One of the major pathologies underlying age-related skeletal muscle failure is insulin resistance, which alters glucose metabolism [3,4,21,118,130,164]. Numerous studies signify that bee products may protect against muscle wasting by correcting metabolic dysregulations in skeletal muscle via activation of some of the key nutrient sensing molecules [69,96,100,106,109,111]. In this respect, bee pollen permitted mTORC1 to mitigate anabolic resistance through the regulation of muscle protein and muscle growth in malnourished sarcopenic old rats [36]. Royal jelly and CAPE restored muscle mass and metabolism through activation of AKT, a substrate of mTOR [96,111]. Polyphenols in propolis [70], CAPE [111], and 10-HDA [106] activated AMPK resulting in enhanced skeletal muscle glucose uptake. In the meantime, royal jelly improved mitochondrial biogenesis in skeletal muscle via activation of AMPK [106]. AMPK and mTOR are master regulators of metabolism and autophagy [2,165]; they keep muscle integrity by stimulating protein synthesis [21,22]. Accordingly, all these findings denote that bee products represent a promising nutritional strategy that can tackle skeletal muscle wasting in old age by correcting its underling metabolic causes. However, the detailed physiological processes involved still need to be deeply unraveled in further investigations.