PMC:7601109 / 40633-41460
Annnotations
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T55 | 28-34 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T248 | 9-15 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
| T249 | 28-34 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
| T250 | 49-56 | Body_part | denotes | insulin | http://purl.org/sig/ont/fma/fma83365 |
| T251 | 61-68 | Body_part | denotes | glucose | http://purl.org/sig/ont/fma/fma82743 |
| T252 | 77-84 | Body_part | denotes | Insulin | http://purl.org/sig/ont/fma/fma83365 |
| T253 | 138-146 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T254 | 165-171 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
| T255 | 221-233 | Body_part | denotes | sarcoplasmic | http://purl.org/sig/ont/fma/fma67717 |
| T256 | 234-255 | Body_part | denotes | endoplasmic reticulum | http://purl.org/sig/ont/fma/fma63842 |
| T257 | 306-313 | Body_part | denotes | glucose | http://purl.org/sig/ont/fma/fma82743 |
| T258 | 343-355 | Body_part | denotes | cell surface | http://purl.org/sig/ont/fma/fma67653 |
| T259 | 343-347 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T260 | 360-367 | Body_part | denotes | glucose | http://purl.org/sig/ont/fma/fma82743 |
| T261 | 398-404 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
| T262 | 405-412 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T263 | 462-473 | Body_part | denotes | amino acids | http://purl.org/sig/ont/fma/fma82739 |
| T264 | 486-492 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
| T265 | 568-575 | Body_part | denotes | Insulin | http://purl.org/sig/ont/fma/fma83365 |
| T266 | 591-598 | Body_part | denotes | glucose | http://purl.org/sig/ont/fma/fma82743 |
| T267 | 641-647 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
| T268 | 730-736 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
| T269 | 800-807 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T92 | 591-610 | Disease | denotes | glucose intolerance | http://purl.obolibrary.org/obo/MONDO_0001076 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T530 | 0-15 | http://purl.obolibrary.org/obo/UBERON_0001134 | denotes | Skeletal muscle |
| T531 | 0-15 | http://purl.obolibrary.org/obo/UBERON_0014892 | denotes | Skeletal muscle |
| T532 | 0-15 | http://www.ebi.ac.uk/efo/EFO_0000888 | denotes | Skeletal muscle |
| T533 | 49-56 | http://purl.obolibrary.org/obo/PR_000009054 | denotes | insulin |
| T534 | 77-84 | http://purl.obolibrary.org/obo/PR_000009054 | denotes | Insulin |
| T535 | 150-155 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T536 | 156-171 | http://purl.obolibrary.org/obo/UBERON_0001134 | denotes | skeletal muscle |
| T537 | 156-171 | http://purl.obolibrary.org/obo/UBERON_0014892 | denotes | skeletal muscle |
| T538 | 156-171 | http://www.ebi.ac.uk/efo/EFO_0000888 | denotes | skeletal muscle |
| T539 | 343-347 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T540 | 398-404 | http://purl.obolibrary.org/obo/UBERON_0001630 | denotes | muscle |
| T541 | 398-404 | http://purl.obolibrary.org/obo/UBERON_0005090 | denotes | muscle |
| T542 | 398-404 | http://www.ebi.ac.uk/efo/EFO_0000801 | denotes | muscle |
| T543 | 398-404 | http://www.ebi.ac.uk/efo/EFO_0001949 | denotes | muscle |
| T544 | 477-492 | http://purl.obolibrary.org/obo/UBERON_0001134 | denotes | skeletal muscle |
| T545 | 477-492 | http://purl.obolibrary.org/obo/UBERON_0014892 | denotes | skeletal muscle |
| T546 | 477-492 | http://www.ebi.ac.uk/efo/EFO_0000888 | denotes | skeletal muscle |
| T547 | 568-575 | http://purl.obolibrary.org/obo/PR_000009054 | denotes | Insulin |
| T548 | 641-647 | http://purl.obolibrary.org/obo/UBERON_0001630 | denotes | muscle |
| T549 | 641-647 | http://purl.obolibrary.org/obo/UBERON_0005090 | denotes | muscle |
| T550 | 641-647 | http://www.ebi.ac.uk/efo/EFO_0000801 | denotes | muscle |
| T551 | 641-647 | http://www.ebi.ac.uk/efo/EFO_0001949 | denotes | muscle |
| T552 | 721-736 | http://purl.obolibrary.org/obo/UBERON_0001134 | denotes | skeletal muscle |
| T553 | 721-736 | http://purl.obolibrary.org/obo/UBERON_0014892 | denotes | skeletal muscle |
| T554 | 721-736 | http://www.ebi.ac.uk/efo/EFO_0000888 | denotes | skeletal muscle |
| T555 | 752-762 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T556 | 790-799 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activated |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T590 | 49-56 | Chemical | denotes | insulin | http://purl.obolibrary.org/obo/CHEBI_145810 |
| T591 | 61-68 | Chemical | denotes | glucose | http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167 |
| T593 | 77-84 | Chemical | denotes | Insulin | http://purl.obolibrary.org/obo/CHEBI_5931 |
| T594 | 138-146 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T595 | 191-198 | Chemical | denotes | calcium | http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320 |
