PMC:7601109 / 30658-32614 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7601109","sourcedb":"PMC","sourceid":"7601109","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7601109","text":"The role that inflammation plays in skeletal muscle is not quite clear as it looks. Inflammatory mediators behave in a dual fashion in muscle cells. During injury, cytokines and chemokines stimulate muscle repair and regeneration via activation of myoblasts, a core event in muscle remodeling [108]. Similarly, serum and muscle levels of IL-6 temporarily increase following physical exercise, and IL-6 blocks the activity of catabolic cytokines such as TNF-α. On the other hand, chronic inflammation in muscle cells, which correlates with persistent mitochondrial dysfunction and metabolic dysregulation, pathologically activates muscle fiber transformation and atrophy, eventually resulting in the development of sarcopenia [23,114]. It seems that bee products also act dually in skeletal muscle: they support the activity of cytokines that promote muscle remodeling [108] and suppress muscle-consuming cytokines [38,101,108]. In this regard, treating undifferentiated C2C12 myoblasts with ethanolic extracts of Brazilian propolis (100 μg/mL for 8 h) triggered the migration of RAW264 macrophage and increased their production of angiogenic factors (e.g., vascular endothelial growth factor A (VEGF-A) and metalloproteinase-12 (MMP-12)), chemokines (e.g., CCL-2 and CCL-5), and cytokines (e.g., IL-6, which increased by 40-folds). Propolis inhibited the expression of IL-1β and TNF-α at 4, 8, and 12 h of incubation. These effects were nuclear factor kappa B (NF-κB)-dependent given that propolis simultaneously increased nuclear translocation of p65 and p50 NF-κB proteins 3 h after treatment. Meanwhile, inhibiting IκB kinase (IKK) by BMS-345541 profoundly hindered the effect of propolis on the expression of CCL-2, CCL-5, and IL-6 by 66%, 81%, and 69%, respectively. Propolis also enhanced the expression of MAIL/IκBζ. This molecule modulates chromatin and selectively induces the production of IL-6, leukemia inhibitory factor (LIF), and CCL-2 [108].","tracks":[{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T30","span":{"begin":311,"end":316},"obj":"Body_part"},{"id":"T31","span":{"begin":473,"end":477},"obj":"Body_part"}],"attributes":[{"id":"A30","pred":"uberon_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A31","pred":"uberon_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/UBERON_0002398"},{"subj":"T30","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T31","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T137","span":{"begin":45,"end":51},"obj":"Body_part"},{"id":"T138","span":{"begin":135,"end":147},"obj":"Body_part"},{"id":"T139","span":{"begin":142,"end":147},"obj":"Body_part"},{"id":"T140","span":{"begin":164,"end":173},"obj":"Body_part"},{"id":"T141","span":{"begin":178,"end":188},"obj":"Body_part"},{"id":"T142","span":{"begin":199,"end":205},"obj":"Body_part"},{"id":"T143","span":{"begin":248,"end":257},"obj":"Body_part"},{"id":"T144","span":{"begin":275,"end":281},"obj":"Body_part"},{"id":"T145","span":{"begin":311,"end":316},"obj":"Body_part"},{"id":"T146","span":{"begin":321,"end":327},"obj":"Body_part"},{"id":"T147","span":{"begin":338,"end":340},"obj":"Body_part"},{"id":"T148","span":{"begin":397,"end":399},"obj":"Body_part"},{"id":"T149","span":{"begin":435,"end":444},"obj":"Body_part"},{"id":"T150","span":{"begin":473,"end":477},"obj":"Body_part"},{"id":"T151","span":{"begin":503,"end":515},"obj":"Body_part"},{"id":"T152","span":{"begin":510,"end":515},"obj":"Body_part"},{"id":"T153","span":{"begin":630,"end":642},"obj":"Body_part"},{"id":"T154","span":{"begin":790,"end":796},"obj":"Body_part"},{"id":"T155","span":{"begin":827,"end":836},"obj":"Body_part"},{"id":"T156","span":{"begin":850,"end":856},"obj":"Body_part"},{"id":"T157","span":{"begin":887,"end":893},"obj":"Body_part"},{"id":"T158","span":{"begin":904,"end":913},"obj":"Body_part"},{"id":"T159","span":{"begin":976,"end":985},"obj":"Body_part"},{"id":"T160","span":{"begin":1086,"end":1096},"obj":"Body_part"},{"id":"T161","span":{"begin":1239,"end":1249},"obj":"Body_part"},{"id":"T162","span":{"begin":1279,"end":1288},"obj":"Body_part"},{"id":"T163","span":{"begin":1296,"end":1298},"obj":"Body_part"},{"id":"T164","span":{"begin":1369,"end":1373},"obj":"Body_part"},{"id":"T165","span":{"begin":1369,"end":1371},"obj":"Body_part"},{"id":"T166","span":{"begin":1566,"end":1574},"obj":"Body_part"},{"id":"T167","span":{"begin":1