PMC:7640975 / 2532-3719 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T18","span":{"begin":69,"end":84},"obj":"Body_part"},{"id":"T19","span":{"begin":112,"end":119},"obj":"Body_part"},{"id":"T20","span":{"begin":124,"end":129},"obj":"Body_part"},{"id":"T21","span":{"begin":183,"end":199},"obj":"Body_part"},{"id":"T22","span":{"begin":200,"end":216},"obj":"Body_part"},{"id":"T23","span":{"begin":211,"end":216},"obj":"Body_part"},{"id":"T24","span":{"begin":347,"end":353},"obj":"Body_part"},{"id":"T25","span":{"begin":405,"end":421},"obj":"Body_part"},{"id":"T26","span":{"begin":422,"end":433},"obj":"Body_part"},{"id":"T27","span":{"begin":506,"end":510},"obj":"Body_part"},{"id":"T28","span":{"begin":550,"end":557},"obj":"Body_part"},{"id":"T29","span":{"begin":646,"end":656},"obj":"Body_part"},{"id":"T30","span":{"begin":665,"end":681},"obj":"Body_part"},{"id":"T31","span":{"begin":676,"end":681},"obj":"Body_part"},{"id":"T32","span":{"begin":761,"end":765},"obj":"Body_part"},{"id":"T33","span":{"begin":793,"end":798},"obj":"Body_part"},{"id":"T34","span":{"begin":908,"end":924},"obj":"Body_part"},{"id":"T35","span":{"begin":919,"end":924},"obj":"Body_part"},{"id":"T36","span":{"begin":1130,"end":1135},"obj":"Body_part"}],"attributes":[{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma7200"},{"id":"A19","pred":"fma_id","subj":"T19","obj":"http://purl.org/sig/ont/fma/fma7207"},{"id":"A20","pred":"fma_id","subj":"T20","obj":"http://purl.org/sig/ont/fma/fma7208"},{"id":"A21","pred":"fma_id","subj":"T21","obj":"http://purl.org/sig/ont/fma/fma7200"},{"id":"A22","pred":"fma_id","subj":"T22","obj":"http://purl.org/sig/ont/fma/fma66768"},{"id":"A23","pred":"fma_id","subj":"T23","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A24","pred":"fma_id","subj":"T24","obj":"http://purl.org/sig/ont/fma/fma82505"},{"id":"A25","pred":"fma_id","subj":"T25","obj":"http://purl.org/sig/ont/fma/fma7200"},{"id":"A26","pred":"fma_id","subj":"T26","obj":"http://purl.org/sig/ont/fma/fma62122"},{"id":"A27","pred":"fma_id","subj":"T27","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A28","pred":"fma_id","subj":"T28","obj":"http://purl.org/sig/ont/fma/fma7207"},{"id":"A29","pred":"fma_id","subj":"T29","obj":"http://purl.org/sig/ont/fma/fma7199"},{"id":"A30","pred":"fma_id","subj":"T30","obj":"http://purl.org/sig/ont/fma/fma66768"},{"id":"A31","pred":"fma_id","subj":"T31","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A32","pred":"fma_id","subj":"T32","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A33","pred":"fma_id","subj":"T33","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A34","pred":"fma_id","subj":"T34","obj":"http://purl.org/sig/ont/fma/fma66768"},{"id":"A35","pred":"fma_id","subj":"T35","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A36","pred":"fma_id","subj":"T36","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"PDCoV has an obvious enteropathogenic characteristic in pigs.1,6 The small intestine of pigs, in particular the jejunum and ileum, are the primary target organs of PDCoV, and porcine small intestinal epithelial cells (IPEC) are the main sites of PDCoV replication in vivo.1,8,9 Histopathologic analyses showed that PDCoV infection not only causes villus atrophy and fall-off but also leads to necrosis of small intestinal enterocytes in infected pigs.1,6 Currently, an immortalized, nontumorigenic IPEC-J2 cell line, originally established using the jejunum of a newborn unsuckled piglet,10 has been shown to exhibit high similarities to porcine intestinal primary epithelial cells,11 and thus can better simulate the porcine physiological state than any other cell lines. At present, IPEC-J2 cells have been successfully utilized as an ideal in vitro model system for investigating the interactions between epithelial cells and porcine enteric viruses, such as porcine rotavirus,12 porcine endemic diarrhea virus (PEDV),13 and transmissible gastroenteritis virus (TGEV).14 Recently, Jung and colleagues demonstrated that IPEC-J2 cells are quite susceptible to PDCoV infection in