PMC:7640975 / 43821-44959 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T379","span":{"begin":57,"end":65},"obj":"Body_part"},{"id":"T380","span":{"begin":88,"end":93},"obj":"Body_part"},{"id":"T381","span":{"begin":183,"end":191},"obj":"Body_part"},{"id":"T382","span":{"begin":527,"end":535},"obj":"Body_part"},{"id":"T383","span":{"begin":623,"end":631},"obj":"Body_part"},{"id":"T384","span":{"begin":704,"end":712},"obj":"Body_part"},{"id":"T385","span":{"begin":783,"end":791},"obj":"Body_part"}],"attributes":[{"id":"A379","pred":"fma_id","subj":"T379","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A380","pred":"fma_id","subj":"T380","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A381","pred":"fma_id","subj":"T381","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A382","pred":"fma_id","subj":"T382","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A383","pred":"fma_id","subj":"T383","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A384","pred":"fma_id","subj":"T384","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A385","pred":"fma_id","subj":"T385","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"KEGG pathway analysis of the 78 differentially expressed proteins identified in IPEC-J2 cells upon PDCoV infection. (A) KEGG pathway classification of the 78 differentially expressed proteins. The ordinate text indicates the name of biological functions which were classified into 6 KEGG pathway categories, including organismal systems (OS), metabolism (M), human diseases (HD), genetic information processing (GIP), environmental information processing (EIP), and cellular processes (CP). The abscissa displays the number of proteins in each category. (B) The top 20 significant pathways of the significantly upregulated proteins. (C) The top 20 significant pathways of the significantly downregulated proteins. (D) KEGG pathway enrichment analysis of the differentially expressed proteins. The abscissa text displays the name and classification of the KEGG pathways. Each column represents a pathway, and the height of the column implies the enrichment rate. The color manifests the significance of the enrichment (p-value), and the darker the color, the more significant the enrichment of the pathway (Fisher’s exact test; *p \u003c 0.05)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T72","span":{"begin":105,"end":114},"obj":"Disease"},{"id":"T73","span":{"begin":375,"end":377},"obj":"Disease"}],"attributes":[{"id":"A72","pred":"mondo_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A73","pred":"mondo_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/MONDO_0007739"}],"text":"KEGG pathway analysis of the 78 differentially expressed proteins identified in IPEC-J2 cells upon PDCoV infection. (A) KEGG pathway classification of the 78 differentially expressed proteins. The ordinate text indicates the name of biological functions which were classified into 6 KEGG pathway categories, including organismal systems (OS), metabolism (M), human diseases (HD), genetic information processing (GIP), environmental information processing (EIP), and cellular processes (CP). The abscissa displays the number of proteins in each category. (B) The top 20 significant pathways of the significantly upregulated proteins. (C) The top 20 significant pathways of the significantly downregulated proteins. (D) KEGG pathway enrichment analysis of the differentially expressed proteins. The abscissa text displays the name and classification of the KEGG pathways. Each column represents a pathway, and the height of the column implies the enrichment rate. The color manifests the significance of the enrichment (p-value), and the darker the color, the more significant the enrichment of the pathway (Fisher’s exact test; *p \u003c 0.05)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T497","span":{"begin":88,"end":93},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T498","span":{"begin":117,"end":118},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T499","span":{"begin":359,"end":364},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T500","span":{"begin":486,"end":488},"obj":"http://purl.obolibrary.org/obo/PR_000005794"},{"id":"T501","span":{"begin":555,"end":556},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T502","span":{"begin":893,"end":894},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T503","span":{"begin":1121,"end":1125},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"}],"text":"KEGG pathway analysis of the 78 differentially expressed proteins identified in IPEC-J2 cells upon PDCoV infection. (A) KEGG pathway classification of the 78 differentially expressed proteins. The ordinate text indicates the name of biological functions which were classified into 6 KEGG pathway categories, including organismal systems (OS), metabolism (M), human diseases (HD), genetic information processing (GIP), environmental information processing (EIP), and cellular processes (CP). The abscissa displays the number of proteins in each category. (B) The top 20 significant pathways of the significantly upregulated proteins. (C) The top 20 significant pathways of the significantly downregulated proteins. (D) KEGG pathway enrichment analysis of the differentially expressed proteins. The abscissa text displays the name and classification of the KEGG pathways. Each column represents a pathway, and the height of the column implies the enrichment rate. The color manifests the significance of the enrichment (p-value), and the darker the color, the more significant the enrichment of the pathway (Fisher’s exact test; *p \u003c 0.05)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T403","span":{"begin":57,"end":65},"obj":"Chemical"},{"id":"T404","span":{"begin":183,"end":191},"obj":"Chemical"},{"id":"T405","span":{"begin":375,"end":377},"obj":"Chemical"},{"id":"T406","span":{"begin":412,"end":415},"obj":"Chemical"},{"id":"T407","span":{"begin":486,"end":488},"obj":"Chemical"},{"id":"T409","span":{"begin":527,"end":535},"obj":"Chemical"},{"id":"T410","span":{"begin":623,"end":631},"obj":"Chemical"},{"id":"T411","span":{"begin":704,"end":712},"obj":"Chemical"},{"id":"T412","span":{"begin":783,"end":791},"obj":"Chemical"}],"attributes":[{"id":"A403","pred":"chebi_id","subj":"T403","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A404","pred":"chebi_id","subj":"T404","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A405","pred":"chebi_id","subj":"T405","obj":"http://purl.obolibrary.org/obo/CHEBI_73925"},{"id":"A406","pred":"chebi_id","subj":"T406","obj":"http://purl.obolibrary.org/obo/CHEBI_80165"},{"id":"A407","pred":"chebi_id","subj":"T407","obj":"http://purl.obolibrary.org/obo/CHEBI_3380"},{"id":"A408","pred":"chebi_id","subj":"T407","obj":"http://purl.obolibrary.org/obo/CHEBI_73461"},{"id":"A409","pred":"chebi_id","subj":"T409","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A410","pred":"chebi_id","subj":"T410","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A411","pred":"chebi_id","subj":"T411","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A412","pred":"chebi_id","subj":"T412","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"KEGG