731,"end":1733},"obj":"Body_part"},{"id":"T168","span":{"begin":1848,"end":1857},"obj":"Body_part"},{"id":"T169","span":{"begin":1900,"end":1902},"obj":"Body_part"}],"attributes":[{"id":"A137","pred":"fma_id","subj":"T137","obj":"http://purl.org/sig/ont/fma/fma32558"},{"id":"A138","pred":"fma_id","subj":"T138","obj":"http://purl.org/sig/ont/fma/fma67328"},{"id":"A139","pred":"fma_id","subj":"T139","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A140","pred":"fma_id","subj":"T140","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A141","pred":"fma_id","subj":"T141","obj":"http://purl.org/sig/ont/fma/fma241981"},{"id":"A142","pred":"fma_id","subj":"T142","obj":"http://purl.org/sig/ont/fma/fma32558"},{"id":"A143","pred":"fma_id","subj":"T143","obj":"http://purl.org/sig/ont/fma/fma70335"},{"id":"A144","pred":"fma_id","subj":"T144","obj":"http://purl.org/sig/ont/fma/fma32558"},{"id":"A145","pred":"fma_id","subj":"T145","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A146","pred":"fma_id","subj":"T146","obj":"http://purl.org/sig/ont/fma/fma32558"},{"id":"A147","pred":"fma_id","subj":"T147","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A148","pred":"fma_id","subj":"T148","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A149","pred":"fma_id","subj":"T149","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A150","pred":"fma_id","subj":"T150","obj":"http://purl.org/sig/ont/fma/fma9712"},{"id":"A151","pred":"fma_id","subj":"T151","obj":"http://purl.org/sig/ont/fma/fma67328"},{"id":"A152","pred":"fma_id","subj":"T152","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A153","pred":"fma_id","subj":"T153","obj":"http://purl.org/sig/ont/fma/fma67328"},{"id":"A154","pred":"fma_id","subj":"T154","obj":"http://purl.org/sig/ont/fma/fma32558"},{"id":"A155","pred":"fma_id","subj":"T155","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A156","pred":"fma_id","subj":"T156","obj":"http://purl.org/sig/ont/fma/fma32558"},{"id":"A157","pred":"fma_id","subj":"T157","obj":"http://purl.org/sig/ont/fma/fma32558"},{"id":"A158","pred":"fma_id","subj":"T158","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A159","pred":"fma_id","subj":"T159","obj":"http://purl.org/sig/ont/fma/fma70335"},{"id":"A160","pred":"fma_id","subj":"T160","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A161","pred":"fma_id","subj":"T161","obj":"http://purl.org/sig/ont/fma/fma241981"},{"id":"A162","pred":"fma_id","subj":"T162","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A163","pred":"fma_id","subj":"T163","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A164","pred":"fma_id","subj":"T164","obj":"http://purl.org/sig/ont/fma/fma86583"},{"id":"A165","pred":"fma_id","subj":"T165","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A166","pred":"fma_id","subj":"T166","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A167","pred":"fma_id","subj":"T167","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A168","pred":"fma_id","subj":"T168","obj":"http://purl.org/sig/ont/fma/fma67526"},{"id":"A169","pred":"fma_id","subj":"T169","obj":"http://purl.org/sig/ont/fma/fma86578"},{"subj":"T137","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T138","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T139","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T140","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T141","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T142","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T143","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T144","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T145","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T146","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T147","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T148","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T149","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T150","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T151","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T152","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T153","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T154","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T155","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T156","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T157","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T158","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T159","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T160","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