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PMC:7601109 / 70696-72057 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T598 61-67 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T599 79-86 Body_part denotes insulin http://purl.org/sig/ont/fma/fma83365
T600 112-119 Body_part denotes glucose http://purl.org/sig/ont/fma/fma82743
T601 216-222 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T602 282-288 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T603 478-484 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T604 485-492 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T605 497-503 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T606 583-589 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T607 772-778 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T608 779-786 Body_part denotes glucose http://purl.org/sig/ont/fma/fma82743
T609 870-876 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T610 990-996 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T611 1022-1029 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T612 1174-1180 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T123 216-230 Disease denotes muscle wasting http://purl.obolibrary.org/obo/MONDO_0004323
T124 514-526 Disease denotes malnourished http://purl.obolibrary.org/obo/MONDO_0006873
T125 1174-1188 Disease denotes muscle wasting http://purl.obolibrary.org/obo/MONDO_0004323

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1153 52-67 http://purl.obolibrary.org/obo/UBERON_0001134 denotes skeletal muscle
T1154 52-67 http://purl.obolibrary.org/obo/UBERON_0014892 denotes skeletal muscle
T1155 52-67 http://www.ebi.ac.uk/efo/EFO_0000888 denotes skeletal muscle
T1156 79-86 http://purl.obolibrary.org/obo/PR_000009054 denotes insulin
T1157 216-222 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T1158 216-222 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T1159 216-222 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T1160 216-222 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T1161 273-288 http://purl.obolibrary.org/obo/UBERON_0001134 denotes skeletal muscle
T1162 273-288 http://purl.obolibrary.org/obo/UBERON_0014892 denotes skeletal muscle
T1163 273-288 http://www.ebi.ac.uk/efo/EFO_0000888 denotes skeletal muscle
T1164 293-303 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T1165 478-484 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T1166 478-484 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T1167 478-484 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T1168 478-484 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T1169 497-503 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T1170 497-503 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T1171 497-503 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T1172 497-503 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T1173 548-550 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T1174 583-589 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T1175 583-589 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T1176 583-589 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T1177 583-589 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T1178 618-628 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T1179 637-638 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1180 726-735 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T1181 763-778 http://purl.obolibrary.org/obo/UBERON_0001134 denotes skeletal muscle
T1182 763-778 http://purl.obolibrary.org/obo/UBERON_0014892 denotes skeletal muscle
T1183 763-778 http://www.ebi.ac.uk/efo/EFO_0000888 denotes skeletal muscle
T1184 861-876 http://purl.obolibrary.org/obo/UBERON_0001134 denotes skeletal muscle
T1185 861-876 http://purl.obolibrary.org/obo/UBERON_0014892 denotes skeletal muscle
T1186 861-876 http://www.ebi.ac.uk/efo/EFO_0000888 denotes skeletal muscle
T1187 881-891 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T1188 990-996 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T1189 990-996 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T1190 990-996 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T1191 990-996 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T1192 1116-1117 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T1193 1165-1180 http://purl.obolibrary.org/obo/UBERON_0001134 denotes skeletal muscle
T1194 1165-1180 http://purl.obolibrary.org/obo/UBERON_0014892 denotes skeletal muscle
T1195 1165-1180 http://www.ebi.ac.uk/efo/EFO_0000888 denotes skeletal muscle

