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PMC:7601109 / 2910-6142 JSONTXT

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LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T2 1318-1322 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T3 1511-1515 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T84139 121-127 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T62520 180-184 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T10106 633-639 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T48615 783-790 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T61490 870-873 Body_part denotes gut http://purl.org/sig/ont/fma/fma7199
T52504 895-898 Body_part denotes gut http://purl.org/sig/ont/fma/fma7199
T32643 1318-1322 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T83622 1511-1515 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T97716 2455-2462 Body_part denotes hormone http://purl.org/sig/ont/fma/fma12278
T78890 2652-2659 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T18548 2873-2878 Body_part denotes teeth http://purl.org/sig/ont/fma/fma314001
T75563 2959-2965 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T29941 2994-3001 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T5314 3217-3223 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T17 100-110 Disease denotes sarcopenia http://purl.obolibrary.org/obo/MONDO_0006516
T18 449-473 Disease denotes type 2 diabetes mellitus http://purl.obolibrary.org/obo/MONDO_0005148
T19 456-464 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T20 633-647 Disease denotes muscle wasting http://purl.obolibrary.org/obo/MONDO_0004323
T21 999-1011 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T22 1166-1190 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T23 1192-1200 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T24 1245-1255 Disease denotes sarcopenia http://purl.obolibrary.org/obo/MONDO_0006516
T25 1476-1485 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T26 1572-1580 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T27 1886-1896 Disease denotes sarcopenia http://purl.obolibrary.org/obo/MONDO_0006516
T28 2136-2144 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T29 2604-2614 Disease denotes sarcopenia http://purl.obolibrary.org/obo/MONDO_0006516
T30 3125-3135 Disease denotes sarcopenia http://purl.obolibrary.org/obo/MONDO_0006516

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T35774 112-127 http://purl.obolibrary.org/obo/UBERON_0001134 denotes skeletal muscle
T4366 112-127 http://purl.obolibrary.org/obo/UBERON_0014892 denotes skeletal muscle
T73667 112-127 http://www.ebi.ac.uk/efo/EFO_0000888 denotes skeletal muscle
T64354 193-194 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T32328 633-639 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T72292 633-639 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T7419 633-639 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T84772 633-639 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T88808 728-729 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T46996 796-799 http://purl.obolibrary.org/obo/UBERON_0001013 denotes fat
T52401 870-873 http://purl.obolibrary.org/obo/UBERON_0001007 denotes gut
T23471 870-873 http://purl.obolibrary.org/obo/UBERON_0001555 denotes gut
T68933 870-873 http://www.ebi.ac.uk/efo/EFO_0000834 denotes gut
T11530 895-898 http://purl.obolibrary.org/obo/UBERON_0001007 denotes gut
T49620 895-898 http://purl.obolibrary.org/obo/UBERON_0001555 denotes gut
T32612 895-898 http://www.ebi.ac.uk/efo/EFO_0000834 denotes gut
T40154 1306-1308 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T17295 1361-1362 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T7537 1533-1536 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T38921 1911-1912 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T82771 2146-2148 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T7480 2151-2152 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T18967 2202-2208 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T49570 2369-2374 http://purl.obolibrary.org/obo/CLO_0001195 denotes 2 [19
T85988 2743-2751 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T56401 2814-2824 http://purl.obolibrary.org/obo/UBERON_0005409 denotes (GI) tract
T13108 2959-2965 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T28523 2959-2965 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T6036 2959-2965 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T62249 2959-2965 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T59129 3208-3223 http://purl.obolibrary.org/obo/UBERON_0001134 denotes skeletal muscle
T93231 3208-3223 http://purl.obolibrary.org/obo/UBERON_0014892 denotes skeletal muscle
T55365 3208-3223 http://www.ebi.ac.uk/efo/EFO_0000888 denotes skeletal muscle

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T12 348-356 Chemical denotes radicals http://purl.obolibrary.org/obo/CHEBI_26519
T13 522-524 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T14 783-790 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T15 2434-2446 Chemical denotes testosterone http://purl.obolibrary.org/obo/CHEBI_17347
T16 2448-2462 Chemical denotes growth hormone http://purl.obolibrary.org/obo/CHEBI_37845
T17 2455-2462 Chemical denotes hormone http://purl.obolibrary.org/obo/CHEBI_24621
T18 2477-2485 Chemical denotes steroids http://purl.obolibrary.org/obo/CHEBI_35341
T19 2652-2659 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T20 2815-2817 Chemical denotes GI http://purl.obolibrary.org/obo/CHEBI_73907
T21 2994-3001 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T22 3020-3025 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T56212 272-277 http://purl.obolibrary.org/obo/GO_0007568 denotes aging
T81684 999-1011 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T87054 1058-1063 http://purl.obolibrary.org/obo/GO_0007568 denotes aging
T76041 2448-2454 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T45761 2880-2885 http://purl.obolibrary.org/obo/GO_0050909 denotes taste
T38870 3194-3199 http://purl.obolibrary.org/obo/GO_0007568 denotes aging

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T6 456-473 Phenotype denotes diabetes mellitus http://purl.obolibrary.org/obo/HP_0000819
T7 633-647 Phenotype denotes muscle wasting http://purl.obolibrary.org/obo/HP_0003202
T8 1016-1032 Phenotype denotes oxidative stress http://purl.obolibrary.org/obo/HP_0025464
T9 2043-2048 Phenotype denotes falls http://purl.obolibrary.org/obo/HP_0002527
T10 2865-2878 Phenotype denotes loss of teeth http://purl.obolibrary.org/obo/HP_0006480