T161","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T162","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T163","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T164","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T165","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T166","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T167","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T168","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T169","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T70","span":{"begin":14,"end":26},"obj":"Disease"},{"id":"T71","span":{"begin":156,"end":162},"obj":"Disease"},{"id":"T72","span":{"begin":487,"end":499},"obj":"Disease"},{"id":"T73","span":{"begin":714,"end":724},"obj":"Disease"},{"id":"T74","span":{"begin":1638,"end":1641},"obj":"Disease"},{"id":"T75","span":{"begin":1906,"end":1914},"obj":"Disease"}],"attributes":[{"id":"A70","pred":"mondo_id","subj":"T70","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A71","pred":"mondo_id","subj":"T71","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A72","pred":"mondo_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A73","pred":"mondo_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/MONDO_0006516"},{"id":"A74","pred":"mondo_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/MONDO_0006687"},{"id":"A75","pred":"mondo_id","subj":"T75","obj":"http://purl.obolibrary.org/obo/MONDO_0005059"},{"subj":"T70","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T71","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T72","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T73","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T74","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T75","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T304","span":{"begin":36,"end":51},"obj":"http://purl.obolibrary.org/obo/UBERON_0001134"},{"id":"T305","span":{"begin":36,"end":51},"obj":"http://purl.obolibrary.org/obo/UBERON_0014892"},{"id":"T306","span":{"begin":36,"end":51},"obj":"http://www.ebi.ac.uk/efo/EFO_0000888"},{"id":"T307","span":{"begin":117,"end":118},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T308","span":{"begin":135,"end":147},"obj":"http://purl.obolibrary.org/obo/CL_0000187"},{"id":"T309","span":{"begin":199,"end":205},"obj":"http://purl.obolibrary.org/obo/UBERON_0001630"},{"id":"T310","span":{"begin":199,"end":205},"obj":"http://purl.obolibrary.org/obo/UBERON_0005090"},{"id":"T311","span":{"begin":199,"end":205},"obj":"http://www.ebi.ac.uk/efo/EFO_0000801"},{"id":"T312","span":{"begin":199,"end":205},"obj":"http://www.ebi.ac.uk/efo/EFO_0001949"},{"id":"T313","span":{"begin":234,"end":244},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T314","span":{"begin":259,"end":260},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T315","span":{"begin":275,"end":281},"obj":"http://purl.obolibrary.org/obo/UBERON_0001630"},{"id":"T316","span":{"begin":275,"end":281},"obj":"http://purl.obolibrary.org/obo/UBERON_0005090"},{"id":"T317","span":{"begin":275,"end":281},"obj":"http://www.ebi.ac.uk/efo/EFO_0000801"},{"id":"T318","span":{"begin":275,"end":281},"obj":"http://www.ebi.ac.uk/efo/EFO_0001949"},{"id":"T319","span":{"begin":321,"end":327},"obj":"http://purl.obolibrary.org/obo/UBERON_0001630"},{"id":"T320","span":{"begin":321,"end":327},"obj":"http://purl.obolibrary.org/obo/UBERON_0005090"},{"id":"T321","span":{"begin":321,"end":327},"obj":"http://www.ebi.ac.uk/efo/EFO_0000801"},{"id":"T322","span":{"begin":321,"end":327},"obj":"http://www.ebi.ac.uk/efo/EFO_0001949"},{"id":"T323","span":{"begin":413,"end":421},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T324","span":{"begin":503,"end":515},"obj":"http://purl.obolibrary.org/obo/CL_0000187"},{"id":"T325","span":{"begin":620,"end":629},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T326","span":{"begin":630,"end":636},"obj":"http://purl.obolibrary.org/obo/UBERON_0001630"},{"id":"T327","span":{"begin":630,"end":636},"obj":"http://purl.obolibrary.org/obo/UBERON_0005090"},{"id":"T328","span":{"begin":630,"end":636},"obj":"http://www.ebi.ac.uk/efo/EFO_0000801"},{"id":"T329","span":{"begin":630,"end":636},"obj":"http://www.ebi.ac.uk/efo/EFO_0001949"},{"id":"T330","span":{"begin":781,"end":796},"obj":"http://purl.obolibrary.org/obo/UBERON_0001134"},{"id":"T331","span":{"begin":781,"end":796},"obj":"http://purl.obolibrary.org/obo/UBERON_0014892"},{"id":"T332","span":{"begin":781,"end":796},"obj":"http://www.ebi.ac.uk/efo/EFO_0000888"},{"id":"T333","span":{"begin":815,"end":