PMC:7605643 / 33361-35428
Annnotations
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T43 | 492-496 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T44 | 800-805 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T45 | 806-818 | Body_part | denotes | gall bladder | http://purl.obolibrary.org/obo/UBERON_0002110 |
| T46 | 811-818 | Body_part | denotes | bladder | http://purl.obolibrary.org/obo/UBERON_0001255 |
| T47 | 820-826 | Body_part | denotes | testis | http://purl.obolibrary.org/obo/UBERON_0000473 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T164 | 492-496 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T165 | 497-522 | Body_part | denotes | alveolar epithelial cells | http://purl.org/sig/ont/fma/fma62499 |
| T166 | 517-522 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T167 | 735-739 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T168 | 782-789 | Body_part | denotes | tissues | http://purl.org/sig/ont/fma/fma9637 |
| T169 | 791-798 | Body_part | denotes | kidneys | http://purl.org/sig/ont/fma/fma7203 |
| T170 | 800-805 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T171 | 806-818 | Body_part | denotes | gall bladder | http://purl.org/sig/ont/fma/fma7202 |
| T172 | 820-826 | Body_part | denotes | testis | http://purl.org/sig/ont/fma/fma7210 |
| T173 | 853-858 | Body_part | denotes | lungs | http://purl.org/sig/ont/fma/fma68877 |
| T174 | 1014-1021 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T175 | 1034-1046 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T176 | 1180-1188 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T177 | 1256-1269 | Body_part | denotes | cell membrane | http://purl.org/sig/ont/fma/fma63841 |
| T178 | 1256-1260 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T179 | 1368-1372 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T180 | 1514-1522 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T181 | 1633-1637 | Body_part | denotes | body | http://purl.org/sig/ont/fma/fma256135 |
| T182 | 1833-1840 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T183 | 1906-1910 | Body_part | denotes | body | http://purl.org/sig/ont/fma/fma256135 |
| T184 | 1925-1932 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T104 | 51-59 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T105 | 62-72 | Disease | denotes | infections | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T106 | 164-172 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T107 | 378-386 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T108 | 422-430 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T109 | 462-470 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T110 | 1084-1092 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T111 | 1108-1116 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T112 | 1120-1128 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T113 | 1337-1345 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T114 | 1377-1386 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T115 | 1607-1616 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T116 | 1693-1701 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T375 | 108-113 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T376 | 151-154 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T377 | 176-177 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T378 | 229-232 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T379 | 339-340 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T380 | 492-496 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T381 | 492-496 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T382 | 506-516 | http://purl.obolibrary.org/obo/CL_0000066 | denotes | epithelial |
| T383 | 517-522 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T384 | 735-739 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T385 | 762-770 | http://purl.obolibrary.org/obo/UBERON_0005409 | denotes | GI tract |
| T386 | 791-798 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | kidneys |
| T387 | 791-798 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | kidneys |
| T388 | 791-798 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | kidneys |
| T389 | 800-805 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T390 | 800-805 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T391 | 820-826 | http://www.ebi.ac.uk/efo/EFO_0000984 | denotes | testis |
| T392 | 853-858 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lungs |
| T393 | 993-994 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T394 | 1058-1063 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T395 | 1129-1134 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T396 | 1256-1260 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T397 | 1261-1269 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T398 | 1368-1372 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T399 | 1530-1539 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T400 | 1671-1680 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T401 | 1811-1816 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T402 | 1850-1857 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signals |
| T403 | 1873-1878 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T404 | 1923-1924 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T405 | 2041-2046 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T328 | 201-205 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T329 | 209-218 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T330 | 295-300 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T331 | 531-542 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T332 | 561-563 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T333 | 636-647 | Chemical | denotes | Angiotensin | http://purl.obolibrary.org/obo/CHEBI_2719 |
