PMC:7601109 / 91445-92229 JSONTXT

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T170","span":{"begin":451,"end":465},"obj":"Body_part"},{"id":"T171","span":{"begin":459,"end":465},"obj":"Body_part"},{"id":"T172","span":{"begin":670,"end":684},"obj":"Body_part"},{"id":"T173","span":{"begin":678,"end":684},"obj":"Body_part"}],"attributes":[{"id":"A170","pred":"uberon_id","subj":"T170","obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"A171","pred":"uberon_id","subj":"T171","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A172","pred":"uberon_id","subj":"T172","obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"A173","pred":"uberon_id","subj":"T173","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"}],"text":"Oral 10-HDA (12-60 mg/kg body weight/d/4 months) Obese old rats and stressed mice as models of sarcopenia and depression (male and female Sprague-Dawley and 2-months old male and female BALB/c) EG1 and EG2: aged obese rats on 10-HDA (12 or 24 mg/kg/d for 3.5 months)EG3 and EG4: stressed BALB/c mice on 10-HDA (30 or 60 mg/kg/d for 4 months)CG1 and CG2: untreated aged obese rats and untreated stressed BALB/c mice Body weight, weight of abdominal adipose tissue, and muscle mass. 10-HDA significantly increased weight gain and weight maintenance in aged rats/mice undergoing behavioral stress without any change in diet consumption. It also significantly decreased adipose tissue in female animals and increased muscle mass in male rodents compared with untreated controls. [54]"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T802","span":{"begin":25,"end":29},"obj":"Body_part"},{"id":"T803","span":{"begin":418,"end":422},"obj":"Body_part"},{"id":"T804","span":{"begin":451,"end":465},"obj":"Body_part"},{"id":"T805","span":{"begin":471,"end":477},"obj":"Body_part"},{"id":"T806","span":{"begin":670,"end":684},"obj":"Body_part"},{"id":"T807","span":{"begin":717,"end":723},"obj":"Body_part"}],"attributes":[{"id":"A802","pred":"fma_id","subj":"T802","obj":"http://purl.org/sig/ont/fma/fma256135"},{"id":"A803","pred":"fma_id","subj":"T803","obj":"http://purl.org/sig/ont/fma/fma256135"},{"id":"A804","pred":"fma_id","subj":"T804","obj":"http://purl.org/sig/ont/fma/fma20110"},{"id":"A805","pred":"fma_id","subj":"T805","obj":"http://purl.org/sig/ont/fma/fma32558"},{"id":"A806","pred":"fma_id","subj":"T806","obj":"http://purl.org/sig/ont/fma/fma20110"},{"id":"A807","pred":"fma_id","subj":"T807","obj":"http://purl.org/sig/ont/fma/fma32558"}],"text":"Oral 10-HDA (12-60 mg/kg body weight/d/4 months) Obese old rats and stressed mice as models of sarcopenia and depression (male and female Sprague-Dawley and 2-months old male and female BALB/c) EG1 and EG2: aged obese rats on 10-HDA (12 or 24 mg/kg/d for 3.5 months)EG3 and EG4: stressed BALB/c mice on 10-HDA (30 or 60 mg/kg/d for 4 months)CG1 and CG2: untreated aged obese rats and untreated stressed BALB/c mice Body weight, weight of abdominal adipose tissue, and muscle mass. 10-HDA significantly increased weight gain and weight maintenance in aged rats/mice undergoing behavioral stress without any change in diet consumption. It also significantly decreased adipose tissue in female animals and increased muscle mass in male rodents compared with untreated controls. [54]"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T148","span":{"begin":96,"end":106},"obj":"Disease"},{"id":"T149","span":{"begin":111,"end":121},"obj":"Disease"}],"attributes":[{"id":"A148","pred":"mondo_id","subj":"T148","obj":"http://purl.obolibrary.org/obo/MONDO_0006516"},{"id":"A149","pred":"mondo_id","subj":"T149","obj":"http://purl.obolibrary.org/obo/MONDO_0002050"}],"text":"Oral 