PMC:7601109 / 25600-26669 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7601109","sourcedb":"PMC","sourceid":"7601109","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7601109","text":"Several lines of evidence support the anti-allergic effect of propolis and royal jelly. This effect involves inhibiting mast cell degranulation, suppressing cysteinyl-leukotriene release, as well as reducing serum histamine, IgG, and IgE levels in various allergic conditions by suppressing histamine H1 receptor [37,39,92]. Nevertheless, rare allergic reactions to bee products other than bee venom are documented in the literature. They are most frequent in small children [80,93]. Examples of such reactions comprise contact dermatitis in beekeepers following the handling of propolis, as well as contact stomatitis and oral mucositis after the usage of lozenges containing propolis [80]. Hence, bee products should be used with caution, especially in people with known allergies, pregnant and lactating women, and small children [61]. In addition, bee products can be safely consumed after adequate processing. Processing involves removal of known allergens such as enzyme treatment of royal jelly and filtration of bee venom by stepped-gradient open column 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