PMC:7605643 / 7010-7919 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7605643","sourcedb":"PMC","sourceid":"7605643","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7605643","text":"ACE2 interaction network and hypothesis\nACE2 is the proposed attachment site for SARS-CoV-2 in humans. Protein interaction studies were conducted around this protein to understand how the attachment of virus with ACE2 affects the pathology in human system. Computational protein-interaction analysis provides the knowledge about the indirect and probable interactions which might be occurring with the query protein. This is a very useful approach for predicting the new interactions of proteins in the in-vivo system. Cytoscape v3.7.2 (Shannon et al., 2003) was used to design the interaction network. BiNGO plugin was used for the analysis and prediction of overrepresented pathways in master network (Maere et al., 2005). Overrepresented pathways are the set of pathways which are collectively taken-up by the set of proteins under study. This helps in understanding the final fate of protein-interactions.","divisions":[{"label":"title","span":{"begin":0,"end":39}}],"tracks":[{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T14","span":{"begin":61,"end":76},"obj":"Body_part"}],"attributes":[{"id":"A14","pred":"uberon_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/UBERON_4200047"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T27","span":{"begin":103,"end":110},"obj":"Body_part"},{"id":"T28","span":{"begin":158,"end":165},"obj":"Body_part"},{"id":"T29","span":{"begin":271,"end":278},"obj":"Body_part"},{"id":"T30","span":{"begin":408,"end":415},"obj":"Body_part"},{"id":"T31","span":{"begin":487,"end":495},"obj":"Body_part"},{"id":"T32","span":{"begin":820,"end":828},"obj":"Body_part"},{"id":"T33","span":{"begin":888,"end":895},"obj":"Body_part"}],"attributes":[{"id":"A27","pred":"fma_id","subj":"T27","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A28","pred":"fma_id","subj":"T28","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A29","pred":"fma_id","subj":"T29","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A30","pred":"fma_id","subj":"T30","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A31","pred":"fma_id","subj":"T31","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A32","pred":"fma_id","subj":"T32","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A33","pred":"fma_id","subj":"T33","obj":"http://purl.org/sig/ont/fma/fma67257"},{"subj":"T27","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T28","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T29","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T30","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T31","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T32","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T33","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T28","span":{"begin":81,"end":89},"obj":"Disease"}],"attributes":[{"id":"A28","pred":"mondo_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T28","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T63","span":{"begin":95,"end":101},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T64","span":{"begin":202,"end":207},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T65","span":{"begin":243,"end":248},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T66","span":{"begin":425,"end":426},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T63","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T64","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T65","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T66","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T41","span":{"begin":103,"end":110},"obj":"Chemical"},{"id":"T42","span":{"begin":158,"end":165},"obj":"Chemical"},{"id":"T43","span":{"begin":271,"end":278},"obj":"Chemical"},{"id":"T44","span":{"begin":408,"end":415},"obj":"Chemical"},{"id":"T45","span":{"begin":487,"end":495},"obj":"Chemical"},{"id":"T46","span":{"begin":820,"end":828},"obj":"Chemical"},{"id":"T47","span":{"begin":888,"end":895},"obj":"Chemical"}],"attributes":[{"id":"A41","pred":"chebi_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/CHEBI_16541"},{"id":"A42","pred":"chebi_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A43","pred":"chebi_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A44","pred":"chebi_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A45","pred":"chebi_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A46","pred":"chebi_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A47","pred":"chebi_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"subj":"T41","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T42","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T43","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T44","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T45","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T46","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T47","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T50","span":{"begin":0,"end":39},"obj":"Sentence"},{"id":"T51","span":{"begin":40,"end":102},"obj":"Sentence"},{"id":"T52","span":{"begin":103,"end":256},"obj":"Sentence"},{"id":"T53","span":{"begin":257,"end":416},"obj":"Sentence"},{"id":"T54","span":{"begin":417,"end":518},"obj":"Sentence"},{"id":"T55","span":{"begin":519,"end":602},"obj":"Sentence"},{"id":"T56","span":{"begin":603,"end":724},"obj":"Sentence"},{"id":"T57","span":{"begin":725,"end":841},"obj":"Sentence"},{"id":"T58","span":{"begin":842,"end":909},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T50","pred":"source","obj":"LitCovid-sentences"},{"subj":"T51","pred":"source","obj":"LitCovid-sentences"},{"subj":"T52","pred":"source","obj":"LitCovid-sentences"},{"subj":"T53","pred":"source","obj":"LitCovid-sentences"},{"subj":"T54","pred":"source","obj":"LitCovid-sentences"},{"subj":"T55","pred":"source","obj":"LitCovid-sentences"},{"subj":"T56","pred":"source","obj":"LitCovid-sentences"},{"subj":"T57","pred":"source","obj":"LitCovid-sentences"},{"subj":"T58","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"181","span":{"begin":0,"end":4},"obj":"Gene"},{"id":"187","span":{"begin":40,"end":44},"obj":"Gene"},{"id":"188","span":{"begin":213,"end":217},"obj":"Gene"},{"id":"189","span":{"begin":81,"end":91},"obj":"Species"},{"id":"190","span":{"begin":95,"end":101},"obj":"Species"},{"id":"191","span":{"begin":243,"end":248},"obj":"Species"}],"attributes":[{"id":"A181","pred":"tao:has_database_id","subj":"181","obj":"Gene:59272"},{"id":"A187","pred":"tao:has_database_id","subj":"187","obj":"Gene:59272"},{"id":"A188","pred":"tao:has_database_id","subj":"188","obj":"Gene:59272"},{"id":"A189","pred":"tao:has_database_id","subj":"189","obj":"Tax:2697049"},{"id":"A190","pred":"tao:has_database_id","subj":"190","obj":"Tax:9606"},{"id":"A191","pred":"tao:has_database_id","subj":"191","obj":"Tax:9606"},{"subj":"181","pred":"source","obj":"LitCovid-PubTator"},{"subj":"187","pred":"source","obj":"LitCovid-PubTator"},{"subj":"188","pred":"source","obj":"LitCovid-PubTator"},{"subj":"189","pred":"source","obj":"LitCovid-PubTator"},{"subj":"190","pred":"source","obj":"LitCovid-PubTator"},{"subj":"191","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-UBERON","color":"#e793ec","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#93eccd"},{"id":"LitCovid-PD-MONDO","color":"#ecb393"},{"id":"LitCovid-PD-CLO","color":"#9993ec"},{"id":"LitCovid-PD-CHEBI","color":"#a6ec93"},{"id":"LitCovid-sentences","color":"#ec93c0"},{"id":"LitCovid-PubTator","color":"#93daec"}]}]}}