10-HDA (12-60 mg/kg body weight/d/4 months) Obese old rats and stressed mice as models of sarcopenia and depression (male and female Sprague-Dawley and 2-months old male and female BALB/c) EG1 and EG2: aged obese rats on 10-HDA (12 or 24 mg/kg/d for 3.5 months)EG3 and EG4: stressed BALB/c mice on 10-HDA (30 or 60 mg/kg/d for 4 months)CG1 and CG2: untreated aged obese rats and untreated stressed BALB/c mice Body weight, weight of abdominal adipose tissue, and muscle mass. 10-HDA significantly increased weight gain and weight maintenance in aged rats/mice undergoing behavioral stress without any change in diet consumption. It also significantly decreased adipose tissue in female animals and increased muscle mass in male rodents compared with untreated controls. [54]"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T1602","span":{"begin":37,"end":40},"obj":"http://purl.obolibrary.org/obo/CLO_0050605"},{"id":"T1603","span":{"begin":123,"end":127},"obj":"http://purl.obolibrary.org/obo/UBERON_0003101"},{"id":"T1604","span":{"begin":123,"end":127},"obj":"http://www.ebi.ac.uk/efo/EFO_0000970"},{"id":"T1605","span":{"begin":132,"end":138},"obj":"http://purl.obolibrary.org/obo/UBERON_0003100"},{"id":"T1606","span":{"begin":171,"end":175},"obj":"http://purl.obolibrary.org/obo/UBERON_0003101"},{"id":"T1607","span":{"begin":171,"end":175},"obj":"http://www.ebi.ac.uk/efo/EFO_0000970"},{"id":"T1608","span":{"begin":180,"end":186},"obj":"http://purl.obolibrary.org/obo/UBERON_0003100"},{"id":"T1609","span":{"begin":451,"end":465},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T1610","span":{"begin":471,"end":477},"obj":"http://purl.obolibrary.org/obo/UBERON_0001630"},{"id":"T1611","span":{"begin":471,"end":477},"obj":"http://purl.obolibrary.org/obo/UBERON_0005090"},{"id":"T1612","span":{"begin":471,"end":477},"obj":"http://www.ebi.ac.uk/efo/EFO_0000801"},{"id":"T1613","span":{"begin":471,"end":477},"obj":"http://www.ebi.ac.uk/efo/EFO_0001949"},{"id":"T1614","span":{"begin":670,"end":684},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"T1615","span":{"begin":688,"end":694},"obj":"http://purl.obolibrary.org/obo/UBERON_0003100"},{"id":"T1616","span":{"begin":695,"end":702},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_33208"},{"id":"T1617","span":{"begin":717,"end":723},"obj":"http://purl.obolibrary.org/obo/UBERON_0001630"},{"id":"T1618","span":{"begin":717,"end":723},"obj":"http://purl.obolibrary.org/obo/UBERON_0005090"},{"id":"T1619","span":{"begin":717,"end":723},"obj":"http://www.ebi.ac.uk/efo/EFO_0000801"},{"id":"T1620","span":{"begin":717,"end":723},"obj":"http://www.ebi.ac.uk/efo/EFO_0001949"},{"id":"T1621","span":{"begin":732,"end":736},"obj":"http://purl.obolibrary.org/obo/UBERON_0003101"},{"id":"T1622","span":{"begin":732,"end":736},"obj":"http://www.ebi.ac.uk/efo/EFO_0000970"}],"text":"Oral 10-HDA (12-60 mg/kg body weight/d/4 months) Obese old rats and stressed mice as models of sarcopenia and depression (male and female Sprague-Dawley and 2-months old male and female BALB/c) EG1 and EG2: aged obese rats on 10-HDA (12 or 24 mg/kg/d for 3.5 months)EG3 and EG4: stressed BALB/c mice on 10-HDA (30 or 60 mg/kg/d for 4 months)CG1 and CG2: untreated aged obese rats and untreated stressed BALB/c mice Body weight, weight of abdominal adipose tissue, and muscle mass. 10-HDA significantly increased weight gain and weight maintenance in aged rats/mice undergoing behavioral stress without any change in diet consumption. It also significantly decreased