| T334 | 762-764 | Chemical | denotes | GI | http://purl.obolibrary.org/obo/CHEBI_73907 |
| T335 | 772-781 | Chemical | denotes | endocrine | http://purl.obolibrary.org/obo/CHEBI_24621 |
| T336 | 1014-1021 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T337 | 1034-1046 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T338 | 1180-1188 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T339 | 1514-1522 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T340 | 1833-1840 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T341 | 1925-1932 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T533 | 599-628 | http://purl.obolibrary.org/obo/GO_0006898 | denotes | receptor-mediated endocytosis |
| T534 | 617-628 | http://purl.obolibrary.org/obo/GO_0006897 | denotes | endocytosis |
| T535 | 709-739 | http://purl.obolibrary.org/obo/GO_0046718 | denotes | viral entry into the host cell |
| T536 | 1348-1372 | http://purl.obolibrary.org/obo/GO_0044409 | denotes | entry into the host cell |
| T537 | 1530-1547 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signaling pathway |
| T538 | 1530-1539 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T539 | 1671-1689 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signaling pathways |
| T540 | 1671-1680 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T187 | 0-146 | Sentence | denotes | In order to come up with the medications to manage SARS-CoV-2 infections, it is important to understand the virus-receptor recognition mechanisms. |
| T188 | 147-275 | Sentence | denotes | WHO has declared COVID-19 as a global pandemic and no drug or antiviral treatment has yet been formulated to combat the disease. |
| T189 | 276-461 | Sentence | denotes | Hence, repurposing drugs available for other diseases could be a potential treatment strategy against SARS-CoV-2 and can be processed further for COVID-19 trials (Rosa & Santos, 2020) . |
| T190 | 462-629 | Sentence | denotes | SARS-CoV-2 is known to affect lung alveolar epithelial cells via the angiotensin-converting enzyme II (ACE2) as an entry receptor, using receptor-mediated endocytosis. |
| T191 | 630-740 | Sentence | denotes | ACE2 (Angiotensin converting enzyme 2) is an important player in mediating the viral entry into the host cell. |
| T192 | 741-941 | Sentence | denotes | ACE2 is expressed in GI tract, endocrine tissues, kidneys, liver/gall bladder, testis and to smaller extents in lungs and is known to regulate cardiovascular functions, renal functions, and fertility. |
| T193 | 942-1136 | Sentence | denotes | The newly conferred function for ACE2 is, it being a receptor for the S-protein i.e. spikes glycoprotein of all the human coronavirus such as SARS-CoV, HCoV-NL63 and SARS-CoV-2 (COVID-19 virus). |
| T194 | 1137-1296 | Sentence | denotes | The Receptor Binding Domain (RBD) of spike proteins and ACE2 receptors come in direct contact and initiate fusion with cell membrane (Kim, 2020; Robson, 2020). |
| T195 | 1297-1481 | Sentence | denotes | Since this interaction is essential for SARS-CoV-2 entry into the host cell and infection, this S-RBD–ACE2 interface can be the main target for vaccine developers (Shang et al., 2020). |
| T196 | 1482-1638 | Sentence | denotes | Also, most importantly the next proteins in the signaling pathway after attachment of S-RBD-ACE2 will decide the fate of the infection and severity in body. |
| T197 | 1639-1774 | Sentence | denotes | The information about disturbed signaling pathways in COVID-19 is of utmost importance as this can guide the route and treatment plans. |
| T198 | 1775-1911 | Sentence | denotes | It is well known that attachment of virus to the receptor protein releases signals which help the virus to replicate and spread in body. |
| T199 | 1912-2067 | Sentence | denotes | Therefore, a protein interaction network was sketched around ACE2 to decipher the pathways which will be impacted instantly when virus will attach to ACE2. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 736 | 565-569 | Gene | denotes | ACE2 | Gene:59272 |
| 737 | 630-634 | Gene | denotes | ACE2 | Gene:59272 |
| 738 | 741-745 | Gene | denotes | ACE2 | Gene:59272 |
| 739 | 975-979 | Gene | denotes | ACE2 | Gene:59272 |
| 740 | 1193-1197 | Gene | denotes | ACE2 | Gene:59272 |
| 741 | 1399-1403 | Gene | denotes | ACE2 | Gene:59272 |
| 742 | 1574-1578 | Gene | denotes | ACE2 | Gene:59272 |
| 743 | 1973-1977 | Gene | denotes | ACE2 | Gene:59272 |
| 744 | 2062-2066 | Gene | denotes | ACE2 | Gene:59272 |
| 745 | 1568-1569 | Gene | denotes | S | Gene:43740568 |
| 746 | 1393-1394 | Gene | denotes | S | Gene:43740568 |
| 747 | 378-388 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 748 | 462-472 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 749 | 1058-1075 | Species | denotes | human coronavirus | Tax:694448 |
| 750 | 1084-1092 | Species | denotes | SARS-CoV | Tax:694009 |
| 751 | 1094-1103 | Species | denotes | HCoV-NL63 | Tax:277944 |
| 752 | 1108-1118 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 753 | 1120-1134 | Species | denotes | COVID-19 virus | Tax:2697049 |
| 754 | 1337-1347 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 755 | 51-72 | Disease | denotes | SARS-CoV-2 infections | MESH:C000657245 |
| 756 | 164-172 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 757 | 422-430 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 758 | 800-818 | Disease | denotes | liver/gall bladder | MESH:D005706 |
| 759 | 1377-1386 | Disease | denotes | infection | MESH:D007239 |
| 760 | 1607-1616 | Disease | denotes | infection | MESH:D007239 |
| 761 | 1693-1701 | Disease | denotes | COVID-19 | MESH:C000657245 |