PMC:7601109 / 25600-26669 JSONTXT

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T16","span":{"begin":208,"end":213},"obj":"Body_part"},{"id":"T17","span":{"begin":394,"end":399},"obj":"Body_part"},{"id":"T18","span":{"begin":1024,"end":1029},"obj":"Body_part"}],"attributes":[{"id":"A16","pred":"uberon_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A17","pred":"uberon_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/UBERON_0007113"},{"id":"A18","pred":"uberon_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/UBERON_0007113"}],"text":"Several lines of evidence support the anti-allergic effect of propolis and royal jelly. This effect involves inhibiting mast cell degranulation, suppressing cysteinyl-leukotriene release, as well as reducing serum histamine, IgG, and IgE levels in various allergic conditions by suppressing histamine H1 receptor [37,39,92]. Nevertheless, rare allergic reactions to bee products other than bee venom are documented in the literature. They are most frequent in small children [80,93]. Examples of such reactions comprise contact dermatitis in beekeepers following the handling of propolis, as well as contact stomatitis and oral mucositis after the usage of lozenges containing propolis [80]. Hence, bee products should be used with caution, especially in people with known allergies, pregnant and lactating women, and small children [61]. In addition, bee products can be safely consumed after adequate processing. Processing involves removal of known allergens such as enzyme treatment of royal jelly and filtration of bee venom by stepped-gradient open column [2,94]."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T52442","span":{"begin":120,"end":129},"obj":"Body_part"},{"id":"T7654","span":{"begin":125,"end":129},"obj":"Body_part"},{"id":"T21762","span":{"begin":208,"end":213},"obj":"Body_part"},{"id":"T56782","span":{"begin":214,"end":223},"obj":"Body_part"},{"id":"T44961","span":{"begin":225,"end":228},"obj":"Body_part"},{"id":"T89548","span":{"begin":234,"end":237},"obj":"Body_part"},{"id":"T15375","span":{"begin":291,"end":300},"obj":"Body_part"},{"id":"T96020","span":{"begin":301,"end":312},"obj":"Body_part"}],"attributes":[{"id":"A40617","pred":"fma_id","subj":"T52442","obj":"http://purl.org/sig/ont/fma/fma66784"},{"id":"A91990","pred":"fma_id","subj":"T7654","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A1662","pred":"fma_id","subj":"T21762","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A60969","pred":"fma_id","subj":"T56782","obj":"http://purl.org/sig/ont/fma/fma61806"},{"id":"A41535","pred":"fma_id","subj":"T44961","obj":"http://purl.org/sig/ont/fma/fma62872"},{"id":"A57416","pred":"fma_id","subj":"T89548","obj":"http://purl.org/sig/ont/fma/fma62875"},{"id":"A15072","pred":"fma_id","subj":"T15375","obj":"http://purl.org/sig/ont/fma/fma61806"},{"id":"A89770","pred":"fma_id","subj":"T96020","obj":"http://purl.org/sig/ont/fma/fma61983"}],"text":"Several lines of evidence support the anti-allergic effect of propolis and royal jelly. This effect involves inhibiting mast cell degranulation, suppressing cysteinyl-leukotriene release, as well as reducing serum histamine, IgG, and IgE levels in various allergic conditions by suppressing histamine H1 receptor [37,39,92]. Nevertheless, rare allergic reactions to bee products other than bee venom are documented in the literature. They are most frequent in small children [80,93]. Examples of such reactions comprise contact dermatitis in beekeepers following the handling of propolis, as well as contact stomatitis and oral mucositis after the usage of lozenges containing propolis [80]. Hence, bee products should be used with caution, especially in people with known allergies, pregnant and lactating women, and small children [61]. In addition, bee products can be safely consumed after adequate processing. Processing involves removal of known allergens such as enzyme treatment of royal jelly and filtration of bee venom by stepped-gradient open column [2,94]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T50","span":{"begin":43,"end":51},"obj":"Disease"},{"id":"T51","span":{"begin":256,"end":264},"obj":"Disease"},{"id":"T52","span":{"begin":344,"end":362},"obj":"Disease"},{"id":"T54","span":{"begin":344,"end":352},"obj":"Disease"},{"id":"T55","span":{"begin":520,"end":538},"obj":"Disease"},{"id":"T56","span":{"begin":528,"end":538},"obj":"Disease"},{"id":"T57","span":{"begin":608,"end":618},"obj":"Disease"},{"id":"T58","span":{"begin":623,"end":637},"obj":"Disease"},{"id":"T59","span":{"begin":628,"end":637},"obj":"Disease"}],"attributes":[{"id":"A50","pred":"mondo_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/MONDO_0004980"},{"id":"A51","pred":"mondo_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/MONDO_0004980"},{"id":"A52","pred":"mondo_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/MONDO_0000605"},{"id":"A53","pred":"mondo_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/MONDO_0005271"},{"id":"A54","pred":"mondo_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/MONDO_0004980"},{"id":"A55","pred":"mondo_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/MONDO_0005480"},{"id":"A56","pred":"mondo_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/MONDO_0002406"},{"id":"A57","pred":"mondo_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/MONDO_0004842"},{"id":"A58","pred":"mondo_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/MONDO_0004842"},{"id":"A59","pred":"mondo_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/MONDO_0000888"},{"id":"A60","pred":"mondo_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/MONDO_0020579"}],"text":"Several lines of evidence support the anti-allergic effect of propolis and royal jelly. This effect involves inhibiting mast cell degranulation, suppressing cysteinyl-leukotriene release, as well as reducing serum histamine, IgG, and IgE levels in various allergic conditions by suppressing histamine H1 receptor [37,39,92]. Nevertheless, rare allergic reactions to bee products other than bee venom are documented in the literature. They are most frequent in small children [80,93]. Examples of such reactions comprise contact dermatitis in beekeepers following the handling of propolis, as well as contact stomatitis and oral mucositis after the usage of lozenges containing propolis [80]. Hence, bee products should be used with caution, especially in people with known allergies, pregnant and lactating women, and small children [61]. In addition, bee products can be safely consumed after adequate processing. Processing involves removal of known allergens such as enzyme treatment of royal jelly and filtration of bee venom by stepped-gradient open column [2,94]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T224","span":{"begin":125,"end":129},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Several lines of evidence support the anti-allergic effect of propolis and royal jelly. This effect involves inhibiting mast cell degranulation, suppressing cysteinyl-leukotriene release, as well as reducing serum histamine, IgG, and IgE levels in various allergic conditions by suppressing histamine H1 receptor [37,39,92]. Nevertheless, rare allergic reactions to bee products other than bee venom are documented in the literature. They are most frequent in small children [80,93]. Examples of such reactions comprise contact dermatitis in beekeepers following the handling of propolis, as well as contact stomatitis and oral mucositis after the usage of lozenges containing propolis [80]. Hence, bee products should be used with caution, especially in people with known allergies, pregnant and lactating women, and small children [61]. In addition, bee products can be safely consumed after adequate processing. Processing involves removal of known allergens such as enzyme treatment of royal jelly and filtration of bee venom by stepped-gradient open column [2,94]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T403","span":{"begin":75,"end":86},"obj":"Chemical"},{"id":"T404","span":{"begin":157,"end":166},"obj":"Chemical"},{"id":"T406","span":{"begin":167,"end":178},"obj":"Chemical"},{"id":"T407","span":{"begin":214,"end":223},"obj":"Chemical"},{"id":"T409","span":{"begin":291,"end":300},"obj":"Chemical"},{"id":"T411","span":{"begin":394,"end":399},"obj":"Chemical"},{"id":"T412","span":{"begin":990,"end":1001},"obj":"Chemical"},{"id":"T413","span":{"begin":1024,"end":1029},"obj":"Chemical"}],"attributes":[{"id":"A403","pred":"chebi_id","subj":"T403","obj":"http://purl.obolibrary.org/obo/CHEBI_78665"},{"id":"A404","pred":"chebi_id","subj":"T404","obj":"http://purl.obolibrary.org/obo/CHEBI_23511"},{"id":"A405","pred":"chebi_id","subj":"T404","obj":"http://purl.obolibrary.org/obo/CHEBI_32460"},{"id":"A406","pred":"chebi_id","subj":"T406","obj":"http://purl.obolibrary.org/obo/CHEBI_25029"},{"id":"A407","pred":"chebi_id","subj":"T407","obj":"http://purl.obolibrary.org/obo/CHEBI_18295"},{"id":"A408","pred":"chebi_id","subj":"T407","obj":"http://purl.obolibrary.org/obo/CHEBI_58432"},{"id":"A409","pred":"chebi_id","subj":"T409","obj":"http://purl.obolibrary.org/obo/CHEBI_18295"},{"id":"A410","pred":"chebi_id","subj":"T409","obj":"http://purl.obolibrary.org/obo/CHEBI_58432"},{"id":"A411","pred":"chebi_id","subj":"T411","obj":"http://purl.obolibrary.org/obo/CHEBI_78505"},{"id":"A412","pred":"chebi_id","subj":"T412","obj":"http://purl.obolibrary.org/obo/CHEBI_78665"},{"id":"A413","pred":"chebi_id","subj":"T413","obj":"http://purl.obolibrary.org/obo/CHEBI_78505"}],"text":"Several