823},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T334","span":{"begin":850,"end":856},"obj":"http://purl.obolibrary.org/obo/UBERON_0001630"},{"id":"T335","span":{"begin":850,"end":856},"obj":"http://purl.obolibrary.org/obo/UBERON_0005090"},{"id":"T336","span":{"begin":850,"end":856},"obj":"http://www.ebi.ac.uk/efo/EFO_0000801"},{"id":"T337","span":{"begin":850,"end":856},"obj":"http://www.ebi.ac.uk/efo/EFO_0001949"},{"id":"T338","span":{"begin":887,"end":893},"obj":"http://purl.obolibrary.org/obo/UBERON_0001630"},{"id":"T339","span":{"begin":887,"end":893},"obj":"http://purl.obolibrary.org/obo/UBERON_0005090"},{"id":"T340","span":{"begin":887,"end":893},"obj":"http://www.ebi.ac.uk/efo/EFO_0000801"},{"id":"T341","span":{"begin":887,"end":893},"obj":"http://www.ebi.ac.uk/efo/EFO_0001949"},{"id":"T342","span":{"begin":970,"end":975},"obj":"http://purl.obolibrary.org/obo/CLO_0050871"},{"id":"T343","span":{"begin":1079,"end":1085},"obj":"http://purl.obolibrary.org/obo/CLO_0008752"},{"id":"T344","span":{"begin":1079,"end":1085},"obj":"http://purl.obolibrary.org/obo/CLO_0051424"},{"id":"T345","span":{"begin":1192,"end":1193},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T346","span":{"begin":1200,"end":1201},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T347","span":{"begin":1388,"end":1392},"obj":"http://purl.obolibrary.org/obo/CLO_0001382"},{"id":"T348","span":{"begin":1458,"end":1459},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T349","span":{"begin":1465,"end":1466},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T350","span":{"begin":1564,"end":1565},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T351","span":{"begin":1620,"end":1621},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T352","span":{"begin":1820,"end":1821},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"}],"attributes":[{"subj":"T304","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T305","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T306","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T307","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T308","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T309","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T310","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T311","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T312","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T313","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T314","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T315","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T316","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T317","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T318","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T319","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T320","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T321","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T322","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T323","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T324","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T325","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T326","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T327","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T328","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T329","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T330","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T331","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T332","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T333","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T334","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T335","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T336","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T337","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T338","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T339","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T340","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T341","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T342","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T343","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T344","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T345","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T346","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T347","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T348","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