PMC:7605337 / 11785-12453 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7605337","sourcedb":"PMC","sourceid":"7605337","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7605337","text":"nCOV-2019 shares 76% sequence similarity with SARS-2002 spike protein, 73% sequence identity for RBD and 50% for the RBM.1 Bat coronavirus RaTG13 seems to be the closest relative of nCOV-2019 sharing about 93% sequence identity in the spike protein.6 The sequence alignment of SARS-2002 (accession number: AFR58742), SARS-civet (accession number: AY304486.1), Bat RaTG13 (accession number: MN996532.1), and nCOV-2019 (accession number: MN908947.1) is shown in Figure 2.6 To investigate the roles of critical mutations on the complex stability of nCOV-2019 with ACE2, mCSM-PPI2 webserver32 was used to find the residues in nCOV-2019 that are at the interface with ACE2.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T39","span":{"begin":62,"end":69},"obj":"Body_part"},{"id":"T40","span":{"begin":241,"end":248},"obj":"Body_part"}],"attributes":[{"id":"A39","pred":"fma_id","subj":"T39","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A40","pred":"fma_id","subj":"T40","obj":"http://purl.org/sig/ont/fma/fma67257"},{"subj":"T39","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T40","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T88","span":{"begin":0,"end":9},"obj":"Disease"},{"id":"T89","span":{"begin":46,"end":50},"obj":"Disease"},{"id":"T90","span":{"begin":182,"end":191},"obj":"Disease"},{"id":"T91","span":{"begin":277,"end":281},"obj":"Disease"},{"id":"T92","span":{"begin":317,"end":321},"obj":"Disease"},{"id":"T93","span":{"begin":407,"end":416},"obj":"Disease"},{"id":"T94","span":{"begin":546,"end":555},"obj":"Disease"},{"id":"T95","span":{"begin":622,"end":631},"obj":"Disease"}],"attributes":[{"id":"A88","pred":"mondo_id","subj":"T88","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A89","pred":"mondo_id","subj":"T89","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A90","pred":"mondo_id","subj":"T90","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A91","pred":"mondo_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A92","pred":"mondo_id","subj":"T92","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A93","pred":"mondo_id","subj":"T93","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A94","pred":"mondo_id","subj":"T94","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A95","pred":"mondo_id","subj":"T95","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T88","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T89","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T90","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T91","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T92","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T93","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T94","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T95","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T45","span":{"begin":62,"end":69},"obj":"Chemical"},{"id":"T46","span":{"begin":241,"end":248},"obj":"Chemical"}],"attributes":[{"id":"A45","pred":"chebi_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A46","pred":"chebi_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"subj":"T45","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T46","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T61","span":{"begin":0,"end":668},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T61","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"333","span":{"begin":235,"end":240},"obj":"Gene"},{"id":"334","span":{"begin":561,"end":565},"obj":"Gene"},{"id":"335","span":{"begin":663,"end":667},"obj":"Gene"},{"id":"337","span":{"begin":56,"end":61},"obj":"Gene"},{"id":"338","span":{"begin":0,"end":4},"obj":"Species"},{"id":"339","span":{"begin":123,"end":145},"obj":"Species"},{"id":"340","span":{"begin":182,"end":186},"obj":"Species"},{"id":"341","span":{"begin":407,"end":411},"obj":"Species"},{"id":"342","span":{"begin":546,"end":550},"obj":"Species"},{"id":"343","span":{"begin":622,"end":626},"obj":"Species"},{"id":"346","span":{"begin":390,"end":400},"obj":"CellLine"},{"id":"347","span":{"begin":436,"end":446},"obj":"CellLine"}],"attributes":[{"id":"A333","pred":"tao:has_database_id","subj":"333","obj":"Gene:43740568"},{"id":"A334","pred":"tao:has_database_id","subj":"334","obj":"Gene:59272"},{"id":"A335","pred":"tao:has_database_id","subj":"335","obj":"Gene:59272"},{"id":"A337","pred":"tao:has_database_id","subj":"337","obj":"Gene:43740568"},{"id":"A338","pred":"tao:has_database_id","subj":"338","obj":"Tax:2697049"},{"id":"A339","pred":"tao:has_database_id","subj":"339","obj":"Tax:2709072"},{"id":"A340","pred":"tao:has_database_id","subj":"340","obj":"Tax:2697049"},{"id":"A341","pred":"tao:has_database_id","subj":"341","obj":"Tax:2697049"},{"id":"A342","pred":"tao:has_database_id","subj":"342","obj":"Tax:2697049"},{"id":"A343","pred":"tao:has_database_id","subj":"343","obj":"Tax:2697049"},{"id":"A346","pred":"tao:has_database_id","subj":"346","obj":"CVCL:U508"},{"id":"A347","pred":"tao:has_database_id","subj":"347","obj":"CVCL:U508"},{"subj":"333","pred":"source","obj":"LitCovid-PubTator"},{"subj":"334","pred":"source","obj":"LitCovid-PubTator"},{"subj":"335","pred":"source","obj":"LitCovid-PubTator"},{"subj":"337","pred":"source","obj":"LitCovid-PubTator"},{"subj":"338","pred":"source","obj":"LitCovid-PubTator"},{"subj":"339","pred":"source","obj":"LitCovid-PubTator"},{"subj":"340","pred":"source","obj":"LitCovid-PubTator"},{"subj":"341","pred":"source","obj":"LitCovid-PubTator"},{"subj":"342","pred":"source","obj":"LitCovid-PubTator"},{"subj":"343","pred":"source","obj":"LitCovid-PubTator"},{"subj":"346","pred":"source","obj":"LitCovid-PubTator"},{"subj":"347","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#e693ec","default":true},{"id":"LitCovid-PD-MONDO","color":"#93eccc"},{"id":"LitCovid-PD-CHEBI","color":"#ecb293"},{"id":"LitCovid-sentences","color":"#9893ec"},{"id":"LitCovid-PubTator","color":"#a7ec93"}]}]}}