pathway analysis of the 78 differentially expressed proteins identified in IPEC-J2 cells upon PDCoV infection. (A) KEGG pathway classification of the 78 differentially expressed proteins. The ordinate text indicates the name of biological functions which were classified into 6 KEGG pathway categories, including organismal systems (OS), metabolism (M), human diseases (HD), genetic information processing (GIP), environmental information processing (EIP), and cellular processes (CP). The abscissa displays the number of proteins in each category. (B) The top 20 significant pathways of the significantly upregulated proteins. (C) The top 20 significant pathways of the significantly downregulated proteins. (D) KEGG pathway enrichment analysis of the differentially expressed proteins. The abscissa text displays the name and classification of the KEGG pathways. Each column represents a pathway, and the height of the column implies the enrichment rate. The color manifests the significance of the enrichment (p-value), and the darker the color, the more significant the enrichment of the pathway (Fisher’s exact test; *p \u003c 0.05)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T211","span":{"begin":343,"end":353},"obj":"http://purl.obolibrary.org/obo/GO_0008152"},{"id":"T212","span":{"begin":466,"end":484},"obj":"http://purl.obolibrary.org/obo/GO_0009987"},{"id":"T213","span":{"begin":486,"end":488},"obj":"http://purl.obolibrary.org/obo/GO_0009987"}],"text":"KEGG pathway analysis of the 78 differentially expressed proteins identified in IPEC-J2 cells upon PDCoV infection. (A) KEGG pathway classification of the 78 differentially expressed proteins. The ordinate text indicates the name of biological functions which were classified into 6 KEGG pathway categories, including organismal systems (OS), metabolism (M), human diseases (HD), genetic information processing (GIP), environmental information processing (EIP), and cellular processes (CP). The abscissa displays the number of proteins in each category. (B) The top 20 significant pathways of the significantly upregulated proteins. (C) The top 20 significant pathways of the significantly downregulated proteins. (D) KEGG pathway enrichment analysis of the differentially expressed proteins. The abscissa text displays the name and classification of the KEGG pathways. Each column represents a pathway, and the height of the column implies the enrichment rate. The color manifests the significance of the enrichment (p-value), and the darker the color, the more significant the enrichment of the pathway (Fisher’s exact test; *p \u003c 0.05)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T285","span":{"begin":193,"end":490},"obj":"Sentence"},{"id":"T286","span":{"begin":491,"end":792},"obj":"Sentence"},{"id":"T287","span":{"begin":793,"end":869},"obj":"Sentence"},{"id":"T288","span":{"begin":870,"end":961},"obj":"Sentence"},{"id":"T289","span":{"begin":962,"end":1138},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"KEGG pathway analysis of the 78 differentially expressed proteins identified in IPEC-J2 cells upon PDCoV infection. (A) KEGG pathway classification of the 78 differentially expressed proteins. The ordinate text indicates the name of biological functions which were classified into 6 KEGG pathway categories, including organismal systems (OS), metabolism (M), human diseases (HD), genetic information processing (GIP), environmental information processing (EIP), and cellular processes (CP). The abscissa displays the number of proteins in each category. (B) The top 20 significant pathways of the significantly upregulated proteins. (C) The top 20 significant pathways of the significantly downregulated proteins. (D) KEGG pathway enrichment analysis of the differentially expressed proteins. The abscissa text displays the name and classification of the KEGG pathways. Each column represents a pathway, and the height of the column implies the enrichment rate. The color manifests the significance of the enrichment (p-value), and the darker the color, the more significant the enrichment of the pathway (Fisher’s exact test; *p \u003c 0.05)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"752","span":{"begin":359,"end":364},"obj":"Species"},{"id":"753","span":{"begin":105,"end":114},"obj":"Disease"},{"id":"754","span":{"begin":375,"end":377},"obj":"Disease"},{"id":"755","span":{"begin":80,"end":87},"obj":"CellLine"}],"attributes":[{"id":"A752","pred":"tao:has_database_id","subj":"752","obj":"Tax:9606"},{"id":"A753","pred":"tao:has_database_id","subj":"753","obj":"MESH:D007239"},{"id":"A754","pred":"tao:has_database_id","subj":"754","obj":"MESH:D006816"},{"id":"A755","pred":"tao:has_database_id","subj":"755","obj":"CVCL:2246"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"KEGG pathway analysis of the 78 differentially expressed proteins identified in IPEC-J2 cells upon PDCoV infection. (A) KEGG pathway classification of the 78 differentially expressed proteins. The ordinate text indicates the name of biological functions which were classified into 6 KEGG pathway categories, including organismal systems (OS), metabolism (M), human diseases (HD), genetic information processing (GIP), environmental information processing (EIP), and cellular processes (CP). The abscissa displays the number of proteins in each category. (B) The top 20 significant pathways of the significantly upregulated proteins. (C) The top 20 significant pathways of the significantly downregulated proteins. (D) KEGG pathway enrichment analysis of the differentially expressed proteins. The abscissa text displays the name and classification of the KEGG pathways. Each column represents a pathway, and the height of the column implies the enrichment rate. The color manifests the significance of the enrichment (p-value), and the darker the color, the more significant the enrichment of the pathway (Fisher’s exact test; *p \u003c 0.05)."}