adipose tissue in female animals and increased muscle mass in male rodents compared with untreated controls. [54]"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T86714","span":{"begin":8,"end":11},"obj":"Chemical"},{"id":"T49346","span":{"begin":123,"end":127},"obj":"Chemical"},{"id":"T45424","span":{"begin":171,"end":175},"obj":"Chemical"},{"id":"T479","span":{"begin":231,"end":234},"obj":"Chemical"},{"id":"T19942","span":{"begin":308,"end":311},"obj":"Chemical"},{"id":"T12826","span":{"begin":488,"end":491},"obj":"Chemical"},{"id":"T482","span":{"begin":732,"end":736},"obj":"Chemical"}],"attributes":[{"id":"A48313","pred":"chebi_id","subj":"T86714","obj":"http://purl.obolibrary.org/obo/CHEBI_17314"},{"id":"A67708","pred":"chebi_id","subj":"T49346","obj":"http://purl.obolibrary.org/obo/CHEBI_30780"},{"id":"A43440","pred":"chebi_id","subj":"T45424","obj":"http://purl.obolibrary.org/obo/CHEBI_30780"},{"id":"A92784","pred":"chebi_id","subj":"T479","obj":"http://purl.obolibrary.org/obo/CHEBI_17314"},{"id":"A49907","pred":"chebi_id","subj":"T19942","obj":"http://purl.obolibrary.org/obo/CHEBI_17314"},{"id":"A93383","pred":"chebi_id","subj":"T12826","obj":"http://purl.obolibrary.org/obo/CHEBI_17314"},{"id":"A46873","pred":"chebi_id","subj":"T482","obj":"http://purl.obolibrary.org/obo/CHEBI_30780"}],"text":"Oral 10-HDA (12-60 mg/kg body weight/d/4 months) Obese old rats and stressed mice as models of sarcopenia and depression (male and female Sprague-Dawley and 2-months old male and female BALB/c) EG1 and EG2: aged obese rats on 10-HDA (12 or 24 mg/kg/d for 3.5 months)EG3 and EG4: stressed BALB/c mice on 10-HDA (30 or 60 mg/kg/d for 4 months)CG1 and CG2: untreated aged obese rats and untreated stressed BALB/c mice Body weight, weight of abdominal adipose tissue, and muscle mass. 10-HDA significantly increased weight gain and weight maintenance in aged rats/mice undergoing behavioral stress without any change in diet consumption. It also significantly decreased adipose tissue in female animals and increased muscle mass in male rodents compared with untreated controls. [54]"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T93","span":{"begin":111,"end":121},"obj":"Phenotype"},{"id":"T94","span":{"begin":516,"end":527},"obj":"Phenotype"},{"id":"T95","span":{"begin":660,"end":684},"obj":"Phenotype"}],"attributes":[{"id":"A93","pred":"hp_id","subj":"T93","obj":"http://purl.obolibrary.org/obo/HP_0000716"},{"id":"A94","pred":"hp_id","subj":"T94","obj":"http://purl.obolibrary.org/obo/HP_0004324"},{"id":"A95","pred":"hp_id","subj":"T95","obj":"http://purl.obolibrary.org/obo/HP_0040063"}],"text":"Oral 10-HDA (12-60 mg/kg body weight/d/4 months) Obese old rats and stressed mice as models of sarcopenia and depression (male and female Sprague-Dawley and 2-months old male and female BALB/c) EG1 and EG2: aged obese rats on 10-HDA (12 or 24 mg/kg/d for 3.5 months)EG3 and EG4: stressed BALB/c mice on 10-HDA (30 or 60 mg/kg/d for 4 months)CG1 and CG2: untreated aged obese rats and untreated stressed BALB/c mice Body weight, weight of abdominal adipose tissue, and muscle mass. 10-HDA significantly increased weight gain and weight maintenance in aged rats/mice undergoing behavioral stress without any change in diet consumption. It also significantly decreased adipose tissue in female animals and increased muscle mass in male rodents compared with untreated controls. [54]"}