vitro.8"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T4","span":{"begin":69,"end":84},"obj":"Body_part"},{"id":"T5","span":{"begin":75,"end":84},"obj":"Body_part"},{"id":"T6","span":{"begin":112,"end":119},"obj":"Body_part"},{"id":"T7","span":{"begin":124,"end":129},"obj":"Body_part"},{"id":"T8","span":{"begin":154,"end":160},"obj":"Body_part"},{"id":"T9","span":{"begin":183,"end":199},"obj":"Body_part"},{"id":"T10","span":{"begin":405,"end":421},"obj":"Body_part"},{"id":"T11","span":{"begin":550,"end":557},"obj":"Body_part"}],"attributes":[{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/UBERON_0002108"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/UBERON_0000160"},{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/UBERON_0002115"},{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/UBERON_0002116"},{"id":"A8","pred":"uberon_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"},{"id":"A9","pred":"uberon_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/UBERON_0002108"},{"id":"A10","pred":"uberon_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/UBERON_0002108"},{"id":"A11","pred":"uberon_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/UBERON_0002115"}],"text":"PDCoV has an obvious enteropathogenic characteristic in pigs.1,6 The small intestine of pigs, in particular the jejunum and ileum, are the primary target organs of PDCoV, and porcine small intestinal epithelial cells (IPEC) are the main sites of PDCoV replication in vivo.1,8,9 Histopathologic analyses showed that PDCoV infection not only causes villus atrophy and fall-off but also leads to necrosis of small intestinal enterocytes in infected pigs.1,6 Currently, an immortalized, nontumorigenic IPEC-J2 cell line, originally established using the jejunum of a newborn unsuckled piglet,10 has been shown to exhibit high similarities to porcine intestinal primary epithelial cells,11 and thus can better simulate the porcine physiological state than any other cell lines. At present, IPEC-J2 cells have been successfully utilized as an ideal in vitro model system for investigating the interactions between epithelial cells and porcine enteric viruses, such as porcine rotavirus,12 porcine endemic diarrhea virus (PEDV),13 and transmissible gastroenteritis virus (TGEV).14 Recently, Jung and colleagues demonstrated that IPEC-J2 cells are quite susceptible to PDCoV infection in vitro.8"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T7","span":{"begin":321,"end":330},"obj":"Disease"},{"id":"T8","span":{"begin":999,"end":1007},"obj":"Disease"},{"id":"T9","span":{"begin":1042,"end":1057},"obj":"Disease"},{"id":"T10","span":{"begin":1167,"end":1176},"obj":"Disease"}],"attributes":[{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A8","pred":"mondo_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/MONDO_0001673"},{"id":"A9","pred":"mondo_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/MONDO_0002269"},{"id":"A10","pred":"mondo_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"PDCoV has an obvious enteropathogenic characteristic in pigs.1,6 The small intestine of pigs, in particular the jejunum and ileum, are the primary target organs of PDCoV, and porcine small intestinal epithelial cells (IPEC) are the main sites of PDCoV replication in vivo.1,8,9 Histopathologic analyses showed that PDCoV infection not only causes villus atrophy and fall-off but also leads to necrosis of small intestinal enterocytes in infected pigs.1,6 Currently, an immortalized, nontumorigenic IPEC-J2 cell line, originally established using the jejunum of a newborn unsuckled piglet,10 has been shown to exhibit high similarities to porcine intestinal primary epithelial cells,11 and thus can better simulate the porcine physiological state than any other cell lines. At present, IPEC-J2 cells have been successfully utilized as an ideal in vitro model system for investigating the interactions between epithelial cells and porcine enteric viruses, such as porcine rotavirus,12 porcine endemic diarrhea virus (PEDV),13 and transmissible gastroenteritis virus (TGEV).14 