1253","obj":"MESH:D007239"},{"id":"A1254","pred":"tao:has_database_id","subj":"1254","obj":"CVCL:2246"},{"id":"A1255","pred":"tao:has_database_id","subj":"1255","obj":"CVCL:2246"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The present study provides the first systematic analysis of the global protein profiles of PDCoV-infected IPEC-J2 cells using a quantitative proteomics approach in which iTRAQ was coupled to LC-MS/MS. A total of 78 DEPs, including 23 upregulated proteins and 55 downregulated proteins, were identified in PDCoV-infected IPEC-J2 cells at 24 hpi. Bioinformatics analyses further revealed that a majority of the DEPs were involved in various crucial biological processes and signaling pathways, such as digestive system, immune system, signal transduction, and RIG-I-like receptor, mTOR, PI3K-AKT, autophagy, and cell cycle signaling pathways. Although further investigations are required to elucidate the functions of the DEPs of interest, our current data provide valuable clues for the in-depth investigation of pathogenic mechanisms of PDCoV and defense mechanisms of host cells."}