PMC:7605337 / 36031-37624
Annnotations
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T235 | 38-42 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T236 | 50-59 | Disease | denotes | nCOV-2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T237 | 123-132 | Disease | denotes | nCOV-2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T238 | 209-213 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T239 | 274-283 | Disease | denotes | nCOV-2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T240 | 371-375 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T241 | 454-458 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T242 | 466-475 | Disease | denotes | nCOV-2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T243 | 511-515 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T244 | 596-600 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T245 | 687-696 | Disease | denotes | nCOV-2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T246 | 801-805 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T247 | 988-997 | Disease | denotes | nCOV-2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T248 | 1111-1115 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T249 | 1150-1159 | Disease | denotes | nCOV-2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T250 | 1258-1267 | Disease | denotes | nCOV-2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T251 | 1400-1404 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T252 | 1421-1430 | Disease | denotes | nCOV-2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T253 | 1489-1493 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T254 | 1521-1530 | Disease | denotes | nCOV-2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T237 | 60-63 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T238 | 133-136 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T239 | 137-138 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T240 | 645-646 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T241 | 898-900 | http://purl.obolibrary.org/obo/CLO_0050509 | denotes | 27 |
T242 | 906-907 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T243 | 1034-1035 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T110 | 89-97 | Chemical | denotes | hydrogen | http://purl.obolibrary.org/obo/CHEBI_49637 |
T111 | 647-651 | Chemical | denotes | salt | http://purl.obolibrary.org/obo/CHEBI_24866|http://purl.obolibrary.org/obo/CHEBI_26710 |
T113 | 840-844 | Chemical | denotes | salt | http://purl.obolibrary.org/obo/CHEBI_24866|http://purl.obolibrary.org/obo/CHEBI_26710 |
T115 | 1036-1040 | Chemical | denotes | salt | http://purl.obolibrary.org/obo/CHEBI_24866|http://purl.obolibrary.org/obo/CHEBI_26710 |
T117 | 1184-1188 | Chemical | denotes | salt | http://purl.obolibrary.org/obo/CHEBI_24866|http://purl.obolibrary.org/obo/CHEBI_26710 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T239 | 0-114 | Sentence | denotes | The evolution of the coronavirus from SARS-COV to nCOV-2019 has reshaped the interfacial hydrogen bonds with ACE2. |
T240 | 115-183 | Sentence | denotes | G502 in nCOV-2019 has a persistent H-bond with residue K353 on ACE2. |
T241 | 184-265 | Sentence | denotes | This residue was G488 in SARS-COV, which also makes the H-bond with K353 on ACE2. |
T242 | 266-342 | Sentence | denotes | Q493 in nCOV-2019 makes H-bond with E35 and another H-bond with K31 on ACE2. |
T243 | 343-426 | Sentence | denotes | This residue was an N479 in SARS-COV, which only makes one H-bond with K31 on ACE2. |
T244 | 427-520 | Sentence | denotes | An important mutation from SARS-COV to nCOV-2019 is residue Q498, which was Y484 in SARS-COV. |
T245 | 521-631 | Sentence | denotes | Q498 makes two H-bonds with residues D38 and K353 on ACE2, whereas Y484 in SARS-COV does not make any H-bonds. |
T246 | 632-776 | Sentence | denotes | Importantly, a salt bridge between K417 and D30 in the nCOV-2019/ACE2 complex contributes to the total binding energy by −12.34 ± 0.23 kcal/mol. |
T247 | 777-887 | Sentence | denotes | This residue is V404 in SARS-COV which is not able to make any salt-bridge and does not make H-bond with ACE2. |