Recently, Jung and colleagues demonstrated that IPEC-J2 cells are quite susceptible to PDCoV infection in vitro.8"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T33","span":{"begin":6,"end":9},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T34","span":{"begin":69,"end":84},"obj":"http://purl.obolibrary.org/obo/UBERON_0002108"},{"id":"T35","span":{"begin":112,"end":119},"obj":"http://purl.obolibrary.org/obo/UBERON_0002115"},{"id":"T36","span":{"begin":124,"end":129},"obj":"http://purl.obolibrary.org/obo/UBERON_0002116"},{"id":"T37","span":{"begin":154,"end":160},"obj":"http://purl.obolibrary.org/obo/UBERON_0003103"},{"id":"T38","span":{"begin":183,"end":199},"obj":"http://purl.obolibrary.org/obo/UBERON_0002108"},{"id":"T39","span":{"begin":200,"end":210},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T40","span":{"begin":211,"end":216},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T41","span":{"begin":405,"end":421},"obj":"http://purl.obolibrary.org/obo/UBERON_0002108"},{"id":"T42","span":{"begin":506,"end":515},"obj":"http://purl.obolibrary.org/obo/CLO_0000031"},{"id":"T43","span":{"begin":550,"end":557},"obj":"http://purl.obolibrary.org/obo/UBERON_0002115"},{"id":"T44","span":{"begin":561,"end":562},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T45","span":{"begin":591,"end":594},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T46","span":{"begin":646,"end":656},"obj":"http://purl.obolibrary.org/obo/UBERON_0000160"},{"id":"T47","span":{"begin":646,"end":656},"obj":"http://www.ebi.ac.uk/efo/EFO_0000834"},{"id":"T48","span":{"begin":665,"end":675},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T49","span":{"begin":676,"end":681},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T50","span":{"begin":682,"end":684},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"},{"id":"T51","span":{"begin":761,"end":771},"obj":"http://purl.obolibrary.org/obo/CLO_0000031"},{"id":"T52","span":{"begin":793,"end":798},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T53","span":{"begin":908,"end":918},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T54","span":{"begin":919,"end":924},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T55","span":{"begin":945,"end":952},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T56","span":{"begin":1008,"end":1013},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T57","span":{"begin":1058,"end":1063},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T58","span":{"begin":1130,"end":1135},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"PDCoV has an obvious enteropathogenic characteristic in pigs.1,6 The small intestine of pigs, in particular the jejunum and ileum, are the primary target organs of PDCoV, and porcine small intestinal epithelial cells (IPEC) are the main sites of PDCoV replication in vivo.1,8,9 Histopathologic analyses showed that PDCoV infection not only causes villus atrophy and fall-off but also leads to necrosis of small intestinal enterocytes in infected pigs.1,6 Currently, an immortalized, nontumorigenic IPEC-J2 cell line, originally established using the jejunum of a newborn unsuckled piglet,10 has been shown to exhibit high similarities to porcine intestinal primary epithelial cells,11 and thus can better simulate the porcine physiological state than any other cell lines. At present, IPEC-J2 cells have been successfully utilized as an ideal in vitro model system for investigating the interactions between epithelial cells and porcine enteric viruses, such as porcine rotavirus,12 porcine endemic diarrhea virus (PEDV),13 and transmissible gastroenteritis virus (TGEV).14 Recently, Jung and colleagues demonstrated that IPEC-J2 cells are quite susceptible to PDCoV infection in vitro.8"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T5","span":{"begin":999,"end":1007},"obj":"Phenotype"}],"attributes":[{"id":"A5","pred":"hp_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/HP_0002014"}],"text":"PDCoV has an obvious enteropathogenic characteristic in pigs.1,6 The small intestine of pigs, in particular the