{"project":"LitCovid-sentences","denotations":[{"id":"T579","span":{"begin":0,"end":483},"obj":"Sentence"},{"id":"T580","span":{"begin":485,"end":637},"obj":"Sentence"},{"id":"T581","span":{"begin":638,"end":784},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Oral 10-HDA (12-60 mg/kg body weight/d/4 months) Obese old rats and stressed mice as models of sarcopenia and depression (male and female Sprague-Dawley and 2-months old male and female BALB/c) EG1 and EG2: aged obese rats on 10-HDA (12 or 24 mg/kg/d for 3.5 months)EG3 and EG4: stressed BALB/c mice on 10-HDA (30 or 60 mg/kg/d for 4 months)CG1 and CG2: untreated aged obese rats and untreated stressed BALB/c mice Body weight, weight of abdominal adipose tissue, and muscle mass. 10-HDA significantly increased weight gain and weight maintenance in aged rats/mice undergoing behavioral stress without any change in diet consumption. It also significantly decreased adipose tissue in female animals and increased muscle mass in male rodents compared with untreated controls. [54]"}

{"project":"LitCovid-PubTator","denotations":[{"id":"2790","span":{"begin":343,"end":346},"obj":"Gene"},{"id":"2901","span":{"begin":60,"end":64},"obj":"Species"},{"id":"2902","span":{"begin":78,"end":82},"obj":"Species"},{"id":"2903","span":{"begin":220,"end":224},"obj":"Species"},{"id":"2904","span":{"begin":297,"end":301},"obj":"Species"},{"id":"2905","span":{"begin":377,"end":381},"obj":"Species"},{"id":"2906","span":{"begin":412,"end":416},"obj":"Species"},{"id":"2907","span":{"begin":559,"end":563},"obj":"Species"},{"id":"2908","span":{"begin":564,"end":568},"obj":"Species"},{"id":"2974","span":{"begin":196,"end":199},"obj":"Gene"},{"id":"2989","span":{"begin":5,"end":11},"obj":"Chemical"},{"id":"3036","span":{"begin":96,"end":121},"obj":"Disease"},{"id":"3037","span":{"begin":214,"end":219},"obj":"Disease"},{"id":"3038","span":{"begin":371,"end":376},"obj":"Disease"}],"attributes":[{"id":"A2790","pred":"tao:has_database_id","subj":"2790","obj":"Gene:231042"},{"id":"A2901","pred":"tao:has_database_id","subj":"2901","obj":"Tax:10116"},{"id":"A2902","pred":"tao:has_database_id","subj":"2902","obj":"Tax:10090"},{"id":"A2903","pred":"tao:has_database_id","subj":"2903","obj":"Tax:10116"},{"id":"A2904","pred":"tao:has_database_id","subj":"2904","obj":"Tax:10090"},{"id":"A2905","pred":"tao:has_database_id","subj":"2905","obj":"Tax:10116"},{"id":"A2906","pred":"tao:has_database_id","subj":"2906","obj":"Tax:10090"},{"id":"A2907","pred":"tao:has_database_id","subj":"2907","obj":"Tax:10116"},{"id":"A2908","pred":"tao:has_database_id","subj":"2908","obj":"Tax:10090"},{"id":"A2974","pred":"tao:has_database_id","subj":"2974","obj":"Gene:305391"},{"id":"A3036","pred":"tao:has_database_id","subj":"3036","obj":"MESH:D000275"},{"id":"A3037","pred":"tao:has_database_id","subj":"3037","obj":"MESH:D009765"},{"id":"A3038","pred":"tao:has_database_id","subj":"3038","obj":"MESH:D009765"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Oral 10-HDA (12-60 mg/kg body weight/d/4 months) Obese old rats and stressed mice as models of sarcopenia and depression (male and female Sprague-Dawley and 2-months old male and female BALB/c) EG1 and EG2: aged obese rats on 10-HDA (12 or 24 mg/kg/d for 3.5 months)EG3 and EG4: stressed BALB/c mice on 10-HDA (30 or 60 mg/kg/d for 4 months)CG1 and CG2: untreated aged obese rats and untreated stressed BALB/c mice Body weight, weight of abdominal adipose tissue, and muscle mass. 10-HDA significantly increased weight gain and weight maintenance in aged rats/mice undergoing behavioral stress without any change in diet consumption. It also significantly decreased adipose tissue in female animals and increased muscle mass in male rodents compared with untreated controls. [54]"}