PMC:7605337 / 33141-34116
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T54 | 5-12 | Body_part | denotes | alanine | http://purl.org/sig/ont/fma/fma82749 |
| T55 | 398-405 | Body_part | denotes | alanine | http://purl.org/sig/ont/fma/fma82749 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T218 | 82-91 | Disease | denotes | nCOV-2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T219 | 381-390 | Disease | denotes | nCOV-2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T220 | 467-476 | Disease | denotes | nCOV-2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T221 | 907-916 | Disease | denotes | nCOV-2019 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T213 | 101-102 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T214 | 180-181 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T215 | 245-247 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
| T216 | 491-494 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T217 | 550-551 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T100 | 5-12 | Chemical | denotes | alanine | http://purl.obolibrary.org/obo/CHEBI_16449 |
| T101 | 398-405 | Chemical | denotes | alanine | http://purl.obolibrary.org/obo/CHEBI_16449 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T207 | 0-162 | Sentence | denotes | Most alanine substitutions exhibited similar or lower total binding affinities to nCOV-2019, however a few mutants had higher binding affinity than the wild type. |
| T208 | 163-293 | Sentence | denotes | Mutant Y489A had a total binding energy of −61.78 ± 2.59 kcal/mol which was about 11 kcal/mol lower than wild type binding energy. |
| T209 | 294-391 | Sentence | denotes | Mutants G446A, G447A, and T478I also demonstrated higher total binding affinities than nCOV-2019. |
| T210 | 392-477 | Sentence | denotes | Other alanine substitutions had similar or lower total binding energy than nCOV-2019. |
| T211 | 478-593 | Sentence | denotes | Mutant G502A has the lowest binding affinity among all the mutants with a binding energy of −24.31 ± 2.98 kcal/mol. |
| T212 | 594-739 | Sentence | denotes | Mutant systems K417A, L455A, T500A, and N501A are the other mutants with total binding affinities significantly lower than the wild type complex. |
| T213 | 740-848 | Sentence | denotes | The electrostatic component of binding contributes the most to the low binding affinities for these mutants. |
| T214 | 849-975 | Sentence | denotes | The contribution of RBM residues to binding with ACE2 for nCOV-2019 was mapped to the RBD structure and is shown in Figure 9B. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 733 | 898-902 | Gene | denotes | ACE2 | Gene:59272 |
| 734 | 82-86 | Species | denotes | nCOV | Tax:2697049 |
| 735 | 381-385 | Species | denotes | nCOV | Tax:2697049 |
| 736 | 467-471 | Species | denotes | nCOV | Tax:2697049 |
| 737 | 907-911 | Species | denotes | nCOV | Tax:2697049 |
| 738 | 5-12 | Chemical | denotes | alanine | MESH:D000409 |
| 739 | 398-405 | Chemical | denotes | alanine | MESH:D000409 |