jejunum and ileum, are the primary target organs of PDCoV, and porcine small intestinal epithelial cells (IPEC) are the main sites of PDCoV replication in vivo.1,8,9 Histopathologic analyses showed that PDCoV infection not only causes villus atrophy and fall-off but also leads to necrosis of small intestinal enterocytes in infected pigs.1,6 Currently, an immortalized, nontumorigenic IPEC-J2 cell line, originally established using the jejunum of a newborn unsuckled piglet,10 has been shown to exhibit high similarities to porcine intestinal primary epithelial cells,11 and thus can better simulate the porcine physiological state than any other cell lines. At present, IPEC-J2 cells have been successfully utilized as an ideal in vitro model system for investigating the interactions between epithelial cells and porcine enteric viruses, such as porcine rotavirus,12 porcine endemic diarrhea virus (PEDV),13 and transmissible gastroenteritis virus (TGEV).14 Recently, Jung and colleagues demonstrated that IPEC-J2 cells are quite susceptible to PDCoV infection in vitro.8"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T13","span":{"begin":393,"end":401},"obj":"http://purl.obolibrary.org/obo/GO_0070265"},{"id":"T14","span":{"begin":393,"end":401},"obj":"http://purl.obolibrary.org/obo/GO_0019835"},{"id":"T15","span":{"begin":393,"end":401},"obj":"http://purl.obolibrary.org/obo/GO_0008219"},{"id":"T16","span":{"begin":393,"end":401},"obj":"http://purl.obolibrary.org/obo/GO_0001906"}],"text":"PDCoV has an obvious enteropathogenic characteristic in pigs.1,6 The small intestine of pigs, in particular the jejunum and ileum, are the primary target organs of PDCoV, and porcine small intestinal epithelial cells (IPEC) are the main sites of PDCoV replication in vivo.1,8,9 Histopathologic analyses showed that PDCoV infection not only causes villus atrophy and fall-off but also leads to necrosis of small intestinal enterocytes in infected pigs.1,6 Currently, an immortalized, nontumorigenic IPEC-J2 cell line, originally established using the jejunum of a newborn unsuckled piglet,10 has been shown to exhibit high similarities to porcine intestinal primary epithelial cells,11 and thus can better simulate the porcine physiological state than any other cell lines. At present, IPEC-J2 cells have been successfully utilized as an ideal in vitro model system for investigating the interactions between epithelial cells and porcine enteric viruses, such as porcine rotavirus,12 porcine endemic diarrhea virus (PEDV),13 and transmissible gastroenteritis virus (TGEV).14 Recently, Jung and colleagues demonstrated that IPEC-J2 cells are quite susceptible to PDCoV infection in vitro.8"}

{"project":"LitCovid-sentences","denotations":[{"id":"T13","span":{"begin":0,"end":772},"obj":"Sentence"},{"id":"T14","span":{"begin":773,"end":1187},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"PDCoV has an obvious enteropathogenic characteristic in pigs.1,6 The small intestine of pigs, in particular the jejunum and ileum, are the primary target organs of PDCoV, and porcine small intestinal epithelial cells (IPEC) are the main sites of PDCoV replication in vivo.1,8,9 Histopathologic analyses showed that PDCoV infection not only causes villus atrophy and fall-off but also leads to necrosis of small intestinal enterocytes in infected pigs.1,6 Currently, an immortalized, nontumorigenic IPEC-J2 cell line, originally established using the jejunum of a newborn unsuckled piglet,10 has been shown to exhibit high similarities to porcine intestinal primary epithelial cells,11 and thus can better simulate the porcine physiological state than any other cell lines. At present, IPEC-J2 cells have been successfully utilized as an ideal in vitro model system for investigating the interactions between epithelial cells and porcine enteric viruses, such as porcine rotavirus,12 porcine endemic diarrhea virus (PEDV),13 and transmissible gastroenteritis virus (TGEV).14 Recently, Jung and colleagues demonstrated that IPEC-J2 cells are quite susceptible to PDCoV infection in vitro.8"}