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T19 0-2 Sentence denotes 1.
T20 3-15 Sentence denotes Introduction
T21 16-166 Sentence denotes While the numbers of older adults are expanding all over the world, the pandemic of sarcopenia, skeletal muscle loss/weakness is also on the rise [1].
T22 167-310 Sentence denotes Loss of lean body mass is a direct effect of the inflammatory and oxidative conditions that develop with aging [1,2]—described as inflammaging.
T23 311-608 Sentence denotes Both inflammatory mediators and free radicals, which are highly expressed in older seniors and in patients with chronic diseases, such as type 2 diabetes mellitus, cause remarkable shrinkage of fast-twitch type II fibers promoting their transformation into the slow-twitch type I fibers [1,3,4,5].
T24 609-819 Sentence denotes Research indicates that muscle wasting may develop after adolescence (at the beginning of the third decade of life) as a result of sedentary lifestyle and improper diet (low protein/high fat/low fiber) [6,7,8].
T25 820-1098 Sentence denotes These behavioral factors alter the composition of gut microbiota promoting gut dysbiosis, which allows the passage of bacterial endotoxins into the systemic circulation to induce inflammation and oxidative stress same as in immunological aging that occurs during old age [9,10].
T26 1099-1310 Sentence denotes Longitudinal data show that the currently-occurring global crisis, coronavirus disease 2019 (COVID-19), is likely to aggravate the development of sarcopenia in young groups by promoting unhealthy lifestyle [11].
T27 1311-1497 Sentence denotes On one hand, physical inactivity is increasing as a result of the lockdown measures and stay home strategies adopted by most governments to limit the spread of this infection [11,12,13].
T28 1498-1739 Sentence denotes On the other hand, food production has been seriously affected during the COVID-19 outbreak along with increase in food prices, which prompt people to consume unhealthy/processed foods since they are cheaper than fresh and healthy ones [14].
T29 1740-1942 Sentence denotes Given its high prevalence in the general population, which ranges between 5 and 40% in western countries and increases up to 50% in advanced age, sarcopenia is considered a public health problem [4,15].
T30 1943-2150 Sentence denotes It causes progressive decline of functional capacity, contributes to frailty, increases the risk of falls and hospitalization in old people [16,17], and leads to poor outcomes in patients with COVID-19 [18].
T31 2151-2332 Sentence denotes A large number of pharmacological agents are being tested as anti-sarcopenic agents such as bimagrumab (BYM338), enobasarm (GTx-024), trevogrumab (REGN1033), and sarconeos (BIO101).
T32 2333-2376 Sentence denotes Most trials are in phase 1 or phase 2 [19].
T33 2377-2532 Sentence denotes In addition, outcomes of commonly used treatments (e.g., testosterone, growth hormone, and anabolic steroids) have been rather unsatisfactory [4,20,21,22].
T34 2533-2677 Sentence denotes Therefore, the most appropriate strategies for preventing and treating sarcopenia are limited to physical exercise and protein-rich diet [6,21].
T35 2678-2769 Sentence denotes Nevertheless, old people tend to be less compliant with physical activity programs [23,24].
T36 2770-3034 Sentence denotes Meanwhile, problems of the gastrointestinal (GI) tract that develop during advanced age (e.g., loss of teeth, taste, smell, and decreased absorption) as well as anabolic resistance of aged muscle limit potential benefits of protein-rich food in this group [25,26].
T37 3035-3232 Sentence denotes Therefore, it is of importance to search for novel preventive and curative strategies for sarcopenia, which can take into account the multifactorial nature of aging-related skeletal muscle failure.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
59 409-417 Species denotes patients Tax:9606
60 100-110 Disease denotes sarcopenia MESH:D055948
61 121-141 Disease denotes muscle loss/weakness MESH:D018908
62 423-439 Disease denotes chronic diseases MESH:D002908
63 449-473 Disease denotes type 2 diabetes mellitus MESH:D003924
69 1087-1090 Gene denotes age Gene:81759
70 796-799 Gene denotes fat Gene:83720
71 633-647 Disease denotes muscle wasting MESH:D009133
72 899-908 Disease denotes dysbiosis MESH:D064806
73 999-1011 Disease denotes inflammation MESH:D007249
80 1639-1645 Species denotes people Tax:9606
81 1166-1190 Disease denotes coronavirus disease 2019 MESH:C000657245
82 1192-1200 Disease denotes COVID-19 MESH:C000657245
83 1245-1255 Disease denotes sarcopenia MESH:D055948
84 1476-1485 Disease denotes infection MESH:D007239
85 1572-1580 Disease denotes COVID-19 MESH:C000657245
106 2448-2462 Gene denotes growth hormone Gene:81668
107 2854-2857 Gene denotes age Gene:81759
108 1881-1884 Gene denotes age Gene:81759
109 2076-2082 Species denotes people Tax:9606
110 2122-2130 Species denotes patients Tax:9606
111 2696-2702 Species denotes people Tax:9606
112 2243-2253 Chemical denotes bimagrumab MESH:C000596367
113 2255-2261 Chemical denotes BYM338 MESH:C000596367
114 2264-2273 Chemical denotes enobasarm
115 2275-2282 Chemical denotes GTx-024 MESH:C547106
116 2285-2296 Chemical denotes trevogrumab
117 2298-2306 Chemical denotes REGN1033
118 2434-2446 Chemical denotes testosterone MESH:D013739
119 2477-2485 Chemical denotes steroids MESH:D013256
120 1886-1896 Disease denotes sarcopenia MESH:D055948
121 2136-2144 Disease denotes COVID-19 MESH:C000657245
122 2604-2614 Disease denotes sarcopenia MESH:D055948
123 2865-2878 Disease denotes loss of teeth MESH:D018677
124 3125-3135 Disease denotes sarcopenia MESH:D055948
125 3208-3231 Disease denotes skeletal muscle failure MESH:D017093