PMC:7601109 / 90332-90908 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7601109","sourcedb":"PMC","sourceid":"7601109","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7601109","text":"Intragastric 10-HDA (1.6 mM/kg body weight) In vitroL6 myotubes obtained from Osaka biobankIn vivo7-weeks old male C57BL/6J mice In vitroEG: 10-HDACG1: AICAR (1 mM)CG2: DMSO (0.1%)In vivoEG: 10-HDA (1.6 mM)CG1: gum Arabic (5%) Glucose uptake, AMPK signaling, and Glut4 translocation. 10-HDA increased glucose uptake into L6 myotubes following AMPK activation and Glut4 translocation to the plasma membrane. AMPK activation was induced by the upstream kinase Ca²/calmodulin-dependent kinase β, independent of changes in AMP:ATP ratio and the liver kinase B1 pathway. 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