{"project":"LitCovid-PubTator","denotations":[{"id":"85","span":{"begin":56,"end":60},"obj":"Species"},{"id":"86","span":{"begin":88,"end":92},"obj":"Species"},{"id":"87","span":{"begin":446,"end":450},"obj":"Species"},{"id":"88","span":{"begin":962,"end":979},"obj":"Species"},{"id":"89","span":{"begin":1015,"end":1019},"obj":"Species"},{"id":"90","span":{"begin":1028,"end":1063},"obj":"Species"},{"id":"91","span":{"begin":1065,"end":1069},"obj":"Species"},{"id":"92","span":{"begin":175,"end":182},"obj":"Species"},{"id":"93","span":{"begin":638,"end":645},"obj":"Species"},{"id":"94","span":{"begin":718,"end":725},"obj":"Species"},{"id":"95","span":{"begin":929,"end":936},"obj":"Species"},{"id":"96","span":{"begin":983,"end":990},"obj":"Species"},{"id":"97","span":{"begin":315,"end":330},"obj":"Disease"},{"id":"98","span":{"begin":354,"end":361},"obj":"Disease"},{"id":"99","span":{"begin":393,"end":401},"obj":"Disease"},{"id":"100","span":{"begin":437,"end":445},"obj":"Disease"},{"id":"101","span":{"begin":999,"end":1007},"obj":"Disease"},{"id":"102","span":{"begin":1167,"end":1176},"obj":"Disease"},{"id":"103","span":{"begin":498,"end":505},"obj":"CellLine"},{"id":"104","span":{"begin":785,"end":792},"obj":"CellLine"},{"id":"105","span":{"begin":1122,"end":1129},"obj":"CellLine"}],"attributes":[{"id":"A85","pred":"tao:has_database_id","subj":"85","obj":"Tax:9823"},{"id":"A86","pred":"tao:has_database_id","subj":"86","obj":"Tax:9823"},{"id":"A87","pred":"tao:has_database_id","subj":"87","obj":"Tax:9823"},{"id":"A88","pred":"tao:has_database_id","subj":"88","obj":"Tax:10913"},{"id":"A89","pred":"tao:has_database_id","subj":"89","obj":"Tax:28295"},{"id":"A90","pred":"tao:has_database_id","subj":"90","obj":"Tax:11149"},{"id":"A91","pred":"tao:has_database_id","subj":"91","obj":"Tax:11149"},{"id":"A92","pred":"tao:has_database_id","subj":"92","obj":"Tax:28344"},{"id":"A93","pred":"tao:has_database_id","subj":"93","obj":"Tax:28344"},{"id":"A94","pred":"tao:has_database_id","subj":"94","obj":"Tax:28344"},{"id":"A95","pred":"tao:has_database_id","subj":"95","obj":"Tax:28344"},{"id":"A96","pred":"tao:has_database_id","subj":"96","obj":"Tax:28344"},{"id":"A97","pred":"tao:has_database_id","subj":"97","obj":"MESH:D007239"},{"id":"A98","pred":"tao:has_database_id","subj":"98","obj":"MESH:D001284"},{"id":"A99","pred":"tao:has_database_id","subj":"99","obj":"MESH:D009336"},{"id":"A100","pred":"tao:has_database_id","subj":"100","obj":"MESH:D007239"},{"id":"A101","pred":"tao:has_database_id","subj":"101","obj":"MESH:D003967"},{"id":"A102","pred":"tao:has_database_id","subj":"102","obj":"MESH:D007239"},{"id":"A103","pred":"tao:has_database_id","subj":"103","obj":"CVCL:2246"},{"id":"A104","pred":"tao:has_database_id","subj":"104","obj":"CVCL:2246"},{"id":"A105","pred":"tao:has_database_id","subj":"105","obj":"CVCL:2246"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"PDCoV has an obvious enteropathogenic characteristic in pigs.1,6 The small intestine of pigs, in particular the jejunum and ileum, are the primary target organs of PDCoV, and porcine small intestinal epithelial cells (IPEC) are the main sites of PDCoV replication in vivo.1,8,9 Histopathologic analyses showed that PDCoV infection not only causes villus atrophy and fall-off but also leads to necrosis of small intestinal enterocytes in infected pigs.1,6 Currently, an immortalized, nontumorigenic IPEC-J2 cell line, originally established using the jejunum of a newborn unsuckled piglet,10 has been shown to exhibit high similarities to porcine intestinal primary epithelial cells,11 and thus can better simulate the porcine physiological state than any other cell lines. At present, IPEC-J2 cells have been successfully utilized as an ideal in vitro model system for investigating the interactions between epithelial cells and porcine enteric viruses, such as porcine rotavirus,12 porcine endemic diarrhea virus (PEDV),13 and transmissible gastroenteritis virus (TGEV).14 Recently, Jung and colleagues demonstrated that IPEC-J2 cells are quite susceptible to PDCoV infection in vitro.8"}