PMC:7605337 / 44194-45012 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7605337","sourcedb":"PMC","sourceid":"7605337","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7605337","text":"To better characterize the functional motions of RBD, DCCM for all systems are constructed and shown in Figure 6 and Figure S6. nCOV-2019 showed a large correlation between the α4-L1- β5 and α5- L4- β5 regions. This correlation was stronger in SARS-COV and few mutants such as Y449A, G447A, and E484A. Another important correlation in nCOV-2019 is inside L3 and β6. This correlation is stronger in nCOV-2019 than SARS-COV due to the presence of β6 which makes the loop to adopt correlated motions. Few mutants impact the correlation in this region such as N487A. Interestingly, mutant F486A which is in L3 and participates in binding by π-stacking interaction with Y83 on ACE2, disrupts the DCCM of wild-type nCOV-2019 and introduces strong correlation in the extended loop region as well as the core structure of 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