PMC:7601109 / 46567-46990 JSONTXT

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T71","span":{"begin":396,"end":410},"obj":"Body_part"},{"id":"T72","span":{"begin":404,"end":410},"obj":"Body_part"}],"attributes":[{"id":"A71","pred":"uberon_id","subj":"T71","obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"A72","pred":"uberon_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"}],"text":"Phosphorylation of AMPK results in activation of the insulin receptor (IR) and subsequent phosphorylation of PI3K followed by activation of AKT and protein kinase C (PKC) leading to GLUT4 translocation and subsequent activation of several molecules that modulate insulin-stimulated glucose transport, eventually leading to glucose influx into cells of several tissues such as skeletal muscle and adipose tissue [69,70,111]."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T326","span":{"begin":53,"end":60},"obj":"Body_part"},{"id":"T327","span":{"begin":148,"end":155},"obj":"Body_part"},{"id":"T328","span":{"begin":263,"end":270},"obj":"Body_part"},{"id":"T329","span":{"begin":282,"end":289},"obj":"Body_part"},{"id":"T330","span":{"begin":323,"end":330},"obj":"Body_part"},{"id":"T331","span":{"begin":343,"end":348},"obj":"Body_part"},{"id":"T332","span":{"begin":360,"end":367},"obj":"Body_part"},{"id":"T333","span":{"begin":385,"end":391},"obj":"Body_part"},{"id":"T334","span":{"begin":396,"end":410},"obj":"Body_part"}],"attributes":[{"id":"A326","pred":"fma_id","subj":"T326","obj":"http://purl.org/sig/ont/fma/fma83365"},{"id":"A327","pred":"fma_id","subj":"T327","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A328","pred":"fma_id","subj":"T328","obj":"http://purl.org/sig/ont/fma/fma83365"},{"id":"A329","pred":"fma_id","subj":"T329","obj":"http://purl.org/sig/ont/fma/fma82743"},{"id":"A330","pred":"fma_id","subj":"T330","obj":"http://purl.org/sig/ont/fma/fma82743"},{"id":"A331","pred":"fma_id","subj":"T331","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A332","pred":"fma_id","subj":"T332","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A333","pred":"fma_id","subj":"T333","obj":"http://purl.org/sig/ont/fma/fma32558"},{"id":"A334","pred":"fma_id","subj":"T334","obj":"http://purl.org/sig/ont/fma/fma20110"}],"text":"Phosphorylation of AMPK results in activation of the insulin receptor (IR) and subsequent phosphorylation of PI3K followed by activation of AKT and protein kinase C (PKC) leading to GLUT4 translocation and subsequent activation of several molecules that modulate insulin-stimulated glucose transport, eventually leading to glucose influx into cells of several tissues such as skeletal muscle and adipose tissue [69,70,111]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T658","span":{"begin":35,"end":45},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T659","span":{"begin":53,"end":69},"obj":"http://purl.obolibrary.org/obo/PR_000009064"},{"id":"T660","span":{"begin":71,"end":73},"obj":"http://purl.obolibrary.org/obo/PR_000009064"},{"id":"T661","span":{"begin":126,"end":136},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T662","span":{"begin":217,"end":227},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T663","span":{"begin":263,"end":270},"obj":"http://purl.obolibrary.org/obo/PR_000009054"},{"id":"T664","span":{"begin":343,"end":348},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T665","span":{"begin":376,"end":391},"obj":"http://purl.obolibrary.org/obo/UBERON_0001134"},{"id":"T666","span":{"begin":376,"end":391},"obj":"http://purl.obolibrary.org/obo/UBERON_0014892"},{"id":"T667","span":{"begin":376,"end":391},"obj":"http://www.ebi.ac.uk/efo/EFO_0000888"},{"id":"T668","span":{"begin":396,"end":410},"obj":"http://purl.obolibrary.org/obo/UBERON_0001013"}],"text":"Phosphorylation of AMPK results in activation of the insulin receptor (IR) and subsequent phosphorylation of PI3K followed by activation of AKT and protein kinase C (PKC) leading to GLUT4 translocation and subsequent activation of several molecules that modulate insulin-stimulated glucose transport, eventually leading to glucose influx into cells of several tissues such as skeletal muscle and adipose tissue [69,70,111]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T698","span":{"begin":53,"end":60},"obj":"Chemical"},{"id":"T699","span":{"begin":71,"end":73},"obj":"Chemical"},{"id":"T700","span":{"begin":148,"end":155},"obj":"Chemical"},{"id":"T701","span":{"begin":239,"end":248},"obj":"Chemical"},{"id":"T702","span":{"begin":263,"end":270},"obj":"Chemical"},{"id":"T703","span":{"begin":282,"end":289},"obj":"Chemical"},{"id":"T705","span":{"begin":323,"end":330},"obj":"Chemical"}],"attributes":[{"id":"A698","pred":"chebi_id","subj":"T698","obj":"http://purl.obolibrary.org/obo/CHEBI_145810"},{"id":"A699","pred":"chebi_id","subj":"T699","obj":"http://purl.obolibrary.org/obo/CHEBI_74061"},{"id":"A700","pred":"chebi_id","subj":"T700","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A701","pred":"chebi_id","subj":"T701","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A702","pred":"chebi_id","subj":"T702","obj":"http://purl.obolibrary.org/obo/CHEBI_145810"},{"id":"A703","pred":"chebi_id","subj":"T703","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A704","pred":"chebi_id","subj":"T703","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"},{"id":"A705","pred":"chebi_id","subj":"T705","obj":"http://purl.obolibrary.org/obo/CHEBI_17234"},{"id":"A706","pred":"chebi_id","subj":"T705","obj":"http://purl.obolibrary.org/obo/CHEBI_4167"}],"text":"Phosphorylation of AMPK results in activation of the insulin receptor (IR) and subsequent phosphorylation of PI3K followed by activation of AKT and protein kinase C (PKC) leading to GLUT4 translocation and subsequent activation of several molecules that modulate insulin-stimulated glucose transport, eventually leading to glucose influx into cells of several tissues such as skeletal muscle and adipose tissue [69,70,111]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T185","span":{"begin":0,"end":15},"obj":"http://purl.obolibrary.org/obo/GO_0016310"},{"id":"T186","span":{"begin":19,"end":23},"obj":"http://purl.obolibrary.org/obo/GO_0050405"},{"id":"T187","span":{"begin":19,"end":23},"obj":"http://purl.obolibrary.org/obo/GO_0047322"},{"id":"T188","span":{"begin":19,"end":23},"obj":"http://purl.obolibrary.org/obo/GO_0004691"},{"id":"T189","span":{"begin":90,"end":105},"obj":"http://purl.obolibrary.org/obo/GO_0016310"},{"id":"T190","span":{"begin":109,"end":113},"obj":"http://purl.obolibrary.org/obo/GO_0016303"},{"id":"T191","span":{"begin":163,"end":170},"obj":"http://purl.obolibrary.org/obo/GO_0004697"},{"id":"T192","span":{"begin":282,"end":299},"obj":"http://purl.obolibrary.org/obo/GO_1904659"},{"id":"T193","span":{"begin":290,"end":299},"obj":"http://purl.obolibrary.org/obo/GO_0006810"}],"text":"Phosphorylation of AMPK results in activation of the insulin receptor (IR) and subsequent phosphorylation of PI3K followed by activation of AKT and protein kinase C (PKC) leading to GLUT4 translocation and subsequent activation of several molecules that modulate insulin-stimulated glucose transport, eventually leading to glucose influx into cells of several tissues such as skeletal muscle and adipose tissue [69,70,111]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T284","span":{"begin":0,"end":423},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Phosphorylation of AMPK results in activation of the insulin receptor (IR) and subsequent phosphorylation of PI3K followed by activation of AKT and protein kinase C (PKC) leading to GLUT4 translocation and subsequent activation of several molecules that modulate insulin-stimulated glucose transport, eventually leading to glucose influx into cells of several tissues such as skeletal muscle and adipose tissue [69,70,111]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1101","span":{"begin":19,"end":23},"obj":"Gene"},{"id":"1102","span":{"begin":53,"end":69},"obj":"Gene"},{"id":"1103","span":{"begin":140,"end":143},"obj":"Gene"},{"id":"1104","span":{"begin":182,"end":187},"obj":"Gene"},{"id":"1105","span":{"begin":263,"end":270},"obj":"Gene"},{"id":"1116","span":{"begin":282,"end":289},"obj":"Chemical"},{"id":"1117","span":{"begin":323,"end":330},"obj":"Chemical"}],"attributes":[{"id":"A1101","pred":"tao:has_database_id","subj":"1101","obj":"Gene:78975"},{"id":"A1102","pred":"tao:has_database_id","subj":"1102","obj":"Gene:24954"},{"id":"A1103","pred":"tao:has_database_id","subj":"1103","obj":"Gene:24185"},{"id":"A1104","pred":"tao:has_database_id","subj":"1104","obj":"Gene:25139"},{"id":"A1105","pred":"tao:has_database_id","subj":"1105","obj":"Gene:3630"},{"id":"A1116","pred":"tao:has_database_id","subj":"1116","obj":"MESH:D005947"},{"id":"A1117","pred":"tao:has_database_id","subj":"1117","obj":"MESH:D005947"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Phosphorylation of AMPK results in activation of the insulin receptor (IR) and subsequent phosphorylation of PI3K followed by activation of AKT and protein kinase C (PKC) leading to GLUT4 translocation and subsequent activation of several molecules that modulate insulin-stimulated glucose transport, eventually leading to glucose influx into cells of several tissues such as skeletal muscle and adipose tissue [69,70,111]."}