T349","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T350","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T351","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T352","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T439","span":{"begin":338,"end":340},"obj":"Chemical"},{"id":"T441","span":{"begin":397,"end":399},"obj":"Chemical"},{"id":"T443","span":{"begin":1185,"end":1193},"obj":"Chemical"},{"id":"T444","span":{"begin":1229,"end":1232},"obj":"Chemical"},{"id":"T446","span":{"begin":1257,"end":1260},"obj":"Chemical"},{"id":"T447","span":{"begin":1267,"end":1270},"obj":"Chemical"},{"id":"T448","span":{"begin":1296,"end":1298},"obj":"Chemical"},{"id":"T450","span":{"begin":1369,"end":1371},"obj":"Chemical"},{"id":"T452","span":{"begin":1461,"end":1463},"obj":"Chemical"},{"id":"T455","span":{"begin":1560,"end":1562},"obj":"Chemical"},{"id":"T458","span":{"begin":1566,"end":1574},"obj":"Chemical"},{"id":"T459","span":{"begin":1713,"end":1716},"obj":"Chemical"},{"id":"T460","span":{"begin":1720,"end":1723},"obj":"Chemical"},{"id":"T461","span":{"begin":1731,"end":1733},"obj":"Chemical"},{"id":"T463","span":{"begin":1829,"end":1837},"obj":"Chemical"},{"id":"T464","span":{"begin":1900,"end":1902},"obj":"Chemical"},{"id":"T466","span":{"begin":1944,"end":1947},"obj":"Chemical"}],"attributes":[{"id":"A439","pred":"chebi_id","subj":"T439","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A440","pred":"chebi_id","subj":"T439","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A441","pred":"chebi_id","subj":"T441","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A442","pred":"chebi_id","subj":"T441","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A443","pred":"chebi_id","subj":"T443","obj":"http://purl.obolibrary.org/obo/CHEBI_79381"},{"id":"A444","pred":"chebi_id","subj":"T444","obj":"http://purl.obolibrary.org/obo/CHEBI_340824"},{"id":"A445","pred":"chebi_id","subj":"T444","obj":"http://purl.obolibrary.org/obo/CHEBI_59761"},{"id":"A446","pred":"chebi_id","subj":"T446","obj":"http://purl.obolibrary.org/obo/CHEBI_3478"},{"id":"A447","pred":"chebi_id","subj":"T447","obj":"http://purl.obolibrary.org/obo/CHEBI_3478"},{"id":"A448","pred":"chebi_id","subj":"T448","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A449","pred":"chebi_id","subj":"T448","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A450","pred":"chebi_id","subj":"T450","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A451","pred":"chebi_id","subj":"T450","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A452","pred":"chebi_id","subj":"T452","obj":"http://purl.obolibrary.org/obo/CHEBI_141424"},{"id":"A453","pred":"chebi_id","subj":"T452","obj":"http://purl.obolibrary.org/obo/CHEBI_25573"},{"id":"A454","pred":"chebi_id","subj":"T452","obj":"http://purl.obolibrary.org/obo/CHEBI_1224"},{"id":"A455","pred":"chebi_id","subj":"T455","obj":"http://purl.obolibrary.org/obo/CHEBI_141424"},{"id":"A456","pred":"chebi_id","subj":"T455","obj":"http://purl.obolibrary.org/obo/CHEBI_25573"},{"id":"A457","pred":"chebi_id","subj":"T455","obj":"http://purl.obolibrary.org/obo/CHEBI_1224"},{"id":"A458","pred":"chebi_id","subj":"T458","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A459","pred":"chebi_id","subj":"T459","obj":"http://purl.obolibrary.org/obo/CHEBI_3478"},{"id":"A460","pred":"chebi_id","subj":"T460","obj":"http://purl.obolibrary.org/obo/CHEBI_3478"},{"id":"A461","pred":"chebi_id","subj":"T461","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A462","pred":"chebi_id","subj":"T461","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A463","pred":"chebi_id","subj":"T463","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A464","pred":"chebi_id","subj":"T464","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A465","pred":"chebi_id","subj":"T464","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A466","pred":"chebi_id","subj":"T466","obj":"http://purl.obolibrary.org/obo/CHEBI_3478"},{"subj":"T439","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T441","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T443","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T444","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T446","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T447","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T448","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T450","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T452","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T455","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