lines of evidence support the anti-allergic effect of propolis and royal jelly. This effect involves inhibiting mast cell degranulation, suppressing cysteinyl-leukotriene release, as well as reducing serum histamine, IgG, and IgE levels in various allergic conditions by suppressing histamine H1 receptor [37,39,92]. Nevertheless, rare allergic reactions to bee products other than bee venom are documented in the literature. They are most frequent in small children [80,93]. Examples of such reactions comprise contact dermatitis in beekeepers following the handling of propolis, as well as contact stomatitis and oral mucositis after the usage of lozenges containing propolis [80]. Hence, bee products should be used with caution, especially in people with known allergies, pregnant and lactating women, and small children [61]. In addition, bee products can be safely consumed after adequate processing. Processing involves removal of known allergens such as enzyme treatment of royal jelly and filtration of bee venom by stepped-gradient open column [2,94]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T33","span":{"begin":109,"end":143},"obj":"http://purl.obolibrary.org/obo/GO_0043305"},{"id":"T34","span":{"begin":120,"end":143},"obj":"http://purl.obolibrary.org/obo/GO_0043303"}],"text":"Several lines of evidence support the anti-allergic effect of propolis and royal jelly. This effect involves inhibiting mast cell degranulation, suppressing cysteinyl-leukotriene release, as well as reducing serum histamine, IgG, and IgE levels in various allergic conditions by suppressing histamine H1 receptor [37,39,92]. Nevertheless, rare allergic reactions to bee products other than bee venom are documented in the literature. They are most frequent in small children [80,93]. Examples of such reactions comprise contact dermatitis in beekeepers following the handling of propolis, as well as contact stomatitis and oral mucositis after the usage of lozenges containing propolis [80]. Hence, bee products should be used with caution, especially in people with known allergies, pregnant and lactating women, and small children [61]. In addition, bee products can be safely consumed after adequate processing. Processing involves removal of known allergens such as enzyme treatment of royal jelly and filtration of bee venom by stepped-gradient open column [2,94]."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T28","span":{"begin":520,"end":538},"obj":"Phenotype"},{"id":"T29","span":{"begin":608,"end":618},"obj":"Phenotype"}],"attributes":[{"id":"A28","pred":"hp_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/HP_0032282"},{"id":"A29","pred":"hp_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/HP_0010280"}],"text":"Several lines of evidence support the anti-allergic effect of propolis and royal jelly. This effect involves inhibiting mast cell degranulation, suppressing cysteinyl-leukotriene release, as well as reducing serum histamine, IgG, and IgE levels in various allergic conditions by suppressing histamine H1 receptor [37,39,92]. Nevertheless, rare allergic reactions to bee products other than bee venom are documented in the literature. They are most frequent in small children [80,93]. Examples of such reactions comprise contact dermatitis in beekeepers following the handling of propolis, as well as contact stomatitis and oral mucositis after the usage of lozenges containing propolis [80]. Hence, bee products should be used with caution, especially in people with known allergies, pregnant and lactating women, and small children [61]. In addition, bee products can be safely consumed after adequate processing. Processing involves removal of known allergens such as enzyme treatment of royal jelly and filtration of bee venom by stepped-gradient open column [2,94]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T166","span":{"begin":0,"end":87},"obj":"Sentence"},{"id":"T167","span":{"begin":88,"end":324},"obj":"Sentence"},{"id":"T168","span":{"begin":325,"end":433},"obj":"Sentence"},{"id":"T169","span":{"begin":434,"end":483},"obj":"Sentence"},{"id":"T170","span":{"begin":484,"end":691},"obj":"Sentence"},{"id":"T171","span":{"begin":692,"end":838},"obj":"Sentence"},{"id":"T172","span":{"begin":839,"end":914},"obj":"Sentence"},{"id":"T173","span":{"begin":915,"end":1069},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Several lines of evidence support the anti-allergic effect of propolis and royal jelly. This effect involves inhibiting mast cell degranulation, suppressing cysteinyl-leukotriene release, as well as reducing serum histamine, IgG, and IgE levels in various allergic conditions by suppressing histamine H1 receptor [37,39,92]. Nevertheless, rare allergic reactions to bee products other than bee venom are documented in the literature. They are most frequent in small children [80,93]. Examples of such reactions comprise contact dermatitis in beekeepers following the handling of propolis, as well as contact stomatitis and oral mucositis after the usage of lozenges containing propolis [80]. Hence, bee products should be used with caution, especially in people with known allergies, pregnant and lactating women, and small children [61]. In addition, bee products can be safely consumed after adequate processing. Processing involves removal of known allergens such as enzyme treatment of royal jelly and filtration of bee venom by stepped-gradient open column [2,94]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"498","span":{"begin":291,"end":312},"obj":"Gene"},{"id":"499","span":{"begin":466,"end":474},"obj":"Species"},{"id":"500","span":{"begin":755,"end":761},"obj":"Species"},{"id":"501","span":{"begin":807,"end":812},"obj":"Species"},{"id":"502","span":{"begin":824,"end":832},"obj":"Species"},{"id":"503","span":{"begin":75,"end":86},"obj":"Chemical"},{"id":"504","span":{"begin":157,"end":178},"obj":"Chemical"},{"id":"505","span":{"begin":214,"end":223},"obj":"Chemical"},{"id":"506","span":{"begin":43,"end":51},"obj":"Disease"},{"id":"507","span":{"begin":256,"end":264},"obj":"Disease"},{"id":"508","span":{"begin":344,"end":362},"obj":"Disease"},{"id":"509","span":{"begin":528,"end":538},"obj":"Disease"},{"id":"510","span":{"begin":608,"end":618},"obj":"Disease"},{"id":"511","span":{"begin":623,"end":637},"obj":"Disease"}],"attributes":[{"id":"A498","pred":"tao:has_database_id","subj":"498","obj":"Gene:24448"},{"id":"A499","pred":"tao:has_database_id","subj":"499","obj":"Tax:9606"},{"id":"A500","pred":"tao:has_database_id","subj":"500","obj":"Tax:9606"},{"id":"A501","pred":"tao:has_database_id","subj":"501","obj":"Tax:9606"},{"id":"A502","pred":"tao:has_database_id","subj":"502","obj":"Tax:9606"},{"id":"A503","pred":"tao:has_database_id","subj":"503","obj":"MESH:C058787"},{"id":"A504","pred":"tao:has_database_id","subj":"504","obj":"MESH:C112381"},{"id":"A505","pred":"tao:has_database_id","subj":"505","obj":"MESH:D006632"},{"id":"A506","pred":"tao:has_database_id","subj":"506","obj":"MESH:D004342"},{"id":"A507","pred":"tao:has_database_id","subj":"507","obj":"MESH:D004342"},{"id":"A508","pred":"tao:has_database_id","subj":"508","obj":"MESH:D004342"},{"id":"A509","pred":"tao:has_database_id","subj":"509","obj":"MESH:D003872"},{"id":"A510","pred":"tao:has_database_id","subj":"510","obj":"MESH:D013280"},{"id":"A511","pred":"tao:has_database_id","subj":"511","obj":"MESH:D009059"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Several lines of evidence support the anti-allergic effect of propolis and royal jelly. This effect involves inhibiting mast cell degranulation, suppressing cysteinyl-leukotriene release, as well as reducing serum histamine, IgG, and IgE levels in various allergic conditions by suppressing histamine H1 receptor [37,39,92]. Nevertheless, rare allergic reactions to bee products other than bee venom are documented in the literature. They are most frequent in small children [80,93]. Examples of such reactions comprise contact dermatitis in beekeepers following the handling of propolis, as well as contact stomatitis and oral mucositis after the usage of lozenges containing propolis [80]. Hence, bee products should be used with caution, especially in people with known allergies, pregnant and lactating women, and small children [61]. In addition, bee products can be safely consumed after adequate processing. Processing involves removal of known allergens such as enzyme treatment of royal jelly and filtration of bee venom by stepped-gradient open column [2,94]."}