PMC:7605643 / 9294-9882 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T34","span":{"begin":366,"end":374},"obj":"Body_part"},{"id":"T35","span":{"begin":479,"end":486},"obj":"Body_part"},{"id":"T36","span":{"begin":487,"end":494},"obj":"Body_part"}],"attributes":[{"id":"A34","pred":"fma_id","subj":"T34","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A35","pred":"fma_id","subj":"T35","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A36","pred":"fma_id","subj":"T36","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"Cytoscape v3.7.2 was used to create master network, which comprised of total 2693 nodes and 3736 edges. The master network had clustering coefficient of 0.562 and was divided into clusters using k-means clustering and the most tightly knit cluster around ACE2 was chosen (Figure 1(a)). Network Analysis revealed various hub nodes in the network. Hub nodes are those proteins which control the disperse of signaling in the network (Figure 1(a)). Major hub nodes obtained from the protein-protein interaction network was ACE2, INS, AKT1, VEGFA, IL-6, NOS3, JUN, IL-10, HIF1A etc. (Table 1)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T76","span":{"begin":281,"end":282},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T77","span":{"begin":405,"end":414},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T78","span":{"begin":440,"end":441},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Cytoscape v3.7.2 was used to create master network, which comprised of total 2693 nodes and 3736 edges. The master network had clustering coefficient of 0.562 and was divided into clusters using k-means clustering and the most tightly knit cluster around ACE2 was chosen (Figure 1(a)). Network Analysis revealed various hub nodes in the network. Hub nodes are those proteins which control the disperse of signaling in the network (Figure 1(a)). Major hub nodes obtained from the protein-protein interaction network was ACE2, INS, AKT1, VEGFA, IL-6, NOS3, JUN, IL-10, HIF1A etc. (Table 1)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T55","span":{"begin":366,"end":374},"obj":"Chemical"},{"id":"T56","span":{"begin":479,"end":486},"obj":"Chemical"},{"id":"T57","span":{"begin":487,"end":494},"obj":"Chemical"},{"id":"T58","span":{"begin":543,"end":545},"obj":"Chemical"},{"id":"T60","span":{"begin":560,"end":562},"obj":"Chemical"}],"attributes":[{"id":"A55","pred":"chebi_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A56","pred":"chebi_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A57","pred":"chebi_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A58","pred":"chebi_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A59","pred":"chebi_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A60","pred":"chebi_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A61","pred":"chebi_id","subj":"T60","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"}],"text":"Cytoscape v3.7.2 was used to create master network, which comprised of total 2693 nodes and 3736 edges. The master network had clustering coefficient of 0.562 and was divided into clusters using k-means clustering and the most tightly knit cluster around ACE2 was chosen (Figure 1(a)). Network Analysis revealed various hub nodes in the network. Hub nodes are those proteins which control the disperse of signaling in the network (Figure 1(a)). Major hub nodes obtained from the protein-protein interaction network was ACE2, INS, AKT1, VEGFA, IL-6, NOS3, JUN, IL-10, HIF1A etc. (Table 1)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T14","span":{"begin":405,"end":414},"obj":"http://purl.obolibrary.org/obo/GO_0023052"}],"text":"Cytoscape v3.7.2 was used to create master network, which comprised of total 2693 nodes and 3736 edges. The master network had clustering coefficient of 0.562 and was divided into clusters using k-means clustering and the most tightly knit cluster around ACE2 was chosen (Figure 1(a)). Network Analysis revealed various hub nodes in the network. Hub nodes are those proteins which control the disperse of signaling in the network (Figure 1(a)). Major hub nodes obtained from the protein-protein interaction network was ACE2, INS, AKT1, VEGFA, IL-6, NOS3, JUN, IL-10, HIF1A etc. (Table 1)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T77","span":{"begin":0,"end":103},"obj":"Sentence"},{"id":"T78","span":{"begin":104,"end":285},"obj":"Sentence"},{"id":"T79","span":{"begin":286,"end":345},"obj":"Sentence"},{"id":"T80","span":{"begin":346,"end":444},"obj":"Sentence"},{"id":"T81","span":{"begin":445,"end":588},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Cytoscape v3.7.2 was used to create master network, which comprised of total 2693 nodes and 3736 edges. The master network had clustering coefficient of 0.562 and was divided into clusters using k-means clustering and the most tightly knit cluster around ACE2 was chosen (Figure 1(a)). Network Analysis revealed various hub nodes in the network. Hub nodes are those proteins which control the disperse of signaling in the network (Figure 1(a)). Major hub nodes obtained from the protein-protein interaction network was ACE2, INS, AKT1, VEGFA, IL-6, NOS3, JUN, IL-10, HIF1A etc. (Table 1)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"220","span":{"begin":255,"end":259},"obj":"Gene"},{"id":"221","span":{"begin":519,"end":523},"obj":"Gene"},{"id":"222","span":{"begin":530,"end":534},"obj":"Gene"},{"id":"223","span":{"begin":536,"end":541},"obj":"Gene"},{"id":"224","span":{"begin":543,"end":547},"obj":"Gene"},{"id":"225","span":{"begin":560,"end":565},"obj":"Gene"},{"id":"226","span":{"begin":567,"end":572},"obj":"Gene"},{"id":"227","span":{"begin":451,"end":454},"obj":"Gene"},{"id":"228","span":{"begin":346,"end":349},"obj":"Gene"},{"id":"229","span":{"begin":320,"end":323},"obj":"Gene"}],"attributes":[{"id":"A220","pred":"tao:has_database_id","subj":"220","obj":"Gene:59272"},{"id":"A221","pred":"tao:has_database_id","subj":"221","obj":"Gene:59272"},{"id":"A222","pred":"tao:has_database_id","subj":"222","obj":"Gene:207"},{"id":"A223","pred":"tao:has_database_id","subj":"223","obj":"Gene:7422"},{"id":"A224","pred":"tao:has_database_id","subj":"224","obj":"Gene:3569"},{"id":"A225","pred":"tao:has_database_id","subj":"225","obj":"Gene:3586"},{"id":"A226","pred":"tao:has_database_id","subj":"226","obj":"Gene:3091"},{"id":"A227","pred":"tao:has_database_id","subj":"227","obj":"Gene:1993"},{"id":"A228","pred":"tao:has_database_id","subj":"228","obj":"Gene:1993"},{"id":"A229","pred":"tao:has_database_id","subj":"229","obj":"Gene:1993"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Cytoscape v3.7.2 was used to create master network, which comprised of total 2693 nodes and 3736 edges. The master network had clustering coefficient of 0.562 and was divided into clusters using k-means clustering and the most tightly knit cluster around ACE2 was chosen (Figure 1(a)). Network Analysis revealed various hub nodes in the network. Hub nodes are those proteins which control the disperse of signaling in the network (Figure 1(a)). Major hub nodes obtained from the protein-protein interaction network was ACE2, INS, AKT1, VEGFA, IL-6, NOS3, JUN, IL-10, HIF1A etc. (Table 1)."}