T458","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T459","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T460","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T461","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T463","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T464","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T466","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T42","span":{"begin":14,"end":26},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T43","span":{"begin":217,"end":229},"obj":"http://purl.obolibrary.org/obo/GO_0031099"},{"id":"T44","span":{"begin":487,"end":499},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T45","span":{"begin":1178,"end":1184},"obj":"http://purl.obolibrary.org/obo/GO_0040007"}],"attributes":[{"subj":"T42","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T43","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T44","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T45","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T32","span":{"begin":550,"end":575},"obj":"Phenotype"},{"id":"T33","span":{"begin":1906,"end":1914},"obj":"Phenotype"}],"attributes":[{"id":"A32","pred":"hp_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/HP_0003287"},{"id":"A33","pred":"hp_id","subj":"T33","obj":"http://purl.obolibrary.org/obo/HP_0001909"},{"subj":"T32","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T33","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T201","span":{"begin":0,"end":83},"obj":"Sentence"},{"id":"T202","span":{"begin":84,"end":148},"obj":"Sentence"},{"id":"T203","span":{"begin":149,"end":299},"obj":"Sentence"},{"id":"T204","span":{"begin":300,"end":459},"obj":"Sentence"},{"id":"T205","span":{"begin":460,"end":734},"obj":"Sentence"},{"id":"T206","span":{"begin":735,"end":927},"obj":"Sentence"},{"id":"T207","span":{"begin":928,"end":1331},"obj":"Sentence"},{"id":"T208","span":{"begin":1332,"end":1417},"obj":"Sentence"},{"id":"T209","span":{"begin":1418,"end":1595},"obj":"Sentence"},{"id":"T210","span":{"begin":1596,"end":1771},"obj":"Sentence"},{"id":"T211","span":{"begin":1772,"end":1823},"obj":"Sentence"},{"id":"T212","span":{"begin":1824,"end":1956},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T201","pred":"source","obj":"LitCovid-sentences"},{"subj":"T202","pred":"source","obj":"LitCovid-sentences"},{"subj":"T203","pred":"source","obj":"LitCovid-sentences"},{"subj":"T204","pred":"source","obj":"LitCovid-sentences"},{"subj":"T205","pred":"source","obj":"LitCovid-sentences"},{"subj":"T206","pred":"source","obj":"LitCovid-sentences"},{"subj":"T207","pred":"source","obj":"LitCovid-sentences"},{"subj":"T208","pred":"source","obj":"LitCovid-sentences"},{"subj":"T209","pred":"source","obj":"LitCovid-sentences"},{"subj":"T210","pred":"source","obj":"LitCovid-sentences"},{"subj":"T211","pred":"source","obj":"LitCovid-sentences"},{"subj":"T212","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"632","span":{"begin":338,"end":342},"obj":"Gene"},{"id":"633","span":{"begin":397,"end":401},"obj":"Gene"},{"id":"634","span":{"begin":453,"end":458},"obj":"Gene"},{"id":"635","span":{"begin":1157,"end":1193},"obj":"Gene"},{"id":"636","span":{"begin":1195,"end":1201},"obj":"Gene"},{"id":"637","span":{"begin":1229,"end":1235},"obj":"Gene"},{"id":"638","span":{"begin":1257,"end":1262},"obj":"Gene"},{"id":"639","span":{"begin":1267,"end":1272},"obj":"Gene"},{"id":"640","span":{"begin":1296,"end":1300},"obj":"Gene"},{"id":"641","span":{"begin":1369,"end":1374},"obj":"Gene"},{"id":"642","span":{"begin":1379,"end":1384},"obj":"Gene"},{"id":"643","span":{"begin":1437,"end":1459},"obj":"Gene"},{"id":"644","span":{"begin":1461,"end":1466},"obj":"Gene"},{"id":"645","span":{"begin":1548,"end":1551},"obj":"Gene"},{"id":"646","span":{"begin":1560,"end":1565},"obj":"Gene"},{"id":"647","span":{"begin":1713,"end":1718},"obj":"Gene"},{"id":"648","span":{"begin":1720,"end":1725},"obj":"Gene"},{"id":"649","span":{"begin":1731,"end":1735},"obj":"Gene"},{"id":"650","span":{"begin":1813,"end":1817},"obj":"Gene"},{"id":"651","span":{"begin":1818,"end":1822},"obj":"Gene"},{"id":"652","span":{"begin":1900,"end":1904},"obj":"Gene"},{"id":"653","span":{"begin":1906,"end":1932},"obj":"Gene"},{"id":"654","span":{"begin":1934,"end":1937},"obj":"Gene"},{"id":"655","span":{"begin":1944,"end":1949},"obj":"Gene"},{"id":"656","span":{"begin":14,"end":26},"obj":"Disease"},{"id":"657","span":{"begin":487,"end":499},"obj":"Disease"},{"id":"658","span":{"begin":550,"end":575},"obj":"Disease"},{"id":"659","