T248 | 888-1033 | Sentence | denotes | Gao et al.27 used a FEP approach and showed that mutation V404 to K417 lowers the binding energy of nCOV-2019 RBD to ACE2 by −2.2 ± 0.9 kcal/mol. |
T249 | 1034-1125 | Sentence | denotes | A salt bridge between R426 on RBD and E329 on ACE2 stabilizes the complex in SARS-COV/ACE2. |
T250 | 1126-1219 | Sentence | denotes | This residue is N439 in nCOV-2019 which is unable to make salt-bridge with ACE2 residue E329. |
T251 | 1220-1391 | Sentence | denotes | One of the most observed mutations in nCOV-2019 according to the GISAID database is N439K which recovers some of the electrostatic interactions with ACE2 at this position. |
T252 | 1392-1466 | Sentence | denotes | Y436 in SARS-COV and Y449 in nCOV-2019 both make H-bonds with D38 on ACE2. |
T253 | 1467-1593 | Sentence | denotes | The unchanged T486 in SARS-COV corresponds to T500 in nCOV-2019, both of which make consistent H-bonds with ACE2 residue D355. |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
850 | 109-113 | Gene | denotes | ACE2 | Gene:59272 |
851 | 178-182 | Gene | denotes | ACE2 | Gene:59272 |
852 | 260-264 | Gene | denotes | ACE2 | Gene:59272 |
853 | 337-341 | Gene | denotes | ACE2 | Gene:59272 |
854 | 421-425 | Gene | denotes | ACE2 | Gene:59272 |
855 | 574-578 | Gene | denotes | ACE2 | Gene:59272 |
856 | 697-701 | Gene | denotes | ACE2 | Gene:59272 |
857 | 882-886 | Gene | denotes | ACE2 | Gene:59272 |
858 | 1005-1009 | Gene | denotes | ACE2 | Gene:59272 |
859 | 1080-1084 | Gene | denotes | ACE2 | Gene:59272 |
860 | 1120-1124 | Gene | denotes | ACE2 | Gene:59272 |
861 | 1201-1205 | Gene | denotes | ACE2 | Gene:59272 |
862 | 1369-1373 | Gene | denotes | ACE2 | Gene:59272 |
863 | 1461-1465 | Gene | denotes | ACE2 | Gene:59272 |
864 | 1575-1579 | Gene | denotes | ACE2 | Gene:59272 |
865 | 414-417 | Gene | denotes | K31 | Gene:3881 |
866 | 330-333 | Gene | denotes | K31 | Gene:3881 |
867 | 21-32 | Species | denotes | coronavirus | Tax:11118 |
868 | 38-46 | Species | denotes | SARS-COV | Tax:694009 |
869 | 50-54 | Species | denotes | nCOV | Tax:2697049 |
870 | 123-127 | Species | denotes | nCOV | Tax:2697049 |
871 | 209-217 | Species | denotes | SARS-COV | Tax:694009 |
872 | 274-278 | Species | denotes | nCOV | Tax:2697049 |
873 | 371-379 | Species | denotes | SARS-COV | Tax:694009 |
874 | 454-462 | Species | denotes | SARS-COV | Tax:694009 |
875 | 466-470 | Species | denotes | nCOV | Tax:2697049 |
876 | 511-519 | Species | denotes | SARS-COV | Tax:694009 |
877 | 596-604 | Species | denotes | SARS-COV | Tax:694009 |
878 | 687-691 | Species | denotes | nCOV | Tax:2697049 |
879 | 801-809 | Species | denotes | SARS-COV | Tax:694009 |
880 | 988-992 | Species | denotes | nCOV | Tax:2697049 |
881 | 1111-1119 | Species | denotes | SARS-COV | Tax:694009 |
882 | 1150-1154 | Species | denotes | nCOV | Tax:2697049 |
883 | 1258-1262 | Species | denotes | nCOV | Tax:2697049 |
884 | 1400-1408 | Species | denotes | SARS-COV | Tax:694009 |
885 | 1421-1425 | Species | denotes | nCOV | Tax:2697049 |
886 | 1489-1497 | Species | denotes | SARS-COV | Tax:694009 |
887 | 1521-1525 | Species | denotes | nCOV | Tax:2697049 |
888 | 89-97 | Chemical | denotes | hydrogen | MESH:D006859 |
889 | 115-119 | Chemical | denotes | G502 | |
890 | 170-174 | Chemical | denotes | K353 | |
891 | 201-205 | Chemical | denotes | G488 | |
892 | 252-256 | Chemical | denotes | K353 | |
893 | 363-367 | Chemical | denotes | N479 | |
894 | 487-491 | Chemical | denotes | Q498 | |
895 | 503-507 | Chemical | denotes | Y484 | |
896 | 521-525 | Chemical | denotes | Q498 | |
897 | 588-592 | Chemical | denotes | Y484 | |
898 | 667-671 | Chemical | denotes | K417 | |
899 | 793-797 | Chemical | denotes | V404 | |
900 | 954-958 | Chemical | denotes | K417 | |
901 | 1056-1060 | Chemical | denotes | R426 | |
902 | 1072-1076 | Chemical | denotes | E329 | |
903 | 1142-1146 | Chemical | denotes | N439 | |
904 | 1214-1218 | Chemical | denotes | E329 | |
905 | 1392-1396 | Chemical | denotes | Y436 | |
906 | 1413-1417 | Chemical | denotes | Y449 | |
907 | 1588-1592 | Chemical | denotes | D355 |