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T39620 79-86 Chemical denotes insulin http://purl.obolibrary.org/obo/CHEBI_145810
T24654 112-119 Chemical denotes glucose http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167
T16888 323-331 Chemical denotes nutrient http://purl.obolibrary.org/obo/CHEBI_33284
T227 340-349 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T52782 485-492 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T22684 569-573 Chemical denotes CAPE http://purl.obolibrary.org/obo/CHEBI_8062
T88172 697-701 Chemical denotes CAPE http://purl.obolibrary.org/obo/CHEBI_8062
T231 716-719 Chemical denotes HDA http://purl.obolibrary.org/obo/CHEBI_17314
T44665 779-786 Chemical denotes glucose http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167
T90963 812-823 Chemical denotes royal jelly http://purl.obolibrary.org/obo/CHEBI_78665
T19069 1022-1029 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T329 112-130 http://purl.obolibrary.org/obo/GO_0006006 denotes glucose metabolism
T330 120-130 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T331 323-339 http://purl.obolibrary.org/obo/GO_0009594 denotes nutrient sensing
T332 464-474 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T333 504-510 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T334 599-609 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T335 736-740 http://purl.obolibrary.org/obo/GO_0050405 denotes AMPK
T336 736-740 http://purl.obolibrary.org/obo/GO_0047322 denotes AMPK
T337 736-740 http://purl.obolibrary.org/obo/GO_0004691 denotes AMPK
T338 779-793 http://purl.obolibrary.org/obo/GO_0046323 denotes glucose uptake
T339 787-793 http://purl.obolibrary.org/obo/GO_0098739 denotes uptake
T340 787-793 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T341 895-899 http://purl.obolibrary.org/obo/GO_0050405 denotes AMPK
T342 895-899 http://purl.obolibrary.org/obo/GO_0047322 denotes AMPK
T343 895-899 http://purl.obolibrary.org/obo/GO_0004691 denotes AMPK
T344 907-911 http://purl.obolibrary.org/obo/GO_0050405 denotes AMPK
T345 907-911 http://purl.obolibrary.org/obo/GO_0047322 denotes AMPK
T346 907-911 http://purl.obolibrary.org/obo/GO_0004691 denotes AMPK
T347 932-956 http://purl.obolibrary.org/obo/GO_0019222 denotes regulators of metabolism
T348 946-956 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T349 961-970 http://purl.obolibrary.org/obo/GO_0016236 denotes autophagy
T350 961-970 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T351 1022-1039 http://purl.obolibrary.org/obo/GO_0006412 denotes protein synthesis
T352 1030-1039 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T72 79-97 Phenotype denotes insulin resistance http://purl.obolibrary.org/obo/HP_0000855
T73 216-230 Phenotype denotes muscle wasting http://purl.obolibrary.org/obo/HP_0003202
T74 1174-1188 Phenotype denotes muscle wasting http://purl.obolibrary.org/obo/HP_0003202

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T422 0-152 Sentence denotes One of the major pathologies underlying age-related skeletal muscle failure is insulin resistance, which alters glucose metabolism [3,4,21,118,130,164].
T423 153-374 Sentence denotes Numerous studies signify that bee products may protect against muscle wasting by correcting metabolic dysregulations in skeletal muscle via activation of some of the key nutrient sensing molecules [69,96,100,106,109,111].
T424 375-552 Sentence denotes In this respect, bee pollen permitted mTORC1 to mitigate anabolic resistance through the regulation of muscle protein and muscle growth in malnourished sarcopenic old rats [36].
T425 553-666 Sentence denotes Royal jelly and CAPE restored muscle mass and metabolism through activation of AKT, a substrate of mTOR [96,111].
T426 667-794 Sentence denotes Polyphenols in propolis [70], CAPE [111], and 10-HDA [106] activated AMPK resulting in enhanced skeletal muscle glucose uptake.
T427 795-906 Sentence denotes In the meantime, royal jelly improved mitochondrial biogenesis in skeletal muscle via activation of AMPK [106].
T428 907-1048 Sentence denotes AMPK and mTOR are master regulators of metabolism and autophagy [2,165]; they keep muscle integrity by stimulating protein synthesis [21,22].
T429 1049-1245 Sentence denotes Accordingly, all these findings denote that bee products represent a promising nutritional strategy that can tackle skeletal muscle wasting in old age by correcting its underling metabolic causes.
T430 1246-1361 Sentence denotes However, the detailed physiological processes involved still need to be deeply unraveled in further investigations.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1614 79-86 Gene denotes insulin Gene:3630
1615 413-419 Gene denotes mTORC1 Gene:382056
1616 632-635 Gene denotes AKT Gene:24185
1617 652-656 Gene denotes mTOR Gene:56718
1618 736-740 Gene denotes AMPK Gene:78975
1619 895-899 Gene denotes AMPK Gene:78975
1620 907-911 Gene denotes AMPK Gene:78975
1621 916-920 Gene denotes mTOR Gene:56718
1622 1196-1199 Gene denotes age Gene:81759
1623 40-43 Gene denotes age Gene:81759
1624 542-546 Species denotes rats Tax:10116
1625 569-573 Chemical denotes CAPE MESH:C055494
1627 779-786 Chemical denotes glucose MESH:D005947
1628 61-75 Disease denotes muscle failure MESH:D017093
1629 112-130 Disease denotes glucose metabolism MESH:D044882
1630 216-230 Disease denotes muscle wasting MESH:D009133
1631 1174-1188 Disease denotes muscle wasting MESH:D009133