span":{"begin":662,"end":669},"obj":"Disease"},{"id":"660","span":{"begin":714,"end":724},"obj":"Disease"},{"id":"661","span":{"begin":1079,"end":1085},"obj":"CellLine"}],"attributes":[{"id":"A632","pred":"tao:has_database_id","subj":"632","obj":"Gene:24498"},{"id":"A633","pred":"tao:has_database_id","subj":"633","obj":"Gene:24498"},{"id":"A634","pred":"tao:has_database_id","subj":"634","obj":"Gene:24835"},{"id":"A635","pred":"tao:has_database_id","subj":"635","obj":"Gene:83785"},{"id":"A636","pred":"tao:has_database_id","subj":"636","obj":"Gene:83785"},{"id":"A637","pred":"tao:has_database_id","subj":"637","obj":"Gene:117033"},{"id":"A638","pred":"tao:has_database_id","subj":"638","obj":"Gene:24770"},{"id":"A639","pred":"tao:has_database_id","subj":"639","obj":"Gene:81780"},{"id":"A640","pred":"tao:has_database_id","subj":"640","obj":"Gene:24498"},{"id":"A641","pred":"tao:has_database_id","subj":"641","obj":"Gene:24493"},{"id":"A642","pred":"tao:has_database_id","subj":"642","obj":"Gene:24835"},{"id":"A643","pred":"tao:has_database_id","subj":"643","obj":"Gene:18033"},{"id":"A644","pred":"tao:has_database_id","subj":"644","obj":"Gene:18033"},{"id":"A645","pred":"tao:has_database_id","subj":"645","obj":"Gene:25716"},{"id":"A646","pred":"tao:has_database_id","subj":"646","obj":"Gene:18033"},{"id":"A647","pred":"tao:has_database_id","subj":"647","obj":"Gene:24770"},{"id":"A648","pred":"tao:has_database_id","subj":"648","obj":"Gene:81780"},{"id":"A649","pred":"tao:has_database_id","subj":"649","obj":"Gene:24498"},{"id":"A650","pred":"tao:has_database_id","subj":"650","obj":"Gene:304005"},{"id":"A651","pred":"tao:has_database_id","subj":"651","obj":"Gene:304005"},{"id":"A652","pred":"tao:has_database_id","subj":"652","obj":"Gene:24498"},{"id":"A653","pred":"tao:has_database_id","subj":"653","obj":"Gene:60584"},{"id":"A654","pred":"tao:has_database_id","subj":"654","obj":"Gene:60584"},{"id":"A655","pred":"tao:has_database_id","subj":"655","obj":"Gene:24770"},{"id":"A656","pred":"tao:has_database_id","subj":"656","obj":"MESH:D007249"},{"id":"A657","pred":"tao:has_database_id","subj":"657","obj":"MESH:D007249"},{"id":"A658","pred":"tao:has_database_id","subj":"658","obj":"MESH:D028361"},{"id":"A659","pred":"tao:has_database_id","subj":"659","obj":"MESH:D001284"},{"id":"A660","pred":"tao:has_database_id","subj":"660","obj":"MESH:D055948"},{"id":"A661","pred":"tao:has_database_id","subj":"661","obj":"CVCL:4478"},{"subj":"632","pred":"source","obj":"LitCovid-PubTator"},{"subj":"633","pred":"source","obj":"LitCovid-PubTator"},{"subj":"634","pred":"source","obj":"LitCovid-PubTator"},{"subj":"635","pred":"source","obj":"LitCovid-PubTator"},{"subj":"636","pred":"source","obj":"LitCovid-PubTator"},{"subj":"637","pred":"source","obj":"LitCovid-PubTator"},{"subj":"638","pred":"source","obj":"LitCovid-PubTator"},{"subj":"639","pred":"source","obj":"LitCovid-PubTator"},{"subj":"640","pred":"source","obj":"LitCovid-PubTator"},{"subj":"641","pred":"source","obj":"LitCovid-PubTator"},{"subj":"642","pred":"source","obj":"LitCovid-PubTator"},{"subj":"643","pred":"source","obj":"LitCovid-PubTator"},{"subj":"644","pred":"source","obj":"LitCovid-PubTator"},{"subj":"645","pred":"source","obj":"LitCovid-PubTator"},{"subj":"646","pred":"source","obj":"LitCovid-PubTator"},{"subj":"647","pred":"source","obj":"LitCovid-PubTator"},{"subj":"648","pred":"source","obj":"LitCovid-PubTator"},{"subj":"649","pred":"source","obj":"LitCovid-PubTator"},{"subj":"650","pred":"source","obj":"LitCovid-PubTator"},{"subj":"651","pred":"source","obj":"LitCovid-PubTator"},{"subj":"652","pred":"source","obj":"LitCovid-PubTator"},{"subj":"653","pred":"source","obj":"LitCovid-PubTator"},{"subj":"654","pred":"source","obj":"LitCovid-PubTator"},{"subj":"655","pred":"source","obj":"LitCovid-PubTator"},{"subj":"656","pred":"source","obj":"LitCovid-PubTator"},{"subj":"657","pred":"source","obj":"LitCovid-PubTator"},{"subj":"658","pred":"source","obj":"LitCovid-PubTator"},{"subj":"659","pred":"source","obj":"LitCovid-PubTator"},{"subj":"660","pred":"source","obj":"LitCovid-PubTator"},{"subj":"661","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-UBERON","color":"#dd93ec","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#93ecc3"},{"id":"LitCovid-PD-MONDO","color":"#eca993"},{"id":"LitCovid-PD-CLO","color":"#9396ec"},{"id":"LitCovid-PD-CHEBI","color":"#b0ec93"},{"id":"LitCovid-PD-GO-BP","color":"#ec93ca"},{"id":"LitCovid-PD-HP","color":"#93e4ec"},{"id":"LitCovid-sentences","color":"#ecd993"},{"id":"LitCovid-PubTator","color":"#bf93ec"}]}]}}