| T597 | 306-313 | Chemical | denotes | glucose | http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167 |
| T599 | 360-367 | Chemical | denotes | glucose | http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167 |
| T601 | 405-412 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T602 | 462-473 | Chemical | denotes | amino acids | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T603 | 462-467 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T604 | 468-473 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T605 | 568-575 | Chemical | denotes | Insulin | http://purl.obolibrary.org/obo/CHEBI_5931 |
| T606 | 591-598 | Chemical | denotes | glucose | http://purl.obolibrary.org/obo/CHEBI_17234|http://purl.obolibrary.org/obo/CHEBI_4167 |
| T608 | 671-690 | Chemical | denotes | hypoglycemic agents | http://purl.obolibrary.org/obo/CHEBI_35526 |
| T609 | 699-708 | Chemical | denotes | metformin | http://purl.obolibrary.org/obo/CHEBI_6801 |
| T610 | 766-775 | Chemical | denotes | adenosine | http://purl.obolibrary.org/obo/CHEBI_16335 |
| T611 | 800-807 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T88 | 61-75 | http://purl.obolibrary.org/obo/GO_0046323 | denotes | glucose uptake |
| T89 | 69-75 | http://purl.obolibrary.org/obo/GO_0098739 | denotes | uptake |
| T90 | 69-75 | http://purl.obolibrary.org/obo/GO_0098657 | denotes | uptake |
| T91 | 109-134 | http://purl.obolibrary.org/obo/GO_0006119 | denotes | oxidative phosphorylation |
| T92 | 119-134 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
| T93 | 191-211 | http://purl.obolibrary.org/obo/GO_0051209 | denotes | calcium mobilization |
| T94 | 306-325 | http://purl.obolibrary.org/obo/GO_1904659 | denotes | glucose transporter |
| T95 | 360-374 | http://purl.obolibrary.org/obo/GO_0046323 | denotes | glucose uptake |
| T96 | 368-374 | http://purl.obolibrary.org/obo/GO_0098739 | denotes | uptake |
| T97 | 368-374 | http://purl.obolibrary.org/obo/GO_0098657 | denotes | uptake |
| T98 | 405-422 | http://purl.obolibrary.org/obo/GO_0006412 | denotes | protein synthesis |
| T99 | 413-422 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T100 | 737-747 | http://purl.obolibrary.org/obo/GO_0008152 | denotes | metabolism |
| T101 | 816-820 | http://purl.obolibrary.org/obo/GO_0050405 | denotes | AMPK |
| T102 | 816-820 | http://purl.obolibrary.org/obo/GO_0047322 | denotes | AMPK |
| T103 | 816-820 | http://purl.obolibrary.org/obo/GO_0004691 | denotes | AMPK |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T43 | 568-586 | Phenotype | denotes | Insulin resistance | http://purl.obolibrary.org/obo/HP_0000855 |
| T44 | 591-610 | Phenotype | denotes | glucose intolerance | http://purl.obolibrary.org/obo/HP_0001952 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T252 | 0-76 | Sentence | denotes | Skeletal muscle is the main tissue that utilizes insulin for glucose uptake. |
| T253 | 77-375 | Sentence | denotes | Insulin regulates mitochondrial oxidative phosphorylation of proteins in human skeletal muscle and contributes to calcium mobilization from the sarcoplasmic-endoplasmic reticulum to mitochondria to stimulate the translocation of glucose transporter 4 (GLUT4) to the cell surface for glucose uptake. |
| T254 | 376-567 | Sentence | denotes | This process improves muscle protein synthesis in healthy people when the delivery of amino acids to skeletal muscle is increased, eventually leading to increased muscular mass [124,125,126]. |
| T255 | 568-653 | Sentence | denotes | Insulin resistance and glucose intolerance increase with old age evoking muscle loss. |
| T256 | 654-827 | Sentence | denotes | In this respect, hypoglycemic agents such as metformin can improve skeletal muscle metabolism via activation of adenosine monophosphate activated protein kinase (AMPK) [21]. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 926 | 306-327 | Gene | denotes | glucose transporter 4 | Gene:6517 |
| 927 | 329-334 | Gene | denotes | GLUT4 | Gene:6517 |
| 928 | 568-575 | Gene | denotes | Insulin | Gene:3630 |
| 929 | 816-820 | Gene | denotes | AMPK | Gene:78975 |
| 930 | 77-84 | Gene | denotes | Insulin | Gene:3630 |
| 931 | 49-56 | Gene | denotes | insulin | Gene:3630 |
| 932 | 629-632 | Gene | denotes | age | Gene:81759 |
| 933 | 150-155 | Species | denotes | human | Tax:9606 |
| 934 | 434-440 | Species | denotes | people | Tax:9606 |
| 935 | 61-68 | Chemical | denotes | glucose | MESH:D005947 |
| 936 | 191-198 | Chemical | denotes | calcium | MESH:D002118 |
| 937 | 360-367 | Chemical | denotes | glucose | MESH:D005947 |
| 938 | 591-598 | Chemical | denotes | glucose | MESH:D005947 |
| 939 | 699-708 | Chemical | denotes | metformin | MESH:D008687 |
| 940 | 766-775 | Chemical | denotes | adenosine | MESH:D000241 |
| 941 | 641-652 | Disease | denotes | muscle loss | MESH:D009135 |